Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF microcirculation through coordinated ciliary beating. Although the ependyma is a highly specialized brain interface with barrier, trophic, and perhaps even regenerative capacity, it remains a misfit in the canon of glial neurobiology. We provide an update to seminal reviews in the field by conducting a scoping review of the post-2010 mature multiciliated ependymal cell literature. We delineate how recent findings have either called into question or substantiated classical views of the ependymal cell. Beyond this synthesis, we document the basic methodologies and study characteristics used to describe multiciliated ependymal cells since 1980. Our review serves as a comprehensive resource for future investigations of mature multiciliated ependymal cells.

成熟的多纤毛室管膜细胞排列在脑室中，在脑室之间形成部分屏障，并通过协调睫状跳动调节局部 CSF 微循环。尽管室管膜是一个高度专业化的大脑接口，具有屏障、营养甚至再生能力，但它在神经胶质神经生物学的经典中仍然不合适。我们通过对 2010 年后成熟的多纤毛室管膜细胞文献进行范围审查，为该领域的开创性审查提供了更新。我们描述了最近的发现如何质疑或证实室管膜细胞的经典观点。除了这种综合之外，我们还记录了自 1980 年以来用于描述多纤毛室管膜细胞的基本方法和研究特征。我们的综述为未来研究成熟多纤毛室管膜细胞提供了全面的资源。