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Antigen presentation by MHC-II is shaped by competitive and cooperative allosteric mechanisms of peptide exchange Structure (IF 4.4) Pub Date : 2024-12-20 Matthias Günther, Jana Sticht, Christian Freund, Thomas Höfer
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Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM Structure (IF 4.4) Pub Date : 2024-12-20 Kavita A. Iyer, Takuya Kobayashi, Takashi Murayama, Montserrat Samsó
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Systematic characterization of indel variants using a yeast-based protein folding sensor Structure (IF 4.4) Pub Date : 2024-12-19 Sven Larsen-Ledet, Søren Lindemose, Aleksandra Panfilova, Sarah Gersing, Caroline H. Suhr, Aitana Victoria Genzor, Heleen Lanters, Sofie V. Nielsen, Kresten Lindorff-Larsen, Jakob R. Winther, Amelie Stein, Rasmus Hartmann-Petersen
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Conformational response of αIIbβ3 and αVβ3 integrins to force Structure (IF 4.4) Pub Date : 2024-12-19 Reza Kolasangiani, Khashayar Farzanian, Yunfeng Chen, Martin A. Schwartz, Tamara C. Bidone
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Near-atomic cryo-EM structure of the light-harvesting complex LH2 from the sulfur purple bacterium Ectothiorhodospira haloalkaliphila Structure (IF 4.4) Pub Date : 2024-12-17 Anna D. Burtseva, Timur N. Baymukhametov, Maxim A. Bolshakov, Zoya К. Makhneva, Andrey V. Mardanov, Andrey M. Tsedilin, Huawei Zhang, Vladimir.O. Popov, Aleksandr A. Ashikhmin, Konstantin M. Boyko
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Structural insights into subunit-dependent functional regulation in epithelial sodium channels Structure (IF 4.4) Pub Date : 2024-12-11 Alexandra Houser, Isabelle Baconguis
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Automated fibril structure calculations in Xplor-NIH Structure (IF 4.4) Pub Date : 2024-12-10 Alexander M. Barclay, Moses H. Milchberg, Owen A. Warmuth, Marcus D. Tuttle, Christopher J. Dennis, Charles D. Schwieters, Chad M. Rienstra
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Ion coupling and inhibitory mechanisms of the human presynaptic high-affinity choline transporter CHT1 Structure (IF 4.4) Pub Date : 2024-12-09 Yunlong Qiu, Yiwei Gao, Qinru Bai, Yan Zhao
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Assembly of the Xrn2/Rat1–Rai1–Rtt103 termination complexes in mesophilic and thermophilic organisms Structure (IF 4.4) Pub Date : 2024-12-09 Alzbeta Dikunova, Nikola Noskova, Jan H. Overbeck, Martin Polak, David Stelzig, David Zapletal, Karel Kubicek, Jiri Novacek, Remco Sprangers, Richard Stefl
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Cost-benefit analysis of cryogenic electron tomography subtomogram averaging of chaperonin MmCpn at near atomic resolution Structure (IF 4.4) Pub Date : 2024-12-06 Yanyan Zhao, Michael F. Schmid, Wah Chiu
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Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy Structure (IF 4.4) Pub Date : 2024-12-05 Wei-Feng Xue
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Mechanistic and structural insights into EstS1 esterase: A potent broad-spectrum phthalate diester degrading enzyme Structure (IF 4.4) Pub Date : 2024-12-05 Shalja Verma, Shweta Choudhary, Kamble Amith Kumar, Jai Krishna Mahto, Anil Kumar Vamsi K, Ishani Mishra, Vellanki Bhanu Prakash, Debabrata Sircar, Shailly Tomar, Ashwani Kumar Sharma, Jitin Singla, Pravindra Kumar
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Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation? Structure (IF 4.4) Pub Date : 2024-12-05 Mineyuki Mizuguchi
In this issue of Structure, Nguyen et al.1 reveal that amyloid fibrils of the transthyretin (TTR) V30M variant from the heart and nerves of the same patient exhibit structural homogeneity. This finding is crucial for advancing our understanding of V30M-TTR amyloid deposition, which leads to fatal ATTRv amyloidosis.
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A finger that gets in the way: When binding isn’t just about the bound state Structure (IF 4.4) Pub Date : 2024-12-05 David Neuhaus, Katherine Stott
In this issue of Structure, Viennet et al.1 report a study characterizing the DNA binding by a three-zinc-finger fragment from the transcription factor BCL11A, with the unusual feature that an interfinger interaction in the free protein is disrupted during binding, which provides a positive entropic contribution that enhances the affinity.
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The universal Rhs shell structure accommodates various toxins inside and different functional decorations on the outside Structure (IF 4.4) Pub Date : 2024-12-05
In this issue of Structure, Kielkopf et al.1 report the crystal structures of Rhs proteins that are genetically fused to the type VI secretion system …
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Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease Structure (IF 4.4) Pub Date : 2024-12-04 Peter Rory Hall, Thibault Jouen-Tachoire, Marcus Schewe, Peter Proks, Thomas Baukrowitz, Elisabeth P. Carpenter, Simon Newstead, Karin E.J. Rödström, Stephen J. Tucker
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Unveiling the structural proteome of an Alzheimer’s disease rat brain model Structure (IF 4.4) Pub Date : 2024-11-29 Elnaz Khalili Samani, S.M. Naimul Hasan, Matthew Waas, Alexander F.A. Keszei, Xiaoxiao Xu, Mahtab Heydari, Mary Elizabeth Hill, JoAnne McLaurin, Thomas Kislinger, Mohammad T. Mazhab-Jafari
Studying native protein structures at near-atomic resolution in a crowded environment presents challenges. Consequently, understanding the structural intricacies of proteins within pathologically affected tissues often relies on mass spectrometry and proteomic analysis. Here, we utilized cryoelectron microscopy (cryo-EM) and the Build and Retrieve (BaR) method to investigate protein complexes’ structural
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Protein translocation through α-helical channels and insertases Structure (IF 4.4) Pub Date : 2024-11-25 Jingxia Chen, Xueyin Zhou, Yuqi Yang, Long Li
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The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail Structure (IF 4.4) Pub Date : 2024-11-22 Patryk Ludzia, Midori Ishii, Gauri Deák, Christos Spanos, Marcus D. Wilson, Christina Redfield, Bungo Akiyoshi
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Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography Structure (IF 4.4) Pub Date : 2024-11-21 Joao Ramos, Valerie Laux, Sax A. Mason, Marie-Hélène Lemée, Matthew W. Bowler, Kay Diederichs, Michael Haertlein, V. Trevor Forsyth, Estelle Mossou, Sine Larsen, Annette E. Langkilde
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Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers Structure (IF 4.4) Pub Date : 2024-11-19 Anna Yudenko, Sergey Bukhdruker, Pavel Shishkin, Sergey Rodin, Anastasia Burtseva, Aleksandr Petrov, Natalia Pigareva, Alexey Sokolov, Egor Zinovev, Igor Eliseev, Alina Remeeva, Egor Marin, Alexey Mishin, Valentin Gordeliy, Ivan Gushchin, Aleksandr Ischenko, Valentin Borshchevskiy
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The ALS drug riluzole binds to the C-terminal domain of SARS-CoV-2 nucleocapsid protein and has antiviral activity Structure (IF 4.4) Pub Date : 2024-11-13 María Ángeles Márquez-Moñino, Clara M. Santiveri, Patricia de León, Sergio Camero, Ramón Campos-Olivas, M. Ángeles Jiménez, Margarita Sáiz, Beatriz González, José Manuel Pérez-Cañadillas
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Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation Structure (IF 4.4) Pub Date : 2024-11-13 Cheng Li, Yunqiang Bian, Yiting Tang, Lingyu Meng, Peipei Yin, Ye Hong, Jun Cheng, Yuchen Li, Jie Lin, Chao Tang, Chunlai Chen, Wenfei Li, Zhi Qi
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Structural and biochemical insights into the mechanism of the anti-CRISPR protein AcrIE3 Structure (IF 4.4) Pub Date : 2024-11-13 Jasung Koo, Gyujin Lee, Changkon Park, Hyejin Oh, Sung-Hyun Hong, Jeong-Yong Suh, Euiyoung Bae
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Mechanism of negative μ-opioid receptor modulation by sodium ions Structure (IF 4.4) Pub Date : 2024-11-12 Neil J. Thomson, Ulrich Zachariae
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Targeting adhesion G protein-coupled receptors. Current status and future perspectives Structure (IF 4.4) Pub Date : 2024-11-08 Fabian Liessmann, Lukas von Bredow, Jens Meiler, Ines Liebscher
G protein-coupled receptors (GPCRs) orchestrate many physiological functions and are a crucial target in drug discovery. Adhesion GPCRs (aGPCRs), the second largest family within this superfamily, are promising yet underexplored targets for treating various diseases, including obesity, psychiatric disorders, and cancer. However, the receptors’ unique and complex structure and miscellaneous interactions
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Structure, function, surf, repeat: A week at Lorne Proteins 2024 Structure (IF 4.4) Pub Date : 2024-11-07 Rosemary J. Cater, Renae M. Ryan, Jonathan S. Oakhill, Peter Czabotar, James M. Murphy, Melissa J. Call
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Multi-step shapeshifting of SARS-CoV-2 Omicron spikes during fusion Structure (IF 4.4) Pub Date : 2024-11-07 Wang Xu, Yang Han, Maolin Lu
In this issue of Structure, Dey et al.1 employ single-molecule FRET to map the conformational trajectory of Omicron spikes during fusion, revealing a transition from pre-fusion to post-fusion through two intermediates. This study highlights the roles of acidic environments, Ca2+, and receptors in promoting SARS-CoV-2 cell entry.
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Traces of convergent evolution left in the structure of EgtB-IV Structure (IF 4.4) Pub Date : 2024-11-07 Taku Mizutani, Ikuro Abe
The enzymatically regioselective catalyzed incorporation of cysteine sulfoxide into histidine generates physiologically important antioxidants such as ergothioneine and ovothiol. In this issue of Structure, Ireland et al.1 report the crystal structure of EgtB-IV, which provides insights into the convergent evolution of sulfoxide synthase.
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Ringing the changes: Regulation of Parkin activity by different ubiquitin and ubiquitin-like proteins Structure (IF 4.4) Pub Date : 2024-11-07 Shalini Iyer, Chittaranjan Das
Phosphorylation of ubiquitin and the ubiquitin-like domain of Parkin, mediated by the kinase PINK1, is essential for the liberation of the E3 ligase from its autoinhibited state. In this issue of Structure, Lenka et al.1 provide the structural basis for the specificity and stronger Parkin activation by phospho-NEDD8 compared to phospho-ubiquitin.
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Visualizing the dual interaction of calcineurin with PI4KA and FAM126A Structure (IF 4.4) Pub Date : 2024-11-07 Qingtong Zhou, Xiao Liu, Ming-Wei Wang
In this issue of Structure, Shaw et al.1 visualize the PI4KA-TTC7B-FAM126A-calcineurin complex by combining cryo-EM, HDX-MS, and AlphaFold3, and reveal a dual interaction of calcineurin with PI4KA and FAM126A. This work promotes our understanding of calcineurin-regulated PI4KA activity and paves the way for further exploration of the roles of PI4KA in the plasma membrane.
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AI-driven mechanistic analysis of conformational dynamics in CNNM/CorC Mg2+ transporters Structure (IF 4.4) Pub Date : 2024-11-06 Jie Ma, Xingyu Song, Yosuke Funato, Xinyu Teng, Yichen Huang, Hiroaki Miki, Wenning Wang, Motoyuki Hattori
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IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding Structure (IF 4.4) Pub Date : 2024-11-06 Rawia Hamid, Danica J. Walsh, Eleonora Diamanti, Diana Aguilar, Antoine Lacour, Mostafa M. Hamed, Anna K.H. Hirsch
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Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane Structure (IF 4.4) Pub Date : 2024-11-05 Chrysa Soteriou, Mengfan Xu, Simon D. Connell, Arwen I.I. Tyler, Antreas C. Kalli, James L. Thorne
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Archaeal NusA2 is the ancestor of ribosomal protein eS7 in eukaryotes Structure (IF 4.4) Pub Date : 2024-11-05 Duy Khanh Phung, Simona Pilotto, Dorota Matelska, Fabian Blombach, Nikos Pinotsis, Ladislav Hovan, Francesco Luigi Gervasio, Finn Werner
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LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates Structure (IF 4.4) Pub Date : 2024-11-04 Saskia Lesire, Rodrigo Lata, Yannick Hoogvliets, Kune Herrebosch, Paulien Van De Velde, Anouk Speleers, Frauke Christ, Siska Van Belle, Zeger Debyser
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Structure-function analyses of human TRPV6 ancestral and derived haplotypes Structure (IF 4.4) Pub Date : 2024-11-04 Arthur Neuberger, Alexey Shalygin, Yury A. Trofimov, Irina I. Veretenenko, Kirill D. Nadezhdin, Nikolay A. Krylov, Thomas Gudermann, Roman G. Efremov, Vladimir Chubanov, Alexander I. Sobolevsky
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Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus Structure (IF 4.4) Pub Date : 2024-11-04 Wenping Wu, Han Fang, Huimin He, Jingyi Wu, Zijun Gong, Chunyang Li, Xinkai Pei, Xiaoling Xu
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High-resolution cryo-EM analysis of a Streptococcus pyogenes M-protein/human plasminogen complex Structure (IF 4.4) Pub Date : 2024-11-04 Bradley M. Readnour, Sheiny Tjia-Fleck, Nathan R. McCann, Yetunde A. Ayinuola, Francis J. Castellino
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Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation Structure (IF 4.4) Pub Date : 2024-11-01 Zhihan Bo, Thomas Rowntree, Steven Johnson, Hilman Nurmahdi, Richard J. Suckling, Johan Hill, Boguslawa Korona, Philip C. Weisshuhn, Devon Sheppard, Yao Meng, Shaoyan Liang, Edward D. Lowe, Susan M. Lea, Christina Redfield, Penny A. Handford
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GeoNet enables the accurate prediction of protein-ligand binding sites through interpretable geometric deep learning Structure (IF 4.4) Pub Date : 2024-11-01 Jiyun Han, Shizhuo Zhang, Mingming Guan, Qiuyu Li, Xin Gao, Juntao Liu
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Tau seeds catalyze fibril-type structures from GFP tau biosensor cells Structure (IF 4.4) Pub Date : 2024-11-01 Jinliang Wang, Christopher K. Williams, Michael A. DeTure, Shino D. Magaki, Dennis W. Dickson, Harry V. Vinters, Paul M. Seidler
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Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution Structure (IF 4.4) Pub Date : 2024-10-30 Shuvankar Dey, Purba Pahari, Srija Mukherjee, James B. Munro, Dibyendu Kumar Das
(Structure 32, 1910–1925.e1–e6; November 7, 2024)
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T6SS-associated Rhs toxin-encapsulating shells: Structural and bioinformatical insights into bacterial weaponry and self-protection Structure (IF 4.4) Pub Date : 2024-10-30 Claudia S. Kielkopf, Mikhail M. Shneider, Petr G. Leiman, Nicholas M.I. Taylor
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Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination Structure (IF 4.4) Pub Date : 2024-10-28 Donggyun Kim, Weijing Liu, Rosa Viner, Vadim Cherezov
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Three-dimensional structures of Vibrio cholerae typing podophage VP1 in two states Structure (IF 4.4) Pub Date : 2024-10-28 Hao Pang, Fenxia Fan, Jing Zheng, Hao Xiao, Zhixue Tan, Jingdong Song, Biao Kan, Hongrong Liu
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Structural insight into rabies virus neutralization revealed by an engineered antibody scaffold Structure (IF 4.4) Pub Date : 2024-10-28 Ashwini Kedari, Rommel Iheozor-Ejiofor, Petja Salminen, Hasan Uğurlu, Anna R. Mäkelä, Lev Levanov, Olli Vapalahti, Vesa P. Hytönen, Kalle Saksela, Ilona Rissanen
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Structural requirements for the specific binding of CRABP2 to cyclin D3 Structure (IF 4.4) Pub Date : 2024-10-26 Martyna W. Pastok, Charles W.E. Tomlinson, Shannon Turberville, Abbey M. Butler, Arnaud Baslé, Martin E.M. Noble, Jane A. Endicott, Ehmke Pohl, Natalie J. Tatum
(Structure 32, 2301–2315.e1–e6; December 5, 2024)
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ANTIPASTI: Interpretable prediction of antibody binding affinity exploiting normal modes and deep learning Structure (IF 4.4) Pub Date : 2024-10-25 Kevin Michalewicz, Mauricio Barahona, Barbara Bravi
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Exploiting cryo-EM structures of actomyosin-5a to reveal the physical properties of its lever Structure (IF 4.4) Pub Date : 2024-10-24 Molly S.C. Gravett, David P. Klebl, Oliver G. Harlen, Daniel J. Read, Stephen P. Muench, Sarah A. Harris, Michelle Peckham
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The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures Structure (IF 4.4) Pub Date : 2024-10-22 William J. Bradshaw, Gemma Harris, Opher Gileadi, Vittorio L. Katis
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Insights into the distinct membrane targeting mechanisms of WDR91 family proteins Structure (IF 4.4) Pub Date : 2024-10-18 Xinli Ma, Jian Li, Nan Liu, Surajit Banerjee, Xiaotong Hu, Xiaoyu Wang, Jianshu Dong, Kangdong Liu, Chonglin Yang, Zigang Dong
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Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6 Structure (IF 4.4) Pub Date : 2024-10-17 Thibault Viennet, Maolu Yin, Abhilash Jayaraj, Woojin Kim, Zhen-Yu J. Sun, Yuko Fujiwara, Kevin Zhang, Davide Seruggia, Hyuk-Soo Seo, Sirano Dhe-Paganon, Stuart H. Orkin, Haribabu Arthanari
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ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity Structure (IF 4.4) Pub Date : 2024-10-17 Binh An Nguyen, Shumaila Afrin, Anna Yakubovska, Virender Singh, Rose Pedretti, Parker Bassett, Maja Pekala, Jaime Vaquer Alicea, Peter Kunach, Lanie Wang, Andrew Lemoff, Barbara Kluve-Beckerman, Lorena Saelices
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Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins Structure (IF 4.4) Pub Date : 2024-10-16 Robert Karari Njenga, Julian Boele, Friedel Drepper, Kasturica Sinha, Eirini Marouda, Pitter F. Huesgen, Crysten Blaby-Haas, Hans-Georg Koch
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Structural requirements for the specific binding of CRABP2 to cyclin D3 Structure (IF 4.4) Pub Date : 2024-10-16 Martyna W. Pastok, Charles W.E. Tomlinson, Shannon Turberville, Abbey M. Butler, Arnaud Baslé, Martin E.M. Noble, Jane A. Endicott, Ehmke Pohl, Natalie J. Tatum
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PARG inhibition induces nuclear aggregation of PARylated PARP1 Structure (IF 4.4) Pub Date : 2024-10-14 Sateja Paradkar, Julia Purcell, Annie Cui, Sam Friedman, Katelyn J. Noronha, Matthew A. Murray, Ranjini K. Sundaram, Ranjit S. Bindra, Ryan B. Jensen
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Structural basis for the ligand promiscuity of the hydroxamate siderophore binding protein FtsB from Streptococcus pyogenes Structure (IF 4.4) Pub Date : 2024-10-11 Jorge Fernandez-Perez, Akinobu Senoo, Jose M.M. Caaveiro, Makoto Nakakido, Susana de Vega, Ichiro Nakagawa, Kouhei Tsumoto
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Structural dissection of the CMP-pseudaminic acid synthetase, PseF Structure (IF 4.4) Pub Date : 2024-10-10 Tessa Keenan, Andrew R. Cowan, Emily K.P. Flack, Natasha E. Hatton, Abigail J. Walklett, Gavin H. Thomas, Glyn R. Hemsworth, Martin A. Fascione
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PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network Structure (IF 4.4) Pub Date : 2024-10-09 Andrew D. Huber, Wenwei Lin, Shyaron Poudel, Darcie J. Miller, Taosheng Chen