The enzymatically regioselective catalyzed incorporation of cysteine sulfoxide into histidine generates physiologically important antioxidants such as ergothioneine and ovothiol. In this issue of Structure, Ireland et al.¹ report the crystal structure of EgtB-IV, which provides insights into the convergent evolution of sulfoxide synthase.

中文翻译：

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EgtB-IV 结构中留下的趋同进化痕迹


半胱氨酸亚砜在酶促区域选择性催化下掺入组氨酸中，产生生理上重要的抗氧化剂，如麦角硫因和卵硫醇。在本期 Structure中，Ireland et ^al.1 报道了 EgtB-IV 的晶体结构，为亚砜合酶的趋同进化提供了见解。