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TDRD1 phase separation drives intermitochondrial cement assembly to promote piRNA biogenesis and fertility Dev. Cell (IF 10.7) Pub Date : 2024-07-18
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Brain responses to intermittent fasting and the healthy living diet in older adults Cell Metab. (IF 27.7) Pub Date : 2024-07-16
No Abstract
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Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer Cancer Cell (IF 48.8) Pub Date : 2024-07-18
Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.
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Transcription factor dependencies identify BAF-dependent cancers Cancer Cell (IF 48.8) Pub Date : 2024-07-18
In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple myeloma and POU2F3-subtype small cell lung cancer, highlighting potential therapeutic applications for BAF complex inhibitors/degraders.
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Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies Cancer Cell (IF 48.8) Pub Date : 2024-07-18
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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer Cancer Cell (IF 48.8) Pub Date : 2024-07-18
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Tumor-infiltrating lymphocytes: A new hope Cancer Cell (IF 48.8) Pub Date : 2024-07-18
Tumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2. Here, we review the historical development of TIL therapy and discuss potential solutions to ongoing roadblocks that may result in broader and improved
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Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity Cancer Cell (IF 48.8) Pub Date : 2024-07-18
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Regulation of and challenges in targeting NAD+ metabolism Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-18 Marie E. Migaud, Mathias Ziegler, Joseph A. Baur
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An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-19
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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-18 Olivier Saulnier, Jamie Zagozewski, Lisa Liang, Liam D. Hendrikse, Paul Layug, Victor Gordon, Kimberly A. Aldinger, Parthiv Haldipur, Stephanie Borlase, Ludivine Coudière-Morrison, Ting Cai, Emma Martell, Naomi M. Gonzales, Gareth Palidwor, Christopher J. Porter, Stéphane Richard, Tanveer Sharif, Kathleen J. Millen, Brad W. Doble, Michael D. Taylor, Tamra E. Werbowetski-Ogilvie
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The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway Mol. Cell (IF 14.5) Pub Date : 2024-07-17
The twenty-three Fanconi anemia (FA) proteins cooperate in the FA/BRCA pathway to repair DNA interstrand cross-links (ICLs). The cell division cycle a…
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The guide-RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex Mol. Cell (IF 14.5) Pub Date : 2024-07-17
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Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory Mol. Cell (IF 14.5) Pub Date : 2024-07-17
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Functional and structural insights into RAS effector proteins Mol. Cell (IF 14.5) Pub Date : 2024-07-17
RAS proteins are conserved guanosine triphosphate (GTP) hydrolases (GTPases) that act as molecular binary switches and play vital roles in numerous cellular processes. Upon GTP binding, RAS GTPases adopt an active conformation and interact with specific proteins termed RAS effectors that contain a conserved ubiquitin-like domain, thereby facilitating downstream signaling. Over 50 effector proteins
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A pair of E3 ubiquitin ligases control immunity and flowering by targeting different ELF3 proteins in rice Dev. Cell (IF 10.7) Pub Date : 2024-07-17
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Defining context-dependent m6A RNA methylomes in Arabidopsis Dev. Cell (IF 10.7) Pub Date : 2024-07-17
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E3 ubiquitin ligase IPI1 controls rice immunity and flowering via both E3 ligase-dependent and -independent pathways Dev. Cell (IF 10.7) Pub Date : 2024-07-17
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RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release Mol. Cell (IF 14.5) Pub Date : 2024-07-16
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Cellular and pathological functions of tau Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-16 Celeste Parra Bravo, Sarah A. Naguib, Li Gan
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GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver Cell Death Differ. (IF 13.7) Pub Date : 2024-07-16 Jia-Hui Zhu, Shen-Xi Ouyang, Guo-Yan Zhang, Qi Cao, Rujuan Xin, Hang Yin, Jing-Wen Wu, Yan Zhang, Zhen Zhang, Yi Liu, Jiang-Tao Fu, Yi-Ting Chen, Jie Tong, Jia-Bao Zhang, Jian Liu, Fu-Ming Shen, Dong-Jie Li, Pei Wang
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Ubiquitin-specific protease 1 facilitates hepatocellular carcinoma progression by modulating mitochondrial fission and metabolic reprogramming via cyclin-dependent kinase 5 stabilization Cell Death Differ. (IF 13.7) Pub Date : 2024-07-15 Saiyan Bian, Wenkai Ni, Linlin Zhou, Yun Tong, Chengchen Dai, Xuying Zhao, Yuwei Qiang, Jie Gao, Yifu Xiao, Wei Liu, Changsheng Chen, Shengli Lin, Jianing Gong, Suming Zhao, Yinqi Chen, Zhaoyi Lin, Dong Liu, Hui Zhao, Wenjie Zheng
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Competition between two HUSH complexes orchestrates the immune response to retroelement invasion Mol. Cell (IF 14.5) Pub Date : 2024-07-15
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The discovery of cyclin-dependent kinases Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-15 Paul Nurse
Paul Nurse discusses how a 1971 paper by Culotti and Hartwell inspired him to investigate the cell cycle in fission yeast, and how these genetics studies led to the discovery of cyclin-dependent kinases.
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-15 Jiechao Zhou, Yang ‘an Chuang, Javier Redding-Ochoa, Rongzhen Zhang, Alexander J. Platero, Alexander H. Barrett, Juan C. Troncoso, Paul F. Worley, Wenchi Zhang
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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-15 Annemarie Schwab, Zhigang Rao, Jie Zhang, André Gollowitzer, Katharina Siebenkäs, Nino Bindel, Elisabetta D’Avanzo, Ruthger van Roey, Yussuf Hajjaj, Ece Özel, Isabell Armstark, Leonhard Bereuter, Fengting Su, Julia Grander, Ehsan Bonyadi Rad, Arwin Groenewoud, Felix B. Engel, George W. Bell, Whitney S. Henry, José Pedro Friedmann Angeli, Marc P. Stemmler, Simone Brabletz, Andreas Koeberle, Thomas Brabletz
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Polycomb function in early mouse development Cell Death Differ. (IF 13.7) Pub Date : 2024-07-12 Livia Condemi, Ivano Mocavini, Sergi Aranda, Luciano Di Croce
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Base-resolution m5C profiling across the mammalian transcriptome by bisulfite-free enzyme-assisted chemical labeling approach Mol. Cell (IF 14.5) Pub Date : 2024-07-12 Liang Lu, Xiaoting Zhang, Yuenan Zhou, Zuokun Shi, Xiwen Xie, Xinyue Zhang, Liaoliao Gao, Anbo Fu, Cong Liu, Bo He, Xushen Xiong, Yafei Yin, Qingqing Wang, Chengqi Yi, Xiaoyu Li
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Shifts in keratin isoform expression activate motility signals during wound healing Dev. Cell (IF 10.7) Pub Date : 2024-07-12 Benjamin A. Nanes, Kushal Bhatt, Evgenia Azarova, Divya Rajendran, Sabahat Munawar, Tadamoto Isogai, Kevin M. Dean, Gaudenz Danuser
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Full-length GSDME mediates pyroptosis independent from cleavage Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Bo Zhou, Zhi-hong Jiang, Meng-ran Dai, Yuan-li Ai, Li Xiao, Chuan-qi Zhong, Liu-Zheng Wu, Qi-tao Chen, Hang-zi Chen, Qiao Wu
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Pressure sensing of lysosomes enables control of TFEB responses in macrophages Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Whijin Kwon, Subothan Inpanathan, Blayne A. Sayed, Roberto J. Botelho, Amra Saric, Stefan Uderhardt, Spencer A. Freeman
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Neutrophil-derived migrasomes are an essential part of the coagulation system Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Dong Jiang, Lin Jiao, Qing Li, Renxiang Xie, Haohao Jia, ShiHui Wang, Yining Chen, Siyuan Liu, Dandan Huang, Jiajia Zheng, Wenhao Song, Ying Li, JianFeng Chen, Jinsong Li, Binwu Ying, Li Yu
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Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1 Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Sharon Spizzichino, Federica Di Fonzo, Chiara Marabelli, Angela Tramonti, Antonio Chaves-Sanjuan, Alessia Parroni, Giovanna Boumis, Francesca Romana Liberati, Alessio Paone, Linda Celeste Montemiglio, Matteo Ardini, Arjen J. Jakobi, Alok Bharadwaj, Paolo Swuec, Gian Gaetano Tartaglia, Alessandro Paiardini, Roberto Contestabile, Antonello Mai, Dante Rotili, Francesco Fiorentino, Francesca Cutruzzolà
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Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Mei-Sheng Xiao, Arun Prasath Damodaran, Thomas Gonatopoulos-Pournatzis
We talk to corresponding author Thomas Gonatopoulos-Pournatzis and co-first authors Arun Prasath Damodaran and Mei-Sheng Xiao about their paper “Genome-scale exon perturbation screens uncover exons critical for cell fitness” (in this issue of Molecular Cell) and get insights into their findings, career trajectories, and future directions in the pre-mRNA processing field.
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Chaperones in concert: Orchestrating co-translational protein folding in the cell Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Bob Schiffrin, Antonio N. Calabrese
In this issue of Molecular Cell, Roeselová et al.1 provide insights into co-translational folding of a multidomain protein in bacteria, revealing how the chaperones Trigger Factor, DnaJ, and DnaK work together to facilitate the folding of nascent chains.
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Assigning function to an unexplored Integrator module Mol. Cell (IF 14.5) Pub Date : 2024-07-11 William Garland, Jérôme O. Rouvière, Torben Heick Jensen
In this issue of Molecular Cell, Razew et al.1 and Sabath et al.2 assign function to an unexplored module of the Integrator (INT) complex, expanding the toolbox of this genome-wide attenuator of RNA polymerase II (RNAPII) transcription.
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Thrifty tissues prefer recycled purines over new-cleotides Mol. Cell (IF 14.5) Pub Date : 2024-07-11 David Sokolov, Lucas B. Sullivan
In two recent studies appearing in Cell1 and Cell Metabolism,2 Tran et al. and Wu et al. describe underappreciated nuance in organismal and cellular purine nucleotide salvage pathways and identify purine salvage as a metabolic limitation for tumor growth.
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The molecular basis of tRNA selectivity by human pseudouridine synthase 3 Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Ting-Yu Lin, Leon Kleemann, Jakub Jeżowski, Dominika Dobosz, Michał Rawski, Paulina Indyka, Grzegorz Ważny, Rahul Mehta, Andrzej Chramiec-Głąbik, Łukasz Koziej, Tristan Ranff, Christian Fufezan, Mateusz Wawro, Jakub Kochan, Joanna Bereta, Sebastian A. Leidel, Sebastian Glatt
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Dynamic BTB-domain filaments promote clustering of ZBTB proteins Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Lucija Mance, Nicolas Bigot, Edison Zhamungui Sánchez, Franck Coste, Natalia Martín-González, Siham Zentout, Marin Biliškov, Zofia Pukało, Aanchal Mishra, Catherine Chapuis, Ana-Andreea Arteni, Axelle Lateur, Stéphane Goffinont, Virginie Gaudon, Ibtissam Talhaoui, Ignacio Casuso, Martine Beaufour, Norbert Garnier, Franck Artzner, Martine Cadene, Marcin Józef Suskiewicz
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Polymerization of ZBTB transcription factors regulates chromatin occupancy Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Paul M.C. Park, Jiho Park, Jared Brown, Moritz Hunkeler, Shourya S. Roy Burman, Katherine A. Donovan, Hojong Yoon, Radosław P. Nowak, Mikołaj Słabicki, Benjamin L. Ebert, Eric S. Fischer
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Human yolk sac-derived innate lymphoid-biased multipotent progenitors emerge prior to hematopoietic stem cell formation Dev. Cell (IF 10.7) Pub Date : 2024-07-11 Yanli Ni, Guoju You, Yandong Gong, Xiaoyu Su, Yuan Du, Xiaoshuang Wang, Xiaochen Ding, Qingfeng Fu, Man Zhang, Tao Cheng, Yu Lan, Bing Liu, Chen Liu
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Construction of multilayered small intestine-like tissue by reproducing interstitial flow Cell Stem Cell (IF 19.8) Pub Date : 2024-07-11 Sayaka Deguchi, Kaori Kosugi, Naoki Takeishi, Yukio Watanabe, Shiho Morimoto, Ryosuke Negoro, Fuki Yokoi, Hiroki Futatsusako, May Nakajima-Koyama, Mio Iwasaki, Takuya Yamamoto, Yoshiya Kawaguchi, Yu-suke Torisawa, Kazuo Takayama
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RNA scaffolds the Golgi ribbon by forming condensates with GM130 Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-11 Yijun Zhang, Joachim Seemann
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Endoplasmic reticulum exit sites are segregated for secretion based on cargo size Dev. Cell (IF 10.7) Pub Date : 2024-07-10 Sonashree Saxena, Ombretta Foresti, Aofei Liu, Stefania Androulaki, Maria Pena Rodriguez, Ishier Raote, Meir Aridor, Bianxiao Cui, Vivek Malhotra
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Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells Cell Death Differ. (IF 13.7) Pub Date : 2024-07-10 Yuan-Tong Liu, Lei Chen, Shu-Jin Li, Wu-Yin Wang, Yuan-Yuan Wang, Qi-Chao Yang, An Song, Meng-Jie Zhang, Wen-Tao Mo, Hao Li, Chuan-Yu Hu, Zhi-Jun Sun
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Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress Mol. Cell (IF 14.5) Pub Date : 2024-07-08 Johannes Pilic, Benjamin Gottschalk, Benjamin Bourgeois, Hansjörg Habisch, Zhanat Koshenov, Furkan E. Oflaz, Yusuf C. Erdogan, Seyed M. Miri, Esra N. Yiğit, Mehmet Ş. Aydın, Gürkan Öztürk, Emrah Eroglu, Varda Shoshan-Barmatz, Tobias Madl, Wolfgang F. Graier, Roland Malli
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Slc25a3-dependent copper transport controls flickering-induced Opa1 processing for mitochondrial safeguard Dev. Cell (IF 10.7) Pub Date : 2024-07-09 Daisuke Murata, Shubhrajit Roy, Svetlana Lutsenko, Miho Iijima, Hiromi Sesaki
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GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development Dev. Cell (IF 10.7) Pub Date : 2024-07-08 Fan Zhao, Zejin Cui, Pengfei Wang, Zhishan Zhao, Kaixiang Zhu, Yadan Bai, Xuexiao Jin, Lie Wang, Linrong Lu
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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation Cell Metab. (IF 27.7) Pub Date : 2024-07-09 Lynn Bonetti, Veronika Horkova, Melanie Grusdat, Joseph Longworth, Luana Guerra, Henry Kurniawan, Davide G. Franchina, Leticia Soriano-Baguet, Carole Binsfeld, Charlène Verschueren, Sabine Spath, Anouk Ewen, Eric Koncina, Jean-Jacques Gérardy, Takumi Kobayashi, Catherine Dostert, Sophie Farinelle, Janika Härm, Yu-Tong Fan, Ying Chen, Dirk Brenner
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Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells Cell Stem Cell (IF 19.8) Pub Date : 2024-07-09 Jaya Lakshmi Thangaraj, Michael Coffey, Edith Lopez, Dan S. Kaufman
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A human pluripotent stem cell-based somitogenesis model using microfluidics Cell Stem Cell (IF 19.8) Pub Date : 2024-07-08 Yue Liu, Yung Su Kim, Xufeng Xue, Yuchuan Miao, Norio Kobayashi, Shiyu Sun, Robin Zhexuan Yan, Qiong Yang, Olivier Pourquié, Jianping Fu
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Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies Cell Stem Cell (IF 19.8) Pub Date : 2024-07-08
Allogeneic cellular immunotherapies hold promise for broad clinical implementation but face limitations due to potential rejection of donor cells by t…
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Immune cell triads reprogram exhausted CD8+ T cells for effective tumor elimination Cancer Cell (IF 48.8) Pub Date : 2024-07-08 Veronica Lise, Ines Malenica, Rahul Roychoudhuri, Enrico Lugli
In this issue of Cancer Cell, Espinosa-Carrasco et al. show that the efficacy of cancer immunotherapies depends upon the formation of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4+ and CD8+ T cells. This interaction reprograms tumor-specific CD8+ T cells to exert potent effector functions and eradicate established solid tumors.
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Medulloblastoma subgrouping at first sight Cancer Cell (IF 48.8) Pub Date : 2024-07-08 Marc Remke, Vijay Ramaswamy
Recent incorporation of the four primary medulloblastoma subgroups into the WHO Classification of Central Nervous System Tumors necessitates globally accessible methods to discern subgroups. In this issue of Cancer Cell, Wang et al. develop a rapid and reliable machine learning workflow for pre-operative subgroup determination using routine magnetic resonance imaging.