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The ribosome termination complex remodels release factor RF3 and ejects GDP Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-19 Li Li, Mariia Yu. Rybak, Jinzhong Lin, Matthieu G. Gagnon
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Structural basis of NEAT1 lncRNA maturation and menRNA instability Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-18 Ilias Skeparnias, Jinwei Zhang
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The power of scientific collaborations and the future of structural biology Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-15 Pedro Beltrao
The idea of a scientific discovery is often linked to the eureka moment of a lone scientist, which then transforms our thinking. However, scientific discoveries are never made by individuals in isolation. They build on the work of countless researchers, and often require interdisciplinary and collaborative teams of researchers.
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A roadmap for ribosome assembly in human mitochondria Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-11 Elena Lavdovskaia, Elisa Hanitsch, Andreas Linden, Martin Pašen, Venkatapathi Challa, Yehor Horokhovskyi, Hanna P. Roetschke, Franziska Nadler, Luisa Welp, Emely Steube, Marleen Heinrichs, Mandy Mong-Quyen Mai, Henning Urlaub, Juliane Liepe, Ricarda Richter-Dennerlein
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Resolving chaperone-assisted protein folding on the ribosome at the peptide level Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-10 Thomas E. Wales, Aleksandra Pajak, Alžběta Roeselová, Santosh Shivakumaraswamy, Steven Howell, Svend Kjær, F. Ulrich Hartl, John R. Engen, David Balchin
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Obscure DNA sequences unveil a new cancer target Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-08 Agnel Sfeir
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AlphaFold3 takes a step toward decoding molecular behavior and biological computation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-08 Rohit Roy, Hashim M. Al-Hashimi
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VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-08 Sven M. Lange, Matthew R. McFarland, Frederic Lamoliatte, Thomas Carroll, Logesvaran Krshnan, Anna Pérez-Ràfols, Dominika Kwasna, Linnan Shen, Iona Wallace, Isobel Cole, Lee A. Armstrong, Axel Knebel, Clare Johnson, Virginia De Cesare, Yogesh Kulathu
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Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-02 Léa Mammri, Paul T. Conduit
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cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-02 Marina C. Nocente, Anida Mesihovic Karamitsos, Emilie Drouineau, Manon Soleil, Waad Albawardi, Cécile Dulary, Florence Ribierre, Hélène Picaud, Olivier Alibert, Joël Acker, Marie Kervella, Jean-Christophe Aude, Nick Gilbert, Françoise Ochsenbein, Sophie Chantalat, Matthieu Gérard
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Structural basis of MALAT1 RNA maturation and mascRNA biogenesis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-02 Ilias Skeparnias, Charles Bou-Nader, Dimitrios G. Anastasakis, Lixin Fan, Yun-Xing Wang, Markus Hafner, Jinwei Zhang
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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-01 Ruth M. Saecker, Andreas U. Mueller, Brandon Malone, James Chen, William C. Budell, Venkata P. Dandey, Kashyap Maruthi, Joshua H. Mendez, Nina Molina, Edward T. Eng, Laura Y. Yen, Clinton S. Potter, Bridget Carragher, Seth A. Darst
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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-01 Julian R. Braxton, Hao Shao, Eric Tse, Jason E. Gestwicki, Daniel R. Southworth
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Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-07-01 Wenxin Hu, Amit Kumar, Syed Faraz Ahmed, Shijiao Qi, David K. G. Ma, Honglin Chen, Gurjeet J. Singh, Joshua M. L. Casan, Michelle Haber, Ilia Voskoboinik, Matthew R. McKay, Joseph A. Trapani, Paul G. Ekert, Mohamed Fareh
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The tRNA methyltransferase METTL6 requires seryl-tRNA synthetase for tRNASer targeting Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-25
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Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-25 Philipp Throll, Luciano G. Dolce, Palma Rico-Lastres, Katharina Arnold, Laura Tengo, Shibom Basu, Stefanie Kaiser, Robert Schneider, Eva Kowalinski
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Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16 Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-25 Huasong Ai, Zaozhen He, Zhiheng Deng, Guo-Chao Chu, Qiang Shi, Zebin Tong, Jia-Bin Li, Man Pan, Lei Liu
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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-25 Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Stephen Shoebridge, Marvin Skulsuppaisarn, Emily Maria Watts, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens
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Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-19 Duc-Duy Vu, Alessio Bonucci, Manon Brenière, Metztli Cisneros-Aguirre, Philippe Pelupessy, Ziqing Wang, Ludovic Carlier, Guillaume Bouvignies, Patricia Cortes, Aneel K. Aggarwal, Martin Blackledge, Zoher Gueroui, Valérie Belle, Jeremy M. Stark, Mauro Modesti, Fabien Ferrage
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Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-19 Anshumali Mittal, Matthew F. Martin, Elena J. Levin, Christopher Adams, Meng Yang, Laurent Provins, Adrian Hall, Martin Procter, Marie Ledecq, Alexander Hillisch, Christian Wolff, Michel Gillard, Peter S. Horanyi, Jonathan A. Coleman
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Structure of the poxvirus core Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-18 Fasséli Coulibaly
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Structural basis for the dynamic chaperoning of disordered clients by Hsp90 Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-18 Xiaozhan Qu, Shuo Zhao, Chanjuan Wan, Lei Zhu, Tuo Ji, Paolo Rossi, Junfeng Wang, Charalampos G. Kalodimos, Chao Wang, Weiya Xu, Chengdong Huang
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Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-18 Qian Li, Jun Zhang, Cory Haluska, Xiang Zhang, Lei Wang, Guangfeng Liu, Zhaoning Wang, Duo Jin, Tong Cheng, Hongxia Wang, Yuan Tian, Xiangxi Wang, Lei Sun, Xiaolan Zhao, Zhenguo Chen, Lanfeng Wang
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The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-13 Feng Wang, Qing He, Nina Y. Yao, Michael E. O’Donnell, Huilin Li
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Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-12
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PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-12 Hiroaki Fujita, Yu-ki Tanaka, Seiryo Ogata, Noriyuki Suzuki, Sota Kuno, Uladzimir Barayeu, Takaaki Akaike, Yasumitsu Ogra, Kazuhiro Iwai
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Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-12 Hossein Batebi, Guillermo Pérez-Hernández, Sabrina N. Rahman, Baoliang Lan, Antje Kamprad, Mingyu Shi, David Speck, Johanna K. S. Tiemann, Ramon Guixà-González, Franziska Reinhardt, Peter F. Stadler, Makaía M. Papasergi-Scott, Georgios Skiniotis, Patrick Scheerer, Brian K. Kobilka, Jesper M. Mathiesen, Xiangyu Liu, Peter W. Hildebrand
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The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-06 Samuel Holvec, Charles Barchet, Antony Lechner, Léo Fréchin, S. Nimali T. De Silva, Isabelle Hazemann, Philippe Wolff, Ottilie von Loeffelholz, Bruno P. Klaholz
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XIST dampens X chromosome activity in a SPEN-dependent manner during early human development Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-04 Charbel Alfeghaly, Gaël Castel, Emmanuel Cazottes, Madeleine Moscatelli, Eva Moinard, Miguel Casanova, Juliette Boni, Kasturi Mahadik, Jenna Lammers, Thomas Freour, Louis Chauviere, Carla Piqueras, Ruben Boers, Joachim Boers, Joost Gribnau, Laurent David, Jean-François Ouimette, Claire Rougeulle
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Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-04 Vivien Horváth, Raquel Garza, Marie E. Jönsson, Pia A. Johansson, Anita Adami, Georgia Christoforidou, Ofelia Karlsson, Laura Castilla Vallmanya, Symela Koutounidou, Patricia Gerdes, Ninoslav Pandiloski, Christopher H. Douse, Johan Jakobsson
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Allosteric competition and inhibition in AMPA receptors Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-04 W. Dylan Hale, Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Vasanthi Jayaraman, Albert Y. Lau, Richard L. Huganir, Edward C. Twomey
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ATG16L1 induces the formation of phagophore-like membrane cups Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-06-04 Jagan Mohan, Satish B. Moparthi, Christine Girard-Blanc, Daniele Campisi, Stéphane Blanchard, Charlotte Nugues, Sowmya Rama, Audrey Salles, Esthel Pénard, Stéphane Vassilopoulos, Thomas Wollert
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How Mcm10 converts the pre-replication complex into two diverging DNA forks Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-31
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Building up complexity in structural biology studies Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-30 Eva Nogales
Macromolecules are involved in myriads of interactions that regulate their cellular function. While years of structural biology progress was built by reducing this complexity, a molecular understanding of biological processes requires the characterization of ever larger and more dynamic molecular assemblies. Cryo-electron microscopy is rising to this challenge.
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A unifying model for membrane protein biogenesis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-29 Ramanujan S. Hegde, Robert J. Keenan
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MYC phase separation selectively modulates the transcriptome Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-29 Junjiao Yang, Chan-I Chung, Jessica Koach, Hongjiang Liu, Ambuja Navalkar, Hao He, Zhimin Ma, Qian Zhao, Xiaoyu Yang, Liang He, Tanja Mittag, Yin Shen, William A. Weiss, Xiaokun Shu
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XPD stalled on cross-linked DNA provides insight into damage verification Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-28 Jochen Kuper, Tamsanqa Hove, Sarah Maidl, Hermann Neitz, Florian Sauer, Maximilian Kempf, Till Schroeder, Elke Greiter, Claudia Höbartner, Caroline Kisker
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The explosive discovery of TNT in early mouse embryos Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-24 Chad S. Driscoll, Jaehwan Kim, Jason G. Knott
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Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-24 Meng Zhu, Maciej Meglicki, Adiyant Lamba, Peizhe Wang, Christophe Royer, Karen Turner, Muhammad Abdullah Jauhar, Celine Jones, Tim Child, Kevin Coward, Jie Na, Magdalena Zernicka-Goetz
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Structural insights into PPP2R5A degradation by HIV-1 Vif Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-24 Yingxia Hu, Krista A. Delviks-Frankenberry, Chunxiang Wu, Fidel Arizaga, Vinay K. Pathak, Yong Xiong
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The commander complex is the Swiss Army knife of endosomal trafficking Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-23 Natalya Leneva, Oleksiy Kovtun
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TET activity safeguards pluripotency throughout embryonic dormancy Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-23 Maximilian Stötzel, Chieh-Yu Cheng, Ibrahim A. IIik, Abhishek Sampath Kumar, Persia Akbari Omgba, Vera A. van der Weijden, Yufei Zhang, Martin Vingron, Alexander Meissner, Tuğçe Aktaş, Helene Kretzmer, Aydan Bulut-Karslioğlu
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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-21 Yihe Huang, Sushant Kumar, Junuk Lee, Wei Lü, Juan Du
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eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-21 Yuichi Shichino, Tomokazu Yamaguchi, Kazuhiro Kashiwagi, Mari Mito, Mari Takahashi, Takuhiro Ito, Nicholas T. Ingolia, Keiji Kuba, Shintaro Iwasaki
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The RNA world Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-20
This issue of Nature Structural & Molecular Biology presents studies investigating RNA processing, including mechanisms of splicing, biogenesis of the splicing machinery, decoding of mRNA by the ribosome, and deadenylation of mRNA for degradation. We are also delighted to be publishing News & Views and Comment pieces that reflect on these exciting advances in the field.
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To slide or not to slide: key role of the hexasome in chromatin remodeling revealed Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-20 Daniela Rhodes
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HES4 controls redox balance and supports pyrimidine synthesis and tumor growth Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-20
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Structure and mechanism of lysosome transmembrane acetylation by HGSNAT Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-20 Ruisheng Xu, Yingjie Ning, Fandong Ren, Chenxia Gu, Zhengjiang Zhu, Xuefang Pan, Alexey V. Pshezhetsky, Jingpeng Ge, Jie Yu
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RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-20 Jing He, Aoxue Wang, Qin Zhao, Yejun Zou, Zhuo Zhang, Nannan Sha, Guofang Hou, Bei Zhou, Yi Yang, Tao Chen, Yuzheng Zhao, Yuhui Jiang
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Unwinding of a eukaryotic origin of replication visualized by cryo-EM Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-17 Sarah S. Henrikus, Marta H. Gross, Oliver Willhoft, Thomas Pühringer, Jacob S. Lewis, Allison W. McClure, Julia F. Greiwe, Giacomo Palm, Andrea Nans, John F. X. Diffley, Alessandro Costa
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The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-16 Michael B. Cory, Allen Li, Christina M. Hurley, Peter J. Carman, Ruth A. Pumroy, Zachary M. Hostetler, Ryann M. Perez, Yarra Venkatesh, Xinning Li, Kushol Gupta, E. James Petersson, Rahul M. Kohli
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Mechanisms of transcription and RNA processing Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-14 Lori A. Passmore, Suyang Zhang
Since Nature Structural and Molecular Biology was started 30 years ago, our understanding of transcription and mRNA processing has been revolutionized through structural and mechanistic studies. Here, we present our personal views of the advances in understanding the production of mature eukaryotic mRNAs over the past decade.
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Decoding branch points and unlocking splicing secrets Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-13 Sara R. Downs, Bec Grace, Jeffrey A. Pleiss
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Custom protein nanoparticles for targeted drug delivery Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-09
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Computational design of non-porous pH-responsive antibody nanoparticles Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-09 Erin C. Yang, Robby Divine, Marcos C. Miranda, Andrew J. Borst, Will Sheffler, Jason Z. Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Suna Cheng, Mila Lamb, Paul M. Levine, Sidney Chan, Rebecca Skotheim, Jorge Fallas, George Ueda, Joshua Lubner, Masaharu Somiya, Alena Khmelinskaia, Neil P. King, David Baker
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Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-08 Radhika Malik, Robert E. Johnson, Iban Ubarretxena-Belandia, Louise Prakash, Satya Prakash, Aneel K. Aggarwal
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Illuminating cortactin structure and function at actin filament branches Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-07 Klemens Rottner, Peter Bieling
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The risky business of ADP-ribosylating telomeric DNA Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-07 Ylli Doksani, Francisca Lottersberger
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Deregulated DNA ADP-ribosylation impairs telomere replication Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2024-05-07 Anne R. Wondisford, Junyeop Lee, Robert Lu, Marion Schuller, Josephine Groslambert, Ragini Bhargava, Sandra Schamus-Haynes, Leyneir C. Cespedes, Patricia L. Opresko, Hilda A. Pickett, Jaewon Min, Ivan Ahel, Roderick J. O’Sullivan