Using data from the UK Biobank the researchers analyzed the rare variants in the protein coding region in the genomes of 106,973 women. They identified rare variants that disrupt the function of nine genes that are associated with ANM. Four of these were already known while five were linked to ANM for the first time. Three of the five new genes (PALB2, ETAA1 and HROB) are involved in the DNA damage

Dong et al. relied on a mouse embryonic stem (ES) cell line where the cohesin subunit, RAD21, had been tagged with an auxin-inducible degron, thereby enabling them to induce depletion of cohesin in mouse ES cells. Next, they performed single-cell transcriptomics and single-cell ATAC-seq in control or cohesin-depleted mouse ES cells and used these data to define 776 ACDs across the mouse genome. In

CRISPR–Cas enzymes have enabled us to manipulate the genetic code with unparalleled precision and efficiency. Here I explore the structural and biochemical intricacies that govern the functionality of CRISPR–Cas technologies, emphasizing the need for a nuanced mechanistic understanding to overcome current limitations and pave the way for safer and more effective genome-editing applications in medicine