-
Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features Neuron (IF 14.7) Pub Date : 2024-06-24 Fiona E. Müllner, Botond Roska
Inhibitory interneurons in the dorsolateral geniculate nucleus (dLGN) are situated at the first central synapse of the image-forming visual pathway, but little is known about their function. Given their anatomy, they are expected to be multiplexors, integrating many different retinal channels along their dendrites. Here, using targeted single-cell-initiated rabies tracing, we found that mouse dLGN
-
A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation Neuron (IF 14.7) Pub Date : 2024-06-20 Jiayang Chen, Mary E. Lambo, Xia Ge, Joshua T. Dearborn, Yating Liu, Katherine B. McCullough, Raylynn G. Swift, Dora R. Tabachnick, Lucy Tian, Kevin Noguchi, Joel R. Garbow, John N. Constantino, Harrison W. Gabel, Keith B. Hengen, Susan E. Maloney, Joseph D. Dougherty
-
Cell-type-specific effects of age and sex on human cortical neurons Neuron (IF 14.7) Pub Date : 2024-06-04 Jo-Fan Chien, Hanqing Liu, Bang-An Wang, Chongyuan Luo, Anna Bartlett, Rosa Castanon, Nicholas D. Johnson, Joseph R. Nery, Julia Osteen, Junhao Li, Jordan Altshul, Mia Kenworthy, Cynthia Valadon, Michelle Liem, Naomi Claffey, Carolyn O'Connor, Luise A. Seeker, Joseph R. Ecker, M. Margarita Behrens, Eran A. Mukamel
Altered transcriptional and epigenetic regulation of brain cell types may contribute to cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation and transcriptome sequencing (snmCT-seq) in frontal cortex from young adult and aged donors, we found widespread age- and sex-related variation in specific neuron types. The proportion of inhibitory SST- and VIP-expressing neurons
-
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist Neuron (IF 14.7) Pub Date : 2024-05-31 Alexandra Litvinchuk, Jung H. Suh, Jing L. Guo, Karin Lin, Sonnet S. Davis, Nga Bien-Ly, Eric Tycksen, G. Travis Tabor, Javier Remolina Serrano, Melissa Manis, Xin Bao, Choonghee Lee, Megan Bosch, Enmanuel J. Perez, Carla M. Yuede, Anil G. Cashikar, Jason D. Ulrich, Gilbert Di Paolo, David M. Holtzman
-
Neurobiological basis of stress resilience Neuron (IF 14.7) Pub Date : 2024-05-24 Eric J. Nestler, Scott J. Russo
A majority of humans faced with severe stress maintain normal physiological and behavioral function, a process referred to as resilience. Such stress resilience has been modeled in laboratory animals and, over the past 15 years, has transformed our understanding of stress responses and how to approach the treatment of human stress disorders such as depression, post-traumatic stress disorder (PTSD)
-
What’s the n? On sample size vs. subject number for brain-behavior neurophysiology and neuromodulation Neuron (IF 14.7) Pub Date : 2024-05-22 Wael F. Asaad, Sameer A. Sheth
-
Long-wavelength traveling waves of vasomotion modulate the perfusion of cortex Neuron (IF 14.7) Pub Date : 2024-05-22 Thomas Broggini, Jacob Duckworth, Xiang Ji, Rui Liu, Xinyue Xia, Philipp Mächler, Iftach Shaked, Leon Paul Munting, Satish Iyengar, Michael Kotlikoff, Susanne J. van Veluw, Massimo Vergassola, Gal Mishne, David Kleinfeld
Brain arterioles are active, multicellular complexes whose diameters oscillate at ∼ 0.1 Hz. We assess the physiological impact and spatiotemporal dynamics of vaso-oscillations in the awake mouse. First, vaso-oscillations in penetrating arterioles, which source blood from pial arterioles to the capillary bed, profoundly impact perfusion throughout neocortex. The modulation in flux during resting-state
-
Thriving in neuroscience careers: Three lessons from 12+ years of the BRAINS Program Neuron (IF 14.7) Pub Date : 2024-05-20 Joyce W. Yen, M. Claire Horner-Devine, Erin Carll, Rachel Talney, Sheri J.Y. Mizumori
-
Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins Neuron (IF 14.7) Pub Date : 2024-05-16 Lulu Y. Chen, Man Jiang, Bo Zhang, Ozgun Gokce, Thomas C. Südhof
-
Social Control of Hypothalamus-Mediated Male Aggression Neuron (IF 14.7) Pub Date : 2024-05-16 Taehong Yang, Cindy F. Yang, M. Delara Chizari, Niru Maheswaranathan, Kenneth J. Burke Jr., Maxim Borius, Sayaka Inoue, Michael C. Chiang, Kevin J. Bender, Surya Ganguli, Nirao M. Shah
-
Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex Neuron (IF 14.7) Pub Date : 2024-05-15 Daniela J. Di Bella, Nuria Domínguez-Iturza, Juliana R. Brown, Paola Arlotta
Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the immense diversity and complexity of cell types found in the cerebral cortex, neuroscience has been challenged and inspired to understand how these diverse cells are generated and how they interact with each other to orchestrate the development of this remarkable tissue. Some fundamental questions drive the field’s
-
Nr4a1 regulates cell-specific transcriptional programs in inhibitory GABAergic interneurons Neuron (IF 14.7) Pub Date : 2024-05-15 Min Huang, Simon Pieraut, Jasmine Cao, Filip de Souza Polli, Vincenzo Roncace, Gloria Shen, Carlos Ramos-Medina, HeeYang Lee, Anton Maximov
The patterns of synaptic connectivity and physiological properties of diverse neuron types are shaped by distinct gene sets. Our study demonstrates that, in the mouse forebrain, the transcriptional profiles of inhibitory GABAergic interneurons are regulated by Nr4a1, an orphan nuclear receptor whose expression is transiently induced by sensory experiences and is required for normal learning. Nr4a1
-
Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning Neuron (IF 14.7) Pub Date : 2024-05-15 Chi Ren, Kailong Peng, Ruize Yang, Weikang Liu, Chang Liu, Takaki Komiyama
-
An integrative view of the role of prefrontal cortex in consciousness Neuron (IF 14.7) Pub Date : 2024-05-15 Theofanis I. Panagiotaropoulos
The involvement of the prefrontal cortex (PFC) in consciousness is an ongoing focus of intense investigation. An important question is whether representations of conscious contents and experiences in the PFC are confounded by post-perceptual processes related to cognitive functions. Here, I review recent findings suggesting that neuronal representations of consciously perceived contents—in the absence
-
Toward an interventional science of recovery after coma Neuron (IF 14.7) Pub Date : 2024-05-15 Nicholas D. Schiff
Recovery of consciousness after coma remains one of the most challenging areas for accurate diagnosis and effective therapeutic engagement in the clinical neurosciences. Recovery depends on preservation of neuronal integrity and evolving changes in network function that re-establish environmental responsiveness. It typically occurs in defined steps: it begins with eye opening and unresponsiveness in
-
Can we detect consciousness in newborn infants? Neuron (IF 14.7) Pub Date : 2024-05-15 Claudia Passos-Ferreira
-
Thinking about consciousness Neuron (IF 14.7) Pub Date : 2024-05-15 Christina Konen, Mariela Zirlinger
-
Thalamic contributions to the state and contents of consciousness Neuron (IF 14.7) Pub Date : 2024-05-15 Christopher J. Whyte, Michelle J. Redinbaugh, James M. Shine, Yuri B. Saalmann
Consciousness can be conceptualized as varying along at least two dimensions: the global of consciousness and the of conscious experience. Here, we highlight the cellular and systems-level contributions of the thalamus to conscious state and then argue for thalamic contributions to conscious content, including the integrated, segregated, and continuous nature of our experience. We underscore vital
-
-
-
Neuroecological links of the exposome and One Health Neuron (IF 14.7) Pub Date : 2024-05-08 Agustin Ibanez, Lucia Melloni, Paweł Świeboda, William Hynes, Burcin Ikiz, Rym Ayadi, Massamba Thioye, Consuelo Walss-Bass, Bahar Güntekin, Jyoti Mishra, Mohamed Salama, Sarah Dunlop, Claudia Duran-Aniotz, Harris A. Eyre
-
Neural mechanisms of information seeking Neuron (IF 14.7) Pub Date : 2024-05-03 Kenji Kobayashi, Joseph W. Kable
We ubiquitously seek information to make better decisions. Particularly in the modern age, when more information is available at our fingertips than ever, the information we choose to collect determines the quality of our decisions. Decision neuroscience has long adopted empirical approaches where the information available to decision-makers is fully controlled by the researchers, leaving neural mechanisms
-
Genome sequence analyses identify novel risk loci for multiple system atrophy Neuron (IF 14.7) Pub Date : 2024-05-02 Ruth Chia, Anindita Ray, Zalak Shah, Jinhui Ding, Paola Ruffo, Masashi Fujita, Vilas Menon, Sara Saez-Atienzar, Paolo Reho, Karri Kaivola, Ronald L. Walton, Regina H. Reynolds, Ramita Karra, Shaimaa Sait, Fulya Akcimen, Monica Diez-Fairen, Ignacio Alvarez, Alessandra Fanciulli, Nadia Stefanova, Klaus Seppi, Susanne Duerr, Fabian Leys, Florian Krismer, Victoria Sidoroff, Alexander Zimprich, Walter Pirker
Multiple system atrophy (MSA) is an adult-onset, sporadic synucleinopathy characterized by parkinsonism, cerebellar ataxia, and dysautonomia. The genetic architecture of MSA is poorly understood, and treatments are limited to supportive measures. Here, we performed a comprehensive analysis of whole genome sequence data from 888 European-ancestry MSA cases and 7,128 controls to systematically investigate
-
Locus coeruleus norepinephrine contributes to visual-spatial attention by selectively enhancing perceptual sensitivity Neuron (IF 14.7) Pub Date : 2024-05-02 Supriya Ghosh, John H.R. Maunsell
Selectively focusing on a behaviorally relevant stimulus while ignoring irrelevant stimuli improves perception. Enhanced neuronal response gain is thought to support attention-related improvements in detection and discrimination. However, understanding of the neuronal pathways regulating perceptual sensitivity remains limited. Here, we report that responses of norepinephrine (NE) neurons in the locus
-
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size Neuron (IF 14.7) Pub Date : 2024-05-01 Lin Lin, Jingrong Zhao, Naoto Kubota, Zhelin Li, Yi-Li Lam, Lauren P. Nguyen, Lu Yang, Sheela P. Pokharel, Steven M. Blue, Brian A. Yee, Renee Chen, Gene W. Yeo, Chun-Wei Chen, Liang Chen, Sika Zheng
Mutations in human nonsense-mediated mRNA decay (NMD) factors are enriched in neurodevelopmental disorders. We show that deletion of key NMD factor in mouse embryonic neural progenitor cells causes perinatal microcephaly but deletion in immature neurons does not, indicating NMD’s critical roles in progenitors. knockout (KO) prolongs the cell cycle of radial glia progenitor cells, promotes their transition
-
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons Neuron (IF 14.7) Pub Date : 2024-05-01 Yi Liu, Anthony Flamier, George W. Bell, Annette Jun Diao, Troy W. Whitfield, Hao-Che Wang, Yizhe Wu, Fabian Schulte, Max Friesen, Ruisi Guo, Maisam Mitalipova, X. Shawn Liu, Seychelle M. Vos, Richard A. Young, Rudolf Jaenisch
Mutations in the methyl-DNA-binding protein MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). How MECP2 contributes to transcriptional regulation in normal and disease states is unresolved; it has been reported to be an activator and a repressor. We describe here the first integrated CUT&Tag, transcriptome, and proteome analyses using human neurons with wild-type (WT) and mutant MECP2
-
Treatment of concomitant myasthenia gravis and Lambert-Eaton myasthenic syndrome with autologous CD19-targeted CAR T cells Neuron (IF 14.7) Pub Date : 2024-05-01 Jeremias Motte, Melissa Sgodzai, Christiane Schneider-Gold, Nina Steckel, Thomas Mika, Tobias Hegelmaier, Dominic Borie, Aiden Haghikia, Dimitrios Mougiakakos, Roland Schroers, Ralf Gold
Myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) are autoimmune disorders affecting neuromuscular transmission. Their combined occurrence is rare, and treatment remains challenging. Two women diagnosed with concomitant MG/LEMS experienced severe, increasing disease activity despite multiple immunotherapies. Anti-CD19 chimeric antigen receptor (CAR) T cells have shown promise for
-
Consciousness and sleep Neuron (IF 14.7) Pub Date : 2024-05-01 Giulio Tononi, Melanie Boly, Chiara Cirelli
Sleep is a universal, essential biological process. It is also an invaluable window on consciousness. It tells us that consciousness can be lost but also that it can be regained, in all its richness, when we are disconnected from the environment and unable to reflect. By considering the neurophysiological differences between dreaming and dreamless sleep, we can learn about the substrate of consciousness
-
A systems biology-based identification and in vivo functional screening of Alzheimer’s disease risk genes reveal modulators of memory function Neuron (IF 14.7) Pub Date : 2024-04-30 Adam D. Hudgins, Shiyi Zhou, Rachel N. Arey, Michael G. Rosenfeld, Coleen T. Murphy, Yousin Suh
Genome-wide association studies (GWASs) have uncovered over 75 genomic loci associated with risk for late-onset Alzheimer’s disease (LOAD), but identification of the underlying causal genes remains challenging. Studies of induced pluripotent stem cell (iPSC)-derived neurons from LOAD patients have demonstrated the existence of neuronal cell-intrinsic functional defects. Here, we searched for genetic
-
Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior Neuron (IF 14.7) Pub Date : 2024-04-24 Leslie Jaesun Ha, Hyeon-Gu Yeo, Yu Gyeong Kim, Inhyeok Baek, Eunha Baeg, Young Hee Lee, Jinyoung Won, Yunkyo Jung, Junghyung Park, Chang-Yeop Jeon, Keonwoo Kim, Jisun Min, Youngkyu Song, Jeong-Heon Park, Kyung Rok Nam, Sangkyu Son, Seng Bum Michael Yoo, Sung-hyun Park, Won Seok Choi, Kyung Seob Lim, Jae Yong Choi, Jee-Hyun Cho, Youngjeon Lee, Hyung Jin Choi
Maladaptive feeding behavior is the primary cause of modern obesity. While the causal influence of the lateral hypothalamic area (LHA) on eating behavior has been established in rodents, there is currently no primate-based evidence available on naturalistic eating behaviors. We investigated the role of LHA GABAergic (LHA) neurons in eating using chemogenetics in three macaques. LHA neuron activation
-
Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis Neuron (IF 14.7) Pub Date : 2024-04-22 Shu-Yu Ren, Yu Xia, Bin Yu, Qi-Jing Lei, Peng-Fei Hou, Sheng Guo, Shuang-Ling Wu, Wei Liu, Shao-Fan Yang, Yi-Bin Jiang, Jing-Fei Chen, Kai-Feng Shen, Chun-Qing Zhang, Fei Wang, Mi Yan, Hong Ren, Nian Yang, Jun Zhang, Kuan Zhang, Sen Lin, Tao Li, Qing-Wu Yang, Lan Xiao, Zhang-Xue Hu, Feng Mei
White matter injury (WMI) causes oligodendrocyte precursor cell (OPC) differentiation arrest and functional deficits, with no effective therapies to date. Here, we report increased expression of growth hormone (GH) in the hypoxic neonatal mouse brain, a model of WMI. GH treatment during or post hypoxic exposure rescues hypoxia-induced hypomyelination and promotes functional recovery in adolescent mice
-
Taking consciousness for real: Increasing the ecological validity of the study of conscious vs. unconscious processes Neuron (IF 14.7) Pub Date : 2024-04-22 Liad Mudrik, Rony Hirschhorn, Uri Korisky
The study of consciousness has developed well-controlled, rigorous methods for manipulating and measuring consciousness. Yet, in the process, experimental paradigms grew farther away from everyday conscious and unconscious processes, which raises the concern of ecological validity. In this review, we suggest that the field can benefit from adopting a more ecological approach, akin to other fields of
-
Astrocyte-mediated regulation of BLAWFS1 neurons alleviates risk-assessment deficits in DISC1-N mice Neuron (IF 14.7) Pub Date : 2024-04-19 Xinyi Zhou, Qian Xiao, Yaohui Liu, Shuai Chen, Xirong Xu, Zhigang Zhang, Yuchuan Hong, Jie Shao, Yuewen Chen, Yu Chen, Liping Wang, Fan Yang, Jie Tu
Assessing and responding to threats is vital in everyday life. Unfortunately, many mental illnesses involve impaired risk assessment, affecting patients, families, and society. The brain processes behind these behaviors are not well understood. We developed a transgenic mouse model (disrupted-in-schizophrenia 1 [DISC1]-N) with a disrupted avoidance response in risky settings. Our study utilized single-nucleus
-
Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice Neuron (IF 14.7) Pub Date : 2024-04-19 Hakan Kucukdereli, Oren Amsalem, Trent Pottala, Michelle Lim, Leilani Potgieter, Amanda Hasbrouck, Andrew Lutas, Mark L. Andermann
Elevated anxiety often precedes anorexia nervosa and persists after weight restoration. Patients with anorexia nervosa often describe self-starvation as pleasant, potentially because food restriction can be anxiolytic. Here, we tested whether repeated stress can cause animals to prefer a starvation-like state. We developed a virtual reality place preference paradigm in which head-fixed mice can voluntarily
-
Preferences reveal dissociable encoding across prefrontal-limbic circuits Neuron (IF 14.7) Pub Date : 2024-04-18 Frederic M. Stoll, Peter H. Rudebeck
Individual preferences for the flavor of different foods and fluids exert a strong influence on behavior. Most current theories posit that preferences are integrated with other state variables in the orbitofrontal cortex (OFC), which is thought to derive the relative subjective value of available options to guide choice behavior. Here, we report that instead of a single integrated valuation system
-
Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning Neuron (IF 14.7) Pub Date : 2024-04-17 Dámaris K. Rangel Guerrero, Kira Balueva, Uladzislau Barayeu, Peter Baracskay, Igor Gridchyn, Michele Nardin, Chiara Nina Roth, Peer Wulff, Jozsef Csicsvari
Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape pyramidal cell-firing patterns and regulate network oscillations and related network state transitions. To directly probe their role in the CA1 region, we silenced their activity using optogenetic and chemogenetic tools in mice. Opto-tagged CCKIs revealed a heterogeneous population, and their optogenetic silencing triggered wide
-
Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis Neuron (IF 14.7) Pub Date : 2024-04-12 Anthony D. Umpierre, Bohan Li, Katayoun Ayasoufi, Whitney L. Simon, Shunyi Zhao, Manling Xie, Grace Thyen, Benjamin Hur, Jiaying Zheng, Yue Liang, Dale B. Bosco, Mark A. Maynes, Zhaofa Wu, Xinzhu Yu, Jaeyun Sung, Aaron J. Johnson, Yulong Li, Long-Jun Wu
Microglial calcium signaling is rare in a baseline state but strongly engaged during early epilepsy development. The mechanism(s) governing microglial calcium signaling are not known. By developing an uridine diphosphate (UDP) fluorescent sensor, GRAB, we discovered that UDP release is a conserved response to seizures and excitotoxicity across brain regions. UDP can signal through the microglial-enriched
-
Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states Neuron (IF 14.7) Pub Date : 2024-04-12 Huikun Wang, Rodolfo J. Flores, Hector E. Yarur, Aaron Limoges, Hector Bravo-Rivera, Sanne M. Casello, Niharika Loomba, Juan Enriquez-Traba, Miguel Arenivar, Queenie Wang, Robert Ganley, Charu Ramakrishnan, Lief E. Fenno, Yoon Kim, Karl Deisseroth, Grace Or, Chunyang Dong, Mark A. Hoon, Lin Tian, Hugo A. Tejeda
Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related behavioral states. Dynorphin (Dyn) has been implicated in mediating negative affect and maladaptive behaviors induced by severe threats and is expressed in limbic circuits, including the vmPFC. However, there is a critical
-
Modeling proprioception with task-driven neural network models Neuron (IF 14.7) Pub Date : 2024-04-12 Hansjörg Scherberger
-
Building a science of human pleasure, meaning making, and flourishing Neuron (IF 14.7) Pub Date : 2024-04-11 Morten L. Kringelbach, Peter Vuust, Gustavo Deco
-
Interferons: Invited guests at the brain’s gala banquet Neuron (IF 14.7) Pub Date : 2024-04-11 Mar Márquez-Ropero, Amanda Sierra
-
Somatostatin interneurons control the timing of developmental desynchronization in cortical networks Neuron (IF 14.7) Pub Date : 2024-04-09 Laura Mòdol, Monika Moissidis, Martijn Selten, Fazal Oozeer, Oscar Marín
Synchronous neuronal activity is a hallmark of the developing brain. In the mouse cerebral cortex, activity decorrelates during the second week of postnatal development, progressively acquiring the characteristic sparse pattern underlying the integration of sensory information. The maturation of inhibition seems critical for this process, but the interneurons involved in this crucial transition of
-
Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling Neuron (IF 14.7) Pub Date : 2024-04-09 Saptarshi Biswas, Sanjid Shahriar, Galina Bachay, Panos Arvanitis, Danny Jamoul, William J. Brunken, Dritan Agalliu
Interactions among neuronal, glial, and vascular components are crucial for retinal angiogenesis and blood-retinal barrier (BRB) maturation. Although synaptic dysfunction precedes vascular abnormalities in many retinal pathologies, how neuronal activity, specifically glutamatergic activity, regulates retinal angiogenesis and BRB maturation remains unclear. Using genetic studies in mice, single-cell
-
Speak up & reach out: In defense of biomedical research Neuron (IF 14.7) Pub Date : 2024-04-09 Degan Mesler, Vicki Campbell
-
Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons Neuron (IF 14.7) Pub Date : 2024-04-05 Sandra M.V. Kochan, Meret Cepero Malo, Milica Jevtic, Hannah M. Jahn-Kelleter, Gulzar A. Wani, Kristiano Ndoci, Laura Pérez-Revuelta, Felix Gaedke, Iris Schäffner, Dieter Chichung Lie, Astrid Schauss, Matteo Bergami
Integration of new neurons into adult hippocampal circuits is a process coordinated by local and long-range synaptic inputs. To achieve stable integration and uniquely contribute to hippocampal function, immature neurons are endowed with a critical period of heightened synaptic plasticity, yet it remains unclear which mechanisms sustain this form of plasticity during neuronal maturation. We found that
-
Anesthesia and the neurobiology of consciousness Neuron (IF 14.7) Pub Date : 2024-04-04 George A. Mashour
In the 19 century, the discovery of general anesthesia revolutionized medical care. In the 21 century, anesthetics have become indispensable tools to study consciousness. Here, I review key aspects of the relationship between anesthesia and the neurobiology of consciousness, including interfaces of sleep and anesthetic mechanisms, anesthesia and primary sensory processing, the effects of anesthetics
-
Astrocyte-secreted neurocan controls inhibitory synapse formation and function Neuron (IF 14.7) Pub Date : 2024-04-03 Dolores Irala, Shiyi Wang, Kristina Sakers, Leykashree Nagendren, Francesco Paolo Ulloa Severino, Dhanesh Sivadasan Bindu, Justin T. Savage, Cagla Eroglu
Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse development were identified; however, those that induce inhibitory synaptogenesis remain elusive. Here, we identify neurocan as an astrocyte-secreted inhibitory synaptogenic protein. After secretion from astrocytes, neurocan is cleaved
-
Monitoring norepinephrine release in vivo using next-generation GRABNE sensors Neuron (IF 14.7) Pub Date : 2024-03-27 Jiesi Feng, Hui Dong, Julieta E. Lischinsky, Jingheng Zhou, Fei Deng, Chaowei Zhuang, Xiaolei Miao, Huan Wang, Guochuan Li, Ruyi Cai, Hao Xie, Guohong Cui, Dayu Lin, Yulong Li
Norepinephrine (NE) is an essential biogenic monoamine neurotransmitter. The first-generation NE sensor makes , real-time, cell-type-specific and region-specific NE detection possible, but its low NE sensitivity limits its utility. Here, we developed the second-generation GPCR-activation-based NE sensors (GRAB and GRAB) with a superior response and high sensitivity and selectivity to NE both and .
-
Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus Neuron (IF 14.7) Pub Date : 2024-03-26 Yiyao Zhang, Mursel Karadas, JingJing Liu, Xinyi Gu, Mihály Vöröslakos, Yulong Li, Richard W. Tsien, György Buzsáki
A postulated role of subcortical neuromodulators is to control brain states. Mechanisms by which different neuromodulators compete or cooperate at various temporal scales remain an open question. We investigated the interaction of acetylcholine (ACh) and oxytocin (OXT) at slow and fast timescales during various brain states. Although these neuromodulators fluctuated in parallel during NREM packets
-
An implantable device for wireless monitoring of diverse physio-behavioral characteristics in freely behaving small animals and interacting groups Neuron (IF 14.7) Pub Date : 2024-03-26 Wei Ouyang, Keith J. Kilner, Rachael M.P. Xavier, Yiming Liu, Yinsheng Lu, Sophia M. Feller, Kayla M. Pitts, Mingzheng Wu, Jokubas Ausra, Ian Jones, Yunyun Wu, Haiwen Luan, Jacob Trueb, Elizabeth M. Higbee-Dempsey, Iwona Stepien, Nayereh Ghoreishi-Haack, Chad R. Haney, Hao Li, Yevgenia Kozorovitskiy, Mitra Heshmati, Anthony R. Banks, Sam A. Golden, Cameron H. Good, John A. Rogers
Comprehensive, continuous quantitative monitoring of intricately orchestrated physiological processes and behavioral states in living organisms can yield essential data for elucidating the function of neural circuits under healthy and diseased conditions, for defining the effects of potential drugs and treatments, and for tracking disease progression and recovery. Here, we report a wireless, battery-free
-
TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice Neuron (IF 14.7) Pub Date : 2024-03-21 Xu-Yi Li, Shi-Ya Zhang, Yi-Zhou Hong, Zhi-Gang Chen, Yan Long, Dan-Hua Yuan, Jia-Jia Zhao, Su-Su Tang, Hao Wang, Hao Hong
Although bile acids play a notable role in depression, the pathological significance of the bile acid TGR5 membrane-type receptor in this disorder remains elusive. Using depression models of chronic social defeat stress and chronic restraint stress in male mice, we found that TGR5 in the lateral hypothalamic area (LHA) predominantly decreased in GABAergic neurons, the excitability of which increased
-
P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy Neuron (IF 14.7) Pub Date : 2024-03-20 Denghong Zhang, Wei Zhang, Chen Ming, Xuheng Gao, Huilong Yuan, Xiaojie Lin, Xinru Mao, Chunping Wang, Xiaoyi Guo, Ying Du, Lin Shao, Renzhi Yang, Zhihao Lin, Xilin Wu, Timothy Y. Huang, Zhanxiang Wang, Yun-wu Zhang, Huaxi Xu, Yingjun Zhao
Neuronal loss is the central issue in Alzheimer’s disease (AD), yet no treatment developed so far can halt AD-associated neurodegeneration. Here, we developed a monoclonal antibody (mAb2A7) against 217 site-phosphorylated human tau (p-tau217) and observed that p-tau217 levels positively correlated with brain atrophy and cognitive impairment in AD patients. Intranasal administration efficiently delivered
-
TRPV1 analgesics disturb core body temperature via a biased allosteric mechanism involving conformations distinct from that for nociception Neuron (IF 14.7) Pub Date : 2024-03-15 Yi-Zhe Huang, Jing-Xian Ma, Yu-Jing Bian, Qin-Ru Bai, Yu-Hao Gao, Shu-Ke Di, Yun-Tao Lei, Hui Yang, Xiao-Na Yang, Chang-Yan Shao, Wen-Hui Wang, Peng Cao, Chang-Zhu Li, Michael X. Zhu, Meng-Yang Sun, Ye Yu
Efforts on developing transient receptor potential vanilloid 1 (TRPV1) drugs for pain management have been hampered by deleterious hypo- or hyperthermia caused by TRPV1 agonists/antagonists. Here, we compared the effects of four antagonists on TRPV1 polymodal gating and core body temperature (CBT) in , , and . Neither the effect on proton gating nor drug administration route, hair coverage, CBT rhythmic
-
Simple spike patterns and synaptic mechanisms encoding sensory and motor signals in Purkinje cells and the cerebellar nuclei Neuron (IF 14.7) Pub Date : 2024-03-15 Spencer T. Brown, Mauricio Medina-Pizarro, Meghana Holla, Christopher E. Vaaga, Indira M. Raman
Whisker stimulation in awake mice evokes transient suppression of simple spike probability in crus I/II Purkinje cells. Here, we investigated how simple spike suppression arises synaptically, what it encodes, and how it affects cerebellar output. , monosynaptic parallel fiber (PF)-excitatory postsynaptic currents (EPSCs) facilitated strongly, whereas disynaptic inhibitory postsynaptic currents (IPSCs)
-
Glial KCNQ K+ channels control neuronal output by regulating GABA release from glia in C. elegans Neuron (IF 14.7) Pub Date : 2024-03-08 Bianca Graziano, Lei Wang, Olivia R. White, Daryn H. Kaplan, Jesus Fernandez-Abascal, Laura Bianchi
KCNQs are voltage-gated K channels that control neuronal excitability and are mutated in epilepsy and autism spectrum disorder (ASD). KCNQs have been extensively studied in neurons, but their function in glia is unknown. Using voltage, calcium, and GABA imaging, optogenetics, and behavioral assays, we show here for the first time in () that glial KCNQ channels control neuronal excitability by mediating
-
Functional ultrasound imaging of the human spinal cord Neuron (IF 14.7) Pub Date : 2024-03-07 K.A. Agyeman, D.J. Lee, J. Russin, E.I. Kreydin, W. Choi, A. Abedi, Y.T. Lo, J. Cavaleri, K. Wu, V.R. Edgerton, C. Liu, V.N. Christopoulos
Utilizing the first in-human functional ultrasound imaging (fUSI) of the spinal cord, we demonstrate the integration of spinal functional responses to electrical stimulation. We record and characterize the hemodynamic responses of the spinal cord to a neuromodulatory intervention commonly used for treating pain and increasingly used for the restoration of sensorimotor and autonomic function. We found
-
Cross-hemispheric communication: Insights on lateralized brain functions Neuron (IF 14.7) Pub Date : 2024-03-07 Sebastian Ocklenburg, Zengcai V. Guo
On the surface, the two hemispheres of vertebrate brains look almost perfectly symmetrical, but several motor, sensory, and cognitive systems show a deeply lateralized organization. Importantly, the two hemispheres are connected by various commissures, white matter tracts that cross the brain’s midline and enable cross-hemispheric communication. Cross-hemispheric communication has been suggested to
-
Simultaneous, cortex-wide dynamics of up to 1 million neurons reveal unbounded scaling of dimensionality with neuron number Neuron (IF 14.7) Pub Date : 2024-03-06 Jason Manley, Sihao Lu, Kevin Barber, Jeffrey Demas, Hyewon Kim, David Meyer, Francisca Martínez Traub, Alipasha Vaziri
The brain’s remarkable properties arise from the collective activity of millions of neurons. Widespread application of dimensionality reduction to multi-neuron recordings implies that neural dynamics can be approximated by low-dimensional “latent” signals reflecting neural computations. However, can such low-dimensional representations truly explain the vast range of brain activity, and if not, what
-
Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn Neuron (IF 14.7) Pub Date : 2024-03-06 Mark A. Gradwell, Nofar Ozeri-Engelhard, Jaclyn T. Eisdorfer, Olivier D. Laflamme, Melissa Gonzalez, Aman Upadhyay, Laura Medlock, Tara Shrier, Komal R. Patel, Adin Aoki, Melissa Gandhi, Gloria Abbas-Zadeh, Olisemaka Oputa, Joshua K. Thackray, Matthew Ricci, Arlene George, Nusrath Yusuf, Jessica Keating, Zarghona Imtiaz, Simona A. Alomary, Manon Bohic, Michael Haas, Yurdiana Hernandez, Steven A. Prescott
-
Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex Neuron (IF 14.7) Pub Date : 2024-03-05 Alex Piet, Nick Ponvert, Douglas Ollerenshaw, Marina Garrett, Peter A. Groblewski, Shawn Olsen, Christof Koch, Anton Arkhipov
In complex environments, animals can adopt diverse strategies to find rewards. How distinct strategies differentially engage brain circuits is not well understood. Here, we investigate this question, focusing on the cortical Vip-Sst disinhibitory circuit between vasoactive intestinal peptide-postive (Vip) interneurons and somatostatin-positive (Sst) interneurons. We characterize the behavioral strategies