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Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes Redox Biol. (IF 10.7) Pub Date : 2024-06-22 Yulong Zhang, Zhijun Yu, Mingwei Sun, Ruyue Du, Hanhan Gao, Qiankun Dai, Yan Dong, Cuicui Liu, Menghui Yin, Tingting Xu, Xiaofei Zhang, Jinsong Liu, Jinxin Xu
GPCR-G protein signaling from endosomes plays a crucial role in various physiological and pathological processes. However, the mechanism by which endosomal G protein signaling is terminated remains largely unknown. In this study, we aimed to investigate the regulatory mechanisms involved in terminating the signaling of Gα subunits from endosomes. Through structural analysis and cell-based assays, we
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An active peptide from yak inhibits hypoxia-induced lung injury via suppressing VEGF/MAPK/inflammatory signaling Redox Biol. (IF 10.7) Pub Date : 2024-06-22 Feiyan Yang, Zeyu He, Zhongxing Chu, Wen Li, Guangfan Qu, Han Lu, Yiping Tang, Shuguo Sun, Zhang Luo, Feijun Luo
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NADPH Alters DUOX1 Calcium Responsiveness Redox Biol. (IF 10.7) Pub Date : 2024-06-20 Gregory E. Conner
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Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la/KLF5 pathway Redox Biol. (IF 10.7) Pub Date : 2024-06-20 Xuanxuan Zhang, Jicong Chen, Ruohui Lin, Yaping Huang, Ziyuan Wang, Susu Xu, Lei Wang, Fang Chen, Jian Zhang, Ke Pan, Zhiqi Yin
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Low energy availability increases immune cell formation of reactive oxygen species and impairs exercise performance in female endurance athletes Redox Biol. (IF 10.7) Pub Date : 2024-06-19 Jan S. Jeppesen, Hannah G. Caldwell, Lone O. Lossius, Anna K. Melin, Lasse Gliemann, Jens Bangsbo, Ylva Hellsten
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Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics Redox Biol. (IF 10.7) Pub Date : 2024-06-19 Rebecca L. Koch, James B. Stanton, Susan McClatchy, Gary A. Churchill, Steven W. Craig, Darian N. Williams, Mallory E. Johns, Kylah R. Chase, Dana L. Thiesfeldt, Jessica C. Flynt, Robert Pazdro
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A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflammasome activation, and pyroptosis Redox Biol. (IF 10.7) Pub Date : 2024-06-19 Yunhao Duan, Qinyu Li, Jinjin Wu, Caixia Zhou, Xiuxiang Liu, Jinnan Yue, Xiaoli Chen, Jie Liu, Qi Zhang, Yuzhen Zhang, Lin Zhang
Sphingosine 1-phosphate (S1P), a bioactive lipid molecule, exerts multifaceted effects on cardiovascular functions via S1P receptors, but its effects on cardiac I/R injury are not fully understood. Plasma lipidomics analysis by mass spectrometry revealed that sphingosine lipids, including sphingosine 1-phosphate (S1P), were significantly down-regulated following cardiac I/R injury in mice. The reduced
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The rheumatoid arthritis drug auranofin exerts potent anti-lymphoma effect by stimulating TXNRD-mediated ROS generation and inhibition of energy metabolism Redox Biol. (IF 10.7) Pub Date : 2024-06-18 Mengqi Yang, Jiaxin Liu, Jianan Li, Shijun Wen, Yumin Hu, Wenhua Lu, Jinyun Liu, Peng Huang, Panpan Liu
Since the survival of lymphoma patients who experience disease progression or relapse remains very poor, new therapeutic approaches and effective drugs are urgently needed. Here we show that auranofin (AF), an anti-rheumatoid drug thought to inhibit thioredoxin reductases (TXNRDs) as its mechanism of action, exhibited potent activity against multiple cancer types, especially effective against B cell
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PAR level mediates the link between ROS and inflammatory response in patients with type 2 diabetes mellitus Redox Biol. (IF 10.7) Pub Date : 2024-06-18 Michele Zampieri, Katsyarina Karpach, Gerardo Salerno, Anna Raguzzini, Ilaria Barchetta, Flavia Agata Cimini, Sara Dule, Giovanna De Matteis, Giuseppe Zardo, Marina Borro, Ilaria Peluso, Maria Gisella Cavallo, Anna Reale
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Glucose 6 phosphate dehydrogenase overexpression rescues the loss of cognition in the double transgenic APP/PS1 mouse model of Alzheimer’s disease Redox Biol. (IF 10.7) Pub Date : 2024-06-17 Angela G. Correas, Gloria Olaso-Gonzalez, Marta Roca, Mari Carmen Blanco-Gandía, Carla Nascimento, Agustin Lahoz, Marta Rodriguez-Arias, José Miñarro, Mari Carmen Gomez-Cabrera, José Viña
Mice models of Alzheimer's disease (APP/PS1) typically experience cognitive decline with age. G6PD overexpressing mice (G6PD-Tg) exhibit better protection from age-associated functional decline including improvements in metabolic and muscle functions as well as reduced frailty compared to their wild-type counterparts. Importantly G6PD-Tg mice show diminished accumulation of DNA oxidation in the brain
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Extracellular vesicles from II trimester human amniotic fluid as paracrine conveyors counteracting oxidative stress Redox Biol. (IF 10.7) Pub Date : 2024-06-17 Senesi Giorgia, Guerricchio Laura, Ghelardoni Maddalena, Bertola Nadia, Rebellato Stefano, Grinovero Nicole, Bartolucci Martina, Costa Ambra, Raimondi Andrea, Grange Cristina, Bolis Sara, Massa Valentina, Paladini Dario, Coviello Domenico, Pandolfi Assunta, Bussolati Benedetta, Petretto Andrea, Fazio Grazia, Ravera Silvia, Barile Lucio, Balbi Carolina, Bollini Sveva
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Peroxynitrite reduces Treg cell expansion and function by mediating IL-2R nitration and aggravates multiple sclerosis pathogenesis: One sentence summary: Peroxynitrite-mediated Treg IL-2R nitration impacts on multiple sclerosis Redox Biol. (IF 10.7) Pub Date : 2024-06-15 Meiling Wu, Sulan Yu, Shenyu Yan, Minghui Wu, Lu Zhang, Shuang Chen, Dongyun Shi, Shanlin Liu, Yongping Fan, Xiang Lin, Jiangang Shen
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S-nitrosoglutathione reductase alleviates morphine analgesic tolerance by restricting PKCα S-nitrosation Redox Biol. (IF 10.7) Pub Date : 2024-06-14 Ling-Yan Su, Lijin Jiao, Qianjin Liu, Xinhua Qiao, Ting Xie, Zhiyu Ma, Min Xu, Mao-Sen Ye, Lu-Xiu Yang, Chang Chen, Yong-Gang Yao
Morphine, a typical opiate, is widely used for controlling pain but can lead to various side effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia. At present, however, the mechanisms underlying the development of morphine analgesic tolerance are not fully understood. This tolerance is influenced by various opioid receptor and kinase protein modifications, such as phosphorylation
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The glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6 Redox Biol. (IF 10.7) Pub Date : 2024-06-14 Yiding Bian, Mingming Deng, Jia Liu, Jiaye Li, Qin Zhang, Zilin Wang, Liwei Liao, Jinrui Miao, Ruixia Li, Xiaoming Zhou, Gang Hou
Silicosis is the most common type of pneumoconiosis, having a high incidence in workers chronically exposed to crystalline silica (CS). No specific medication exists for this condition. GHK, a tripeptide naturally occurring in human blood and urine, has antioxidant effects. We aimed to investigate the therapeutic effect of GHK-Cu on silicosis and its potential underlying molecular mechanism. An experimental
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α-Ketoglutarate prevents hyperlipidemia-induced fatty liver mitochondrial dysfunction and oxidative stress by activating the AMPK-pgc-1α/Nrf2 pathway Redox Biol. (IF 10.7) Pub Date : 2024-06-13 Danyu Cheng, Mo Zhang, Yezi Zheng, Min Wang, Yilin Gao, Xudong Wang, Xuyun Liu, Weiqiang Lv, Xin Zeng, Konstantin N. Belosludtsev, Jiacan Su, Lin Zhao, Jiankang Liu
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Manganese porphyrin-based treatment improves fetal-placental development and protects against oxidative damage and NLRP3 inflammasome activation in a rat maternal hypothyroidism model Redox Biol. (IF 10.7) Pub Date : 2024-06-11 Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Bianca Reis Santos, Acácia Eduarda de Jesus Nascimento, Emilly Oliveira Santos, Erikles Macêdo Barbosa, Isabela Oliveira de Macêdo, Letícia Dias Mendonça, José Ferreira Sarmento-Neto, Clarice Santos Pinho, Erick Teixeira dos Santos Coura, Acácio de Sá Santos, Marciel Elio Rodrigues, Júlio Santos Rebouças, Gilson De-Freitas-Silva, Alexandre
Oxidative stress (OS) and endoplasmic reticulum stress (ERS) are at the genesis of placental disorders observed in preeclampsia, intrauterine growth restriction, and maternal hypothyroidism. In this regard, cationic manganese porphyrins (MnPs) comprise potent redox-active therapeutics of high antioxidant and anti-inflammatory potential, which have not been evaluated in metabolic gestational diseases
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Glucose-6-phosphate dehydrogenase alleviates epileptic seizures by repressing reactive oxygen species production to promote signal transducer and activator of transcription 1-mediated N-methyl-d-aspartic acid receptors inhibition Redox Biol. (IF 10.7) Pub Date : 2024-06-11 Liqin Hu, Yan Liu, Ziwei Yuan, Haokun Guo, Ran Duan, Pingyang Ke, Yuan Meng, Xin Tian, Fei Xiao
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Manipulating mitochondrial pyruvate carrier function causes metabolic remodeling in corneal myofibroblasts that ameliorates fibrosis Redox Biol. (IF 10.7) Pub Date : 2024-06-08 Kye-Im Jeon, Ankita Kumar, Paul S. Brookes, Keith Nehrke, Krystel R. Huxlin
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FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury Redox Biol. (IF 10.7) Pub Date : 2024-06-08 Xiaolong Li, Feifei Yuan, Yabing Xiong, Ying Tang, Zhiru Li, Jun Ai, Jinhua Miao, Wenting Ye, Shan Zhou, Qinyu Wu, Xiaoxu Wang, Dan Xu, Jiemei Li, Jiewu Huang, Qiurong Chen, Weiwei Shen, Youhua Liu, Fan Fan Hou, Lili Zhou
Acute kidney injury (AKI) is in high prevalence worldwide but with no therapeutic strategies. Programmed cell death in tubular epithelial cells has been reported to accelerate a variety of AKI, but the major pathways and underlying mechanisms are not defined. Herein, we identified that pyroptosis was responsible for AKI progression and related to ATP depletion in renal tubular cells. We found that
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Activation of Sirtuin3 by honokiol ameliorates alveolar epithelial cell senescence in experimental silicosis via the cGAS-STING pathway Redox Biol. (IF 10.7) Pub Date : 2024-06-08 Qiang Zhou, Guan Yi, Meiyu Chang, Ning Li, Yichun Bai, Haibin Li, Sanqiao Yao
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Retraction notice to: Severe fever with thrombocytopenia syndrome virus induces platelet activation and apoptosis via a reactive oxygen species-dependent pathway [Redox Biol. 65 (2023) 102837] Redox Biol. (IF 10.7) Pub Date : 2024-06-08 Yi-Hui Li, Xue-Hui Wang, Wen-Wu Huang, Ren-Rong Tian, Wei Pang, Yong-Tang Zheng
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Retraction notice to: mtROS-mediated Akt/AMPK/mTOR pathway was involved in Copper-induced autophagy and it attenuates Copper-induced apoptosis in RAW264.7 mouse monocytes [Redox Biol. 41 (2021) 101912] Redox Biol. (IF 10.7) Pub Date : 2024-06-08 Qin Luo, Yuzhen Song, Jingjing Kang, Yuchen Wu, Fengsun Wu, Yueqin Li, Qing Dong, Jun Wang, Chao Song, Hongrui Guo
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Retraction notice to: Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice [Redox Biol. 56 (2022) 102432] Redox Biol. (IF 10.7) Pub Date : 2024-06-08 Wanli Jiang, Chengtai Ma, Jiawei Bai, Xianjin Du
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Dysfunction of astrocytic glycophagy exacerbates reperfusion injury in ischemic stroke Redox Biol. (IF 10.7) Pub Date : 2024-06-07 Haiyun Guo, Yumeng Li, Shiquan Wang, Yongheng Yang, Tiantian Xu, Jianshuai Zhao, Jin Wang, Wenqiang Zuo, Pengju Wang, Guangchao Zhao, Huaning Wang, Wugang Hou, Hailong Dong, Yanhui Cai
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Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury Redox Biol. (IF 10.7) Pub Date : 2024-06-06 Jing Yu, Yu Fu, Jiameng Gao, Qingqing Zhang, Nan Zhang, Zhiyuan Zhang, Xuemei Jiang, Chang Chen, Zongmei Wen
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Activation of Nrf2 inhibits atherosclerosis in ApoE−/− mice through suppressing endothelial cell inflammation and lipid peroxidation Redox Biol. (IF 10.7) Pub Date : 2024-06-06 Lei He, Qinghua Chen, Li Wang, Yujie Pu, Juan Huang, Chak Kwong Cheng, Jiang-Yun Luo, Lijing Kang, Xiao Lin, Li Xiang, Liang Fang, Ben He, Yin Xia, Kathy O. Lui, Yong Pan, Jie Liu, Cheng-Lin Zhang, Yu Huang
Nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor, is critically involved in the regulation of oxidative stress and inflammation. However, the role of endothelial Nrf2 in atherogenesis has yet to be defined. In addition, how endothelial Nrf2 is activated and whether Nrf2 can be targeted for the prevention and treatment of atherosclerosis is not explored. RNA-sequencing and single-cell
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Therapy-induced senescence through the redox lens Redox Biol. (IF 10.7) Pub Date : 2024-06-06 Matius Robert, Brian K. Kennedy, Karen C. Crasta
Therapy-induced senescent tumor cells have emerged as significant drivers of tumor recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production and its associated redox signaling networks are intertwined with initiation and establishment of therapy-induced senescence. Therapy-induced senescent cells influence neighboring cells and the tumor microenvironment via their bioactive
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Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum Redox Biol. (IF 10.7) Pub Date : 2024-06-06 Jiaolei Shangguan, Tao Wu, Li Tian, Yueqian Liu, Lei Zhu, Rui Liu, Jing Zhu, Liang Shi, Mingwen Zhao, Ang Ren
Hydrogen sulfide (HS) has recently been recognized as an important gaseous transmitter with multiple physiological effects in various species. Previous studies have shown that HS alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important quality index of . However, a comprehensive understanding of the physiological effects and molecular mechanisms of HS in remains unexplored. In this
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Sweroside alleviates pressure overload-induced heart failure through targeting CaMKⅡδ to inhibit ROS-mediated NF-κB/NLRP3 in cardiomyocytes Redox Biol. (IF 10.7) Pub Date : 2024-06-04 Dong Wang, Xue Yu, Kuo Gao, Fanghe Li, Xiang Li, Haiyin Pu, Peng Zhang, Shuzhen Guo, Wei Wang
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Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial function Redox Biol. (IF 10.7) Pub Date : 2024-06-04 Tomas Majtan, Thomas Olsen, Jitka Sokolova, Jakub Krijt, Michaela Křížková, Tomoaki Ida, Tamás Ditrói, Hana Hansikova, Ondrej Vit, Jiri Petrak, Ladislav Kuchař, Warren D. Kruger, Péter Nagy, Takaaki Akaike, Viktor Kožich
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ABCC1 deficiency potentiated noise-induced hearing loss in mice by impairing cochlear antioxidant capacity Redox Biol. (IF 10.7) Pub Date : 2024-06-01 Jing Liu, Yijiang Bai, Yong Feng, Xianlin Liu, Bo Pang, Shuai Zhang, Mengzhu Jiang, Anhai Chen, Huping Huang, Yongjia Chen, Jie Ling, Lingyun Mei
The gene belongs to the ATP-binding cassette membrane transporter superfamily, which plays a crucial role in the efflux of various endogenous and exogenous substances. Mutations in can result in autosomal dominant hearing loss. However, the specific roles of ABCC1 in auditory function are not fully understood. Through immunofluorescence, we found that ABCC1 was expressed in microvascular endothelial
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Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β Redox Biol. (IF 10.7) Pub Date : 2024-06-01 Chiara Lanzillotta, Antonella Tramutola, Simona Lanzillotta, Viviana Greco, Sara Pagnotta, Caterina Sanchini, Silvia Di Angelantonio, Elena Forte, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Flavia Agata Cimini, Ilaria Barchetta, Maria Gisella Cavallo, Andrea Urbani, D. Allan Butterfield, Fabio Di Domenico, Bindu D. Paul, Marzia Perluigi, Joao M.N. Duarte, Eugenio Barone
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Exogenous APN protects normal tissues from radiation-induced oxidative damage and fibrosis in mice and prostate cancer patients with higher levels of APN have less radiation-induced toxicities Redox Biol. (IF 10.7) Pub Date : 2024-05-31 Joshua A. McDowell, Elizabeth A. Kosmacek, Michael J. Baine, Oluwaseun Adebisi, Cheng Zheng, Madison M. Bierman, Molly S. Myers, Arpita Chatterjee, Kia T. Liermann-Wooldrik, Andrew Lim, Kristin A. Dickinson, Rebecca E. Oberley-Deegan
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ROS-mediated cytoplasmic localization of CARM1 induces mitochondrial fission through DRP1 methylation Redox Biol. (IF 10.7) Pub Date : 2024-05-31 Yena Cho, Yong Kee Kim
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Retraction notice to: Corrigendum to “Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice” [Redox Biol. 70 (2024) 103036] Redox Biol. (IF 10.7) Pub Date : 2024-05-31 Wanli Jiang, Chengtai Ma, Jiawei Bai, Xianjin Du
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Ferroptosis in health and disease Redox Biol. (IF 10.7) Pub Date : 2024-05-30 Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedorova, José
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A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma Redox Biol. (IF 10.7) Pub Date : 2024-05-30 Zong Miao, Lei Xu, Wei Gu, Yimin Ren, Rong Li, Shuai Zhang, Chao Chen, Hongxiang Wang, Jing Ji, Juxiang Chen
Temozolomide (TMZ) is a widely utilized chemotherapy treatment for patients with glioblastoma (GBM), although drug resistance constitutes a major therapeutic hurdle. Emerging evidence suggests that ferroptosis-mediated therapy could offer an appropriate alternative treatment option against cancer cells that are resistant to certain drugs. However, recurrent gliomas display robust ferroptosis resistance
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Corrigendum to “A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding” [Redox Biol. 72 (2024) 103161] Redox Biol. (IF 10.7) Pub Date : 2024-05-28 Annabel Sorby-Adams, Tracy A. Prime, Jan Lj Miljkovic, Hiran A. Prag, Thomas Krieg, Michael P. Murphy
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Corrigendum to “Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes” [Redox Biol. 71C (2024) 103104] Redox Biol. (IF 10.7) Pub Date : 2024-05-28 Weijun Huang, Depeng Wu, Chaoyang Cai, Hui Yao, Zhenming Tian, Yang Yang, Mao Pang, Limin Rong, Bin Liu
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Microenvironment-triggered cascade metal-polyphenolic nanozyme for ROS/NO synergistic hyperglycemic wound healing Redox Biol. (IF 10.7) Pub Date : 2024-05-28 Shuo Shi, Yaru Han, Jianxing Feng, Jingru Shi, Xiaoling Liu, Bangfeng Fu, Jianlong Wang, Wentao Zhang, Jinyou Duan
Wound infection of hyperglycemic patient often has extended healing period and increased probability due to the high glucose level. However, achieving precise and safe therapy of the hyperglycemic wound with specific wound microenvironment (WME) remains a major challenge. Herein, a WME-activated smart L-Arg/GOx@TA-Fe (LGTF) nanozymatic system composed of generally recognized as safe (GRAS) compound
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Mechano-activated connexin hemichannels and glutathione transport protect lens fiber cells against oxidative insults Redox Biol. (IF 10.7) Pub Date : 2024-05-28 Yuxin Tong, Guangyan Wang, Manuel A. Riquelme, Yu Du, Yumeng Quan, Jialing Fu, Sumin Gu, Jean X. Jiang
Long-lived lens fiber cells require a robust cellular protective function against oxidative insults to maintain their hemostasis and viability; however, the underlying mechanism is largely obscure. In this study, we unveiled a new mechanism that protects lens fiber cells against oxidative stress-induced cell death. We found that mechano-activated connexin (Cx) hemichannels (HCs) mediate the transport
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FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease Redox Biol. (IF 10.7) Pub Date : 2024-05-27 Chen Jiang, Dingyi Yao, Zongtao Liu, Yidan Zheng, Ming Chen, Wai Yen Yim, Qiang Zheng, Tailong Zhang, Lin Fan, Zhengfeng Fan, Bingchuan Geng, Rui Tian, Tingwen Zhou, Weihua Qiao, Jiawei Shi, Fei Li, Li Xu, Yuming Huang, Nianguo Dong
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Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression Redox Biol. (IF 10.7) Pub Date : 2024-05-25 Xuyu Gu, Yifei Zhu, Jincheng Su, Sheng Wang, Xiangyu Su, Xu Ding, Lei Jiang, Xiang Fei, Wentian Zhang
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Cystine/glutamate antiporter xCT controls skeletal muscle glutathione redox, bioenergetics and differentiation Redox Biol. (IF 10.7) Pub Date : 2024-05-25 Michel N. Kanaan, Chantal A. Pileggi, Charbel Y. Karam, Luke S. Kennedy, Claire Fong-McMaster, Miroslava Cuperlovic-Culf, Mary-Ellen Harper
Cysteine, the rate-controlling amino acid in cellular glutathione synthesis is imported as cystine, by the cystine/glutamate antiporter, xCT, and subsequently reduced to cysteine. As glutathione redox is important in muscle regeneration in aging, we hypothesized that xCT exerts upstream control over skeletal muscle glutathione redox, metabolism and regeneration. Bioinformatic analyses of publicly available
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Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectives Redox Biol. (IF 10.7) Pub Date : 2024-05-24 Dengxiong Li, Qingxin Yu, Ruicheng Wu, Zhouting Tuo, Jie Wang, Luxia Ye, Fanglin Shao, Premkamon Chaipanichkul, Koo Han Yoo, Wuran Wei, Uzoamaka Adaobi Okoli, Shi Deng, Mang Ke, William C. Cho, Susan Heavey, Dechao Feng
Recently, numerous studies have reported the interaction between senescence and oxidative stress in cancer. However, there is a lack of a comprehensive understanding of the precise mechanisms involved. Therefore, our review aims to summarize the current findings and elucidate by presenting specific mechanisms that encompass functional pathways, target genes, and related aspects. Pubmed and Web of Science
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An essential role for EROS in redox-dependent endothelial signal transduction Redox Biol. (IF 10.7) Pub Date : 2024-05-24 Markus Waldeck-Weiermair, Apabrita A. Das, Taylor A. Covington, Shambhu Yadav, Jonas Kaynert, Ruby Guo, Priyanga Balendran, Venkata Revanth Thulabandu, Arvind K. Pandey, Fotios Spyropoulos, David C. Thomas, Thomas Michel
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Pyrogallol intermediates elicit beta-amyloid secretion via radical formation and alterations in intracellular trafficking, distinct from pyrogallol-generated superoxide Redox Biol. (IF 10.7) Pub Date : 2024-05-24 Bong-Geum Jang, Boyoung Choi, Min-Ju Kim
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Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer Redox Biol. (IF 10.7) Pub Date : 2024-05-23 Shuohui Dong, Mingguang Zhang, Zhiqiang Cheng, Xiang Zhang, Weili Liang, Songhan Li, Linchuan Li, Qian Xu, Siyi Song, Zitian Liu, Guangwei Yang, Xiang Zhao, Ze Tao, Shuo Liang, Kexin Wang, Guangyong Zhang, Sanyuan Hu
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Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects Redox Biol. (IF 10.7) Pub Date : 2024-05-23 Bing Yu, Qian Wang, Lina Zhang, Jing Lin, Zhuhui Feng, Ziyi Wang, Lingwen Gu, Xue Tian, Songying Luan, Cui Li, Guiqiu Zhao
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A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression Redox Biol. (IF 10.7) Pub Date : 2024-05-22 Joanna Czarnecka-Herok, Kexin Zhu, Jean-Michel Flaman, Delphine Goehrig, Mathieu Vernier, Gabriela Makulyte, Aline Lamboux, Helena Dragic, Muriel Rhinn, Jean-Jacques Médard, Gilles Faury, Philippe Bertolino, Vincent Balter, Romain Debret, Serge Adnot, Nadine Martin, David Bernard
The gene encodes tropoelastin which is used to generate elastic fibers that insure proper tissue elasticity. Decreased amounts of elastic fibers and/or accumulation of bioactive products of their cleavage, named elastokines, are thought to contribute to aging. Cellular senescence, characterized by a stable proliferation arrest and by the senescence-associated secretory phenotype (SASP), increases with
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Development of nitroalkene-based inhibitors to target STING-dependent inflammation Redox Biol. (IF 10.7) Pub Date : 2024-05-21 Fei Chang, Camilla Gunderstofte, Nicole Colussi, Mareena Pitts, Sonia R. Salvatore, Anne L. Thielke, Lucia Turell, Beatriz Alvarez, Raphaela Goldbach-Mansky, Luis Villacorta, Christian K. Holm, Francisco J. Schopfer, Anne Louise Hansen
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The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism Redox Biol. (IF 10.7) Pub Date : 2024-05-21 Felipe Paredes, Holly C. Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M. Crotty, Samantha M. Yeligar, Alvaro A. Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin
Vascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of the mitochondrial protein Poldip2 induces VSMC differentiation both in vivo and in vitro. Further comprehensive biochemical investigations revealed Poldip2's
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Hypoxia and the endometrium: An indispensable role for HIF-1α as therapeutic strategies Redox Biol. (IF 10.7) Pub Date : 2024-05-21 Wanlin Dai, Renhao Guo, Xinni Na, Shuyi Jiang, Junzhi Liang, Cuishan Guo, Yuanyuan Fang, Zhijing Na, Da Li
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Fmp40 ampylase regulates cell survival upon oxidative stress by controlling Prx1 and Trx3 oxidation Redox Biol. (IF 10.7) Pub Date : 2024-05-21 Suchismita Masanta, Aneta Wiesyk, Chiranjit Panja, Sylwia Pilch, Jaroslaw Ciesla, Marta Sipko, Abhipsita De, Tuguldur Enkhbaatar, Roman Maslanka, Adrianna Skoneczna, Roza Kucharczyk
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GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide Redox Biol. (IF 10.7) Pub Date : 2024-05-17 Syed Masood, Hye-Young H. Kim, Edward R. Pennington, Keri A. Tallman, Ned A. Porter, Philip A. Bromberg, Rebecca L. Rice, Avram Gold, Zhenfa Zhang, James M. Samet
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ARID3A enhances chemoresistance of pancreatic cancer via inhibiting PTEN-induced ferroptosis Redox Biol. (IF 10.7) Pub Date : 2024-05-17 Xiaoqi Mao, Jin Xu, Mingming Xiao, Chen Liang, Jie Hua, Jiang Liu, Wei Wang, Xianjun Yu, Qingcai Meng, Si Shi
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Iron accumulation in ovarian microenvironment damages the local redox balance and oocyte quality in aging mice Redox Biol. (IF 10.7) Pub Date : 2024-05-17 Ye Chen, Jiaqi Zhang, Ying Tian, Xiangning Xu, Bicheng Wang, Ziqi Huang, Shuo Lou, Jingyi Kang, Ningning Zhang, Jing Weng, Yuanjing Liang, Wei Ma
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The absence of thioredoxin-interacting protein in alveolar cells exacerbates asthma during obesity Redox Biol. (IF 10.7) Pub Date : 2024-05-17 Ji-Soo Jeong, Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Eun-Hye Chung, Young-Eun Cho, Eui-Ju Hong, Hyo-Jung Kwon, Je-Won Ko, Tae-Won Kim
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Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expression Redox Biol. (IF 10.7) Pub Date : 2024-05-17 Thomas Olsen, Kathrine J. Vinknes, Kristýna Barvíková, Emma Stolt, Sindre Lee-Ødegård, Hannibal Troensegaard, Hanna Johannessen, Amany Elshorbagy, Jitka Sokolová, Jakub Krijt, Michaela Křížková, Tamás Ditrói, Péter Nagy, Bente Øvrebø, Helga Refsum, Magne Thoresen, Kjetil Retterstøl, Viktor Kožich
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Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury Redox Biol. (IF 10.7) Pub Date : 2024-05-16 Dan Wu, Charles B. Spencer, Lilibeth Ortoga, Hao Zhang, Changhong Miao