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Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA Cell Res. (IF 28.1) Pub Date : 2024-06-28 Pengliang Chi, Xiang Wang, Jialu Li, Hui Yang, Kaiju Li, Yuqi Zhang, Shiyi Lin, Leiye Yu, Shiqi Liu, Lu Chen, Ruobing Ren, Jianping Wu, Zhuo Huang, Jia Geng, Dong Deng
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Localized, highly efficient secretion of signaling proteins by migrasomes Cell Res. (IF 28.1) Pub Date : 2024-06-25 Haifeng Jiao, Xiaopeng Li, Ying Li, Yuting Guo, Xiaoyu Hu, Takami Sho, Yiqun Luo, Jinyu Wang, Huizhen Cao, Wanqing Du, Dong Li, Li Yu
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Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors Cell Res. (IF 28.1) Pub Date : 2024-06-24 Xinjing Wang, Wei Wang, Siyi Zou, Zhiwei Xu, Dan Cao, Shuai Zhang, Minzhi Wei, Qian Zhan, Chenlei Wen, Fanlu Li, Hao Chen, Da Fu, Lingxi Jiang, Ming Zhao, Baiyong Shen
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ANT2: the first mammalian mitochondrial RNA transport translocon Cell Res. (IF 28.1) Pub Date : 2024-06-24 Huanhuan Zhu, Weiqiang Lin, Aifu Lin
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine Cell Res. (IF 28.1) Pub Date : 2024-06-19 Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu, Yongliang Wang, Yan-Hui Liu, Jinye Xiong, Qi Qu, Yan Chen, Xiao Tian, Luming Yao, Renxiang Xie, Xiaomin Li, Siwei Chen, Xi Huang, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Baoding Zhang, Bin Jiang, Zhi-Chao Wang, Qinxi Li, Gang Li, Shu-Yong Lin, Li Yu, Hai-Long Piao, Xianming Deng, Jiahuai Han, Chen-Song Zhang, Sheng-Cai
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Pyroptosis: palmitoylation regulates GSDMD activation and pore formation Cell Res. (IF 28.1) Pub Date : 2024-06-18 Ella Hartenian, Petr Broz
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Structural insights into VAChT neurotransmitter recognition and inhibition Cell Res. (IF 28.1) Pub Date : 2024-06-11 Yang Zhang, Fei Dai, Nanhao Chen, Dong Zhou, Chia-Hsueh Lee, Chen Song, Yixiao Zhang, Zhe Zhang
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Tumor microenvironment squeezes out the juice from T cells Cell Res. (IF 28.1) Pub Date : 2024-06-10 Romane Thouenon, Grégory Verdeil
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A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles Cell Res. (IF 28.1) Pub Date : 2024-06-07 Dandan Liang, Liping Zhou, Huixing Zhou, Fulei Zhang, Guojian Fang, Junwei Leng, Yahan Wu, Yuemei Zhang, Anqi Yang, Yi Liu, Yi-Han Chen
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Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1 Cell Res. (IF 28.1) Pub Date : 2024-06-04 Changyao Li, Heng Liu, Jingru Li, Xinheng He, Haoran Zhu, Wei Fu, H. Eric Xu
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Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex Cell Res. (IF 28.1) Pub Date : 2024-06-04 Qiyin An, Yong Wang, Zhenhua Tian, Jie Han, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang, Zengqin Deng
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All-in-one Hangzhou Protocol: killing four birds with one stone Cell Res. (IF 28.1) Pub Date : 2024-05-31 Haopeng Wang, Shizhen Qiu, Mohamad Mohty
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ANT2 functions as a translocon for mitochondrial cross-membrane translocation of RNAs Cell Res. (IF 28.1) Pub Date : 2024-05-29 Pengcheng Wang, Lixiao Zhang, Siyi Chen, Renjian Li, Peipei Liu, Xiang Li, Hongdi Luo, Yujia Huo, Zhirong Zhang, Yiqi Cai, Xu Liu, Jinliang Huang, Guangkeng Zhou, Zhe Sun, Shanwei Ding, Jiahao Shi, Zizhuo Zhou, Ruoxi Yuan, Liang Liu, Sipeng Wu, Geng Wang
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Illuminating the path to pancreatic cancer Cell Res. (IF 28.1) Pub Date : 2024-05-27 Hiroyuki Kato, Nabeel Bardeesy
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Gerogenes and gerosuppression: the pillars of precision geromedicine Cell Res. (IF 28.1) Pub Date : 2024-05-27 Carlos López-Otín, Andrea B. Maier, Guido Kroemer
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No pain, no gain — how nociceptors orchestrate tissue repair Cell Res. (IF 28.1) Pub Date : 2024-05-23 Pavel Hanč, Ulrich H. von Andrian
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DALT: the brain’s border patrol Cell Res. (IF 28.1) Pub Date : 2024-05-22 Jang Hyun Park, Jenolyn F. Alexander, Leon C. D. Smyth, Jonathan Kipnis
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Structural snapshots of human VMAT2 reveal insights into substrate recognition and proton coupling mechanism Cell Res. (IF 28.1) Pub Date : 2024-05-22 Di Wu, Zhuoya Yu, Qihao Chen, Jun Zhao, Bo Huang, Yuhang Wang, Jiawei Su, Na Li, Daohua Jiang, Yan Zhao
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Past, present, and future of cell replacement therapy for parkinson’s disease: a novel emphasis on host immune responses Cell Res. (IF 28.1) Pub Date : 2024-05-22 Tae-Yoon Park, Jeha Jeon, Young Cha, Kwang-Soo Kim
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ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb Cell Res. (IF 28.1) Pub Date : 2024-05-14 Song Li, Xinxing Ouyang, Bing Su
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IS607 TnpB is a hypercompact RNA-guided DNA endonuclease Cell Res. (IF 28.1) Pub Date : 2024-05-14 Hui Yang, Dinshaw J. Patel
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Structural and functional evidence that GPR30 is not a direct estrogen receptor Cell Res. (IF 28.1) Pub Date : 2024-05-14 Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xinheng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H. Eric Xu
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Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1 Cell Res. (IF 28.1) Pub Date : 2024-05-14 Tianxin Wang, Wenqin Tang, Xiaolei Zhu, Zhenyu Lv, Jiayan Chen, Yongze Li, Xiaoyu Sun, Haoyu Lv, Quanchang Gu, Fahui Li, Jiangyun Wang
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Piecing together aminergic polypharmacology Cell Res. (IF 28.1) Pub Date : 2024-05-13 Blake A. Fordyce, Bryan L. Roth
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Network-level time computations in the suprachiasmatic nucleus Cell Res. (IF 28.1) Pub Date : 2024-05-08 Natalie Ness, Marco Brancaccio
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A tale of two calcium channels: structural pharmacology of Cav2.1 and Cav3.2 Cell Res. (IF 28.1) Pub Date : 2024-05-03 Laurent Ferron, Gerald W. Zamponi
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ONE-GO: Direct detection of context-dependent GPCR activity Cell Res. (IF 28.1) Pub Date : 2024-04-30 Aleksey Raskovalov, Donggyun Kim, Vadim Cherezov
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Prometheus 2.0: drug-induced liver regeneration arising Cell Res. (IF 28.1) Pub Date : 2024-04-29 Jan S. Tchorz
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Z-DNA marks the spot for AIRE Cell Res. (IF 28.1) Pub Date : 2024-04-29 Yael Goldfarb, Jakub Abramson
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Structural insights into human exon-defined spliceosome prior to activation Cell Res. (IF 28.1) Pub Date : 2024-04-24 Wenyu Zhang, Xiaofeng Zhang, Xiechao Zhan, Rui Bai, Jianlin Lei, Chuangye Yan, Yigong Shi
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Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation Cell Res. (IF 28.1) Pub Date : 2024-04-19 Xianwen Ye, Zixuan Huang, Yi Li, Mengjiao Wang, Wanyu Meng, Maojian Miao, Jingdong Cheng
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Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2 Cell Res. (IF 28.1) Pub Date : 2024-04-19 Lingyun Xia, Yuanyuan Zhang, Qiang Zhou
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APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease Cell Res. (IF 28.1) Pub Date : 2024-04-12 Hang Liu, Fan Mei, Rongrong Ye, Xinyu Han, Shudan Wang, Yan Ding, Yun Zhi, Keliang Pang, Wei Guo, Bai Lu
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Peripheral cancer remodeling of central neural system Cell Res. (IF 28.1) Pub Date : 2024-04-12 Gray Umbach, Shawn L. Hervey-Jumper
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System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning Cell Res. (IF 28.1) Pub Date : 2024-04-11 Zichen Wang, Jing Yu, Muyue Zhai, Zehua Wang, Kaiwen Sheng, Yu Zhu, Tianyu Wang, Mianzhi Liu, Lu Wang, Miao Yan, Jue Zhang, Ying Xu, Xianhua Wang, Lei Ma, Wei Hu, Heping Cheng
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Structural basis for human Cav3.2 inhibition by selective antagonists Cell Res. (IF 28.1) Pub Date : 2024-04-11 Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan
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Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs Cell Res. (IF 28.1) Pub Date : 2024-04-04 Kuan Ren, Fengxia Zhou, Fan Zhang, Mingyu Yin, Yuwei Zhu, Shouyu Wang, Yan Chen, Tengjin Huang, Zixuan Wu, Jiale He, Anqi Zhang, Changyou Guo, Zhiwei Huang
CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing technologies. Using bioinformatics analysis and biochemical experiments, here we present a new family of RNA-guided DNA endonucleases. Our bioinformatics analysis initially identifies the stable co-occurrence of conserved RAGATH-18-derived RNAs (reRNAs) and their upstream IS607 TnpBs
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Persistent in vivo epigenetic silencing of Pcsk9 Cell Res. (IF 28.1) Pub Date : 2024-04-02 Isabella R. Gengaro, Lei S. Qi
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Substrate and drug recognition mechanisms of SLC19A3 Cell Res. (IF 28.1) Pub Date : 2024-03-19 Yu Dang, Tianyi Zhang, Shabareesh Pidathala, Guopeng Wang, Yijie Wang, Nanhao Chen, Chen Song, Chia-Hsueh Lee, Zhe Zhang
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Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans Cell Res. (IF 28.1) Pub Date : 2024-03-15 Lin Fan, Junwei Liu, Wei Hu, Zexin Chen, Jie Lan, Tongtong Zhang, Yang Zhang, Xianpeng Wu, Zhiwei Zhong, Danyang Zhang, Jinlong Zhang, Rui Qin, Hui Chen, Yunfeng Zong, Jianmin Zhang, Bing Chen, Jun Jiang, Jifang Cheng, Jingyi Zhou, Zhiwei Gao, Zhenjie Liu, Ying Chai, Junqiang Fan, Pin Wu, Yinxuan Chen, Yuefeng Zhu, Kai Wang, Ying Yuan, Pintong Huang, Ying Zhang, Huiqin Feng, Kaichen Song, Xun Zeng
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Metabolic engineering of the paclitaxel anticancer drug Cell Res. (IF 28.1) Pub Date : 2024-03-14 Audrey Oudin, Nicolas Papon, Vincent Courdavault
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Multiple cancer cell types release LIF and Gal3 to hijack neural signals Cell Res. (IF 28.1) Pub Date : 2024-03-11 Qun Xu, Ying Cao, Fanni Kong, Jiaqi Liu, Xin Chen, Yifei Zhao, Chin-Hui Lai, Xin Zhou, Hao Hu, Wei Fu, Jian Chen, Jing Yang
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The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb Cell Res. (IF 28.1) Pub Date : 2024-03-06 Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang
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Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels Cell Res. (IF 28.1) Pub Date : 2024-03-05 Zhangqiang Li, Ye Cong, Tong Wu, Tongtong Wang, Xinyao Lou, Xinyu Yang, Nieng Yan
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MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis Cell Res. (IF 28.1) Pub Date : 2024-03-05 Manuel Beltrán-Visiedo, Siddharth Balachandran, Lorenzo Galluzzi
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T follicular regulatory cells keep B cell-directed autoreactivity in check Cell Res. (IF 28.1) Pub Date : 2024-03-05 Filipa Ribeiro, Luis Graca
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Complement(ing) the microbiome in infants through breastmilk Cell Res. (IF 28.1) Pub Date : 2024-03-05 Samuel P. Nobs, Eran Elinav
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An all-in-one targeted protein degradation platform guided by degradation condensates-bridging bi-specific nanobodies Cell Res. (IF 28.1) Pub Date : 2024-03-05 Wen Jia, Weijie Li, Zengpeng Li, Pilong Li
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Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection Cell Res. (IF 28.1) Pub Date : 2024-02-19 Hergen Spits, Jenny Mjösberg
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CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization Cell Res. (IF 28.1) Pub Date : 2024-02-14 Shizhen Qiu, Jian Chen, Tao Wu, Li Li, Gang Wang, Haitao Wu, Xianmin Song, Xuesong Liu, Haopeng Wang
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Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice Cell Res. (IF 28.1) Pub Date : 2024-02-09 Shuo Wu, Ping Yang, Zilong Geng, Yige Li, Zhizhao Guo, Yingmei Lou, Shasha Zhang, Junhao Xiong, Huan Hu, Xiaoling Guo, William T. Pu, Yan Zhang, Dan Zhu, Bing Zhang
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Convenient synthesis and delivery of a megabase-scale designer accessory chromosome empower biosynthetic capacity Cell Res. (IF 28.1) Pub Date : 2024-02-08 Yuan Ma, Shuxin Su, Zongheng Fu, Chu Zhou, Bin Qiao, Yi Wu, Ying-Jin Yuan
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40 Hz light flickering promotes sleep through cortical adenosine signaling Cell Res. (IF 28.1) Pub Date : 2024-02-08 Xuzhao Zhou, Yan He, Tao Xu, Zhaofa Wu, Wei Guo, Xi Xu, Yuntao Liu, Yi Zhang, Huiping Shang, Libin Huang, Zhimo Yao, Zewen Li, Lingya Su, Zhihui Li, Tao Feng, Shaomin Zhang, Olivia Monteiro, Rodrigo A. Cunha, Zhi-Li Huang, Kang Zhang, Yulong Li, Xiaohong Cai, Jia Qu, Jiang-Fan Chen
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Sensing the toxic aluminum cations in acidic soils Cell Res. (IF 28.1) Pub Date : 2024-02-07 Peter R. Ryan, Jianli Yang
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B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis Cell Res. (IF 28.1) Pub Date : 2024-02-07 Yihan Lin, Zurong Wan, Bo Liu, Jiacheng Yao, Tianqi Li, Fang Yang, Jianhua Sui, Yongshan Zhao, Wanli Liu, Xuyu Zhou, Jianbin Wang, Hai Qi
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MFSD7c functions as a transporter of choline at the blood–brain barrier Cell Res. (IF 28.1) Pub Date : 2024-02-02 Xuan Thi Anh Nguyen, Thanh Nha Uyen Le, Toan Q. Nguyen, Hoa Thi Thuy Ha, Anna Artati, Nancy C. P. Leong, Dat T. Nguyen, Pei Yen Lim, Adelia Vicanatalita Susanto, Qianhui Huang, Ling Fam, Lo Ngah Leong, Isabelle Bonne, Angela Lee, Jorge L. Granadillo, Catherine Gooch, Dejie Yu, Hua Huang, Tuck Wah Soong, Matthew Wook Chang, Markus R. Wenk, Jerzy Adamski, Amaury Cazenave-Gassiot, Long N. Nguyen
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Structural and functional characterization of the endogenous agonist for orphan receptor GPR3 Cell Res. (IF 28.1) Pub Date : 2024-01-30 Geng Chen, Nico Staffen, Zhangsong Wu, Xinyu Xu, Jinheng Pan, Asuka Inoue, Tingyi Shi, Peter Gmeiner, Yang Du, Jun Xu
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Identification of oleic acid as an endogenous ligand of GPR3 Corrections Cell Res. (IF 28.1) Pub Date : 2024-01-29 Yangjie Xiong, Zhenmei Xu, Xinzhi Li, Yuqin Wang, Jing Zhao, Na Wang, Yaning Duan, Ruixue Xia, Zhengbin Han, Yu Qian, Jiale Liang, Anqi Zhang, Changyou Guo, Asuka Inoue, Yu Xia, Zheng Chen, Yuanzheng He
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The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease Cell Res. (IF 28.1) Pub Date : 2024-01-24 Mengrui Wu, Shali Wu, Wei Chen, Yi-Ping Li
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The hidden face of GluD1 at inhibitory synapses Cell Res. (IF 28.1) Pub Date : 2024-01-23 Masayuki Itoh, Michisuke Yuzaki