The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been implicated by several studies; however, the question of how to specifically and efficiently activate cancer cell death while minimizing toxicity to host cells remains unsolved. In a recent paper published in Cell, Wu and Lieberman groups identified a GSDMD agonist that can induce low-level pyroptosis

In a recent study published in Nature, Malamud et al. identified how neutrophil MICL recognizes neutrophil extracellular traps (NETs). This recognition suppresses further neutrophil activation and NET production, thereby preventing a vicious cycle of inflammation.

Correction to: Cell Research https://doi.org/10.1038/s41422-024-00945-0, published online 15 March 2024

Upon announcing the completion of the Human Genome Project (HGP) in 2003, scientific leaders envisaged the transformative promise of the human genome for health and society.1 They anticipated genomics breakthroughs that could touch all of humanity and empower people to have longer healthier lives, ultimately creating a more prosperous society that also wields the human genome responsibly. Two decades

The enhanced myeloid lineage bias of old hematopoietic stem cells (HSCs) has been implicated to underpin the compromised immunity observed upon aging. In a recent paper in Cell, Poscablo and coworkers now present experimental support for also the dysregulated function of platelets seen during aging, emanating at the aged HSC level; they identified an aging- and platelet-specific differentiation pathway

Correction to: Cell Research https://doi.org/10.1038/s41422-024-00963-y, published online 14 May 2024

Correction to: Cell Research https://doi.org/10.1038/s41422-024-00952-1, published online 04 April 2024

An alteration in the lineage bias of aged hematopoietic stem cells (HSCs) has been implicated in the reduced immunity observed upon aging. Ross and colleagues now provide direct support for this hypothesis, demonstrating that a selective depletion of myeloid-biased HSCs in aged mice is accompanied by improvement in several parameters of immunity, uncovering a possible novel therapeutic avenue for counteracting

In two recent studies published in Nature and Science, researchers successfully developed unified AI architectures capable of predicting the structures of all biomolecules. This remarkable advancement is expected to have a profound impact on future biomedical research and drug design by offering crucial information regarding the interactions that govern both physiological and pathological processes