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Multiple sclerosis in Denmark (1950–2023): mean age, sex distribution, incidence and prevalence Brain (IF 10.6) Pub Date : 2024-07-20 Rolf P Holm, Malthe F Wandall-Holm, Melinda Magyari
With rising life expectancy and advancements in disease management, we expect the multiple sclerosis population is getting older. However, evidence supporting this hypothesis remains sparse. Our study aimed to determine whether the mean age of the Danish multiple sclerosis population has increased and to analyse the developments in sex distribution, incidence, and prevalence, all of which affect age
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A Reinterpretation of the Relationship between Persistent and Resurgent Sodium Currents J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Samuel P. Brown, Ryan J. Lawson, Jonathan D. Moreno, Joseph L. Ransdell
The resurgent sodium current (INaR) activates on membrane repolarization, such as during the downstroke of neuronal action potentials. Due to its unique activation properties, INaR is thought to drive high rates of repetitive neuronal firing. However, INaR is often studied in combination with the persistent or noninactivating portion of sodium currents (INaP). We used dynamic clamp to test how INaR
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Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimers Disease and Multiple Sclerosis J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Ainhoa Etxeberria, Yun-An A. Shen, Stephen Vito, Sean M. Silverman, Jose Imperio, Guita Lalehzadeh, Allison L. Soung, Changchun Du, Luke Xie, Man Kin Choy, Yi-chun Hsiao, Hai Ngu, Chang Hoon Cho, Soumitra Ghosh, Gloriia Novikova, Mitchell G. Rezzonico, Rebecca Leahey, Martin Weber, Alvin Gogineni, Justin Elstrott, Monica Xiong, Jacob J. Greene, Kimberly L. Stark, Pamela Chan, Gillie A. Roth, Max Adrian
Human genetics and preclinical studies have identified key contributions of TREM2 to several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically. Here, we characterize the activities of three TREM2 agonist antibodies in multiple mixed-sex mouse models of Alzheimer's disease (AD) pathology and remyelination. Receptor activation and downstream signaling are explored in vitro
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Distinctive Neurophysiological Signatures of Analgesia after Inflammatory Pain in the ACC of Freely Moving Mice J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Samuel T. Kissinger, Estefania O’neil, Baolin Li, Kirk W. Johnson, Jeffrey L. Krajewski, Akihiko S. Kato
Preclinical assessments of pain have often relied upon behavioral measurements and anesthetized neurophysiological recordings. Current technologies enabling large-scale neural recordings, however, have the potential to unveil quantifiable pain signals in conscious animals for preclinical studies. Although pain processing is distributed across many brain regions, the anterior cingulate cortex (ACC)
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A Prelimbic Cortex-Thalamus Circuit Bidirectionally Regulates Innate and Stress-Induced Anxiety-Like Behavior J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Sheng-Rong Zhang, Ding-Yu Wu, Rong Luo, Jian-Lin Wu, Hao Chen, Zi-Ming Li, Jia-Pai Zhuang, Neng-Yuan Hu, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao, Yi-Hua Chen
Anxiety-related disorders respond to cognitive behavioral therapies, which involved the medial prefrontal cortex (mPFC). Previous studies have suggested that subregions of the mPFC have different and even opposite roles in regulating innate anxiety. However, the specific causal targets of their descending projections in modulating innate anxiety and stress-induced anxiety have yet to be fully elucidated
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Computation on Demand: Action-Specific Representations of Visual Task Features Arise during Distinct Movement Phases J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Nina Lee, Lin Lawrence Guo, Adrian Nestor, Matthias Niemeier
The intention to act influences the computations of various task-relevant features. However, little is known about the time course of these computations. Furthermore, it is commonly held that these computations are governed by conjunctive neural representations of the features. But, support for this view comes from paradigms arbitrarily combining task features and affordances, thus requiring representations
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The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Zachary W. Hoisington, Alexandra Salvi, Sophie Laguesse, Yann Ehinger, Chhavi Shukla, Khanhky Phamluong, Dorit Ron
The small G-protein Ras–related C3 botulinum toxin substrate 1 (Rac1) promotes the formation of filamentous actin (F-actin). Actin is a major component of dendritic spines, and we previously found that alcohol alters actin composition and dendritic spine structure in the nucleus accumbens (NAc) and the dorsomedial striatum (DMS). To examine if Rac1 contributes to these alcohol-mediated adaptations
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Development of the Fetal Brain Corticocortical Structural Network during the Second-to-Third Trimester Based on Diffusion MRI J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Ruike Chen, Ruoke Zhao, Haotian Li, Xinyi Xu, Mingyang Li, Zhiyong Zhao, Cong Sun, Guangbin Wang, Dan Wu
During the second-to-third trimester, the neuronal pathways of the fetal brain experience rapid development, resulting in the complex architecture of the interwired network at birth. While diffusion MRI-based tractography has been employed to study the prenatal development of structural connectivity network (SCN) in preterm neonatal and postmortem fetal brains, the in utero development of SCN in the
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Sex Differences in Dopamine Release in Nucleus Accumbens and Dorsal Striatum Determined by Chronic Fast-Scan Cyclic Voltammetry: Effects of Social Housing and Repeated Stimulation J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Ivette L. Gonzalez, Christopher A. Turner, Paras R. Patel, Noah B. Leonardo, Brandon D. Luma, Julianna M. Richie, Dawen Cai, Cynthia A. Chestek, Jill B. Becker
We investigated sex differences in dopamine (DA) release in the nucleus accumbens (NAc) and dorsolateral striatum (DLS) using a chronic 16-channel carbon fiber electrode and fast-scan cyclic voltammetry (FSCV). Electrical stimulation-induced (ES; 60 Hz) DA release was recorded in the NAc of single- or pair-housed male and female rats. When core (NAcC) and shell (NAcS) were recorded simultaneously,
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Selective Enhancement of REM Sleep in Male Rats through Activation of Melatonin MT1 Receptors Located in the Locus Ceruleus Norepinephrine Neurons J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Martha López-Canul, Qianzi He, Tania Sasson, Mohamed Ettaoussi, Danilo De Gregorio, Rafael Ochoa-Sanchez, Helene Catoire, Luca Posa, Guy Rouleau, Jean Martin Beaulieu, Stefano Comai, Gabriella Gobbi
Sleep disorders affect millions of people around the world and have a high comorbidity with psychiatric disorders. While current hypnotics mostly increase non-rapid eye movement sleep (NREMS), drugs acting selectively on enhancing rapid eye movement sleep (REMS) are lacking. This polysomnographic study in male rats showed that the first-in-class selective melatonin MT1 receptor partial agonist UCM871
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Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via {alpha}2{delta}-1 in Spinal Excitatory Neurons J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Yuying Huang (黄玉莹), Jian-Ying Shao (邵建英), Hong Chen (陈红), Jing-Jing Zhou (周京京), Shao-Rui Chen (陈少瑞), Hui-Lin Pan (潘惠麟)
Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506), are commonly used immunosuppressants for preserving transplanted organs and tissues. However, these drugs can cause severe and persistent pain. GluA2-lacking, calcium-permeable AMPA receptors (CP-AMPARs) are implicated in various neurological disorders, including neuropathic pain. It is unclear whether and how constitutive calcineurin
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Distinct Action Signals by Subregions in the Nucleus Accumbens during STOP-Change Performance J. Neurosci. (IF 4.4) Pub Date : 2024-07-17 Sydney E. Ashton, Paul Sharalla, Naru Kang, Adam T. Brockett, Margaret M. McCarthy, Matthew R. Roesch
The nucleus accumbens (NAc) is thought to contribute to motivated behavior by signaling the value of reward-predicting cues and the delivery of anticipated reward. The NAc is subdivided into core and shell, with each region containing different populations of neurons that increase or decrease firing to rewarding events. While there are numerous theories of functions pertaining to these subregions and
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Schizophrenia genomics: genetic complexity and functional insights Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-19 Patrick F. Sullivan, Shuyang Yao, Jens Hjerling-Leffler
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Nested compressed co-representations of multiple sequential experiences during sleep Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-19 Kefei Liu, Jeremie Sibille, George Dragoi
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Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-19 Chen Yan, Valentina Mercaldo, Alexander D. Jacob, Emily Kramer, Andrew Mocle, Adam I. Ramsaran, Lina Tran, Asim J. Rashid, Sungmo Park, Nathan Insel, A. David Redish, Paul W. Frankland, Sheena A. Josselyn
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Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant Brain (IF 10.6) Pub Date : 2024-07-19 Marielle Minere, Martin Mortensen, Valentina Dorovykh, Gary Warnes, Dean Nizetic, Trevor G Smart, Saad B Hannan
GABABRs are key membrane proteins that continually adapt the excitability of the nervous system. These G-protein coupled receptors are activated by the brain’s premier inhibitory neurotransmitter GABA. They are obligate heterodimers composed of GABA-binding GABABR1 and G-protein-coupling GABABR2 subunits. Recently, three variants (G693W, S695I, I705N) have been identified in the gene (GABBR2) encoding
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Shared patterns of glial transcriptional dysregulation link Huntington’s disease and schizophrenia Brain (IF 10.6) Pub Date : 2024-07-19 Nguyen P T Huynh, Mikhail Osipovitch, Rossana Foti, Janna Bates, Benjamin Mansky, Jose C Cano, Abdellatif Benraiss, Chuntao Zhao, Q Richard Lu, Steven A Goldman
Huntington’s disease and juvenile-onset schizophrenia have long been regarded as distinct disorders. However, both manifest cell-intrinsic abnormalities in glial differentiation, with resultant astrocytic dysfunction and hypomyelination. To assess whether a common mechanism might underlie the similar glial pathology of these otherwise disparate conditions, we used comparative correlation network approaches
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Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation Brain (IF 10.6) Pub Date : 2024-07-18 Tilman Schneider-Hohendorf, Christian Wünsch, Simon Falk, Catarina Raposo, Florian Rubelt, Hamid Mirebrahim, Hosseinali Asgharian, Ulrich Schlecht, Daniel Mattox, Wenyu Zhou, Eva Dawin, Marc Pawlitzki, Sarah Lauks, Sven Jarius, Brigitte Wildemann, Joachim Havla, Tania Kümpfel, Miriam-Carolina Schrot, Marius Ringelstein, Markus Kraemer, Carolin Schwake, Thomas Schmitter, Ilya Ayzenberg, Katinka Fischer
Epstein-Barr virus (EBV) infection has long been associated with the development of multiple sclerosis (MS). MS patients have elevated titers of EBV-specific antibodies in serum and show signs of CNS damage only after EBV infection. Regarding CD8+ T-cells, an elevated but ineffective response to EBV was suggested in MS patients, who present with a broader MHC-I-restricted EBV-specific T-cell receptor
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Combined clinical, structural, and cellular studies discriminate pathogenic and benign TRPV4 variants Brain (IF 10.6) Pub Date : 2024-07-18 Sarah H Berth, Linh Vo, Do Hoon Kwon, Tiffany Grider, Yasmine S Damayanti, Gage Kosmanopoulos, Andrew Fox, Alexander R Lau, Patrice Carr, Jack K Donohue, Maya Hoke, Simone Thomas, Chafic Karim, Alex J Fay, Ethan Meltzer, Thomas O Crawford, Rachelle Gaudet, Michael E Shy, Ute A Hellmich, Seok-Yong Lee, Charlotte J Sumner, Brett A McCray
Dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) cause diverse and largely distinct channelopathies, including inherited forms of neuromuscular disease, skeletal dysplasias, and arthropathy. Pathogenic TRPV4 mutations cause gain of ion channel function and toxicity that can be rescued by small molecule TRPV4 antagonists in cellular and animal
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Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-17 Bhanu P. Tewari, AnnaLin M. Woo, Courtney E. Prim, Lata Chaunsali, Dipan C. Patel, Ian F. Kimbrough, Kaliroi Engel, Jack L. Browning, Susan L. Campbell, Harald Sontheimer
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Disentangling genetic risks for development and progression of Alzheimer’s disease Brain (IF 10.6) Pub Date : 2024-07-17 Niklas Mattsson-Carlgren
This scientific commentary refers to ‘Towards cascading genetic risk in Alzheimer’s disease’ by Altmann et al. (https://doi.org/10.1093/brain/awae176).
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The rich information hidden in misspoken discourse Brain (IF 10.6) Pub Date : 2024-07-16 Argye E Hillis
This scientific commentary refers to ‘Artificial intelligence classifies primary progressive aphasia from connected speech’ by Rezaii et al. (https://doi.org/10.1093/brain/awae196).
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Brain inflammation co-localizes highly with tau in mild cognitive impairment due to early-onset Alzheimer’s disease Brain (IF 10.6) Pub Date : 2024-07-16 Johanna Appleton, Quentin Finn, Paolo Zanotti-Fregonara, Meixiang Yu, Alireza Faridar, Mohammad O Nakawah, Carlos Zarate, Maria Carrillo, Bradford C Dickerson, Gil Rabinovici, Liana G Apostolova, Joseph C Masdeu, Belen Pascual
Brain inflammation, with an increased density of microglia and macrophages, is an important component of Alzheimer’s disease (AD) and a potential therapeutic target. However, it is incompletely characterized, particularly in patients whose disease begins before the age of 65 years and, thus, have few co-pathologies. Inflammation has been usefully imaged with translocator protein (TSPO) positron emission
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A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-15 David F. Parks, Aidan M. Schneider, Yifan Xu, Samuel J. Brunwasser, Samuel Funderburk, Danilo Thurber, Tim Blanche, Eva L. Dyer, David Haussler, Keith B. Hengen
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Unlocking opioid neuropeptide dynamics with genetically encoded biosensors Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-15 Chunyang Dong, Raajaram Gowrishankar, Yihan Jin, Xinyi Jenny He, Achla Gupta, Huikun Wang, Nilüfer Sayar-Atasoy, Rodolfo J. Flores, Karan Mahe, Nikki Tjahjono, Ruqiang Liang, Aaron Marley, Grace Or Mizuno, Darren K. Lo, Qingtao Sun, Jennifer L. Whistler, Bo Li, Ivone Gomes, Mark Von Zastrow, Hugo A. Tejeda, Deniz Atasoy, Lakshmi A. Devi, Michael R. Bruchas, Matthew R. Banghart, Lin Tian
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The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes Brain (IF 10.6) Pub Date : 2024-07-15 Siddharth Ramanan, Danyal Akarca, Shalom K Henderson, Matthew A Rouse, Kieren Allinson, Karalyn Patterson, James B Rowe, Matthew A Lambon Ralph
Clinical variants of Alzheimer’s disease and frontotemporal lobar degeneration display a spectrum of cognitive-behavioural changes varying between individuals and over time. Understanding the landscape of these graded individual-/group-level longitudinal variations is critical for precise phenotyping; however, this remains challenging to model. Addressing this challenge, we leverage the National Alzheimer’s
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Systemic inflammatory markers in ageing, Alzheimer’s disease and other dementias Brain (IF 10.6) Pub Date : 2024-07-15 Huimin Cai, Tan Zhao, Yana Pang, Xiaofeng Fu, Ziye Ren, Shuiyue Quan, Longfei Jia
Systemic inflammation with alterations in inflammatory markers is involved in aging and Alzheimer’s disease. However, few studies have investigated the longitudinal trajectories of systemic inflammatory markers during aging and Alzheimer’s disease, and specific markers contributing to Alzheimer’s disease remain undetermined. In this study, a longitudinal cohort (cohort 1: n = 290; controls, 136; preclinical
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Customized antisense oligonucleotide-based therapy for neurofilament-associated Charcot-Marie-Tooth disease Brain (IF 10.6) Pub Date : 2024-07-15 Jessica Medina, Adriana Rebelo, Matt C Danzi, Elizabeth H Jacobs, Isaac R L Xu, Kathleen P Ahrens, Sitong Chen, Jacquelyn Raposo, Christopher Yanick, Stephan Zuchner, Mario A Saporta
DNA-based therapeutics have emerged as a revolutionary approach for addressing the treatment gap in rare inherited conditions by targeting the fundamental genetic causes of disease. Charcot-Marie-Tooth (CMT) disease, a group of inherited neuropathies, represents one of the most prevalent Mendelian disease groups in neurology and is characterized by diverse genetic etiology. Axonal forms of CMT, known
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Synaptic mitochondria glycation contributes to mitochondrial stress and cognitive dysfunction Brain (IF 10.6) Pub Date : 2024-07-13 Sourav Samanta, Firoz Akhter, Renhao Xue, Alexandre A Sosunov, Long Wu, Doris Chen, Ottavio Arancio, Shi Fang Yan, Shirley ShiDu Yan
Mitochondrial and synaptic dysfunction are pathological features of brain aging and cognitive decline. Synaptic mitochondria are vital for meeting the high energy demands of synaptic transmission. However, little is known about the link between age-related metabolic changes and the integrity of synaptic mitochondria. To this end, we investigate the mechanisms of advanced glycation endproducts (AGEs)-mediated
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Inflammation-induced mast cell-derived nerve growth factor: a key player in chronic vulvar pain? Brain (IF 10.6) Pub Date : 2024-07-13 Yaseen Awad-Igbaria, Doron Edelman, Elvira Ianshin, Saher Abu-Ata, Alon Shamir, Jacob Bornstein, Eilam Palzur
Provoked vulvodynia (PV) is characterized by localized chronic vulvar pain. It is associated with a history of recurrent inflammation, mast cell (MC) accumulation, and neuronal sprouting in the vulva. However, the mechanism of how vulvar-inflammation promotes neuronal sprouting and gene-expression adaptation in the spinal cord, leading to hypersensitivity and painful sensations, is unknown. Here, we
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Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-11
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Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Ceruleus Degeneration, and Hippocampal Amyloid-{beta}42 Accumulation J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Kathy Zhang, Yan Zhu, Polina Fenik, Dennis Fleysh, Colin Ly, Steven A. Thomas, Sigrid Veasey
Chronic sleep disruption (CSD), from insufficient or fragmented sleep and is an important risk factor for Alzheimer's disease (AD). Underlying mechanisms are not understood. CSD in mice results in degeneration of locus ceruleus neurons (LCn) and CA1 hippocampal neurons and increases hippocampal amyloid-β42 (Aβ42), entorhinal cortex (EC) tau phosphorylation (p-tau), and glial reactivity. LCn injury
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Dissociated Representation of Binaural Cues in Single-Sided Deafness: Implications for Cochlear Implantation J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Peter Hubka, Leonard Schmidt, Jochen Tillein, Peter Baumhoff, Wiebke Konerding, Rüdiger Land, Mika Sato, Andrej Kral
Congenital single-sided deafness (SSD) leads to an aural preference syndrome that is characterized by overrepresentation of the hearing ear in the auditory system. Cochlear implantation (CI) of the deaf ear is an effective treatment for SSD. However, the newly introduced auditory input in congenital SSD often does not reach expectations in late-implanted CI recipients with respect to binaural hearing
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N-Methyl-D-Aspartate Receptor-Antibody Encephalitis Impairs Maintenance of Attention to Items in Working Memory J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Afrose Dor, Corin Harrison, Sarosh R. Irani, Adam Al-Diwani, John Grogan, Sanjay Manohar
NMDA receptors (NMDARs) may be crucial to working memory (WM). Computational models predict that they sustain neural firing and produce associative memory, which may underpin maintaining and binding information, respectively. We test this in patients with antibodies to NMDAR (n = 10, female) and compare them with healthy control participants (n = 55, 20 male, 35 female). Patients were tested after
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Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Elijah D. Lowenstein, Aristotelis Misios, Sven Buchert, Pierre-Louis Ruffault
The vagal ganglia, comprised of the superior (jugular) and inferior (nodose) ganglia of the vagus nerve, receive somatosensory information from the head and neck or viscerosensory information from the inner organs, respectively. Developmentally, the cranial neural crest gives rise to all vagal glial cells and to neurons of the jugular ganglia, while the epibranchial placode gives rise to neurons of
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G272V and P301L Mutations Induce Isoform Specific Tau Mislocalization to Dendritic Spines and Synaptic Dysfunctions in Cellular Models of 3R and 4R Tau Frontotemporal Dementia J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Ke Yu, Katherine R. Yao, Miguel A. Aguinaga, Jessica M. Choquette, Chengliang Liu, Yuxin Wang, Dezhi Liao
Tau pathologies are detected in the brains of some of the most common neurodegenerative diseases including Alzheimer's disease (AD), Lewy body dementia (LBD), chronic traumatic encephalopathy (CTE), and frontotemporal dementia (FTD). Tau proteins are expressed in six isoforms with either three or four microtubule-binding repeats (3R tau or 4R tau) due to alternative RNA splicing. AD, LBD, and CTE brains
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Speech Prosody Serves Temporal Prediction of Language via Contextual Entrainment J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Yulia Lamekina, Lorenzo Titone, Burkhard Maess, Lars Meyer
Temporal prediction assists language comprehension. In a series of recent behavioral studies, we have shown that listeners specifically employ rhythmic modulations of prosody to estimate the duration of upcoming sentences, thereby speeding up comprehension. In the current human magnetoencephalography (MEG) study on participants of either sex, we show that the human brain achieves this function through
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Trans-synaptic Association of Vesicular Zinc Transporter 3 and Shank3 Supports Synapse-Specific Dendritic Spine Structure and Function in the Mouse Auditory Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Abbey Manning, Philip T. R. Bender, Helen Boyd-Pratt, Benjamin Z. Mendelson, Martin Hruska, Charles T. Anderson
Shank3 is a synaptic scaffolding protein that assists in tethering and organizing structural proteins and glutamatergic receptors in the postsynaptic density of excitatory synapses. The localization of Shank3 at excitatory synapses and the formation of stable Shank3 complexes is regulated by the binding of zinc to the C-terminal sterile-alpha-motif (SAM) domain of Shank3. Mutations in the SAM domain
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Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Rachel L. Weinberg, Suyeon Kim, Zixuan Pang, Sandy Awad, Tyger Hanback, Baohan Pan, Leonie Bettin, Dennis Chang, Michael J. Polydefkis, Lintao Qu, Michael J. Caterina
SLURP1 and SLURP2 are both small secreted members of the Ly6/u-PAR family of proteins and are highly expressed in keratinocytes. Loss-of-function mutations in SLURP1 lead to a rare autosomal recessive palmoplantar keratoderma (PPK), Mal de Meleda (MdM), which is characterized by diffuse, yellowish palmoplantar hyperkeratosis. Some individuals with MdM experience pain in conjunction with the hyperkeratosis
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A Comparison of Rapid Rule-Learning Strategies in Humans and Monkeys J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Vishwa Goudar, Jeong-Woo Kim, Yue Liu, Adam J. O. Dede, Michael J. Jutras, Ivan Skelin, Michael Ruvalcaba, William Chang, Bhargavi Ram, Adrienne L. Fairhall, Jack J. Lin, Robert T. Knight, Elizabeth A. Buffalo, Xiao-Jing Wang
Interspecies comparisons are key to deriving an understanding of the behavioral and neural correlates of human cognition from animal models. We perform a detailed comparison of the strategies of female macaque monkeys to male and female humans on a variant of the Wisconsin Card Sorting Test (WCST), a widely studied and applied task that provides a multiattribute measure of cognitive function and depends
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Obesity Alters POMC and Kisspeptin Neuron Cross Talk Leading to Reduced Luteinizing Hormone in Male Mice J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Pedro A. Villa, Rebecca E. Ruggiero-Ruff, Bradley B. Jamieson, Rebecca E. Campbell, Djurdjica Coss
Obesity is associated with hypogonadism in males, characterized by low testosterone and sperm number. Previous studies determined that these stem from dysregulation of hypothalamic circuitry that regulates reproduction, by unknown mechanisms. Herein, we used mice fed chronic high-fat diet, which mimics human obesity, to determine mechanisms of impairment at the level of the hypothalamus, in particular
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Trying Harder: How Cognitive Effort Sculpts Neural Representations during Working Memory J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Sarah L. Master, Shanshan Li, Clayton E. Curtis
While the exertion of mental effort improves performance on cognitive tasks, the neural mechanisms by which motivational factors impact cognition remain unknown. Here, we used fMRI to test how changes in cognitive effort, induced by changes in task difficulty, impact neural representations of working memory (WM). Participants (both sexes) were precued whether WM difficulty would be hard or easy. We
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Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination J. Neurosci. (IF 4.4) Pub Date : 2024-07-10 Roopa Ravichandar, Farah Gadelkarim, Rupadevi Muthaiah, Nicolas Glynos, Kateryna Murlanova, Nagendra K. Rai, Darpan Saraswat, Jessie J. Polanco, Ranjan Dutta, Dinesh Pal, Fraser J. Sim
Dysregulation of oligodendrocyte progenitor cell (OPC) recruitment and oligodendrocyte differentiation contribute to failure of remyelination in human demyelinating diseases such as multiple sclerosis (MS). Deletion of muscarinic receptor enhances OPC differentiation and remyelination. However, the role of ligand-dependent signaling versus constitutive receptor activation is unknown. We hypothesized
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Annexin A11 mutations are associated with nuclear envelope dysfunction in vivo and in human tissue Brain (IF 10.6) Pub Date : 2024-07-11 Valentina Marchica, Luca Biasetti, Jodi Barnard, Shujing Li, Nikolas Nikolaou, Matthew P Frosch, Diane E Lucente, Mark Eldaief, Andrew King, Manolis Fanto, Claire Troakes, Corinne Houart, Bradley N Smith
Annexin A11 mutations are a rare cause of amyotrophic lateral sclerosis (ALS), wherein replicated protein variants P36R, G38R, D40G and D40Y are located in a small-alpha helix within the long, disordered N-terminus. To elucidate disease mechanisms, we characterised the phenotypes induced by a genetic loss of function (LoF) and by misexpression of G38R and D40G in vivo. Loss of Annexin A11 results in
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Clinical and diagnostic implications of Alzheimer’s disease copathology in Lewy body disease Brain (IF 10.6) Pub Date : 2024-07-11 Lorenzo Barba, Samir Abu-Rumeileh, Henryk Barthel, Federico Massa, Matteo Foschi, Giovanni Bellomo, Lorenzo Gaetani, Dietmar R Thal, Lucilla Parnetti, Markus Otto
Concomitant Alzheimer’s disease (AD) pathology is a frequent event in the context of Lewy body disease (LBD), occurring in approximately half of all cases. Evidence shows that LBD patients with AD copathology show an accelerated disease course, a greater risk of cognitive decline and an overall poorer prognosis. However, LBD-AD cases may show heterogeneous motor and non-motor phenotypes with higher
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Side-effects are often a curse. Can they also be a blessing? Brain (IF 10.6) Pub Date : 2024-07-11 Katja Wiech, Helena Hartmann, Ulrike Bingel
This scientific commentary refers to ‘How side effects can improve treatment efficacy: a randomized trial’ by Schenk et al. (https://doi.org/10.1093/brain/awae132).
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The cerebellum modulates thirst Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-10 Ila Mishra, Bing Feng, Bijoya Basu, Amanda M. Brown, Linda H. Kim, Tao Lin, Mir Abbas Raza, Amelia Moore, Abigayle Hahn, Samantha Bailey, Alaina Sharp, Juan C. Bournat, Claire Poulton, Brian Kim, Amos Langsner, Aaron Sathyanesan, Roy V. Sillitoe, Yanlin He, Atul R. Chopra
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Morphine maladaptively modulates myelination Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Leonie Welberg
Myelin plasticity is involved in several forms of learning in mice. Yalçın et al. now show that it also contributes to maladaptive opioid reward learning. They first showed that phasic optogenetic stimulation of dopamine (DA) neurons in the ventral tegmental area (VTA) increased the number of proliferating oligodendroglia precursor cells (OPCs) selectively in the VTA; this resulted in an increase in
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Real control in virtual rats Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Luis A. Mejia
How neural activity controls naturalistic behavior is a fundamental question in neuroscience. Using deep reinforcement learning to implement inverse dynamics models, Aldarondo et al. trained artificial neural networks that control a biomechanically realistic rat model in a physics simulation engine to imitate the movements of real, freely moving rats. They then related neural activity recorded from
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New datasets from PsychENCODE Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Shari Wiseman
Recently, Science published the latest installment of papers from the PsychENCODE Consortium, a US National Institute of Mental Health (NIMH)-funded collaborative effort to generate genomic data from the brains of both neurotypical individuals and those with neuropsychiatric disorders, including autism spectrum disorder, schizophrenia, major depressive disorder, and post-traumatic stress disorder.
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Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer’s disease Brain (IF 10.6) Pub Date : 2024-07-10 Astrid Devulder, Greet Vanderlinden, Leen Van Langenhoven, Dries Testelmans, Maarten Van Den Bossche, François-Laurent De Winter, Mathieu Vandenbulcke, Rik Vandenberghe, Tom Theys, Koen Van Laere, Wim Van Paesschen
Both sleep alterations and epileptiform activity are associated with the accumulation of amyloid-β and tau pathology and are currently investigated for potential therapeutic interventions in Alzheimer’s disease (AD). However, a bidirectional intertwining relation between sleep and neuronal hyperexcitability might modulate the effects of AD pathology on the corresponding associations. To investigate
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Flexible multitask computation in recurrent networks utilizes shared dynamical motifs Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Laura N. Driscoll, Krishna Shenoy, David Sussillo
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Neurogenic exacerbation of psoriasis Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-08 Darran Yates
Acid-sensing ion channel 3 in nociceptors exacerbates inflammation in psoriasis by inducing the release of calcitonin gene-related peptide from these neurons.
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-08 Noam Gannot, Xingyu Li, Chrystian D. Phillips, Ayse Bilge Ozel, Karin Harumi Uchima Koecklin, John P. Lloyd, Lusi Zhang, Katie Emery, Tomer Stern, Jun Z. Li, Peng Li
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Microglia are dispensable for experience-dependent refinement of mouse visual circuitry Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-08 Thomas C. Brown, Emily C. Crouse, Cecilia A. Attaway, Dana K. Oakes, Sarah W. Minton, Bart G. Borghuis, Aaron W. McGee
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Piezo2 voltage-block regulates mechanical pain sensitivity Brain (IF 10.6) Pub Date : 2024-07-08 Oscar Sánchez-Carranza, Sampurna Chakrabarti, Johannes Kühnemund, Fred Schwaller, Valérie Bégay, Jonathan Alexis García-Contreras, Lin Wang, Gary R Lewin
PIEZO2 is a trimeric mechanically-gated ion channel expressed by most sensory neurones in the dorsal root ganglia. Mechanosensitive PIEZO2 channels are also genetically required for normal touch sensation in both mice and humans. We previously showed that PIEZO2 channels are also strongly modulated by membrane voltage. Specifically, it is only at very positive voltages that all channels are available
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Gba1 E326K renders motor and non-motor symptoms with pathologic α-syn, tau and glial activation Brain (IF 10.6) Pub Date : 2024-07-08 Sin Ho Kweon, Hye Guk Ryu, Seung-Hwan Kwon, Hyeonwoo Park, Saebom Lee, Nam-Shik Kim, Shi-Xun Ma, Hee-Jung Jee, Sangjune Kim, Han Seok Ko
Mutations in the GBA1 gene are common genetic risk factors for Parkinson's disease (PD), disrupting enzymatic activity and causing lysosomal dysfunction, leading to elevated α-synuclein (α-syn) levels. While GBA1's role in synucleinopathy is well-established, recent research underscores neuroinflammation as a significant pathogenic mechanism in GBA1 deficiency. This study investigates neuroinflammation
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Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-05 Yizhak Sofer, Noga Zilkha, Elena Gimpel, Shlomo Wagner, Silvia Gabriela Chuartzman, Tali Kimchi
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Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice Brain (IF 10.6) Pub Date : 2024-07-05 Victoria Gomez-Murcia, Agathe Launay, Kévin Carvalho, Anaëlle Burgard, Céline Meriaux, Raphaëlle Caillierez, Sabiha Eddarkaoui, Devrim Kilinc, Dolores Siedlecki-Wullich, Mélanie Besegher, Séverine Bégard, Bryan Thiroux, Matthieu Jung, Ouada Nebie, Maxence Wisztorski, Nicole Déglon, Claire Montmasson, Alexis-Pierre Bemelmans, Malika Hamdane, Thibaud Lebouvier, Didier Vieau, Isabelle Fournier, Luc Buee
Early pathological upregulation of adenosine A2A receptors (A2ARs), one of the caffeine targets, by neurons is thought to be involved in the development of synaptic and memory deficits in Alzheimer’s disease (AD) but mechanisms remain ill-defined. To tackle this question, we promoted a neuronal upregulation of A2AR in the hippocampus of APP/PS1 mice developing AD-like amyloidogenesis. Our findings
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Orexin Facilitates the Peripheral Chemoreflex via Corticotropin-Releasing Hormone Neurons Projecting to the Nucleus of the Solitary Tract J. Neurosci. (IF 4.4) Pub Date : 2024-07-03 Ruwaida Ben Musa, Jennifer Cornelius-Green, Hua Zhang, De-Pei Li, David D. Kline, Eileen M. Hasser, Kevin J. Cummings
We previously showed that orexin neurons are activated by hypoxia and facilitate the peripheral chemoreflex (PCR)-mediated hypoxic ventilatory response (HVR), mostly by promoting the respiratory frequency response. Orexin neurons project to the nucleus of the solitary tract (nTS) and the paraventricular nucleus of the hypothalamus (PVN). The PVN contributes significantly to the PCR and contains nTS-projecting