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The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway Mol. Cell (IF 14.5) Pub Date : 2024-07-17
The twenty-three Fanconi anemia (FA) proteins cooperate in the FA/BRCA pathway to repair DNA interstrand cross-links (ICLs). The cell division cycle a…
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The guide-RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex Mol. Cell (IF 14.5) Pub Date : 2024-07-17
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Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory Mol. Cell (IF 14.5) Pub Date : 2024-07-17
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Functional and structural insights into RAS effector proteins Mol. Cell (IF 14.5) Pub Date : 2024-07-17
RAS proteins are conserved guanosine triphosphate (GTP) hydrolases (GTPases) that act as molecular binary switches and play vital roles in numerous cellular processes. Upon GTP binding, RAS GTPases adopt an active conformation and interact with specific proteins termed RAS effectors that contain a conserved ubiquitin-like domain, thereby facilitating downstream signaling. Over 50 effector proteins
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RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release Mol. Cell (IF 14.5) Pub Date : 2024-07-16
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Competition between two HUSH complexes orchestrates the immune response to retroelement invasion Mol. Cell (IF 14.5) Pub Date : 2024-07-15
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Base-resolution m5C profiling across the mammalian transcriptome by bisulfite-free enzyme-assisted chemical labeling approach Mol. Cell (IF 14.5) Pub Date : 2024-07-12 Liang Lu, Xiaoting Zhang, Yuenan Zhou, Zuokun Shi, Xiwen Xie, Xinyue Zhang, Liaoliao Gao, Anbo Fu, Cong Liu, Bo He, Xushen Xiong, Yafei Yin, Qingqing Wang, Chengqi Yi, Xiaoyu Li
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Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1 Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Sharon Spizzichino, Federica Di Fonzo, Chiara Marabelli, Angela Tramonti, Antonio Chaves-Sanjuan, Alessia Parroni, Giovanna Boumis, Francesca Romana Liberati, Alessio Paone, Linda Celeste Montemiglio, Matteo Ardini, Arjen J. Jakobi, Alok Bharadwaj, Paolo Swuec, Gian Gaetano Tartaglia, Alessandro Paiardini, Roberto Contestabile, Antonello Mai, Dante Rotili, Francesco Fiorentino, Francesca Cutruzzolà
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Meet the authors: Mei-Sheng Xiao, Arun Prasath Damodaran, and Thomas Gonatopoulos-Pournatzis Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Mei-Sheng Xiao, Arun Prasath Damodaran, Thomas Gonatopoulos-Pournatzis
We talk to corresponding author Thomas Gonatopoulos-Pournatzis and co-first authors Arun Prasath Damodaran and Mei-Sheng Xiao about their paper “Genome-scale exon perturbation screens uncover exons critical for cell fitness” (in this issue of Molecular Cell) and get insights into their findings, career trajectories, and future directions in the pre-mRNA processing field.
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Chaperones in concert: Orchestrating co-translational protein folding in the cell Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Bob Schiffrin, Antonio N. Calabrese
In this issue of Molecular Cell, Roeselová et al.1 provide insights into co-translational folding of a multidomain protein in bacteria, revealing how the chaperones Trigger Factor, DnaJ, and DnaK work together to facilitate the folding of nascent chains.
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Assigning function to an unexplored Integrator module Mol. Cell (IF 14.5) Pub Date : 2024-07-11 William Garland, Jérôme O. Rouvière, Torben Heick Jensen
In this issue of Molecular Cell, Razew et al.1 and Sabath et al.2 assign function to an unexplored module of the Integrator (INT) complex, expanding the toolbox of this genome-wide attenuator of RNA polymerase II (RNAPII) transcription.
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Thrifty tissues prefer recycled purines over new-cleotides Mol. Cell (IF 14.5) Pub Date : 2024-07-11 David Sokolov, Lucas B. Sullivan
In two recent studies appearing in Cell1 and Cell Metabolism,2 Tran et al. and Wu et al. describe underappreciated nuance in organismal and cellular purine nucleotide salvage pathways and identify purine salvage as a metabolic limitation for tumor growth.
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The molecular basis of tRNA selectivity by human pseudouridine synthase 3 Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Ting-Yu Lin, Leon Kleemann, Jakub Jeżowski, Dominika Dobosz, Michał Rawski, Paulina Indyka, Grzegorz Ważny, Rahul Mehta, Andrzej Chramiec-Głąbik, Łukasz Koziej, Tristan Ranff, Christian Fufezan, Mateusz Wawro, Jakub Kochan, Joanna Bereta, Sebastian A. Leidel, Sebastian Glatt
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Dynamic BTB-domain filaments promote clustering of ZBTB proteins Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Lucija Mance, Nicolas Bigot, Edison Zhamungui Sánchez, Franck Coste, Natalia Martín-González, Siham Zentout, Marin Biliškov, Zofia Pukało, Aanchal Mishra, Catherine Chapuis, Ana-Andreea Arteni, Axelle Lateur, Stéphane Goffinont, Virginie Gaudon, Ibtissam Talhaoui, Ignacio Casuso, Martine Beaufour, Norbert Garnier, Franck Artzner, Martine Cadene, Marcin Józef Suskiewicz
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Polymerization of ZBTB transcription factors regulates chromatin occupancy Mol. Cell (IF 14.5) Pub Date : 2024-07-11 Paul M.C. Park, Jiho Park, Jared Brown, Moritz Hunkeler, Shourya S. Roy Burman, Katherine A. Donovan, Hojong Yoon, Radosław P. Nowak, Mikołaj Słabicki, Benjamin L. Ebert, Eric S. Fischer
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Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress Mol. Cell (IF 14.5) Pub Date : 2024-07-08 Johannes Pilic, Benjamin Gottschalk, Benjamin Bourgeois, Hansjörg Habisch, Zhanat Koshenov, Furkan E. Oflaz, Yusuf C. Erdogan, Seyed M. Miri, Esra N. Yiğit, Mehmet Ş. Aydın, Gürkan Öztürk, Emrah Eroglu, Varda Shoshan-Barmatz, Tobias Madl, Wolfgang F. Graier, Roland Malli
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Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle Mol. Cell (IF 14.5) Pub Date : 2024-07-03 Robert Ietswaart, Brendan M. Smalec, Albert Xu, Karine Choquet, Erik McShane, Ziad Mohamoud Jowhar, Chantal K. Guegler, Autum R. Baxter-Koenigs, Emma R. West, Becky Xu Hua Fu, Luke Gilbert, Stephen N. Floor, L. Stirling Churchman
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CCAR1 promotes DNA repair via alternative splicing Mol. Cell (IF 14.5) Pub Date : 2024-07-03 Mehmet E. Karasu, Leonard Jahnke, Brian J. Joseph, Yerkezhan Amerzhanova, Aleksei Mironov, Xuan Shu, Markus S. Schröder, Ana Gvozdenovic, Irene Sala, Mihaela Zavolan, Stefanie Jonas, Jacob E. Corn
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Cas12a domain flexibility guides R-loop formation and forces RuvC resetting Mol. Cell (IF 14.5) Pub Date : 2024-07-01 Isabel Strohkendl, Aakash Saha, Catherine Moy, Alexander-Hoi Nguyen, Mohd Ahsan, Rick Russell, Giulia Palermo, David W. Taylor
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An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II Mol. Cell (IF 14.5) Pub Date : 2024-07-01 Haiyan Zhao, Jiaqin Li, Yufei Xiang, Sohail Malik, Supriya V. Vartak, Giovana M.B. Veronezi, Natalie Young, McKayla Riney, Jens Kalchschmidt, Andrea Conte, Seol Kyoung Jung, Srinivas Ramachandran, Robert G. Roeder, Yi Shi, Rafael Casellas, Francisco J. Asturias
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A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation Mol. Cell (IF 14.5) Pub Date : 2024-07-01 Xuehui Lyu, Yingzi Cui, Yinfei Kong, Min Yang, Hui Shen, Shuyun Liao, Shiyu Li, Chenrui An, Haoyi Wang, Zhe Zhang, Jennie Ong, Yan Li, Peng Du
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A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria Mol. Cell (IF 14.5) Pub Date : 2024-06-26 Justin M. Vento, Deniz Durmusoglu, Tianyu Li, Constantinos Patinios, Sean Sullivan, Fani Ttofali, John van Schaik, Yanying Yu, Yanyan Wang, Lars Barquist, Nathan Crook, Chase L. Beisel
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Phase separation as a new form of regulation in innate immunity Mol. Cell (IF 14.5) Pub Date : 2024-06-26 Lei Wang, Wen Zhou
Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The innate immune system encodes many sensor, adaptor, and effector proteins and relies on the assembly of higher-order signaling complexes to activate immune defense. Recent evidence demonstrates that many of the core complexes involved in innate immunity are organized as liquid-like condensates through a mechanism
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Structure of the Hir histone chaperone complex Mol. Cell (IF 14.5) Pub Date : 2024-06-25 Hee Jong Kim, Mary R. Szurgot, Trevor van Eeuwen, M. Daniel Ricketts, Pratik Basnet, Athena L. Zhang, Austin Vogt, Samah Sharmin, Craig D. Kaplan, Benjamin A. Garcia, Ronen Marmorstein, Kenji Murakami
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pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism Mol. Cell (IF 14.5) Pub Date : 2024-06-25 Lauren M. Landau, Neha Chaudhary, Yun Chen Tien, Magdalena Rogozinska, Shakchhi Joshi, Conghui Yao, Joseph Crowley, Karthik Hullahalli, Ian W. Campbell, Matthew K. Waldor, Marcia Haigis, Jonathan C. Kagan
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PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection Mol. Cell (IF 14.5) Pub Date : 2024-06-24 Christopher Ritchie, Lingyin Li
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Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25 Mol. Cell (IF 14.5) Pub Date : 2024-06-24 Jack Daiyang Li, Mikko Taipale, Benjamin J. Blencowe
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Genome-scale exon perturbation screens uncover exons critical for cell fitness Mol. Cell (IF 14.5) Pub Date : 2024-06-24 Mei-Sheng Xiao, Arun Prasath Damodaran, Bandana Kumari, Ethan Dickson, Kun Xing, Tyler A. On, Nikhil Parab, Helen E. King, Alexendar R. Perez, Wilfried M. Guiblet, Gerard Duncan, Anney Che, Raj Chari, Thorkell Andresson, Joana A. Vidigal, Robert J. Weatheritt, Michael Aregger, Thomas Gonatopoulos-Pournatzis
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Mechanism of chaperone coordination during cotranslational protein folding in bacteria Mol. Cell (IF 14.5) Pub Date : 2024-06-21 Alžběta Roeselová, Sarah L. Maslen, Santosh Shivakumaraswamy, Grant A. Pellowe, Steven Howell, Dhira Joshi, Joanna Redmond, Svend Kjær, J. Mark Skehel, David Balchin
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Basis of gene-specific transcription regulation by the Integrator complex Mol. Cell (IF 14.5) Pub Date : 2024-06-20 Kevin Sabath, Amena Nabih, Christian Arnold, Rim Moussa, David Domjan, Judith B. Zaugg, Stefanie Jonas
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Internal mRNA 2′-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer Mol. Cell (IF 14.5) Pub Date : 2024-06-20 Luke R. Frietze, Tao Pan
In this issue, Li et al.1 report internal mRNA 2′-O-methyl (Nm) modification mapping by nanopore sequencing and the effect of Nm on mRNA stability and cancer cell progression.
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A critical role for palmitoylation in pyroptosis Mol. Cell (IF 14.5) Pub Date : 2024-06-20 Zhiqi Sun, Veit Hornung
Three recent publications by Du et al.,1 Balasubramanian et al.,2 and Zhang et al.3 identified palmitoylation on cysteine 191/192 in gasdermin D as a key determinant of gasdermin D membrane translocation and oligomerization, ensuring efficient plasma membrane permeabilization during pyroptosis.
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Driving the wedge: Understanding an improved Cas9 to better engineer others Mol. Cell (IF 14.5) Pub Date : 2024-06-20 Charles J. Lenihan, Scott Bailey
In their recent structural work, Eggers et al.1 rationalize how key mutations in the WED domain of the compact and thermostable Geobacillus stearothermophilus Cas9 bolster its editing efficiency in mammalian cells, and they use these insights to rationally improve another Cas9.
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2′-O-methylation at internal sites on mRNA promotes mRNA stability Mol. Cell (IF 14.5) Pub Date : 2024-06-20 Yanqiang Li, Yang Yi, Xinlei Gao, Xin Wang, Dongyu Zhao, Rui Wang, Li-Sheng Zhang, Boyang Gao, Yadong Zhang, Lili Zhang, Qi Cao, Kaifu Chen
2′-O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and more recently also found at many mRNA internal sites. However, their function and base-resolution stoichiometry remain underexplored. Here, we investigate the transcriptome-wide effect of internal site Nm on mRNA stability. Combining nanopore sequencing with our developed machine learning method, NanoNm, we identify
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A high-throughput synthetic biology approach for studying combinatorial chromatin-based transcriptional regulation Mol. Cell (IF 14.5) Pub Date : 2024-06-20 Miguel A. Alcantar, Max A. English, Jacqueline A. Valeri, James J. Collins
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An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing Mol. Cell (IF 14.5) Pub Date : 2024-06-12 Amanda L. Waterbury, Hui Si Kwok, Ceejay Lee, Domenic N. Narducci, Allyson M. Freedy, Cindy Su, Shaunak Raval, Andrew H. Reiter, William Hawkins, Kwangwoon Lee, Jiaming Li, Samuel M. Hoenig, Michael E. Vinyard, Philip A. Cole, Anders S. Hansen, Steven A. Carr, Malvina Papanastasiou, Brian B. Liau
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K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment Mol. Cell (IF 14.5) Pub Date : 2024-06-12 Harsha Garadi Suresh, Eric Bonneil, Benjamin Albert, Carine Dominique, Michael Costanzo, Carles Pons, Myra Paz David Masinas, Ermira Shuteriqi, David Shore, Anthony K. Henras, Pierre Thibault, Charles Boone, Brenda J. Andrews
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Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP Mol. Cell (IF 14.5) Pub Date : 2024-06-12 Yoann Nicolas, Hélène Bret, Elda Cannavo, Ananya Acharya, Petr Cejka, Valérie Borde, Raphaël Guerois
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Meet the author: Laura Amaya Mol. Cell (IF 14.5) Pub Date : 2024-06-06 Laura Amaya
We talk to first author Laura Amaya about her paper “Pathways for macrophage uptake of cell-free circular RNAs” (in this issue of Molecular Cell), her path to becoming a scientist, and some of the lessons she’s learned along the way.
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eIF4E integrates into stress response Mol. Cell (IF 14.5) Pub Date : 2024-06-06 Xincheng Wu, Shu-Bing Qian
In this issue, Diamond et al.1 and Kim et al.2 report that depletion of eIF4E leads to translational upregulation of GCN4, a key player in the integrated stress response, in an eIF2α phosphorylation-independent manner, suggesting a new mode of translational adaptation.
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The picky mTORC1 in metabolic enzyme degradation Mol. Cell (IF 14.5) Pub Date : 2024-06-06 Yujin Chun, David A. Fruman, Gina Lee
In this issue of Molecular Cell, Yi et al.1 demonstrate that reduced mTORC1 activity induces the CTLH E3 ligase-dependent degradation of HMGCS1, an enzyme in the mevalonate pathway, thus revealing a unique connection between mTORC1 signaling and the degradation of a specific metabolic enzyme via the ubiquitin-proteasome system.
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Long live the RNAs: The guardians of neuronal longevity? Mol. Cell (IF 14.5) Pub Date : 2024-06-06 Lin Lin, Naoto Kubota, Nanaka Kaneshiro, Sika Zheng
In a recent publication in Science, Zocher et al.1 identify and characterize long-lived nuclear RNA in the mouse brain, suggesting their potential roles as guardians of neuronal longevity.
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Depletion of cap-binding protein eIF4E dysregulates amino acid metabolic gene expression Mol. Cell (IF 14.5) Pub Date : 2024-06-06 Paige D. Diamond, Nicholas J. McGlincy, Nicholas T. Ingolia
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eIF4F complex dynamics are important for the activation of the integrated stress response Mol. Cell (IF 14.5) Pub Date : 2024-06-06 Kyusik Q. Kim, Ankanahalli N. Nanjaraj Urs, Victor Lasehinde, Alison C. Greenlaw, Benjamin H. Hudson, Hani S. Zaher
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Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing Mol. Cell (IF 14.5) Pub Date : 2024-06-07 Govind Menon, Eduardo Mateo-Bonmati, Svenja Reeck, Robert Maple, Zhe Wu, Robert Ietswaart, Caroline Dean, Martin Howard
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A CPF-like phosphatase module links transcription termination to chromatin silencing Mol. Cell (IF 14.5) Pub Date : 2024-06-07 Eduardo Mateo-Bonmatí, Miguel Montez, Robert Maple, Marc Fiedler, Xiaofeng Fang, Gerhard Saalbach, Lori A. Passmore, Caroline Dean
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Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function Mol. Cell (IF 14.5) Pub Date : 2024-06-04 Shi-Meng Cao, Hao Wu, Guo-Hua Yuan, Yu-Hang Pan, Jun Zhang, Yu-Xin Liu, Siqi Li, Yi-Feng Xu, Meng-Yuan Wei, Li Yang, Ling-Ling Chen
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Conformational landscape of the type V-K CRISPR-associated transposon integration assembly Mol. Cell (IF 14.5) Pub Date : 2024-06-03 Francisco Tenjo-Castaño, Nicholas Sofos, Luisa S. Stutzke, Piero Temperini, Anders Fuglsang, Tillmann Pape, Pablo Mesa, Guillermo Montoya
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Assembly of the Tn7 targeting complex by a regulated stepwise process Mol. Cell (IF 14.5) Pub Date : 2024-06-03 Yao Shen, Shreya S. Krishnan, Michael T. Petassi, Mark A. Hancock, Joseph E. Peters, Alba Guarné
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CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation Mol. Cell (IF 14.5) Pub Date : 2024-05-31 Isabel C. Lopez-Mejia, Sylviane Lagarrigue, Albert Giralt, Laia Martinez-Carreres, Javier Martín, Sagrario Ortega, Nadège Zanou, Pierre-Damien Denechaud, Judit Castillo-Armengol, Carine Chavey, Meritxell Orpinell, Brigitte Delacuisine, Anita Nasrallah, Caterina Collodet, Lianjun Zhang, Benoît Viollet, D. Grahame Hardie, Lluis Fajas
No Abstract
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Retraction Notice to: A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells Mol. Cell (IF 14.5) Pub Date : 2024-05-31 Jia Z. Shen, Zhixin Qiu, Qiulian Wu, Guoxin Zhang, Rebecca Harris, Dahui Sun, Juha Rantala, William D. Barshop, Linjie Zhao, Deguan Lv, Kwang-Ai Won, James Wohlschlegel, Olle Sangfelt, Heike Laman, Jeremy N. Rich, Charles Spruck
No Abstract
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Structural basis of the Integrator complex assembly and association with transcription factors Mol. Cell (IF 14.5) Pub Date : 2024-05-31 Michal Razew, Angelique Fraudeau, Moritz M. Pfleiderer, Romain Linares, Wojciech P. Galej
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CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release Mol. Cell (IF 14.5) Pub Date : 2024-05-30 Taras Velychko, Eusra Mohammad, Ivan Ferrer-Vicens, Iwan Parfentev, Marcel Werner, Cecilia Studniarek, Björn Schwalb, Henning Urlaub, Shona Murphy, Patrick Cramer, Michael Lidschreiber
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hnRNPM protects against the dsRNA-mediated interferon response by repressing LINE-associated cryptic splicing Mol. Cell (IF 14.5) Pub Date : 2024-05-29 Rong Zheng, Mikayla Dunlap, Georg O.M. Bobkov, Carlos Gonzalez-Figueroa, Khushali J. Patel, Jingyi Lyu, Samuel E. Harvey, Tracey W. Chan, Giovanni Quinones-Valdez, Mudra Choudhury, Charlotte A. Le Roux, Mason D. Bartels, Amy Vuong, Ryan A. Flynn, Howard Y. Chang, Eric L. Van Nostrand, Xinshu Xiao, Chonghui Cheng
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FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo Mol. Cell (IF 14.5) Pub Date : 2024-05-28 Kristina Žumer, Moritz Ochmann, Abrar Aljahani, Aiturgan Zheenbekova, Arjun Devadas, Kerstin Caroline Maier, Petra Rus, Ute Neef, A. Marieke Oudelaar, Patrick Cramer
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Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms Mol. Cell (IF 14.5) Pub Date : 2024-05-24 Alexis V. Stutzman, Christina A. Hill, Robin L. Armstrong, Riya Gohil, Robert J. Duronio, Jill M. Dowen, Daniel J. McKay
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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway Mol. Cell (IF 14.5) Pub Date : 2024-05-23 Sang Ah Yi, Sara Sepic, Brenda A. Schulman, Alban Ordureau, Heeseon An