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The indoors microbiome and human health Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-19 Jack A. Gilbert, Erica M. Hartmann
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Malaria vaccines: a new era of prevention and control Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-18 Patrick E. Duffy, J. Patrick Gorres, Sara A. Healy, Michal Fried
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Tearing CRISPR apart Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-17 Andrea Du Toit
This study shows that the anti-CRISPR protein AcrIF25 inhibits the type I-F CRISPR–Cas system by pulling apart the fully assembled Csy complex.
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Indirect intervention Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-16 Andrea Du Toit
This study shows that accounting for spillover effects increased the cost-effectiveness of combined malaria-elimination interventions.
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Cross-kingdom nutrient exchange in the plant–arbuscular mycorrhizal fungus–bacterium continuum Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-16 Shilong Duan, Gu Feng, Erik Limpens, Paola Bonfante, Xianan Xie, Lin Zhang
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The interplay between diet and the gut microbiome: implications for health and disease Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-15 Fiona C. Ross, Dhrati Patangia, Ghjuvan Grimaud, Aonghus Lavelle, Eugene M. Dempsey, R. Paul Ross, Catherine Stanton
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Busting Cryptococcus with brilacidin Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-08 Agustina Taglialegna
In this study, Diehl et al. report that brilacidin could be a promising antifungal drug against Cryptococcus neoformans.
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Getting wound closure with Alcaligenes Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-08 Agustina Taglialegna
In this study, White et al. report that Alcaligenes faecalis mediates wound repair in diabetic foot ulcers.
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New WHO proposed terminology for respiratory pathogen transmission Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-03 Nancy H. L. Leung, Donald K. Milton
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Bacterial barcoding facilitates plant microbiome studies Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-26 Hualan Liu
This month’s Genome Watch highlights the use of genetic barcoding towards a better understanding of plant–microorganism interactions and colonization dynamics.
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The pathobiology of human fungal infections Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-25 Gordon D. Brown, Elizabeth R. Ballou, Steven Bates, Elaine M. Bignell, Andrew M. Borman, Alexandra C. Brand, Alistair J. P. Brown, Carolina Coelho, Peter C. Cook, Rhys A. Farrer, Nelesh P. Govender, Neil A. R. Gow, William Hope, J. Claire Hoving, Rachael Dangarembizi, Thomas S. Harrison, Elizabeth M. Johnson, Liliane Mukaremera, Mark Ramsdale, Christopher R. Thornton, Jane Usher, Adilia Warris, Duncan
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Pertussis vaccines, epidemiology and evolution Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-21 Matthieu Domenech de Cellès, Pejman Rohani
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Bacteria curb emissions in farmland Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-20 Agustina Taglialegna
In this study, Hiis et al. demonstrate that the N2O-respiring bacterial strain Cloacibacterium sp. CB-01 can reduce nitrous oxide emissions from soil.
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Gassy archaea Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-18 Andrea Du Toit
This study shows that archaea produce catalytically active ultraminimal as well as hybrid [FeFe] hydrogenases.
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Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-18 Yahan Wei, Dennise Palacios Araya, Kelli L. Palmer
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A virus hastens ageing in flies Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-14 Agustina Taglialegna
In this study, Niggs et al. show that Drosophila A virus infection modulates epithelial turnover in the intestine of Drosophila melanogaster, promoting premature intestinal dysplasia and reducing fly lifespan.
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Supra-structures to target lipid II Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-11 Andrea Du Toit
This study reports that plectasin uses a supramolecular antimicrobial mode of action, whereby the oligomerized peptide sequesters lipid II.
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ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-03 William R. Miller, Cesar A. Arias
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Co‐evolution of early Earth environments and microbial life Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-29 Timothy W. Lyons, Christopher J. Tino, Gregory P. Fournier, Rika E. Anderson, William D. Leavitt, Kurt O. Konhauser, Eva E. Stüeken
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Foodborne bacterial pathogens: genome-based approaches for enduring and emerging threats in a complex and changing world Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-24 Alison E. Mather, Matthew W. Gilmour, Stuart W. J. Reid, Nigel P. French
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The gut–airway microbiome axis in health and respiratory diseases Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-22 Mustafa Özçam, Susan V. Lynch
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Defending against plasmids Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-21 Andrea Du Toit
This study reports the mechanism of plasmid clearance by the DNA defence module DdmDE of the Vibrio cholerae seventh pandemic strain.
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Fat, Desulfovibrio and cancer Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-20 Agustina Taglialegna
This study by Chen et al. reveals that a high-fat diet leads to a predominance of Desulfovibrio species in the gut, correlating with a poor prognosis of breast cancer.
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Discovering molecular paradigms of microbial carcinogenesis Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-20 Carrie L. Shaffer
In this Journal Club, Carrie Shaffer discusses a study revealing that infection with CagA-positive Helicobacter pylori strains is associated with an increased risk of developing stomach adenocarcinoma.
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Breaking through the concept barrier to develop broad-spectrum antiviral counter-measures Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-20 Yi Shi
In this Journal Club, Yi Shi discusses a paper reporting that influenza virus infection in humans induces broadly cross-reactive and protective antibodies against the viral neuraminidase.
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Tracking pathogen evolution through climate change Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-16 Lia Bote, Mailis Maes
This Genome Watch article discusses the application of sequencing methods for monitoring the rise of infectious diseases associated with climate change.
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Viruses on the move Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-15 Andrea Du Toit
This study shows how two umbravirus-like viruses induce systemic infection in the plant host in the absence of virus-encoded movement proteins.
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A mosquito symbiont controls flaviviruses Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-10 Agustina Taglialegna
In this study, Zhang et al. report that a bacterial symbiont residing in the gut of Aedes albopictus mosquitoes protects them from flavivirus infection.
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Bacteriocin diversity, function, discovery and application as antimicrobials Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-10 Ivan Sugrue, R. Paul Ross, Colin Hill
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Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-30 Matthew J. Shepherd, Taoran Fu, Niamh E. Harrington, Anastasia Kottara, Kendall Cagney, James D. Chalmers, Steve Paterson, Joanne L. Fothergill, Michael A. Brockhurst
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Mycetocola to the rescue Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-24 Agustina Taglialegna
In this study, Carrasco Flores et al. report that the bacterium Mycetocola lacteus protects the microalga Chlamydomonas reinhardtii from the antagonistic activity of Pseudomonas protegens.
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Nitroplast organelle unveiled Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-24 Ashley York
A recent study reports the existence of a nitrogen-fixing organelle called the ‘nitroplast’.
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The complex life of the HIV-1 full-length RNA Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-24 Ricardo Soto-Rifo
In this Journal Club, Ricardo Soto-Rifo discusses a study on intron-containing HIV-1 RNA, revealing its role as a pathogen-associated molecular pattern in myeloid cells, which has implications for immune activation, inflammation and clinical outcomes.
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Phages get snappy Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-22 Andrea Du Toit
This study shows that a single-stranded RNA phage binds to the Pseudomonas aeruginosa type IV pilus, leading to phage entry into the cell and the detachment of the pilus, which impairs bacterial motility.
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Shaking up that sick feeling with biofilm sugars Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-18 Agustina Taglialegna
In this study, Granton et al. show that biofilm-associated exopolysaccharides produced by Pseudomonas aeruginosa control sickness during lung infection.
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COVID-19 drug discovery and treatment options Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-15 Jasper Fuk-Woo Chan, Shuofeng Yuan, Hin Chu, Siddharth Sridhar, Kwok-Yung Yuen
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Microbial adaptability in changing environments Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-12 Sharon Greenblum
This Genome Watch article highlights the recent use of large-scale monitoring of natural microbiomes to examine feedback between environmental change and microbial adaptation.
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The wound microbiota: microbial mechanisms of impaired wound healing and infection Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-04 Aayushi Uberoi, Amelia McCready-Vangi, Elizabeth A. Grice
The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression
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Microbial food spoilage: impact, causative agents and control strategies Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-03 Abigail B. Snyder, Nicole Martin, Martin Wiedmann
Microbial food spoilage is a major contributor to food waste and, hence, to the negative environmental sustainability impacts of food production and processing. Globally, it is estimated that 15–20% of food is wasted, with waste, by definition, occurring after primary production and harvesting (for example, in households and food service establishments). Although the causative agents of food spoilage
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Drug-resistant tuberculosis: a persistent global health concern Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-22 Maha Farhat, Helen Cox, Marwan Ghanem, Claudia M. Denkinger, Camilla Rodrigues, Mirna S. Abd El Aziz, Handaa Enkh-Amgalan, Debrah Vambe, Cesar Ugarte-Gil, Jennifer Furin, Madhukar Pai
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Antimicrobial treatment and resistance in sexually transmitted bacterial infections Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-20 Jorgen S. Jensen, Magnus Unemo
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Drosophila sperm sabotage by Wolbachia prophage Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-19 Andrea Du Toit
This study reports a mechanism whereby Wolbachia bacteriophage proteins modulate macromolecules of developing Drosophila melanogaster.
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The microbial carbon pump and climate change Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-15 Nianzhi Jiao, Tingwei Luo, Quanrui Chen, Zhao Zhao, Xilin Xiao, Jihua Liu, Zhimin Jian, Shucheng Xie, Helmuth Thomas, Gerhard J. Herndl, Ronald Benner, Micheal Gonsior, Feng Chen, Wei-Jun Cai, Carol Robinson
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Effects of climate change and human activities on vector-borne diseases Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-14 William M. de Souza, Scott C. Weaver
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Hyphae promote Candida albicans fitness and commensalism in the gut Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-12 Andrea Du Toit
This study shows that hyphae formation is critical for Candida albicans gut colonization in the presence of commensal bacteria owing to the production of a hyphal-associated factor.
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Combatting the HIV reservoir Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-07 Agustina Taglialegna
In this study, Armani-Tourret et al. show that the combination of panobinostat and pegylated interferon-α2a transforms the structure and composition of the HIV-1 reservoir and could potentially counter it.
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Blasting away a fungal pathogen Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-07 Agustina Taglialegna
In this study, Liu et al. explore the interplay between a fungal effector and a plant cysteine protease and design a small-molecule compound aimed at targeting this effector to combat rice blast disease.
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The origins of pathogenesis Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-05 Salvador Almagro-Moreno
In this Journal Club, Salvador Almagro-Moreno discusses a study by Kirn et al., which explores the emergence of virulence traits in Vibrio cholerae and demonstrates how the ability of this pathogen to colonize the host shares a common mechanism to its capacity to thrive in natural environments.
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The coral microbiome in sickness, in health and in a changing world Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-03-04 Christian R. Voolstra, Jean-Baptiste Raina, Melanie Dörr, Anny Cárdenas, Claudia Pogoreutz, Cynthia B. Silveira, Amin R. Mohamed, David G. Bourne, Haiwei Luo, Shady A. Amin, Raquel S. Peixoto
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Conservation and similarity of bacterial and eukaryotic innate immunity Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-28 Hannah E. Ledvina, Aaron T. Whiteley
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Monitoring pathogens in wastewater Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-27 Arin Wongprommoon, Chalita Chomkatekaew, Claire Chewapreecha
Wastewater genomic surveillance can transform global viral disease monitoring. This Genome Watch article explores the techniques, analytical pipelines and implications for public health.
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A potential new player in gastric cancer Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-21 Agustina Taglialegna
In this study, Fu et al. show that Streptococcus anginosus promotes gastric tumorigenesis in mice.
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Breaking the mould: rethinking ‘wild type’ in fungal pathogens Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-16 Amelia E. Barber
In this Journal Club, Amelia Barber discusses a study revealing intraspecies heterogeneity in a fungal pathogen, prompting us to re-evaluate the notion of ‘reference’ strains.
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Inactive vents, active producers Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-14 Agustina Taglialegna
In this study, Achberger et al. report that microbial communities of inactive hydrothermal deposits contribute to primary productivity in the deep sea.
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Mapping the microbiome milieu Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-14 Matthew J. Blow
This month’s Genome Watch discusses the application of spatial transcriptomics to investigate the arrangements of microbial communities and their effects on the host.
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A manipulating pair Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-12 Andrea Du Toit
The study provides insights into how insects and their endosymbionts can manipulate plant defences.
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Bacterial architects build the biofilm structures Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-12 Andrea Du Toit
This study shows that the distinct cellular organization across the depth of a biofilm is tightly regulated and has consequences for cell physiology and antibiotic tolerance.
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Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-09 Marie Armani-Tourret, Benjamin Bone, Toong Seng Tan, Weiwei Sun, Maxime Bellefroid, Tine Struyve, Michael Louella, Xu G. Yu, Mathias Lichterfeld
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Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-02-06 Philip J. Rosenthal, Victor Asua, Melissa D. Conrad
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Targeting the HIV-1 Env fusion protein Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-01-23 Andrea Du Toit
This study reports that antibodies that target the fusion peptide on the HIV envelope provide protection to rhesus macaques against mucosal simian-HIV challenge.