-
-
Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex Immunity (IF 25.5) Pub Date : 2024-07-15
-
Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts Immunity (IF 25.5) Pub Date : 2024-07-12 Yoshitaka Taketomi, Takayoshi Higashi, Kuniyuki Kano, Yoshimi Miki, Chika Mochizuki, Shota Toyoshima, Yoshimichi Okayama, Yasumasa Nishito, Susumu Nakae, Satoshi Tanaka, Suzumi M. Tokuoka, Yoshiya Oda, Shigeyuki Shichino, Satoshi Ueha, Kouji Matsushima, Noriyuki Akahoshi, Satoshi Ishii, Jerold Chun, Junken Aoki, Makoto Murakami
-
RIPK1: Inflamed if you do, inflamed if you don’t Immunity (IF 25.5) Pub Date : 2024-07-09 Nicholas W. Hubbard, Andrew Oberst
RIPK1 is known as a driver of cell death and inflammation. In this issue of Immunity, Imai et al. and Mannion et al. find that these same processes are also induced by RIPK1 inactivation and highlight the therapeutic potential of RIPK1 elimination.
-
The pros and confs of IL-18 activation Immunity (IF 25.5) Pub Date : 2024-07-09 Danielle M. Clancy, Julie Andries, Savvas N. Savvides
Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.
-
Scavengers in islets fuel diabetic autoimmunity Immunity (IF 25.5) Pub Date : 2024-07-09 Jadie Y. Moon, Katherine A. Gallagher
Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al.1 examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival
-
Skin deep: Epithelial cell metabolism and chronic skin inflammation Immunity (IF 25.5) Pub Date : 2024-07-09 Eliana R. Solis, Julie M. Jameson
Skin inflammation is potentiated by coordinated epithelial and immune cell metabolism. In this issue of Immunity, Subudhi and Konieczny et al. delineate how HIF1α regulates epithelial cell glycolysis during psoriasis. In turn, lactate is a byproduct that augments type 17 γδ T cell responses to sustain inflammatory skin disease.
-
B cells! Don’t go the wrong way in this tumor Immunity (IF 25.5) Pub Date : 2024-07-09 Guilhem Pupier, Catherine Sautès-Fridman
The association of tertiary lymphoid structures (TLSs) with survival and immunotherapy response brought B cells to center stage. In a pan-cancer B cells atlas in Science, Ma et al. show that germinal center reaction generating anti-tumor antibody-secreting cells (ASCs) from B memory cells in mature TLSs co-exist in tumors with extra-follicular reaction generating auto-reactive ASCs from memory B cells
-
Human determinants of age-dependent patterns of death from infection Immunity (IF 25.5) Pub Date : 2024-07-09 Laurent Abel, Jean-Laurent Casanova
Regardless of microbial virulence (i.e., the global infection-fatality ratio), age generally drives the prevalence of death from infection in unvaccinated humans. Four mortality patterns are recognized: the common U- and L-shaped curves of endemic infections and the unique W- and J-shaped curves of pandemic infections. We suggest that these patterns result from different sets of human genetic and immunological
-
Antibody modulation of B cell responses—Incorporating positive and negative feedback Immunity (IF 25.5) Pub Date : 2024-07-09 Jason G. Cyster, Patrick C. Wilson
Antibodies are powerful modulators of ongoing and future B cell responses. While the concept of antibody feedback has been appreciated for over a century, the topic has seen a surge in interest due to the evidence that the broadening of antibody responses to SARS-CoV-2 after a third mRNA vaccination is a consequence of antibody feedback. Moreover, the discovery that slow antigen delivery can lead to
-
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages Immunity (IF 25.5) Pub Date : 2024-07-09 Sébastien Trzebanski, Jung-Seok Kim, Niss Larossi, Ayala Raanan, Daliya Kancheva, Jonathan Bastos, Montaser Haddad, Aryeh Solomon, Ehud Sivan, Dan Aizik, Jarmila Sekeresova Kralova, Mor Gross-Vered, Sigalit Boura-Halfon, Tsvee Lapidot, Ronen Alon, Kiavash Movahedi, Steffen Jung
No Abstract
-
Primary nasal influenza infection rewires tissue-scale memory response dynamics Immunity (IF 25.5) Pub Date : 2024-07-03 Samuel W. Kazer, Colette Matysiak Match, Erica M. Langan, Marie-Angèle Messou, Thomas J. LaSalle, Elise O’Leary, Jessica Marbourg, Katherine Naughton, Ulrich H. von Andrian, Jose Ordovas-Montanes
-
The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation Immunity (IF 25.5) Pub Date : 2024-07-01 Munesh K. Harioudh, Joseph Perez, Lomon So, Mayank Maheshwari, Thomas S. Ebert, Veit Hornung, Ram Savan, A. Rouf Banday, Michael S. Diamond, Vijay A. Rathinam, Saumendra N. Sarkar
-
Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity Immunity (IF 25.5) Pub Date : 2024-06-21 Henan Xu, Xiao Zhang, Xin Wang, Bo Li, Hang Yu, Yuan Quan, Yan Jiang, Yuling You, Yan Wang, Mingyue Wen, Juan Liu, Min Wang, Bo Zhang, Yixian Li, Xuan Zhang, Qianjin Lu, Chu-Yi Yu, Xuetao Cao
-
A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance Immunity (IF 25.5) Pub Date : 2024-06-20 Randall T. Mertens, Aditya Misra, Peng Xiao, Seungbyn Baek, Joseph M. Rone, Davide Mangani, Kisha N. Sivanathan, Adedamola S. Arojojoye, Samuel G. Awuah, Insuk Lee, Guo-Ping Shi, Boryana Petrova, Jeannette R. Brook, Ana C. Anderson, Richard A. Flavell, Naama Kanarek, Martin Hemberg, Roni Nowarski
-
Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria Immunity (IF 25.5) Pub Date : 2024-06-19 Kelly A. Hagadorn, Mary E. Peterson, Hemanta Kole, Bethany Scott, Jeff Skinner, Ababacar Diouf, Eizo Takashima, Aissata Ongoiba, Safiatou Doumbo, Didier Doumtabe, Shanping Li, Padmapriya Sekar, Mei Yan, Chengsong Zhu, Hikaru Nagaoka, Bernard N. Kanoi, Quan-Zhen Li, Carole Long, Eric O. Long, Kassoum Kayentao, Christine S. Hopp
-
The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program Immunity (IF 25.5) Pub Date : 2024-06-18 Oliver T. Burton, Orian Bricard, Samar Tareen, Vaclav Gergelits, Simon Andrews, Laura Biggins, Carlos P. Roca, Carly Whyte, Steffie Junius, Aleksandra Brajic, Emanuela Pasciuto, Magda Ali, Pierre Lemaitre, Susan M. Schlenner, Harumichi Ishigame, Brian D. Brown, James Dooley, Adrian Liston
-
High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function Immunity (IF 25.5) Pub Date : 2024-06-17 Yifeng Wang, Wen Shao, Xin Liu, Qingtai Liang, Jiaqi Lei, Wenjuan Shi, Miao Mei, Ying Li, Xu Tan, Guocan Yu, Li Yu, Linqi Zhang, Hai Qi
-
Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity Immunity (IF 25.5) Pub Date : 2024-06-14 Rebecca B. Delconte, Mark Owyong, Endi K. Santosa, Katja Srpan, Sam Sheppard, Tomi J. McGuire, Aamna Abbasi, Carlos Diaz-Salazar, Jerold Chun, Inez Rogatsky, Katharine C. Hsu, Stefan Jordan, Miriam Merad, Joseph C. Sun
-
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies Immunity (IF 25.5) Pub Date : 2024-06-14 Barney Viengkhou, Emina Hayashida, Sarah McGlasson, Katie Emelianova, Deborah Forbes, Stewart Wiseman, Joanna Wardlaw, Rovin Verdillo, Sarosh R. Irani, Darragh Duffy, Fredrik Piehl, Lipin Loo, Axel Pagenstecher, G. Greg Neely, Yanick J. Crow, Iain L. Campbell, David P.J. Hunt, Markus J. Hofer
-
Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies Immunity (IF 25.5) Pub Date : 2024-06-13 Nadège Nziza, Wonyeong Jung, Maanasa Mendu, Tina Chen, Boris Julg, Barney Graham, Octavio Ramilo, Asuncion Mejias, Galit Alter
-
Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation Immunity (IF 25.5) Pub Date : 2024-06-13 Albert C. Yeh, Motoko Koyama, Olivia G. Waltner, Simone A. Minnie, Julie R. Boiko, Tamer B. Shabaneh, Shuichiro Takahashi, Ping Zhang, Kathleen S. Ensbey, Christine R. Schmidt, Samuel R.W. Legg, Tomoko Sekiguchi, Ethan Nelson, Shruti S. Bhise, Andrew R. Stevens, Tracy Goodpaster, Saranya Chakka, Scott N. Furlan, Kate A. Markey, Marie E. Bleakley, Geoffrey R. Hill
-
AI and immunology Immunity (IF 25.5) Pub Date : 2024-06-11 Ronald N. Germain, Eliezer M. Van Allen, Gosia Trynka, John S. Tsang, Dominic Grün, Ashley L. Kiemen, Yigong Shi, Aimee Pugh Bernard, Garry P. Nolan
AI is rapidly becoming part of many aspects of daily life, with an impact that reaches all fields of research. We asked investigators to share their thoughts on how AI is changing immunology research, what is necessary to move forward, the potential and the pitfalls, and what will remain unchanged as the field journeys into a new era.
-
Mast cells: The Janus of type 2 inflammation Immunity (IF 25.5) Pub Date : 2024-06-11 Johanna Kotrba, Anne Dudeck
Mast cells (MCs) are effectors in type 2 immunity, well known for their detrimental roles in allergy. In this issue of Immunity, Alhallak et al. now identify a protective role of MCs against exacerbated immune responses mediated by prostaglandin E2 (PGE2)-driven soluble ST2.
-
CD8+ T cell tolerance: It doesn’t translate Immunity (IF 25.5) Pub Date : 2024-06-11 Katharine E. Block, Stephen C. Jameson
The mechanisms that make and break CD8+ T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8+ T cells rapidly adopt an epigenetically and transcriptionally distinct cell state and exhibit impaired protein translation. Breaking tolerance requires both inflammation and increased antigen exposure to augment MYC expression and restore translation
-
Claudin 18 turns up the heat in cancer Immunity (IF 25.5) Pub Date : 2024-06-11 Jialin Zhang, Peter M.K. Westcott
A major barrier to antitumor immunity in solid tumors is T cell exclusion. In this issue of Immunity, De Sanctis et al.1 elucidate how CLDN18 on pancreatic and lung cancer cells enhances infiltration, immunological synapse formation, and activation of cytotoxic T lymphocytes.
-
Not so aDAMant after all: Plasticity of phagocytic microglia Immunity (IF 25.5) Pub Date : 2024-06-11 Aleksandra Deczkowska
Phagocytic microglia such as proliferative region-associated microglia and disease-associated microglia appear in the brain transiently during development and across various brain pathologies, but their function and degree of plasticity remain unclear. In this issue of Immunity, Barclay et al. established a novel Clec7a-CreERT2 mouse line to uncover the plasticity of this cell state and its role in
-
Poking holes in the blood-brain barrier Immunity (IF 25.5) Pub Date : 2024-06-11 Xiyu Ma, Judy Lieberman
Bacterial lipopolysaccharide (LPS) is implicated in disrupting the blood-brain barrier (BBB). In a recent issue of Nature, Wei et al. now show that LPS activates the inflammatory caspases (4, 5, and 11) and gasdermin D (GSDMD) in brain endothelial cells, which triggers their pyroptotic cell death and disrupts the BBB.
-
Challenges and opportunities in long COVID research Immunity (IF 25.5) Pub Date : 2024-06-11 Rebecca E. Hamlin, Catherine A. Blish
Long COVID (LC) is a condition in which patients do not fully recover from the initial SARS-CoV-2 infection but rather have persistent or new symptoms for months to years following the infection. Ongoing research efforts are investigating the pathophysiologic mechanisms of LC and exploring preventative and therapeutic treatment approaches for patients. As a burgeoning area of investigation, LC research
-
Collaboration between distinct SWI/SNF chromatin remodeling complexes directs enhancer selection and activation of macrophage inflammatory genes Immunity (IF 25.5) Pub Date : 2024-06-05 Jingwen Liao, Josephine Ho, Mannix Burns, Emily C. Dykhuizen, Diana C. Hargreaves
-
Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers Immunity (IF 25.5) Pub Date : 2024-06-04 Ariën Schiepers, Marije F.L. van’t Wout, Alvaro Hobbs, Luka Mesin, Gabriel D. Victora
-
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface Immunity (IF 25.5) Pub Date : 2024-05-31 Rachael M. Wolters, James A. Ferguson, Ivette A. Nuñez, Elaine E. Chen, Ty Sornberger, Luke Myers, Svearike Oeverdieck, Sai Sundar Rajan Raghavan, Chandrahaas Kona, Laura S. Handal, Trevor E. Esilu, Edgar Davidson, Benjamin J. Doranz, Taylor B. Engdahl, Nurgun Kose, Lauren E. Williamson, C. Buddy Creech, Katherine N. Gibson-Corley, Andrew B. Ward, James E. Crowe Jr.
-
Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2 Immunity (IF 25.5) Pub Date : 2024-05-30 Kinan Alhallak, Jun Nagai, Kendall Zaleski, Sofia Marshall, Tamara Salloum, Tahereh Derakhshan, Hiroaki Hayashi, Chunli Feng, Radomir Kratchmarov, Juying Lai, Virinchi Kuchibhotla, Airi Nishida, Barbara Balestrieri, Tanya Laidlaw, Daniel F. Dwyer, Joshua A. Boyce
-
An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination Immunity (IF 25.5) Pub Date : 2024-05-30 Kia M. Barclay, Nora Abduljawad, Zuolin Cheng, Min Woo Kim, Lu Zhou, Jin Yang, Justin Rustenhoven, Jose A. Mazzitelli, Leon C.D. Smyth, Dvita Kapadia, Simone Brioschi, Wandy Beatty, JinChao Hou, Naresha Saligrama, Marco Colonna, Guoqiang Yu, Jonathan Kipnis, Qingyun Li
-
Progenitors of distinct lineages shape the diversity of mature type 2 conventional dendritic cells Immunity (IF 25.5) Pub Date : 2024-05-30 Patrick Fernandes Rodrigues, Tihana Trsan, Grozdan Cvijetic, Darya Khantakova, Santosh K. Panda, Zhaoyuan Liu, Florent Ginhoux, Marina Cella, Marco Colonna
-
Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng Immunity (IF 25.5) Pub Date : 2024-05-30 Xin Sun, Yasuharu Nagahama, Shailendra Kumar Singh, Yuuki Kozakai, Hiroshi Nabeshima, Kiyoharu Fukushima, Hiroki Tanaka, Daisuke Motooka, Eriko Fukui, Eric Vivier, Diego Diez, Shizuo Akira
-
Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression Immunity (IF 25.5) Pub Date : 2024-05-29 Zhou Liang, Ziwen Tang, Changjian Zhu, Feng Li, Shuaijiabin Chen, Xu Han, Ruilin Zheng, Xinrong Hu, Ruoni Lin, Qiaoqiao Pei, Changjun Yin, Ji Wang, Ce Tang, Nan Cao, Jincun Zhao, Rong Wang, Xiaoyan Li, Ning Luo, Qiong Wen, Jianwen Yu, Jianbo Li, Xi Xia, Xunhua Zheng, Xin Wang, Naya Huang, Zhong Zhong, Chengqiang Mo, Peisong Chen, Yating Wang, Jinjin Fan, Yun Guo, Haojie Zhong, Jiaqi Liu, Zhenwei Peng
-
Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge Immunity (IF 25.5) Pub Date : 2024-05-23 Irene N. Nkumama, Rodney Ogwang, Dennis Odera, Fauzia Musasia, Kennedy Mwai, Lydia Nyamako, Linda Murungi, James Tuju, Kristin Fürle, Micha Rosenkranz, Rinter Kimathi, Patricia Njuguna, Mainga Hamaluba, Melissa C. Kapulu, Roland Frank, CHMI-SIKA study team, Faith H.A. Osier
-
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death Immunity (IF 25.5) Pub Date : 2024-05-23 Jonathan Mannion, Valentina Gifford, Benjamin Bellenie, Winnie Fernando, Laura Ramos Garcia, Rebecca Wilson, Sidonie Wicky John, Savita Udainiya, Emmanuel C. Patin, Crescens Tiu, Angel Smith, Maria Goicoechea, Andrew Craxton, Nathalia Moraes de Vasconcelos, Naomi Guppy, Kwai-Ming J. Cheung, Nicholas J. Cundy, Olivier Pierrat, Alfie Brennan, Theodoros I. Roumeliotis, Pascal Meier
-
The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects Immunity (IF 25.5) Pub Date : 2024-05-21 Willem Van Der Byl, Simone Nüssing, Timothy J. Peters, Antonio Ahn, Hanjie Li, Guy Ledergor, Eyal David, Andrew S. Koh, Mayura V. Wagle, Christian Deo T. Deguit, Maria N. de Menezes, Avraham Travers, Shienny Sampurno, Kelly M. Ramsbottom, Rui Li, Axel Kallies, Paul A. Beavis, Ralf Jungmann, Maartje M.C. Bastings, Gabrielle T. Belz, Shom Goel, Joseph A. Trapani, Gerald R. Crabtree, Howard Y. Chang,
-
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification Immunity (IF 25.5) Pub Date : 2024-05-21 Joseph Jorssen, Glenn Van Hulst, Kiréna Mollers, Julien Pujol, Georgios Petrellis, Antonio P. Baptista, Sjoerd Schetters, Frédéric Baron, Jo Caers, Bart N. Lambrecht, Benjamin G. Dewals, Fabrice Bureau, Christophe J. Desmet
-
Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance Immunity (IF 25.5) Pub Date : 2024-05-20 Jiping Sun, Youqin Zhang, Qingbing Zhang, Lin Hu, Linfeng Zhao, Hongdong Wang, Yue Yuan, Hongshen Niu, Dongdi Wang, Huasheng Zhang, Jianyue Liu, Xujiao Feng, Xiaohui Su, Ju Qiu, Jing Sun, Heping Xu, Catherine Zhang, Kathleen Wang, Yan Bi, Edgar G. Engleman, Lei Shen
-
Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation Immunity (IF 25.5) Pub Date : 2024-05-20 Ipsita Subudhi, Piotr Konieczny, Aleksandr Prystupa, Rochelle L. Castillo, Erica Sze-Tu, Yue Xing, Daniel Rosenblum, Ilana Reznikov, Ikjot Sidhu, Cynthia Loomis, Catherine P. Lu, Niroshana Anandasabapathy, Mayte Suárez-Fariñas, Johann E. Gudjonsson, Aristotelis Tsirigos, Jose U. Scher, Shruti Naik
-
Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation Immunity (IF 25.5) Pub Date : 2024-05-17 Xin Li, Weili Sun, Mengxing Huang, Liying Gong, Xiaochen Zhang, Li Zhong, Virginie Calderon, Zhenhua Bian, Yi He, Woong-Kyung Suh, Yang Li, Tengfei Song, Yongrui Zou, Zhe-Xiong Lian, Hua Gu
-
CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity Immunity (IF 25.5) Pub Date : 2024-05-15 Neetu Srivastava, Hao Hu, Orion J. Peterson, Anthony N. Vomund, Marta Stremska, Mohammad Zaman, Shilpi Giri, Tiandao Li, Cheryl F. Lichti, Pavel N. Zakharov, Bo Zhang, Nada A. Abumrad, Yi-Guang Chen, Kodi S. Ravichandran, Emil R. Unanue, Xiaoxiao Wan
-
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages Immunity (IF 25.5) Pub Date : 2024-05-14 Sébastien Trzebanski, Jung-Seok Kim, Niss Larossi, Ayala Raanan, Daliya Kancheva, Jonathan Bastos, Montaser Haddad, Aryeh Solomon, Ehud Sivan, Dan Aizik, Jarmila Sekeresova Kralova, Mor Gross-Vered, Sigalit Boura-Halfon, Tsvee Lapidot, Ronen Alon, Kiavash Movahedi, Steffen Jung
-
Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer Immunity (IF 25.5) Pub Date : 2024-05-14 Francesco De Sanctis, Silvia Dusi, Simone Caligola, Cristina Anselmi, Varvara Petrova, Barbara Rossi, Gabriele Angelini, Michael Erdeljan, Stefan Wöll, Anna Melissa Schlitter, Thomas Metzler, Katja Steiger, Zea Borok, Peter Bailey, Aline Bauer, Cornelia Halin, Federico Boschi, Rosalba Giugno, Stefania Canè, Rita Lawlor, Vincenzo Corbo, Aldo Scarpa, Gabriela Constantin, Stefano Ugel, Fulvia Vascotto
-
Immunity by AS03ation: The natural adjuvantage Immunity (IF 25.5) Pub Date : 2024-05-14 Lena Hansen, Jenna J. Guthmiller
Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate
-
Non-canonical IKKs side with N4BP1 against the family Immunity (IF 25.5) Pub Date : 2024-05-14 Dominic De Nardo
The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In this issue of Immunity, Gitlin et al. find that N4BP1 works in concert with the non-canonical IκB kinase (IKK) to limit activity of the IKK complex.
-
Hair care: Stem cells control immune response during wound repair Immunity (IF 25.5) Pub Date : 2024-05-14 Shannon McCarthy, Judith Agudo
Stem cells heal wounds. In this issue of Immunity, Luan et al. demonstrate that epidermal stem cells orchestrate the recruitment of regulatory T (Treg) cells and neutrophils during wound healing. Treg cells facilitate a tolerogenic environment to protect epithelial regeneration while neutrophils promote inflammation to ward off infection.
-
A new superhero, the intraepithelial mast cell, joins the “Guardians of the Gut” Immunity (IF 25.5) Pub Date : 2024-05-14 Aidil Zaini, Nicola L. Harris
The intestinal epithelium interacts with immune cells to support tissue homeostasis and coordinate responses against pathogens. In this issue of Immunity, Yang et al. unveil a central role for mast cell-epithelial cell interactions in orchestrating protective type 2 immune responses following intestinal helminth infection.
-
Astrocytes remember inflammation Immunity (IF 25.5) Pub Date : 2024-05-14 Michael R. Williamson, Benjamin Deneen
Astrocytes respond to all forms of central nervous system maladies. In a recent issue of Nature, Lee et al. demonstrate that astrocytes encode inflammatory stimuli as epigenetic memory, which strengthens responses to subsequent stimuli and exacerbates pathology in disease models.
-
Ironing out the role of ferroptosis in immunity Immunity (IF 25.5) Pub Date : 2024-05-14 Hannah N. Bell, Brent R. Stockwell, Weiping Zou
Ferroptosis is a type of regulated cell death that drives the pathophysiology of many diseases. Oxidative stress is detectable in many types of regulated cell death, but only ferroptosis involves lipid peroxidation and iron dependency. Ferroptosis originates and propagates from several organelles, including the mitochondria, endoplasmic reticulum, Golgi, and lysosomes. Recent data have revealed that
-
Platelets: Orchestrators of immunity in host defense and beyond Immunity (IF 25.5) Pub Date : 2024-05-14 Leo Nicolai, Kami Pekayvaz, Steffen Massberg
Platelets prevent blood loss during vascular injury and contribute to thrombus formation in cardiovascular disease. Beyond these classical roles, platelets are critical for the host immune response. They guard the vasculature against pathogens via specialized receptors, intracellular signaling cascades, and effector functions. Platelets also skew inflammatory responses by instructing innate immune
-
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance Immunity (IF 25.5) Pub Date : 2024-05-13 Tyler E. Billipp, Connie Fung, Lily M. Webeck, Derek B. Sargent, Matthew B. Gologorsky, Zuojia Chen, Margaret M. McDaniel, Darshan N. Kasal, John W. McGinty, Kaitlyn A. Barrow, Lucille M. Rich, Alessio Barilli, Mark Sabat, Jason S. Debley, Chuan Wu, Richard Myers, Michael R. Howitt, Jakob von Moltke
-
The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation Immunity (IF 25.5) Pub Date : 2024-05-13 Takashi Imai, Juan Lin, Göksu Gökberk Kaya, Eunjin Ju, Vangelis Kondylis, Konstantinos Kelepouras, Gianmaria Liccardi, Chun Kim, Manolis Pasparakis
-
Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity Immunity (IF 25.5) Pub Date : 2024-05-13 Marième Ndjim, Imène Gasmi, Fabien Herbert, Charlène Joséphine, Julie Bas, Ali Lamrani, Nathalie Coutry, Sylvain Henry, Valérie S. Zimmermann, Valérie Dardalhon, Marta Campillo Poveda, Evgenia Turtoi, Steeve Thirard, Luc Forichon, Alicia Giordano, Claire Ciancia, Zeinab Homayed, Julie Pannequin, Collette Britton, Eileen Devaney, Tom N. McNeilly, Sylvie Berrard, Andrei Turtoi, Rick M. Maizels, François
-
Structural transitions enable interleukin-18 maturation and signaling Immunity (IF 25.5) Pub Date : 2024-05-10 Ying Dong, Jeffrey P. Bonin, Pascal Devant, Zhuoyi Liang, Alexander I.M. Sever, Julian Mintseris, James M. Aramini, Gang Du, Stephen P. Gygi, Jonathan C. Kagan, Lewis E. Kay, Hao Wu
-
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers Immunity (IF 25.5) Pub Date : 2024-05-08 Sheenam Verma, Matthew J. Dufort, Tayla M. Olsen, Samantha Kimmel, Jasmine C. Labuda, Sam Scharffenberger, Andrew T. McGuire, Oliver J. Harrison
-
Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma Immunity (IF 25.5) Pub Date : 2024-05-03 Alessandra De Leo, Alessio Ugolini, Xiaoqing Yu, Fabio Scirocchi, Delia Scocozza, Barbara Peixoto, Angelica Pace, Luca D’Angelo, James K.C. Liu, Arnold B. Etame, Aurelia Rughetti, Marianna Nuti, Antonio Santoro, Michael A. Vogelbaum, Jose R. Conejo-Garcia, Paulo C. Rodriguez, Filippo Veglia