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An intermediate Rb–E2F activity state safeguards proliferation commitment Nature (IF 50.5) Pub Date : 2024-06-26 Yumi Konagaya, David Rosenthal, Nalin Ratnayeke, Yilin Fan, Tobias Meyer
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Mechanism for the initiation of spliceosome disassembly Nature (IF 50.5) Pub Date : 2024-06-26 Matthias K. Vorländer, Patricia Rothe, Justus Kleifeld, Eric Cormack, Lalitha Veleti, Daria Riabov-Bassat, Laura Fin, Alex W. Phillips, Luisa Cochella, Clemens Plaschka
Pre-mRNA splicing requires the assembly, remodeling, and disassembly of the multi-megadalton ribonucleoprotein complex called the spliceosome1. Recent studies have shed light on spliceosome assembly and remodeling for catalysis2–6, but the mechanism of disassembly remains unclear. Here, we report 2.6 to 3.2 Å resolution cryo-electron microscopy structures of nematode and human terminal intron-lariat
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Buried interface molecular hybrid for inverted perovskite solar cells Nature (IF 50.5) Pub Date : 2024-06-26 Sanwan Liu, Jingbai Li, Wenshan Xiao, Rui Chen, Zhenxing Sun, Yong Zhang, Xia Lei, Shuaifeng Hu, Manuel Kober-Czerny, Jianan Wang, Fumeng Ren, Qisen Zhou, Hasan Raza, You Gao, Yitong Ji, Sibo Li, Huan Li, Longbin Qiu, Wenchao Huang, Yan Zhao, Baomin Xu, Zonghao Liu, Henry J. Snaith, Nam-Gyu Park, Wei Chen
Perovskite solar cells (PSCs) with an “inverted” architecture are a key pathway for commercializing this emerging photovoltaic technology due to the better power conversion efficiency (PCE) and operational stability as compared to the “normal” device structure. Specifically, PCEs of the inverted PSCs have exceeded 25% owing to the development of improved self-assembled molecules (SAMs)1-5 and passivation
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Chemical reservoir computation in a self-organizing reaction network Nature (IF 50.5) Pub Date : 2024-06-26 Mathieu G. Baltussen, Thijs J. de Jong, Quentin Duez, William E. Robinson, Wilhelm T. S. Huck
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Molecular basis for transposase activation by a dedicated AAA+ ATPase Nature (IF 50.5) Pub Date : 2024-06-26 Álvaro de la Gándara, Mercedes Spínola-Amilibia, Lidia Araújo-Bazán, Rafael Núñez-Ramírez, James M. Berger, Ernesto Arias-Palomo
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Zinc mediates control of nitrogen fixation via transcription factor filamentation Nature (IF 50.5) Pub Date : 2024-06-26 Jieshun Lin, Peter K. Bjørk, Marie V. Kolte, Emil Poulsen, Emil Dedic, Taner Drace, Stig U. Andersen, Marcin Nadzieja, Huijun Liu, Hiram Castillo-Michel, Viviana Escudero, Manuel González-Guerrero, Thomas Boesen, Jan Skov Pedersen, Jens Stougaard, Kasper R. Andersen, Dugald Reid
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TnpB homologues exapted from transposons are RNA-guided transcription factors Nature (IF 50.5) Pub Date : 2024-06-26 Tanner Wiegand, Florian T. Hoffmann, Matt W. G. Walker, Stephen Tang, Egill Richard, Hoang C. Le, Chance Meers, Samuel H. Sternberg
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Explainable El Niño predictability from climate mode interactions Nature (IF 50.5) Pub Date : 2024-06-26 Sen Zhao, Fei-Fei Jin, Malte F. Stuecker, Philip R. Thompson, Jong-Seong Kug, Michael J. McPhaden, Mark A. Cane, Andrew T. Wittenberg, Wenju Cai
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Cenozoic history of the tropical marine biodiversity hotspot Nature (IF 50.5) Pub Date : 2024-06-26 Skye Yunshu Tian, Moriaki Yasuhara, Fabien L. Condamine, Huai-Hsuan M. Huang, Allan Gil S. Fernando, Yolanda M. Aguilar, Hita Pandita, Toshiaki Irizuki, Hokuto Iwatani, Caren P. Shin, Willem Renema, Tomoki Kase
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Titanium:sapphire-on-insulator integrated lasers and amplifiers Nature (IF 50.5) Pub Date : 2024-06-26 Joshua Yang, Kasper Van Gasse, Daniil M. Lukin, Melissa A. Guidry, Geun Ho Ahn, Alexander D. White, Jelena Vučković
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Synaptic architecture of leg and wing premotor control networks in Drosophila Nature (IF 50.5) Pub Date : 2024-06-26 Ellen Lesser, Anthony W. Azevedo, Jasper S. Phelps, Leila Elabbady, Andrew Cook, Durafshan Sakeena Syed, Brandon Mark, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman
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Megastudy shows that reminders boost vaccination but adding free rides does not Nature (IF 50.5) Pub Date : 2024-06-26 Katherine L. Milkman, Sean F. Ellis, Dena M. Gromet, Youngwoo Jung, Alex S. Luscher, Rayyan S. Mobarak, Madeline K. Paxson, Ramon A. Silvera Zumaran, Robert Kuan, Ron Berman, Neil A. Lewis, John A. List, Mitesh S. Patel, Christophe Van den Bulte, Kevin G. Volpp, Maryann V. Beauvais, Jonathon K. Bellows, Cheryl A. Marandola, Angela L. Duckworth
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Connectomic reconstruction of a female Drosophila ventral nerve cord Nature (IF 50.5) Pub Date : 2024-06-26 Anthony Azevedo, Ellen Lesser, Jasper S. Phelps, Brandon Mark, Leila Elabbady, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Avinash Khandelwal, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Andrew Cook, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey
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Structural mechanism of bridge RNA-guided recombination Nature (IF 50.5) Pub Date : 2024-06-26 Masahiro Hiraizumi, Nicholas T. Perry, Matthew G. Durrant, Teppei Soma, Naoto Nagahata, Sae Okazaki, Januka S. Athukoralage, Yukari Isayama, James J. Pai, April Pawluk, Silvana Konermann, Keitaro Yamashita, Patrick D. Hsu, Hiroshi Nishimasu
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Experimental observation of repulsively bound magnons Nature (IF 50.5) Pub Date : 2024-06-26 Zhe Wang, Catalin-Mihai Halati, Jean-Sébastien Bernier, Alexey Ponomaryov, Denis I. Gorbunov, Sandra Niesen, Oliver Breunig, J. Michael Klopf, Sergei Zvyagin, Thomas Lorenz, Alois Loidl, Corinna Kollath
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Hotspot shelters stimulate frog resistance to chytridiomycosis Nature (IF 50.5) Pub Date : 2024-06-26 Anthony W. Waddle, Simon Clulow, Amy Aquilina, Erin L. Sauer, Shannon W. Kaiser, Claire Miller, Jennifer A. Flegg, Patricia T. Campbell, Harrison Gallagher, Ivana Dimovski, Yorick Lambreghts, Lee Berger, Lee F. Skerratt, Richard Shine
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Measuring gravitational attraction with a lattice atom interferometer Nature (IF 50.5) Pub Date : 2024-06-26 Cristian D. Panda, Matthew J. Tao, Miguel Ceja, Justin Khoury, Guglielmo M. Tino, Holger Müller
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Unconventional superconductivity in chiral molecule–TaS2 hybrid superlattices Nature (IF 50.5) Pub Date : 2024-06-26 Zhong Wan, Gang Qiu, Huaying Ren, Qi Qian, Yaochen Li, Dong Xu, Jingyuan Zhou, Jingxuan Zhou, Boxuan Zhou, Laiyuan Wang, Ting-Hsun Yang, Zdeněk Sofer, Yu Huang, Kang L. Wang, Xiangfeng Duan
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Brain Chimeroids reveal individual susceptibility to neurotoxic triggers Nature (IF 50.5) Pub Date : 2024-06-26 Noelia Antón-Bolaños, Irene Faravelli, Tyler Faits, Sophia Andreadis, Rahel Kastli, Sebastiano Trattaro, Xian Adiconis, Anqi Wei, Abhishek Sampath Kumar, Daniela J. Di Bella, Matthew Tegtmeyer, Ralda Nehme, Joshua Z. Levin, Aviv Regev, Paola Arlotta
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Transposase-assisted target-site integration for efficient plant genome engineering Nature (IF 50.5) Pub Date : 2024-06-26 Peng Liu, Kaushik Panda, Seth A. Edwards, Ryan Swanson, Hochul Yi, Pratheek Pandesha, Yu-Hung Hung, Gerald Klaas, Xudong Ye, Megan V. Collins, Kaili N. Renken, Larry A. Gilbertson, Veena Veena, C. Nathan Hancock, R. Keith Slotkin
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Bridge RNAs direct programmable recombination of target and donor DNA Nature (IF 50.5) Pub Date : 2024-06-26 Matthew G. Durrant, Nicholas T. Perry, James J. Pai, Aditya R. Jangid, Januka S. Athukoralage, Masahiro Hiraizumi, John P. McSpedon, April Pawluk, Hiroshi Nishimasu, Silvana Konermann, Patrick D. Hsu
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Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair Nature (IF 50.5) Pub Date : 2024-06-26 Parul Mehrotra, Sophia Maschalidi, Laura Boeckaerts, Christian Maueröder, Rochelle Tixeira, Jonathan Pinney, Javier Burgoa Cardás, Vladimir Sukhov, Yunus Incik, Christopher. J. Anderson, Bing Hu, Burcu N. Keçeli, Amanda Goncalves, Lieselotte Vande Walle, Nina Van Opdenbosch, Alexey Sergushichev, Esther Hoste, Umang Jain, Mohamed Lamkanfi, Kodi S. Ravichandran
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Drosophila immune cells transport oxygen through PPO2 protein phase transition Nature (IF 50.5) Pub Date : 2024-06-26 Mingyu Shin, Eunji Chang, Daewon Lee, Nayun Kim, Bumsik Cho, Nuri Cha, Ferdinand Koranteng, Ji-Joon Song, Jiwon Shim
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Terahertz phonon engineering with van der Waals heterostructures Nature (IF 50.5) Pub Date : 2024-06-26 Yoseob Yoon, Zheyu Lu, Can Uzundal, Ruishi Qi, Wenyu Zhao, Sudi Chen, Qixin Feng, Woochang Kim, Mit H. Naik, Kenji Watanabe, Takashi Taniguchi, Steven G. Louie, Michael F. Crommie, Feng Wang
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Observations of diapycnal upwelling within a sloping submarine canyon Nature (IF 50.5) Pub Date : 2024-06-26 Bethan L. Wynne-Cattanach, Nicole Couto, Henri F. Drake, Raffaele Ferrari, Arnaud Le Boyer, Herlé Mercier, Marie-José Messias, Xiaozhou Ruan, Carl P. Spingys, Hans van Haren, Gunnar Voet, Kurt Polzin, Alberto C. Naveira Garabato, Matthew H. Alford
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No massive black holes in the Milky Way halo Nature (IF 50.5) Pub Date : 2024-06-24 Przemek Mróz, Andrzej Udalski, Michał K. Szymański, Igor Soszyński, Łukasz Wyrzykowski, Paweł Pietrukowicz, Szymon Kozłowski, Radosław Poleski, Jan Skowron, Dorota Skowron, Krzysztof Ulaczyk, Mariusz Gromadzki, Krzysztof Rybicki, Patryk Iwanek, Marcin Wrona, Milena Ratajczak
The gravitational wave detectors have unveiled a population of massive black holes that do not resemble those observed in the Milky Way1−3 and whose origin is debated4−6. According to one possible explanation, these black holes may have formed from density fluctuations in the early Universe (primordial black holes)7−9, and they should comprise from several to 100% of dark matter to explain the observed
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Water- and heat-activated dynamic passivation for perovskite photovoltaics Nature (IF 50.5) Pub Date : 2024-06-24 Wei-Ting Wang, Philippe Holzhey, Ning Zhou, Qiang Zhang, Suer Zhou, Elisabeth A. Duijnstee, Kevin J. Rietwyk, Jeng-Yu Lin, Yijie Mu, Yanfeng Zhang, Udo Bach, Chun-Guey Wu, Hin‐Lap Yip, Henry J. Snaith, Shien-Ping Feng
Further improvements in perovskite solar cells (PSCs) require better control of ionic defects in the perovskite photoactive layer during the manufacturing stage and their usage1-5. Here, we report a living passivation strategy using a hindered urea/thiocarbamate bond6-8 Lewis acid-base material (HUBLA), where dynamic covalent bonds with water and heat-activated characteristics can dynamically heal
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Bound star clusters observed in a lensed galaxy 460 Myr after the Big Bang Nature (IF 50.5) Pub Date : 2024-06-24 Angela Adamo, Larry D. Bradley, Eros Vanzella, Adélaïde Claeyssens, Brian Welch, Jose M. Diego, Guillaume Mahler, Masamune Oguri, Keren Sharon, Abdurro’uf, Tiger Yu-Yang Hsiao, Xinfeng Xu, Matteo Messa, Augusto E. Lassen, Erik Zackrisson, Gabriel Brammer, Dan Coe, Vasily Kokorev, Massimo Ricotti, Adi Zitrin, Seiji Fujimoto, Akio K. Inoue, Tom Resseguier, Jane R. Rigby, Yolanda Jiménez-Teja, Rogier
The Cosmic Gems arc is among the brightest and highly magnified galaxies observed at redshift z ∼ 10.21. However, it is an intrinsically UV faint galaxy, in the range of those now thought to drive the reionization of the universe2–4. Hitherto the smallest features resolved in a galaxy at a comparable redshift are between a few hundreds and a few tens of parsecs5,6. Here we report JWST observations
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Language is primarily a tool for communication rather than thought Nature (IF 50.5) Pub Date : 2024-06-19 Evelina Fedorenko, Steven T. Piantadosi, Edward A. F. Gibson
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An alternative broad-specificity pathway for glycan breakdown in bacteria Nature (IF 50.5) Pub Date : 2024-06-19 Seyed Amirhossein Nasseri, Aleksander C. Lazarski, Imke L. Lemmer, Chloe Y. Zhang, Eva Brencher, Hong-Ming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, Liam J. Worrall, Harry Brumer, Natalie C. J. Strynadka, Stephen G. Withers
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Detecting hallucinations in large language models using semantic entropy Nature (IF 50.5) Pub Date : 2024-06-19 Sebastian Farquhar, Jannik Kossen, Lorenz Kuhn, Yarin Gal
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Control of proton transport and hydrogenation in double-gated graphene Nature (IF 50.5) Pub Date : 2024-06-19 J. Tong, Y. Fu, D. Domaretskiy, F. Della Pia, P. Dagar, L. Powell, D. Bahamon, S. Huang, B. Xin, R. N. Costa Filho, L. F. Vega, I. V. Grigorieva, F. M. Peeters, A. Michaelides, M. Lozada-Hidalgo
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Room-temperature spin injection across a chiral perovskite/III–V interface Nature (IF 50.5) Pub Date : 2024-06-19 Matthew P. Hautzinger, Xin Pan, Steven C. Hayden, Jiselle Y. Ye, Qi Jiang, Mickey J. Wilson, Alan J. Phillips, Yifan Dong, Emily K. Raulerson, Ian A. Leahy, Chun-Sheng Jiang, Jeffrey L. Blackburn, Joseph M. Luther, Yuan Lu, Katherine Jungjohann, Z. Valy Vardeny, Joseph J. Berry, Kirstin Alberi, Matthew C. Beard
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Large-scale neurophysiology and single-cell profiling in human neuroscience Nature (IF 50.5) Pub Date : 2024-06-19 Anthony T. Lee, Edward F. Chang, Mercedes F. Paredes, Tomasz J. Nowakowski
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Tunable superconductivity in electron- and hole-doped Bernal bilayer graphene Nature (IF 50.5) Pub Date : 2024-06-19 Chushan Li, Fan Xu, Bohao Li, Jiayi Li, Guoan Li, Kenji Watanabe, Takashi Taniguchi, Bingbing Tong, Jie Shen, Li Lu, Jinfeng Jia, Fengcheng Wu, Xiaoxue Liu, Tingxin Li
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Multiscale topology classifies cells in subcellular spatial transcriptomics Nature (IF 50.5) Pub Date : 2024-06-19 Katherine Benjamin, Aneesha Bhandari, Jessica D. Kepple, Rui Qi, Zhouchun Shang, Yanan Xing, Yanru An, Nannan Zhang, Yong Hou, Tanya L. Crockford, Oliver McCallion, Fadi Issa, Joanna Hester, Ulrike Tillmann, Heather A. Harrington, Katherine R. Bull
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Amazon forest biogeography predicts resilience and vulnerability to drought Nature (IF 50.5) Pub Date : 2024-06-19 Shuli Chen, Scott C. Stark, Antonio Donato Nobre, Luz Adriana Cuartas, Diogo de Jesus Amore, Natalia Restrepo-Coupe, Marielle N. Smith, Rutuja Chitra-Tarak, Hongseok Ko, Bruce W. Nelson, Scott R. Saleska
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Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica Nature (IF 50.5) Pub Date : 2024-06-19 Michael A. Skinnider, Matthieu Gautier, Alan Yue Yang Teo, Claudia Kathe, Thomas H. Hutson, Achilleas Laskaratos, Alexandra de Coucy, Nicola Regazzi, Viviana Aureli, Nicholas D. James, Bernard Schneider, Michael V. Sofroniew, Quentin Barraud, Jocelyne Bloch, Mark A. Anderson, Jordan W. Squair, Grégoire Courtine
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Krause corpuscles are genital vibrotactile sensors for sexual behaviours Nature (IF 50.5) Pub Date : 2024-06-19 Lijun Qi, Michael Iskols, Rachel S. Greenberg, Jia Yin Xiao, Annie Handler, Stephen D. Liberles, David D. Ginty
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Human SARS-CoV-2 challenge uncovers local and systemic response dynamics Nature (IF 50.5) Pub Date : 2024-06-19 Rik G. H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Lorenz Kretschmer, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline M. Boccacino, Waradon Sungnak, Rasa Elmentaite, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley
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Atomic dynamics of electrified solid–liquid interfaces in liquid-cell TEM Nature (IF 50.5) Pub Date : 2024-06-19 Qiubo Zhang, Zhigang Song, Xianhu Sun, Yang Liu, Jiawei Wan, Sophia B. Betzler, Qi Zheng, Junyi Shangguan, Karen C. Bustillo, Peter Ercius, Prineha Narang, Yu Huang, Haimei Zheng
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Computational design of soluble and functional membrane protein analogues Nature (IF 50.5) Pub Date : 2024-06-19 Casper A. Goverde, Martin Pacesa, Nicolas Goldbach, Lars J. Dornfeld, Petra E. M. Balbi, Sandrine Georgeon, Stéphane Rosset, Srajan Kapoor, Jagrity Choudhury, Justas Dauparas, Christian Schellhaas, Simon Kozlov, David Baker, Sergey Ovchinnikov, Alex J. Vecchio, Bruno E. Correia
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A molecular and cellular perspective on human brain evolution and tempo Nature (IF 50.5) Pub Date : 2024-06-19 Feline W. Lindhout, Fenna M. Krienen, Katherine S. Pollard, Madeline A. Lancaster
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The mechanism for directional hearing in fish Nature (IF 50.5) Pub Date : 2024-06-19 Johannes Veith, Thomas Chaigne, Ana Svanidze, Lena Elisa Dressler, Maximilian Hoffmann, Ben Gerhardt, Benjamin Judkewitz
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Glassy gels toughened by solvent Nature (IF 50.5) Pub Date : 2024-06-19 Meixiang Wang, Xun Xiao, Salma Siddika, Mohammad Shamsi, Ethan Frey, Wen Qian, Wubin Bai, Brendan T. O’Connor, Michael D. Dickey
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Direct radical functionalization of native sugars Nature (IF 50.5) Pub Date : 2024-06-19 Yi Jiang, Yi Wei, Qian-Yi Zhou, Guo-Quan Sun, Xia-Ping Fu, Nikita Levin, Yijun Zhang, Wen-Qiang Liu, NingXi Song, Shabaz Mohammed, Benjamin G. Davis, Ming Joo Koh
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dsRNA formation leads to preferential nuclear export and gene expression Nature (IF 50.5) Pub Date : 2024-06-19 Ivo Coban, Jan-Philipp Lamping, Anna Greta Hirsch, Sarah Wasilewski, Orr Shomroni, Oliver Giesbrecht, Gabriela Salinas, Heike Krebber
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Dynamic stereomutation of vinylcyclopropanes with metalloradicals Nature (IF 50.5) Pub Date : 2024-06-19 Marvin Mendel, Teresa M. Karl, Jegor Hamm, Sherif J. Kaldas, Theresa Sperger, Bhaskar Mondal, Franziska Schoenebeck
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Catalytic Glycosylation for Minimally Protected Donors and Acceptors Nature (IF 50.5) Pub Date : 2024-06-17 Qiu-Di Dang, Yi-Hui Deng, Tian-Yu Sun, Yao Zhang, Jun Li, Xia Zhang, Yun-Dong Wu, Dawen Niu
Oligosaccharides have myriad functions throughout biology.1,2 To investigate these functions requires multi-step chemical synthesis of these structurally complex molecules. With a dense concentration of stereocentres and hydroxyl groups, oligosaccharide assembly through O-glycosylation requires simultaneous control of site-, stereo-, and chemoselectivities3,4. Chemists have traditionally relied on
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Hydroamination of alkenes with dinitrogen and titanium polyhydrides Nature (IF 50.5) Pub Date : 2024-06-17 Takanori Shima, Qingde Zhuo, Xiaoxi Zhou, Ping Wu, Ryota Owada, Gen Luo, Zhaomin Hou
An ideal synthesis of alkyl amines would involve the direct use of abundant and easily accessible molecules such as dinitrogen (N2) and feedstock alkenes1-4. However, this ambition remains a great challenge as it is usually difficult to simultaneously activate both N2 and a simple alkene and combine them together through C‒N bond formation. Currently, the synthesis of alkyl amines relies on the use
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Harnessing landrace diversity empowers wheat breeding Nature (IF 50.5) Pub Date : 2024-06-17 Shifeng Cheng, Cong Feng, Luzie U. Wingen, Hong Cheng, Andrew B. Riche, Mei Jiang, Michelle Leverington-Waite, Zejian Huang, Sarah Collier, Simon Orford, Xiaoming Wang, Rajani Awal, Gary Barker, Tom O’Hara, Clare Lister, Ajay Siluveru, Jesús Quiroz-Chávez, Ricardo H. Ramírez-González, Ruth Bryant, Simon Berry, Urmil Bansal, Harbans S. Bariana, Malcolm J. Bennett, Breno Bicego, Lorelei Bilham, James
Harnessing genetic diversity in major staple crops through the development of new breeding capabilities is essential to ensure food security1. Here we examined the genetic and phenotypic diversity of the A.E. Watkins landrace collection2 of bread wheat (Triticum aestivum), a major global cereal, through whole-genome re-sequencing (827 Watkins landraces and 208 modern cultivars) and in-depth field evaluation
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A self-healing multispectral transparent adhesive peptide glass Nature (IF 50.5) Pub Date : 2024-06-12 Gal Finkelstein-Zuta, Zohar A. Arnon, Thangavel Vijayakanth, Or Messer, Orr Simon Lusky, Avital Wagner, Galit Zilberman, Ruth Aizen, Lior Michaeli, Sigal Rencus-Lazar, Sharon Gilead, Sudha Shankar, Mariela Jorgelina Pavan, Dor Aaron Goldstein, Shira Kutchinsky, Tal Ellenbogen, Benjamin A. Palmer, Amir Goldbourt, Maxim Sokol, Ehud Gazit
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A Multimodal Generative AI Copilot for Human Pathology Nature (IF 50.5) Pub Date : 2024-06-12 Ming Y. Lu, Bowen Chen, Drew F. K. Williamson, Richard J. Chen, Melissa Zhao, Aaron K. Chow, Kenji Ikemura, Ahrong Kim, Dimitra Pouli, Ankush Patel, Amr Soliman, Chengkuan Chen, Tong Ding, Judy J. Wang, Georg Gerber, Ivy Liang, Long Phi Le, Anil V. Parwani, Luca L. Weishaupt, Faisal Mahmood
The field of computational pathology[1,2] has witnessed remarkable progress in the development of both task-specific predictive models and task-agnostic self-supervised vision encoders[3,4]. However, despite the explosive growth of generative artificial intelligence (AI), there has been limited study on building general purpose, multimodal AI assistants and copilots[5] tailored to pathology. Here we
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Oligomerization-mediated autoinhibition and cofactor binding of a plant NLR Nature (IF 50.5) Pub Date : 2024-06-12 Shoucai Ma, Chunpeng An, Aaron W. Lawson, Yu Cao, Yue Sun, Eddie Yong Jun Tan, Jinheng Pan, Jan Jirschitzka, Florian Kümmel, Nitika Mukhi, Zhifu Han, Shan Feng, Bin Wu, Paul Schulze-Lefert, Jijie Chai
Nucleotide-binding leucine-rich repeat (NLR) proteins have a pivotal role in plant immunity by recognizing pathogen effectors1,2. Maintaining a balanced immune response is crucial, as excessive NLR expression can lead to unintended autoimmunity3,4. Unlike most NLRs, plant NLR required for cell death 2 (NRC2) belongs to a small NLR group characterized by constitutively high expression without self-activation5
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Interactions between immune cell types facilitate the evolution of immune traits Nature (IF 50.5) Pub Date : 2024-06-12 Tania Dubovik, Martin Lukačišin, Elina Starosvetsky, Benjamin LeRoy, Rachelly Normand, Yasmin Admon, Ayelet Alpert, Yishai Ofran, Max G’Sell, Shai S. Shen-Orr
An essential prerequisite for evolution by natural selection is variation among individuals in traits that affect fitness1. The ability of a system to produce selectable variation, known as evolvability2, thus greatly affects the rate of evolution. The immune system belongs to the fastest evolving components in mammals3, yet the sources of variation in immune traits remain largely unknown4,5. Here
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Maize smart-canopy architecture enhances yield at high densities Nature (IF 50.5) Pub Date : 2024-06-12 Jinge Tian, Chenglong Wang, Fengyi Chen, Wenchao Qin, Hong Yang, Sihang Zhao, Jinliang Xia, Xian Du, Yifan Zhu, Lishuan Wu, Yan Cao, Hong Li, Junhong Zhuang, Shaojiang Chen, Huayuan Zhang, Qiuyue Chen, Mingcai Zhang, Xing Wang Deng, Dezhi Deng, Jigang Li, Feng Tian
Increasing planting density is a key strategy to enhance maize yields1-3. An ideotype for dense planting requires a ‘smart canopy’ with leaf angles at different canopy layers differentially optimized to maximize light interception and photosynthesis4-6, amongst other features. Here, we identified leaf angle architecture of smart canopy 1 (lac1), a natural mutant possessing upright upper leaves, less
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Fabrication of red-emitting perovskite LEDs by stabilizing their octahedral structure Nature (IF 50.5) Pub Date : 2024-06-12 Lingmei Kong, Yuqi Sun, Bin Zhao, Kangyu Ji, Jie Feng, Jianchao Dong, Yuanzhi Wang, Zirui Liu, Shabnum Maqbool, Yunguo Li, Yingguo Yang, Linjie Dai, Wanhee Lee, Changsoon Cho, Samuel D. Stranks, Richard H. Friend, Ning Wang, Neil C. Greenham, Xuyong Yang
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Endoplasmic reticulum–plasma membrane contact gradients direct cell migration Nature (IF 50.5) Pub Date : 2024-06-12 Bo Gong, Jake D. Johnston, Alexander Thiemicke, Alex de Marco, Tobias Meyer
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Ancient Plasmodium genomes shed light on the history of human malaria Nature (IF 50.5) Pub Date : 2024-06-12 Megan Michel, Eirini Skourtanioti, Federica Pierini, Evelyn K. Guevara, Angela Mötsch, Arthur Kocher, Rodrigo Barquera, Raffaela A. Bianco, Selina Carlhoff, Lorenza Coppola Bove, Suzanne Freilich, Karen Giffin, Taylor Hermes, Alina Hiß, Florian Knolle, Elizabeth A. Nelson, Gunnar U. Neumann, Luka Papac, Sandra Penske, Adam B. Rohrlach, Nada Salem, Lena Semerau, Vanessa Villalba-Mouco, Isabelle Abadie
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CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation Nature (IF 50.5) Pub Date : 2024-06-12 Anees Ahmed, Ann M. Joseph, Jordan Zhou, Veronika Horn, Jazib Uddin, Mengze Lyu, Jeremy Goc, Robbyn E. Sockolow, James B. Wing, Eric Vivier, Shimon Sakaguchi, Gregory F. Sonnenberg