In this issue of Structure, Dey et al.1 employ single-molecule FRET to map the conformational trajectory of Omicron spikes during fusion, revealing a transition from pre-fusion to post-fusion through two intermediates. This study highlights the roles of acidic environments, Ca2+, and receptors in promoting SARS-CoV-2 cell entry.

中文翻译：

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SARS-CoV-2 Omicron 在融合过程中尖峰的多步变形


在本期 Structure中，Dey 等人1 采用单分子 FRET 来绘制融合过程中 Omicron 尖峰的构象轨迹，揭示了通过两个中间体从融合前到融合后的转变。本研究强调了酸性环境、Ca2+ 和受体在促进 SARS-CoV-2 细胞进入中的作用。