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Regulation of and challenges in targeting NAD+ metabolism Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-18 Marie E. Migaud, Mathias Ziegler, Joseph A. Baur
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Cellular and pathological functions of tau Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-16 Celeste Parra Bravo, Sarah A. Naguib, Li Gan
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The discovery of cyclin-dependent kinases Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-15 Paul Nurse
Paul Nurse discusses how a 1971 paper by Culotti and Hartwell inspired him to investigate the cell cycle in fission yeast, and how these genetics studies led to the discovery of cyclin-dependent kinases.
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Virus–host warfare by PROTACs Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-09 Kylie J. Walters
The studies that paved the way for the development of PROTACs (proteolysis-targeting chimeras) as therapeutic strategies, and the HPV vaccine.
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Long-lived proteomes in healthy ovaries Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-05 Eytan Zlotorynski
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby supporting the maintenance of the long-lived oocytes.
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Heterochromatin as a balancing act between transcription and gene silencing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-03 Sigurd Braun
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
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Polarized endoplasmic reticulum–plasma membrane contacts in cell migration Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-01 Lisa Heinke
In a recent study, Bong et al. identify a polarized distribution of contact sites between the endoplasmic reticulum and plasma membrane in migrating cells, whereby higher density of contacts in the back of the cells prevents the formation of additional migration fronts.
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Pitfalls in lipid mass spectrometry of mammalian samples — a brief guide for biologists Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-01 Tore Skotland, Kim Ekroos, Jeffrey McDonald, Robert Ahrends, Gerhard Liebisch, Kirsten Sandvig
This Comment discusses erroneous reporting of mass spectrometry analyses of lipids in mammalian samples, and provides recommendations for how to avoid it. Publications that report mass spectrometry analyses of lipids often include lipid species that probably do not exist in the samples. Here we provide recommendations for scientists on submitting lipid data, and for reviewers, editors and readers on
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Resolution in super-resolution microscopy — definition, trade-offs and perspectives Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-01 Kirti Prakash, David Baddeley, Christian Eggeling, Reto Fiolka, Rainer Heintzmann, Suliana Manley, Aleksandra Radenovic, Carlas Smith, Hari Shroff, Lothar Schermelleh
Super-resolution microscopy (SRM) is gaining popularity in biosciences; however, claims about optical resolution are contested and often misleading. In this Viewpoint, experts share their views on resolution and common trade-offs, such as labelling and post-processing, aiming to clarify them for biologists and facilitate deeper understanding and best use of SRM. In this Viewpoint, experts discuss resolution
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Harnessing the deep learning power of foundation models in single-cell omics Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-26 Qin Ma, Yi Jiang, Hao Cheng, Dong Xu
Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require further advancements. In this Comment, we discuss the progress, limitations and best practices in applying foundation models to interrogate data and improve downstream tasks in single-cell omics. This Comment discusses the progress, limitations and best practices in applying foundation
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Identification of RNA structures and their roles in RNA functions Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-26 Xinang Cao, Yueying Zhang, Yiliang Ding, Yue Wan
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Regulation of cellular and systemic sphingolipid homeostasis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-18 Andrew Kuo, Timothy Hla
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Assembly and fission of tubular carriers mediating protein sorting in endosomes Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-17 Navin Gopaldass, Kai-En Chen, Brett Collins, Andreas Mayer
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Monitoring subcellular protein localization at scale in live cells Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-10 Jiří Reiniš, Andreas Reicher
In this Tools of the Trade article, Reiniš and Reicher (Kubicek Lab) describe the development of a multicolour protein-tagging strategy that allows live-cell monitoring of multiple proteins.
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The phosphoinositide PI5P inhibits the Hippo pathway effector YAP Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-10 Kim Baumann
This study uncovered a link between PI5P, PI5P4Ks and the Hippo pathway, whereby PI5P reinforces the inhibition of YAP, the effector of the Hippo pathway.
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A histone code controls positional identity in limb regeneration Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-10 Lisa Heinke
Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves as a segment-specific positional marker in connective tissue cells of axolotls, enabling correct patterning during limb regeneration.
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SenNet recommendations for detecting senescent cells in different tissues Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-03 Vidyani Suryadevara, Adam D. Hudgins, Adarsh Rajesh, Alberto Pappalardo, Alla Karpova, Amit K. Dey, Ann Hertzel, Anthony Agudelo, Azucena Rocha, Bikem Soygur, Birgit Schilling, Chase M. Carver, Cristina Aguayo-Mazzucato, Darren J. Baker, David A. Bernlohr, Diana Jurk, Dilyana B. Mangarova, Ellen M. Quardokus, Elizabeth Ann L. Enninga, Elizabeth L. Schmidt, Feng Chen, Francesca E. Duncan, Francesco
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Splicing regulation through biomolecular condensates and membraneless organelles Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-21 Jimena Giudice, Hao Jiang
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Solving the Wnt nuclear puzzle Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-17 Esther M. Verheyen, Cara J. Gottardi
Verheyen and Gottardi revisit two seminal papers by the Basler, Peifer and Clevers labs elucidating the role of nuclear β-catenin in Wnt signal transduction through its interaction with TCF at Wnt target genes.
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Integrator and U1 snRNPs steer Pol II in the right direction Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-10 Eytan Zlotorynski
Cleavage of promoter-upstream antisense RNAs by the Integrator complex supports the preferential transcription of pre-mRNAs.
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Is amyloid-β a friend or foe? Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-02 Claire S. Durrant
Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to understand their roles in disease and inform therapies, discussing a 2008 paper on amyloid-β from the Arancio lab.
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Translation feedback control in the brain Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-02 Stephanie L. Moon
Stephanie Moon discusses findings that revealed that ribosome stalling can lead to the suppression of translation initiation in the brain, delaying the onset of neurodegeneration.
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Fundamentals of redox regulation in biology Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-30 Helmut Sies, Ryan J. Mailloux, Ursula Jakob
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Epithelial–mesenchymal transition in tissue repair and degeneration Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-29 Khalil Kass Youssef, M. Angela Nieto
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Targeted protein degradation: from mechanisms to clinic Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-29 Jonathan M. Tsai, Radosław P. Nowak, Benjamin L. Ebert, Eric S. Fischer
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The senescence-associated secretory phenotype and its physiological and pathological implications Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-23 Boshi Wang, Jin Han, Jennifer H. Elisseeff, Marco Demaria
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Is endocytosis by caveolae dependent on dynamin? Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-22 Robert G. Parton, Justin W. Taraska, Richard Lundmark
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Relaying gasdermin D to the membrane Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-17 Lisa Heinke
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosis following bacterial infection.
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In memoriam Judy Campisi: spreading cellular senescence Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-12 Fabrizio d’Adda di Fagagna
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.
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Early insights into co-translational assembly of protein complexes Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-12 Ayala Shiber
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the early 1960s.
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Mechanical state transitions in the regulation of tissue form and function Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-10 Yanlan Mao, Sara A. Wickström
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Modelling tauopathies Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-09 Kim Baumann
This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.
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Fibroblast and myofibroblast activation in normal tissue repair and fibrosis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-08 Fereshteh Sadat Younesi, Andrew E. Miller, Thomas H. Barker, Fabio M. V. Rossi, Boris Hinz
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A novel photosystem assembly line worker Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-08 Lisa Heinke
The assembly of large protein–pigment photosystem supercomplexes relies on several assembly factors. Zhang et al. describe a novel assembly factor that evolved during the terrestrialization of land plants.
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Seeing transcription in real time Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-05 Tineke L. Lenstra
Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenous gene.
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Opportunities and challenges in design and optimization of protein function Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-04-02 Dina Listov, Casper A. Goverde, Bruno E. Correia, Sarel Jacob Fleishman
The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calculations, as well as machine learning tools, have dramatically improved protein engineering and design. In this Review, we discuss how these methods
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How ancient RNA survives and what we can learn from it Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-28 Marc R. Friedländer, M. Thomas P. Gilbert
Although normally transient, RNA can persist postmortem when preserved by cold, desiccation or chemical treatment. In this Comment, we discuss how ancient RNA enables the study of gene expression of (pre)historic viruses, plants and animals going back at least as far as the last Ice Age. Friedländer and Gilbert introduce the study of ancient RNA of viruses, plants and animals, and how it can inform
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Single-cell live volume measurements using the fluorescence exclusion method Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-25 Larisa Venkova, Henri Popard
In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion method that now enable simultaneous measurement of cellular and nuclear size as well as investigation of small prokaryotic cells.
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Cellular and molecular mechanisms of skin wound healing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-25 Oscar A. Peña, Paul Martin
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Protein N-terminal acetylation is entering the degradation end game Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-22 Thomas Arnesen, Ine Kjosås, Nina McTiernan
Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation remains cryptic. Four decades ago, the nature of the N terminus was linked to protein stability. In this Comment, we discuss an emerging major role of N-terminal acetylation in shielding the proteome from degradation. Thomas Arnesen and colleagues discuss an emerging major role of
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Localized translation in the embryo Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-21 Ahna Skop, Karen Schindler
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.
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A code within the genetic code Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-21 Susanne Bornelöv
The story of a paper that established the concept of codon optimality and its connection with translation efficiency and mRNA decay.
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Co-transcriptional gene regulation in eukaryotes and prokaryotes Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-20 Morgan Shine, Jackson Gordon, Leonard Schärfen, Dagmar Zigackova, Lydia Herzel, Karla M. Neugebauer
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Spatiotemporal control over cell–matrix interactions using dynamic micropatterns Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-13 Aleksi Isomursu
In this Tools of the Trade article, Isomursu (Ivaska lab) describes a new method for dynamic micropatterning, which enables investigation of cell adhesion and migration on substrates that mimic different extracellular matrix environments.
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A SOX9 switch from regeneration to fibrosis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-08 Kim Baumann
In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.
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Keeping a low cGAS profile in the nucleus Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-03-01 Eytan Zlotorynski
Harmful activity of the DNA sensor cGAS in the nucleus is suppressed by a dedicated ubiquitylation complex.
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Cellular and molecular control of vertebrate somitogenesis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-28 Yuchuan Miao, Olivier Pourquié
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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-27 Jin H. Yang, Anders S. Hansen
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Intrinsic calibration and deformation mapping for expansion microscopy using GelMap Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-21 Josiah B. Passmore, Hugo G. J. Damstra
In this Tools of the Trade article, Hugo Damstra and Josiah Passmore (Kapitein Lab) describe GelMap, which introduces a fluorescent reference grid into the workflow of expansion microscopy experiments, thus enabling a visual readout of sample deformation.
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Live-cell imaging powered by computation Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-20 Hari Shroff, Ilaria Testa, Florian Jug, Suliana Manley
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The cell biology of ferroptosis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-16 Scott J. Dixon, James A. Olzmann
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Emerging mechanistic understanding of cilia function in cellular signalling Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-16 Keren I. Hilgendorf, Benjamin R. Myers, Jeremy F. Reiter
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A catalytic function for mammalian Argonautes Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-14 Joana A. Vidigal
Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi protein argonaute-2.
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Mechanisms and functions of protein S-acylation Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-14 Francisco S. Mesquita, Laurence Abrami, Maurine E. Linder, Shernaz X. Bamji, Bryan C. Dickinson, F. Gisou van der Goot
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AI-driven detection and analysis of label-free protein aggregates Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-08 Khalid A. Ibrahim
In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.
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Condensates burst the bridge for transcription Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-08 Eytan Zlotorynski
A recent study visualizes how enhancer–transcriptional condensate–gene interactions augment gene expression.
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A dynamic culture system that models the intricacy of the mammary gland Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-05 Lei Yuan
In this Tools of the Trade article, Lei Yuan (from the Cai lab) highlights a new culture system that allows in vitro reconstitution of a dynamic miniature mammary gland.
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CRISPR technologies for genome, epigenome and transcriptome editing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-02 Lukas Villiger, Julia Joung, Luke Koblan, Jonathan Weissman, Omar O. Abudayyeh, Jonathan S. Gootenberg
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Bookmarking pluripotency genes Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-02-02 Lisa Heinke
Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.
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Transcription regulation by long non-coding RNAs: mechanisms and disease relevance Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-01-19 Jorge Ferrer, Nadya Dimitrova