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Cancer stem cell mimicry for immune evasion and therapeutic resistance Cell Stem Cell (IF 19.8) Pub Date : 2024-06-25 Phei Er Saw, Qiang Liu, Ping-Pui Wong, Erwei Song
Cancer stem cells (CSCs) are heterogeneous, possess self-renewal attributes, and orchestrate important crosstalk in tumors. We propose that the CSC state represents “mimicry” by cancer cells that leads to phenotypic plasticity. CSC mimicry is suggested as CSCs can impersonate immune cells, vasculo-endothelia, or lymphangiogenic cells to support cancer growth. CSCs facilitate both paracrine and juxtracrine
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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging Cell Stem Cell (IF 19.8) Pub Date : 2024-06-24 Niels Asger Jakobsen, Sven Turkalj, Andy G.X. Zeng, Bilyana Stoilova, Marlen Metzner, Susann Rahmig, Murtaza S. Nagree, Sayyam Shah, Rachel Moore, Batchimeg Usukhbayar, Mirian Angulo Salazar, Grigore-Aristide Gafencu, Alison Kennedy, Simon Newman, Benjamin J.L. Kendrick, Adrian H. Taylor, Rasheed Afinowi-Luitz, Roger Gundle, Bridget Watkins, Kim Wheway, Paresh Vyas
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Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration Cell Stem Cell (IF 19.8) Pub Date : 2024-06-24 Nathalie Saurat, Andrew P. Minotti, Maliha T. Rahman, Trisha Sikder, Chao Zhang, Daniela Cornacchia, Johannes Jungverdorben, Gabriele Ciceri, Doron Betel, Lorenz Studer
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Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms Cell Stem Cell (IF 19.8) Pub Date : 2024-06-21 Shira Landau, Yimu Zhao, Homaira Hamidzada, Gregory M. Kent, Sargol Okhovatian, Rick Xing Ze Lu, Chuan Liu, Karl T. Wagner, Krisco Cheung, Sarah A. Shawky, Daniel Vosoughi, Erika Leigh Beroncal, Ian Fernandes, Carolyn L. Cummins, Ana C. Andreazza, Gordon M. Keller, Slava Epelman, Milica Radisic
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Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells Cell Stem Cell (IF 19.8) Pub Date : 2024-06-14 Jason S. Kirk, Jie Wang, Mark Long, Spencer Rosario, Amanda Tracz, Yibing Ji, Rahul Kumar, Xiaozhuo Liu, Anmbreen Jamroze, Prashant K. Singh, Igor Puzanov, Gurkamal Chatta, Qing Cheng, Jiaoti Huang, Jeffrey L. Wrana, Jonathan Lovell, Han Yu, Song Liu, Michael M. Shen, Tao Liu, Dean G. Tang
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Bioengineered human colon organoids with in vivo-like cellular complexity and function Cell Stem Cell (IF 19.8) Pub Date : 2024-06-13 Olga Mitrofanova, Mikhail Nikolaev, Quan Xu, Nicolas Broguiere, Irineja Cubela, J. Gray Camp, Michael Bscheider, Matthias P. Lutolf
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Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro Cell Stem Cell (IF 19.8) Pub Date : 2024-06-11 Quan Zhou, Mei Wang, Yan Yuan, Xuepeng Wang, Rui Fu, Haifeng Wan, Mingming Xie, Mingxi Liu, Xuejiang Guo, Ying Zheng, Guihai Feng, Qinghua Shi, Xiao-Yang Zhao, Jiahao Sha, Qi Zhou
No Abstract
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From stem cells to regulatory T cells: A tale of plasticity Cell Stem Cell (IF 19.8) Pub Date : 2024-06-06 Mehek Ningoo, Miguel Fribourg
In this issue, Yano et al.1 present a method to obtain suppressive regulatory T (Treg) cells from human induced pluripotent stem cells (hiPSCs). This approach has the potential to address the low Treg cell yields of current ex vivo Treg cell expansion and induction protocols, an unmet challenge for autologous Treg cell treatments.
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CAR macrophages tuning the immune symphony of anti-cancer therapies Cell Stem Cell (IF 19.8) Pub Date : 2024-06-06 Daniela Paasch, Nico Lachmann
Chimeric antigen receptor (CAR) macrophages have broadened the landscape of anti-cancer immunotherapies to combat solid malignancies. Shah et al. introduce CARs to facilitate a CAR macrophage therapy, which aims to recruit and activate T/natural killer cells, further strengthening the overall immune response to decrease pancreatic cancer burden and metastatic spreading.
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Greasing the machinery toward maturation of stem cell-derived β cells Cell Stem Cell (IF 19.8) Pub Date : 2024-06-06 Christos Karampelias, Heiko Lickert
Getting mature and functional stem cell-derived, insulin-producing β cells is an important step for disease modeling, drug screening, and cell replacement therapy. In this issue, Hua et al.1 used single-cell multiomics analysis coupled with chemical screening to identify a crucial role for ceramides in generating mature stem cell-derived β cells.
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Human iPSC-derived CD4+ Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model Cell Stem Cell (IF 19.8) Pub Date : 2024-06-06 Hisashi Yano, Keiko Koga, Takayuki Sato, Tokuyuki Shinohara, Shoichi Iriguchi, Atsushi Matsuda, Kazuki Nakazono, Maki Shioiri, Yasuyuki Miyake, Yoshiaki Kassai, Hitoshi Kiyoi, Shin Kaneko
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Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques Cell Stem Cell (IF 19.8) Pub Date : 2024-06-05 Yongshun Lin, Noriko Sato, Sogun Hong, Kenta Nakamura, Elisa A. Ferrante, Zu Xi Yu, Marcus Y. Chen, Daisy S. Nakamura, Xiulan Yang, Randall R. Clevenger, Timothy J. Hunt, Joni L. Taylor, Kenneth R. Jeffries, Karen J. Keeran, Lauren E. Neidig, Atul Mehta, Robin Schwartzbeck, Shiqin Judy Yu, Conor Kelly, Keron Navarengom, Kazuyo Takeda, Stephen S. Adler, Peter L. Choyke, Jizhong Zou, Charles E. Murry
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Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification Cell Stem Cell (IF 19.8) Pub Date : 2024-05-31 Anish Dattani, Elena Corujo-Simon, Arthur Radley, Tiam Heydari, Yasaman Taheriabkenar, Francesca Carlisle, Simeng Lin, Corin Liddle, Jonathan Mill, Peter W. Zandstra, Jennifer Nichols, Ge Guo
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Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases Cell Stem Cell (IF 19.8) Pub Date : 2024-05-20 Kun Zhang, Ping Wan, Liren Wang, Zhen Wang, Fangzhi Tan, Jie Li, Xiaolong Ma, Jin Cen, Xiang Yuan, Yang Liu, Zhen Sun, Xi Cheng, Yuanhua Liu, Xuhao Liu, Jiazhi Hu, Guisheng Zhong, Dali Li, Qiang Xia, Lijian Hui
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SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production Cell Stem Cell (IF 19.8) Pub Date : 2024-05-20 Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Takayuki Morikawa, Shinya Fujita, Kotaro Shide, Miho Haraguchi, Shinpei Tamaki, Takumi Mikawa, Hiroshi Kondoh, Hiroyasu Nakano, Kenta Sumiyama, Go Nagamatsu, Nobuhito Goda, Shinichiro Okamoto, Ayako Nakamura-Ishizu, Keiyo Takubo
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Modified lentiviral globin gene therapy for pediatric β0/β0 transfusion-dependent β-thalassemia: A single-center, single-arm pilot trial Cell Stem Cell (IF 19.8) Pub Date : 2024-05-16 Shiqi Li, Sikai Ling, Dawei Wang, Xiaoyuan Wang, Fangyuan Hao, Liufan Yin, Zhongtao Yuan, Lin Liu, Lin Zhang, Yu Li, Yingnian Chen, Le Luo, Ying Dai, Lihua Zhang, Lvzhe Chen, Dongjie Deng, Wei Tang, Sujiang Zhang, Sanbin Wang, Yujia Cai
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Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids Cell Stem Cell (IF 19.8) Pub Date : 2024-05-15 Lan Dao, Zhen You, Lu Lu, Tianyang Xu, Avijite Kumer Sarkar, Hui Zhu, Miao Liu, Riccardo Calandrelli, George Yoshida, Pei Lin, Yifei Miao, Sarah Mierke, Srijan Kalva, Haining Zhu, Mingxia Gu, Sudhakar Vadivelu, Sheng Zhong, L. Frank Huang, Ziyuan Guo
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Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics Cell Stem Cell (IF 19.8) Pub Date : 2024-05-15 Suzan Stelloo, Maria Teresa Alejo-Vinogradova, Charlotte A.G.H. van Gelder, Dick W. Zijlmans, Marek J. van Oostrom, Juan Manuel Valverde, Lieke A. Lamers, Teja Rus, Paula Sobrevals Alcaraz, Tilman Schäfers, Cristina Furlan, Pascal W.T.C. Jansen, Marijke P.A. Baltissen, Katharina F. Sonnen, Boudewijn Burgering, Maarten A.F.M. Altelaar, Harmjan R. Vos, Michiel Vermeulen
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Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells Cell Stem Cell (IF 19.8) Pub Date : 2024-05-15 Paul V. Dellorusso, Melissa A. Proven, Fernando J. Calero-Nieto, Xiaonan Wang, Carl A. Mitchell, Felix Hartmann, Meelad Amouzgar, Patricia Favaro, Andrew DeVilbiss, James W. Swann, Theodore T. Ho, Zhiyu Zhao, Sean C. Bendall, Sean Morrison, Berthold Göttgens, Emmanuelle Passegué
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Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells Cell Stem Cell (IF 19.8) Pub Date : 2024-05-15 Tengku Ibrahim Maulana, Claudia Teufel, Madalena Cipriano, Julia Roosz, Lisa Lazarevski, Francijna E. van den Hil, Lukas Scheller, Valeria Orlova, André Koch, Michael Hudecek, Miriam Alb, Peter Loskill
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation Cell Stem Cell (IF 19.8) Pub Date : 2024-05-10 Pratik N.P. Singh, Wei Gu, Shariq Madha, Allen W. Lynch, Paloma Cejas, Ruiyang He, Swarnabh Bhattacharya, Miguel Muñoz Gomez, Matthew G. Oser, Myles Brown, Henry W. Long, Clifford A. Meyer, Qiao Zhou, Ramesh A. Shivdasani
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Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells Cell Stem Cell (IF 19.8) Pub Date : 2024-05-10 Mahliyah Adkins-Threats, Sumimasa Arimura, Yang-Zhe Huang, Margarita Divenko, Sarah To, Heather Mao, Yongji Zeng, Jenie Y. Hwang, Joseph R. Burclaff, Shilpa Jain, Jason C. Mills
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Activating innate immune responses repolarizes hPSC-derived CAR macrophages to improve anti-tumor activity Cell Stem Cell (IF 19.8) Pub Date : 2024-05-08 Jun Shen, Shuzhen Lyu, Yingxi Xu, Shuo Zhang, Li Li, Jinze Li, Junli Mou, Leling Xie, Kejing Tang, Wei Wen, Xuemei Peng, Ying Yang, Yu Shi, Xinjie Li, Min Wang, Xin Li, Jianxiang Wang, Tao Cheng
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ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum Cell Stem Cell (IF 19.8) Pub Date : 2024-05-07 Catarina Martins-Costa, Andrea Wiegers, Vincent A. Pham, Jaydeep Sidhaye, Balint Doleschall, Maria Novatchkova, Thomas Lendl, Marielle Piber, Angela Peer, Paul Möseneder, Marlene Stuempflen, Siu Yu A. Chow, Rainer Seidl, Daniela Prayer, Romana Höftberger, Gregor Kasprian, Yoshiho Ikeuchi, Nina S. Corsini, Jürgen A. Knoblich
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Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor Cell Stem Cell (IF 19.8) Pub Date : 2024-05-03 Tingwei Guo, Fei Pei, Mingyi Zhang, Takahiko Yamada, Jifan Feng, Junjun Jing, Thach-Vu Ho, Yang Chai
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Unveiling the mystery of nuclear RNA homeostasis Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Lin Shan, Ling-Ling Chen
How nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.1 utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.
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Addressing challenges for repairing adult spinal cord with insights from neonates Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Mickey E. Abraham, Joel Martin, Joseph D. Ciacci
Stem cell therapy has emerged as a promising area of scientific investigation, sparking considerable interest, especially in spinal cord injury (SCI). Sun et al.1 discover that the extracellular matrix (ECM) from the neonatal spinal cord transmits biochemical signals to endogenous axons, thus promoting axonal regeneration.
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Actin pushes open a leaky lumen Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Jia Guo, Yue Shao
Using a human stem cell-based model to understand how the human epiblast forms at the very beginning of implantation, Indana et al.1 establish a role for pushing forces that are generated by apical actin polymerization and reveal a two-stage, biomechanics-driven lumen growth process underlying epiblast cavity morphogenesis.
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Sox9-coordinated cellular neighborhoods generate fibrosis Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Darrian Bugg, Jennifer Davis
Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.
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Microbial metabolite steers intestinal stem cell fate under stress Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Shu Zhu, Wen Pan
Recently in Cell Metabolism, Wei et al.1 unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.
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Hallmarks of cancer stemness Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Jia-Jian Loh, Stephanie Ma
Cancer stemness is recognized as a key component of tumor development. Previously coined “cancer stem cells” (CSCs) and believed to be a rare population with rigid hierarchical organization, there is good evidence to suggest that these cells exhibit a plastic cellular state influenced by dynamic CSC-niche interplay. This revelation underscores the need to reevaluate the hallmarks of cancer stemness
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Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Dhiraj Indana, Andrei Zakharov, Youngbin Lim, Alexander R. Dunn, Nidhi Bhutani, Vivek B. Shenoy, Ovijit Chaudhuri
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Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Mohammad Nazim, Chia-Ho Lin, An-Chieh Feng, Wen Xiao, Kyu-Hyeon Yeom, Mulin Li, Allison E. Daly, Xianglong Tan, Ha Vu, Jason Ernst, Michael F. Carey, Stephen T. Smale, Douglas L. Black
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The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Thomas Mortimer, Valentina M. Zinna, Muge Atalay, Carmelo Laudanna, Oleg Deryagin, Guillem Posas, Jacob G. Smith, Elisa García-Lara, Mireia Vaca-Dempere, Leonardo Vinícius Monteiro de Assis, Isabel Heyde, Kevin B. Koronowski, Paul Petrus, Carolina M. Greco, Stephen Forrow, Henrik Oster, Paolo Sassone-Corsi, Patrick-Simon Welz, Pura Muñoz-Cánoves, Salvador Aznar Benitah
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Connie Eaves (May 22, 1944–March 7, 2024) Cell Stem Cell (IF 19.8) Pub Date : 2024-05-02 Ali Turhan, Franck Nicolini, François Lemoine, Laure Coulombel, Saghi Ghaffari
No Abstract
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Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells Cell Stem Cell (IF 19.8) Pub Date : 2024-05-01 Huijuan Hua, Yaqi Wang, Xiaofeng Wang, Shusen Wang, Yunlu Zhou, Yinan Liu, Zhen Liang, Huixia Ren, Sufang Lu, Shuangshuang Wu, Yong Jiang, Yue Pu, Xiang Zheng, Chao Tang, Zhongyang Shen, Cheng Li, Yuanyuan Du, Hongkui Deng
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Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease Cell Stem Cell (IF 19.8) Pub Date : 2024-04-30 Biao Huang, Zipeng Zeng, Sunghyun Kim, Connor C. Fausto, Kari Koppitch, Hui Li, Zexu Li, Xi Chen, Jinjin Guo, Chennan C. Zhang, Tianyi Ma, Pedro Medina, Megan E. Schreiber, Mateo W. Xia, Ariel C. Vonk, Tianyuan Xiang, Tadrushi Patel, Yidan Li, Riana K. Parvez, Balint Der, Zhongwei Li
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Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer Cell Stem Cell (IF 19.8) Pub Date : 2024-04-24 Zahir Shah, Lei Tian, Zhixin Li, Lewei Jin, Jianying Zhang, Zhenlong Li, Tasha Barr, Hejun Tang, Mingye Feng, Michael A. Caligiuri, Jianhua Yu
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Generation of human alveolar epithelial type I cells from pluripotent stem cells Cell Stem Cell (IF 19.8) Pub Date : 2024-04-19 Claire L. Burgess, Jessie Huang, Pushpinder S. Bawa, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Lauren J. Ayers, Michael P. Morley, Apoorva Babu, Carlos Villacorta-Martin, Maria Yampolskaya, Anne Hinds, Bibek R. Thapa, Feiya Wang, Adeline Matschulat, Pankaj Mehta, Edward E. Morrisey, Xaralabos Varelas, Darrell N. Kotton
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Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence Cell Stem Cell (IF 19.8) Pub Date : 2024-04-16 Xue Han, Linqing Xing, Yantao Hong, Xuechun Zhang, Bo Hao, J. Yuyang Lu, Mengyuan Huang, Zuhui Wang, Shaoqian Ma, Ge Zhan, Tong Li, Xiaowen Hao, Yibing Tao, Guanwen Li, Shuqin Zhou, Zheng Zheng, Wen Shao, Yitian Zeng, Dacheng Ma, Wenhao Zhang, Xiaohua Shen
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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons Cell Stem Cell (IF 19.8) Pub Date : 2024-04-15 Osama Al-Dalahmah, Matti Lam, Julie J. McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A. Jakubiak, Rebekka Kühn, Yoon A. Kim, Maria Caterina De Rosa, Claudia A. Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Gunnar Hargus
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Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development Cell Stem Cell (IF 19.8) Pub Date : 2024-04-11 Hsueh-Fu Wu, Kenyi Saito-Diaz, Chia-Wei Huang, Jessica L. McAlpine, Dong Eun Seo, D. Sumner Magruder, Mohamed Ishan, Harrison C. Bergeron, William H. Delaney, Fabio R. Santori, Smita Krishnaswamy, Gerald W. Hart, Ya-Wen Chen, Robert J. Hogan, Hong-Xiang Liu, Natalia B. Ivanova, Nadja Zeltner
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Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques Cell Stem Cell (IF 19.8) Pub Date : 2024-04-09 Byung-Chul Lee, Ashley Gin, Chuanfeng Wu, Komudi Singh, Max Grice, Ryland Mortlock, Diana Abraham, Xing Fan, Yifan Zhou, Aisha AlJanahi, Uimook Choi, Suk See DeRavin, Taehoon Shin, Sogun Hong, Cynthia E. Dunbar
Abstract not available
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Patient-derived tumor-like cell clusters for personalized chemo- and immunotherapies in non-small cell lung cancer Cell Stem Cell (IF 19.8) Pub Date : 2024-04-08 Shenyi Yin, Ying Yu, Nan Wu, Minglei Zhuo, Yanmin Wang, Yanjie Niu, Yiqian Ni, Fang Hu, Cuiming Ding, Hongsheng Liu, Xinghua Cheng, Jin Peng, Juan Li, Yang He, Jiaxin Li, Junyi Wang, Hanshuo Zhang, Xiaoyu Zhai, Bing Liu, Yaqi Wang, Jianzhong Jeff Xi
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Rebuilding and rebooting immunity with stem cells Cell Stem Cell (IF 19.8) Pub Date : 2024-04-08 Laura N. Stankiewicz, Fabio M.V. Rossi, Peter W. Zandstra
Advances in modern medicine have enabled a rapid increase in lifespan and, consequently, have highlighted the immune system as a key driver of age-related disease. Immune regeneration therapies present exciting strategies to address age-related diseases by rebooting the host’s primary lymphoid tissues or rebuilding the immune system directly via biomaterials or artificial tissue. Here, we identify
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Genetic haute couture to block HIV-1 at front doors Cell Stem Cell (IF 19.8) Pub Date : 2024-04-04 Petronela Ancuta
The chemokine receptors CCR5 and CXCR4 are “front doors” for HIV-1 infection in host cells, and their targeting represents a potential solution for a cure. Dudek et al.1 now propose a new gene editing strategy to simultaneously block CCR5- and CXCR4-mediated HIV-1 entry in autologous hematopoietic stem and progenitor cells (HSPCs).
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The difficult translational pathway from animal models to patients Cell Stem Cell (IF 19.8) Pub Date : 2024-04-04 Marina Cavazzana, Annarita Miccio
Lee et al.1 analyzed the impacts of lentiviral vector transduction and CRISPR-Cas9/homology-directed repair editing on hematopoietic stem and progenitor cell (HSPC) engraftment and clonal dynamics. The study suggests that relative to lentiviral-vector-mediated gene addition, homology-directed repair editing is inefficient in vivo and might impair the engraftment and differentiation of HSPCs.
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Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity Cell Stem Cell (IF 19.8) Pub Date : 2024-04-04 Heather M. Sosnoski, Avery D. Posey
Anti-CD19 CAR T cells were among the last decade’s scientific breakthroughs, achieving remarkable remissions in patients with B cell leukemias and lymphomas. Now, the engineered cell therapies are traversing disease indications into autoimmunity and resolving disease symptoms in patients with systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis.1
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Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease Cell Stem Cell (IF 19.8) Pub Date : 2024-04-04 Courtney E. Vishy, Chardai Thomas, Thomas Vincent, Daniel K. Crawford, Matthew M. Goddeeris, Benjamin S. Freedman
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KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury Cell Stem Cell (IF 19.8) Pub Date : 2024-04-04 Jesse D. Lai, Joshua E. Berlind, Gabriella Fricklas, Cecilia Lie, Jean-Paul Urenda, Kelsey Lam, Naomi Sta Maria, Russell Jacobs, Violeta Yu, Zhen Zhao, Justin K. Ichida
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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo Cell Stem Cell (IF 19.8) Pub Date : 2024-04-04 Kenji Namoto, Clara Baader, Vanessa Orsini, Alexandro Landshammer, Eva Breuer, Kieu Trinh Dinh, Rosemarie Ungricht, Monika Pikiolek, Stephane Laurent, Bo Lu, Alexandra Aebi, Katharina Schönberger, Eric Vangrevelinghe, Olivera Evrova, Tianliang Sun, Stefano Annunziato, Julie Lachal, Emily Redmond, Louis Wang, Kristie Wetzel, Jan S. Tchorz
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A simultaneous knockout knockin genome editing strategy in HSPCs potently inhibits CCR5- and CXCR4-tropic HIV-1 infection Cell Stem Cell (IF 19.8) Pub Date : 2024-04-04 Amanda M. Dudek, William N. Feist, Elena J. Sasu, Sofia E. Luna, Kaya Ben-Efraim, Rasmus O. Bak, Alma-Martina Cepika, Matthew H. Porteus
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Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids Cell Stem Cell (IF 19.8) Pub Date : 2024-04-01 Zheng Sun, Zhenni Chen, Man Yin, Xianming Wu, Bo Guo, Xiaokang Cheng, Rui Quan, Yuting Sun, Qi Zhang, Yongheng Fan, Chen Jin, Yanyun Yin, Xianglin Hou, Weiyuan Liu, Muya Shu, Xiaoyu Xue, Ya Shi, Bing Chen, Zhifeng Xiao, Jianwu Dai, Yannan Zhao
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Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment Cell Stem Cell (IF 19.8) Pub Date : 2024-03-26 Adrian A. Epstein, Sara N. Janos, Luca Menozzi, Kelly Pegram, Vaibhav Jain, Logan C. Bisset, Joseph T. Davis, Samantha Morrison, Aswathy Shailaja, Yingqiu Guo, Agnes S. Chao, Khadar Abdi, Blaire Rikard, Junjie Yao, Simon G. Gregory, Kimberley Fisher, Rick Pittman, Al Erkanli, Kathryn E. Gustafson, Caroline W.T. Carrico, Eric J. Benner
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Autofluorescence is a biomarker of neural stem cell activation state Cell Stem Cell (IF 19.8) Pub Date : 2024-03-22 Christopher S. Morrow, Kelsey Tweed, Sabina Farhadova, Alex J. Walsh, Bo P. Lear, Avtar Roopra, Ryan D. Risgaard, Payton C. Klosa, Zachary P. Arndt, Ella R. Peterson, Michelle M. Chi, Allison G. Harris, Melissa C. Skala, Darcie L. Moore
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Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques Cell Stem Cell (IF 19.8) Pub Date : 2024-03-19 Byung-Chul Lee, Ashley Gin, Chuanfeng Wu, Komudi Singh, Max Grice, Ryland Mortlock, Diana Abraham, Xing Fan, Yifan Zhou, Aisha AlJanahi, Uimook Choi, Suk See DeRavin, Taehoon Shin, Sogun Hong, Cynthia E. Dunbar
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Lung repair and regeneration: Advanced models and insights into human disease Cell Stem Cell (IF 19.8) Pub Date : 2024-03-15 Maria C. Basil, Konstantinos-Dionysios Alysandratos, Darrell N. Kotton, Edward E. Morrisey
The respiratory system acts as both the primary site of gas exchange and an important sensor and barrier to the external environment. The increase in incidences of respiratory disease over the past decades has highlighted the importance of developing improved therapeutic approaches. This review will summarize recent research on the cellular complexity of the mammalian respiratory system with a focus
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Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure Cell Stem Cell (IF 19.8) Pub Date : 2024-03-07 Xiang Yuan, Jingqi Wu, Zhen Sun, Jin Cen, Yajing Shu, Chenhua Wang, Hong Li, Dongni Lin, Kun Zhang, Baihua Wu, Anil Dhawan, Ludi Zhang, Lijian Hui
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A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment Cell Stem Cell (IF 19.8) Pub Date : 2024-02-22 Jenna M. Kastenschmidt, Joseph G. Schroers-Martin, Brian J. Sworder, Suhas Sureshchandra, Michael S. Khodadoust, Chih Long Liu, Mari Olsen, David M. Kurtz, Maximilian Diehn, Lisa E. Wagar, Ash A. Alizadeh
Heterogeneity in the tumor microenvironment (TME) of follicular lymphomas (FLs) can affect clinical outcomes. Current immunotherapeutic strategies, including antibody- and cell-based therapies, variably overcome pro-tumorigenic mechanisms for sustained disease control. Modeling the intact FL TME, with its native, syngeneic tumor-infiltrating leukocytes, is a major challenge. Here, we describe an organoid
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An iron rheostat controls hematopoietic stem cell fate Cell Stem Cell (IF 19.8) Pub Date : 2024-02-22 Yun-Ruei Kao, Jiahao Chen, Rajni Kumari, Anita Ng, Aliona Zintiridou, Madhuri Tatiparthy, Yuhong Ma, Maria M. Aivalioti, Deeposree Moulik, Sriram Sundaravel, Daqian Sun, Julie A. Reisz, Juliane Grimm, Nuria Martinez-Lopez, Stephanie Stransky, Simone Sidoli, Ulrich Steidl, Rajat Singh, Angelo D’Alessandro, Britta Will
Mechanisms governing the maintenance of blood-producing hematopoietic stem and multipotent progenitor cells (HSPCs) are incompletely understood, particularly those regulating fate, ensuring long-term maintenance, and preventing aging-associated stem cell dysfunction. We uncovered a role for transitory free cytoplasmic iron as a rheostat for adult stem cell fate control. We found that HSPCs harbor comparatively