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Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin Cell Host Microbe (IF 20.6) Pub Date : 2024-07-19
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Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption Cell Host Microbe (IF 20.6) Pub Date : 2024-07-11 Chao Wu, Fangming Yang, Huanzi Zhong, Jie Hong, Huibin Lin, Mingxi Zong, Huahui Ren, Shaoqian Zhao, Yufei Chen, Zhun Shi, Xingyu Wang, Juan Shen, Qiaoling Wang, Mengshan Ni, Banru Chen, Zhongle Cai, Minchun Zhang, Zhiwen Cao, Kui Wu, Aibo Gao, Ruixin Liu
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Combatting superbugs using the evolutionary record of microbial warfare Cell Host Microbe (IF 20.6) Pub Date : 2024-07-10 Arjun S. Raman
New therapies to treat multi-drug-resistant (MDR) pathogens are needed. Santos-Júnior et al. discover new antimicrobials by leveraging the history of warfare within microbial communities. This study in Cell highlights the immense power of combining large biological databases with emerging computational methods, creating a key resource (AMPSphere) to be used for treating superbugs.
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Chaperones help TACkle phage infection Cell Host Microbe (IF 20.6) Pub Date : 2024-07-10 Shally R. Margolis, Alexander J. Meeske
Bacteria have evolved anti-viral defenses, but the mechanisms of sensing and stopping infection are still under investigation. In this issue of Cell Host & Microbe, Mets, Kurata, Ernits et al. describe how direct sensing of a phage protein by a bacterial toxin-antitoxin-associated chaperone unleashes toxin activity to prevent infection.
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Breathe and bloom: Gut hypoxia limits C. albicans growth Cell Host Microbe (IF 20.6) Pub Date : 2024-07-10 Animesh A. Mishra, Andrew Y. Koh
Multiple host and microbial factors dictate whether Candida albicans can colonize the mammalian gastrointestinal tract. In this issue of Cell Host & Microbe, Savage et al. demonstrate that restoration of intestinal epithelial hypoxia is sufficient to restore Candida albicans colonization resistance, even when other Candida inhibitory effectors remain depleted.
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Opening another door on influenza entry Cell Host Microbe (IF 20.6) Pub Date : 2024-07-10 Daniel H. Goldhill
In this issue of Cell Host & Microbe, Karakus et al. find that an influenza virus enters cells by exclusively binding to a protein instead of sugars.
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Microbiota alert: Proteobacteria consume arginine to dampen omental antitumor immunity Cell Host Microbe (IF 20.6) Pub Date : 2024-07-10 Xian Du, Zuliang Jie, Qiang Zou
The microbiota can impact antitumor immunity, but whether the microbiota regulates omental antitumor immunity remains elusive. In this issue of Cell Host & Microbe, Meza-Perez et al. demonstrated that Proteobacteria consume arginine to increase Treg cell suppressive capacity and inhibit antitumor immune responses, promoting tumor growth in the omentum.
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Mommy’s microbes: Gestational diabetes mellitus shapes the maternal and infant gut microbiome Cell Host Microbe (IF 20.6) Pub Date : 2024-07-10 Ezinne Aja, Jonathan P. Jacobs
Gestational diabetes mellitus (GDM) is associated with increased risk of metabolic and neurodevelopmental disorders in offspring. In this issue of Cell Host & Microbe, Wang et al. provide evidence that changes in the gut microbiome of mothers with GDM may lead to dysbiosis in their infants and altered development in a sex-dependent manner.
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Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification Cell Host Microbe (IF 20.6) Pub Date : 2024-07-02 Haiyuan Shen, Liangliang Zhou, Hao Zhang, Yuanru Yang, Ling Jiang, Dongqing Wu, Hang Shu, Hejiao Zhang, Linxi Xie, Kaichen Zhou, Chen Cheng, Lei Yang, Jiali Jiang, Siya Wang, Yiran Han, Jiayi Zhu, Long Xu, Zhihua Liu, Hua Wang, Shi Yin
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The antagonistic role of an E3 ligase pair in regulating plant NLR-mediated autoimmunity and fungal pathogen resistance Cell Host Microbe (IF 20.6) Pub Date : 2024-07-01 Jun Liu, Yong Yang, Fausto Andres Ortiz-Morea, Yulu Zhou, Derui Liu, Yanyan Huang, Jiarui Zheng, Yan Chen, Liang Kong, Zunyong Liu, Dongdong Ge, Mingli Yong, Wenwei Lin, Eugenia Russinova, Libo Shan, Ping He
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Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring Cell Host Microbe (IF 20.6) Pub Date : 2024-07-01 Shilan Wang, Yingzhi Liu, Wing Hung Tam, Jessica Y.L. Ching, Wenye Xu, Shuai Yan, Biyan Qin, Ling Lin, Ye Peng, Jie Zhu, Chun Pan Cheung, Ka Long Ip, Yuen Man Wong, Pui Kuan Cheong, Yuk Ling Yeung, Wing Him Betty Kan, Ting Fan Leung, Tak Yeung Leung, Eugene B. Chang, David T. Rubin, Lin Zhang
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Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine Cell Host Microbe (IF 20.6) Pub Date : 2024-06-27 Selene Meza-Perez, Mingyong Liu, Aaron Silva-Sanchez, Casey D. Morrow, Peter G. Eipers, Elliot J. Lefkowitz, Travis Ptacek, Christopher D. Scharer, Alexander F. Rosenberg, Dave D. Hill, Rebecca C. Arend, Michael J. Gray, Troy D. Randall
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Multi-omics signatures reveal genomic and functional heterogeneity of Cutibacterium acnes in normal and diseased skin Cell Host Microbe (IF 20.6) Pub Date : 2024-06-26 Tianze Yu, Xiaoqiang Xu, Yang Liu, Xiaokai Wang, Shi Wu, Zhuoqiong Qiu, Xiaochun Liu, Xiaoyu Pan, Chaoying Gu, Shangshang Wang, Lixin Dong, Wei Li, Xu Yao
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A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion Cell Host Microbe (IF 20.6) Pub Date : 2024-06-24 Desmond Richmond-Buccola, Samuel J. Hobbs, Jasmine M. Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S.Y. Lee, Philip J. Kranzusch
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Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases Cell Host Microbe (IF 20.6) Pub Date : 2024-06-24 Adarsh Kumbhari, Thomas N.H. Cheng, Ashwin N. Ananthakrishnan, Bharati Kochar, Kristin E. Burke, Kevin Shannon, Helena Lau, Ramnik J. Xavier, Christopher S. Smillie
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A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice Cell Host Microbe (IF 20.6) Pub Date : 2024-06-20 Lauren A. Hesser, Armando A. Puente, Jack Arnold, Edward Ionescu, Anjali Mirmira, Nidhi Talasani, Jacqueline Lopez, Lisa Maccio-Maretto, Mark Mimee, Cathryn R. Nagler
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H19 influenza A virus exhibits species-specific MHC class II receptor usage Cell Host Microbe (IF 20.6) Pub Date : 2024-06-17 Umut Karakus, Ignacio Mena, Jithesh Kottur, Sara S. El Zahed, Rocío Seoane, Soner Yildiz, Leanne Chen, Magdalena Plancarte, LeAnn Lindsay, Rebecca Halpin, Timothy B. Stockwell, David E. Wentworth, Geert-Jan Boons, Florian Krammer, Silke Stertz, Walter Boyce, Robert P. de Vries, Aneel K. Aggarwal, Adolfo García-Sastre
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Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Deepto Mozumdar, Andrea Fossati, Erica Stevenson, Jingwen Guan, Eliza Nieweglowska, Sanjana Rao, David Agard, Danielle L. Swaney, Joseph Bondy-Denomy
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Streptomyces use umbrella toxins to gently compete with kin Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Fatma Sevde Coskun, Erdal Toprak
In a recent issue of Nature, Zhao et al. have demonstrated that Streptomyces spp. produce “umbrella”-shaped polymorphic toxin particles, a novel class of non-lethal toxins that gently inhibit competitors by arresting hyphal growth in closely related bacteria, unveiling a unique bacterial defense strategy in microbial ecological interactions.1
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Tactical terminase: How a Salmonella prophage navigates oxidative stress Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Sine Lo Svenningsen
Stress-induced prophages commonly “jump ship” by inducing lysis via the host SOS response. In a recent work, Uppalapati et al. reports an alternate, s…
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Gut microbial β-Glucuronidase: A key regulator of endobiotic homeostasis Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Lijun Ning, Jie Hong
Previous studies have explored the role of the gut microbiota in regulating endobiotic homeostasis, but the precise mechanisms remain unclear. In this issue of Cell Host & Microbe, Simpson et al. identified two predominant subtypes of gut microbial β-Glucuronidase (gmGUS) that can reactivate hormones and neurotransmitters to regulate endobiotic homeostasis.
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Response, resistance, and recovery of gut bacteria to human-targeted drug exposure Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Jacobo de la Cuesta-Zuluaga, Leonardo Boldt, Lisa Maier
Survival strategies of human-associated microbes to drug exposure have been mainly studied in the context of bona fide pathogens exposed to antibiotics. Less well understood are the survival strategies of non-pathogenic microbes and host-associated commensal communities to the variety of drugs and xenobiotics to which humans are exposed. The lifestyle of microbial commensals within complex communities
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Mechanisms of bacterial immunity, protection, and survival during interbacterial warfare Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Nolan W. Kennedy, Laurie E. Comstock
Most bacteria live in communities, often with closely related strains and species with whom they must compete for space and resources. Consequently, bacteria have acquired or evolved mechanisms to antagonize competitors through the production of antibacterial toxins. Similar to bacterial systems that combat phage infection and mechanisms to thwart antibiotics, bacteria have also acquired and evolved
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Going viral: The role of mobile genetic elements in bacterial immunity Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Beatriz Beamud, Fabienne Benz, David Bikard
Bacteriophages and other mobile genetic elements (MGEs) pose a significant threat to bacteria, subjecting them to constant attacks. In response, bacteria have evolved a sophisticated immune system that employs diverse defensive strategies and mechanisms. Remarkably, a growing body of evidence suggests that most of these defenses are encoded by MGEs themselves. This realization challenges our traditional
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Intestinal colonization resistance in the context of environmental, host, and microbial determinants Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Simon Woelfel, Marta Salvado Silva, Bärbel Stecher
Microbial communities that colonize the human gastrointestinal (GI) tract defend against pathogens through a mechanism known as colonization resistance (CR). Advances in technologies such as next-generation sequencing, gnotobiotic mouse models, and bacterial cultivation have enhanced our understanding of the underlying mechanisms and the intricate microbial interactions involved in CR. Rather than
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Antibiotic resistance: A key microbial survival mechanism that threatens public health Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Amna Abbas, Alexandra Barkhouse, Dirk Hackenberger, Gerard D. Wright
Antibiotic resistance (AMR) is a global public health threat, challenging the effectiveness of antibiotics in combating bacterial infections. AMR also represents one of the most crucial survival traits evolved by bacteria. Antibiotics emerged hundreds of millions of years ago as advantageous secondary metabolites produced by microbes. Consequently, AMR is equally ancient and hardwired into the genetic
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Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Sophie Helaine, Brian P. Conlon, Kimberly M. Davis, David G. Russell
Antibiotic resistance, typically associated with genetic changes within a bacterial population, is a frequent contributor to antibiotic treatment failures. Antibiotic persistence and tolerance, which we collectively term recalcitrance, represent transient phenotypic changes in the bacterial population that prolong survival in the presence of typically lethal concentrations of antibiotics. Antibiotic
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Nutrient acquisition strategies by gut microbes Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Matthew K. Muramatsu, Sebastian E. Winter
The composition and function of the gut microbiota are intimately tied to nutrient acquisition strategies and metabolism, with significant implications for host health. Both dietary and host-intrinsic factors influence community structure and the basic modes of bacterial energy metabolism. The intestinal tract is rich in carbon and nitrogen sources; however, limited access to oxygen restricts energy-generating
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Bacterial esterases reverse lipopolysaccharide ubiquitylation to block host immunity Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Magdalena Szczesna, Yizhou Huang, Rachel E. Lacoursiere, Francesca Bonini, Vito Pol, Fulya Koc, Beatrice Ward, Paul P. Geurink, Jonathan N. Pruneda, Teresa L.M. Thurston
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Neuropilin invites reoviruses into neurons Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Tom Gallagher
In this issue of Cell Host & Microbe, Shang et al. identify murine neuropilin 1 as a host factor that binds reovirus particles, directing cell entry and contributing to viral dissemination and neurovirulence. This study highlights the reovirus model system to investigate host receptors and their significance in viral pathogenesis.
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From parent to progeny Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Sara Shama, Michelle R. Asbury, Deborah L. O’Connor
How infants acquire their gut microbial communities and the various factors influencing these dynamics remain unclear. In this issue of Cell Host & Microbe, Selma-Royo et al. and Dubois et al. use shotgun metagenomic sequencing to understand the transmission of microbes from parents to infants and delve into factors modifying this process.
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Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Marta Selma-Royo, Léonard Dubois, Serena Manara, Federica Armanini, Raúl Cabrera-Rubio, Mireia Valles-Colomer, Sonia González, Anna Parra-Llorca, Ramon Escuriet, Lars Bode, Cecilia Martínez-Costa, Nicola Segata, Maria Carmen Collado
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Paternal and induced gut microbiota seeding complement mother-to-infant transmission Cell Host Microbe (IF 20.6) Pub Date : 2024-06-12 Léonard Dubois, Mireia Valles-Colomer, Alise Ponsero, Otto Helve, Sture Andersson, Kaija-Leena Kolho, Francesco Asnicar, Katri Korpela, Anne Salonen, Nicola Segata, Willem M. de Vos
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Epithelial hypoxia maintains colonization resistance against Candida albicans Cell Host Microbe (IF 20.6) Pub Date : 2024-06-04 Hannah P. Savage, Derek J. Bays, Connor R. Tiffany, Mariela A.F. Gonzalez, Eli J. Bejarano, Thaynara P. Carvalho, Zheng Luo, Hugo L.P. Masson, Henry Nguyen, Renato L. Santos, Krystle L. Reagan, George R. Thompson, Andreas J. Bäumler
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Mechanism of phage sensing and restriction by toxin-antitoxin-chaperone systems Cell Host Microbe (IF 20.6) Pub Date : 2024-05-30 Toomas Mets, Tatsuaki Kurata, Karin Ernits, Marcus J.O. Johansson, Sophie Z. Craig, Gabriel Medina Evora, Jessica A. Buttress, Roni Odai, Kyo Coppieters‘t Wallant, Jose A. Nakamoto, Lena Shyrokova, Artyom A. Egorov, Christopher Ross Doering, Tetiana Brodiazhenko, Michael T. Laub, Tanel Tenson, Henrik Strahl, Chloe Martens, Alexander Harms, Abel Garcia-Pino, Vasili Hauryliuk
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Salmonella Typhimurium expansion in the inflamed murine gut is dependent on aspartate derived from ROS-mediated microbiota lysis Cell Host Microbe (IF 20.6) Pub Date : 2024-05-27 Woongjae Yoo, Nicolas G. Shealy, Jacob K. Zieba, Teresa P. Torres, Madi Baltagulov, Julia D. Thomas, Catherine D. Shelton, Anna G. McGovern, Nora J. Foegeding, Erin E. Olsan, Mariana X. Byndloss
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Spatially resolved lipidomics shows conditional transfer of lipids produced by Bacteroides thetaiotaomicron into the mouse gut Cell Host Microbe (IF 20.6) Pub Date : 2024-05-24 Claudia Mirretta Barone, Stacey L. Heaver, Lars Gruber, Fabian Zundel, Dai Long Vu, Ruth E. Ley
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Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis Cell Host Microbe (IF 20.6) Pub Date : 2024-05-23 Chaoliang Li, Panrui Zhang, Yadong Xie, Shishan Wang, Meng Guo, Xiaowei Wei, Kaiguang Zhang, Dan Cao, Rongbin Zhou, Sheng Wang, Xinyang Song, Shu Zhu, Wen Pan
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Variability in cell division among anatomical sites shapes Escherichia coli antibiotic survival in a urinary tract infection mouse model Cell Host Microbe (IF 20.6) Pub Date : 2024-05-16 Ariane Amoura, Claire Pistien, Camille Chaligné, Sara Dion, Mélanie Magnan, Antoine Bridier-Nahmias, Alexandra Baron, Françoise Chau, Emmanuel Bourgogne, Minh Le, Erick Denamur, Molly A. Ingersoll, Bruno Fantin, Agnès Lefort, Imane El Meouche
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Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling Cell Host Microbe (IF 20.6) Pub Date : 2024-05-15 Xuemei Wang, Shuang Zhou, Xiaomin Hu, Chuan Ye, Qixing Nie, Kai Wang, Sen Yan, Jun Lin, Feng Xu, Meng Li, Qing Wu, Lulu Sun, Bo Liu, Yi Zhang, Chuyu Yun, Xian Wang, Huiying Liu, Wen-Bing Yin, Dongyu Zhao, Jing Hang, Shuyang Zhang, Changtao Jiang, Yanli Pang
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Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans Cell Host Microbe (IF 20.6) Pub Date : 2024-05-15 Fabienne Benz, Sarah Camara-Wilpert, Jakob Russel, Katharina G. Wandera, Rimvydė Čepaitė, Manuel Ares-Arroyo, José Vicente Gomes-Filho, Frank Englert, Johannes A. Kuehn, Silvana Gloor, Mario Rodríguez Mestre, Aline Cuénod, Mònica Aguilà-Sans, Lorrie Maccario, Adrian Egli, Lennart Randau, Patrick Pausch, Eduardo P.C. Rocha, Chase L. Beisel, Jonas Stenløkke Madsen, David Bikard, Alex R. Hall, Søren Johannes
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Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics Cell Host Microbe (IF 20.6) Pub Date : 2024-05-15 Joshua B. Simpson, Morgan E. Walker, Joshua J. Sekela, Samantha M. Ivey, Parth B. Jariwala, Cameron M. Storch, Mark E. Kowalewski, Amanda L. Graboski, Adam D. Lietzan, William G. Walton, Kacey A. Davis, Erica W. Cloer, Valentina Borlandelli, Yun-Chung Hsiao, Lee R. Roberts, David H. Perlman, Xue Liang, Hermen S. Overkleeft, Aadra P. Bhatt, Kun Lu, Matthew R. Redinbo
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Candidalysin: An unlikely aide for fungal gut commensalism Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08 Jesús A. Romo, Jose L. Lopez-Ribot
Fungi colonize the mammalian gastrointestinal (GI) tract and can adopt both commensal and opportunistic lifestyles. In a recent issue of Nature, Liang et al. unraveled the complex interplay between Candida morphotypes and the gut bacterial microbiota and described a key role for candidalysin in gut colonization.1
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NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits Cell Host Microbe (IF 20.6) Pub Date : 2024-05-09 Pengcheng Shang, Rita dos Santos Natividade, Gwen M. Taylor, Ankita Ray, Olivia L. Welsh, Kay L. Fiske, Danica M. Sutherland, David Alsteens, Terence S. Dermody
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Gut dopamine kick: How gut microbes turn on host receptors to fight pathogens Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08 Eran Gutman, Yael Litvak
Common nutrients in our diet often affect our health through unexpected mechanisms. In a recent issue of Nature, Scott et al. show gut microbes convert dietary tryptophan into metabolites activating intestinal dopamine receptors, which can block attachment of bacterial pathogens to host cells.
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One size might fit all: Indole-3-propionic acid potentiates pan-cancer immunotherapy Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08 Zheshun Pi, Weici Liu, Wenjun Mao
Microbial-based therapies have the potential to combat immunotherapy resistance, extending the boundaries of oncological therapeutics. In a recent issue of Cell, Jia et al. demonstrates an example of microbial collaboration to produce a postbiotic that promotes the stemness program of CD8+ T cells to augment immunotherapy at the pan-cancer level.
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Amino acid bites: Microbial snacking influences host metabolism Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08 Amélie Joly, Filipe De Vadder
The gut microbiota has the capacity to metabolize food-derived molecules. In this issue of Cell Host & Microbe, Li et al. explore how some bacterial species of the gut microbiota can deplete amino acids in the gut lumen, modulating the amino acid landscape and energy metabolism of the host.
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Designing boosting immunogens for HIV-1 vaccine development Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08 Qingbo Liu
Inducing HIV-1 broadly neutralizing antibodies (bnAbs) through vaccination poses exceptional challenges. In this issue of Cell Host & Microbe, Wiehe and colleagues report the elicitation of affinity-matured bnAbs in knock-in mice through boosting immunogen vaccination, which selects for key improbable mutations.
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Slings and arrows: sRNAs mediate intragenomic competition Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08 Micah J. Ferrell, Christopher M. Waters
Bacterial genomes are littered with exogenous: competing DNA elements. Here, Sprenger et al. demonstrate that the Vibrio cholerae prophage VP882 modulates host functions via production of regulatory sRNAs to promote phage development. Alternatively, host sRNAs inhibit the VP882 lytic phase by specifically regulating phage genes.
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Debugging neurodevelopment disorders Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08
Gut bacteria are thought to contribute to neurodevelopmental disorders, but whether they are causal or predictive of disease remains unclear. In a pro…
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Worming into infancy: Exploring helminth-microbiome interactions in early life Cell Host Microbe (IF 20.6) Pub Date : 2024-05-08 Andrei Bogza, Irah L. King, Corinne F. Maurice
There is rapidly growing awareness of microbiome assembly and function in early-life gut health. Although many factors, such as antibiotic use and highly processed diets, impinge on this process, most research has focused on people residing in high-income countries. However, much of the world’s population lives in low- and middle-income countries (LMICs), where, in addition to erratic antibiotic use
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Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction Cell Host Microbe (IF 20.6) Pub Date : 2024-04-25 Kevin Wiehe, Kevin O. Saunders, Victoria Stalls, Derek W. Cain, Sravani Venkatayogi, Joshua S. Martin Beem, Madison Berry, Tyler Evangelous, Rory Henderson, Bhavna Hora, Shi-Mao Xia, Chuancang Jiang, Amanda Newman, Cindy Bowman, Xiaozhi Lu, Mary E. Bryan, Joena Bal, Aja Sanzone, Haiyan Chen, Amanda Eaton, Mark A. Tomai, Christopher B. Fox, Ying K. Tam, Christopher Barbosa, Mattia Bonsignori, Hiromi
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The gut microbiome associates with phenotypic manifestations of post-acute COVID-19 syndrome Cell Host Microbe (IF 20.6) Pub Date : 2024-04-23 Qi Su, Raphaela I. Lau, Qin Liu, Moses K.T. Li, Joyce Wing Yan Mak, Wenqi Lu, Ivan S.F. Lau, Louis H.S. Lau, Giann T.Y. Yeung, Chun Pan Cheung, Whitney Tang, Chengyu Liu, Jessica Y.L. Ching, Pui Kuan Cheong, Francis K.L. Chan, Siew C. Ng
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A phase-separated protein hub modulates resistance to Fusarium head blight in wheat Cell Host Microbe (IF 20.6) Pub Date : 2024-04-23 Yi He, Xiujuan Yang, Xiaobo Xia, Yuhua Wang, Yifan Dong, Lei Wu, Peng Jiang, Xu Zhang, Cong Jiang, Hongxiang Ma, Wujun Ma, Cong Liu, Ryan Whitford, Matthew R. Tucker, Zhengguang Zhang, Gang Li
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Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology Cell Host Microbe (IF 20.6) Pub Date : 2024-04-23 Ting-Ting Li, Xi Chen, Da Huo, Mohammad Arifuzzaman, Shanshan Qiao, Wen-Bing Jin, Huiqing Shi, Xin V. Li, JRI Live Cell Bank Consortium, Iliyan D. Iliev, David Artis, Chun-Jun Guo
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Assessing phage-host population dynamics by reintroducing virulent viruses to synthetic microbiomes Cell Host Microbe (IF 20.6) Pub Date : 2024-04-22 Jacob Wilde, Randy Boyes, Avery V. Robinson, Brendan A. Daisley, Alexander J. Botschner, Dylan J.L. Brettingham, Christine V. Macpherson, Elizabeth Mallory, Emma Allen-Vercoe
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The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice Cell Host Microbe (IF 20.6) Pub Date : 2024-04-22 Sang-Hoon Sin, Anthony B. Eason, Yongbaek Kim, Johann W. Schneider, Blossom Damania, Dirk P. Dittmer
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Burkholderia thailandensis uses a type VI secretion system to lyse protrusions without triggering host cell responses Cell Host Microbe (IF 20.6) Pub Date : 2024-04-18 Miro Thorsten Wilhelm Plum, Hoi Ching Cheung, Patricia Reist Iscar, Yahua Chen, Yunn-Hwen Gan, Marek Basler
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Crafty mimicry grants nuclear pore entry to HIV Cell Host Microbe (IF 20.6) Pub Date : 2024-04-10 Keesiang Lim, Masaharu Hazawa, Richard W. Wong
The size of the nuclear pore should, in principle, prevent HIV-1 entry. However, HIV-1 capsid is able to gain nuclear pore entry. In a recent issue of Nature, Fu et al. and Dickson et al. demonstrate that the HIV-1 capsid mimics the nuclear transport protein karyopherins to access host nuclei.