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Immunological imprinting and risks of influenza B virus infection Nat. Immunol. (IF 27.7) Pub Date : 2024-07-19 Isaac C. L. Chow, Sook-San Wong
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A humanized mouse that mounts specific and mature antibody and autoantibody responses Nat. Immunol. (IF 27.7) Pub Date : 2024-07-18
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T cell dysfunction and therapeutic intervention in cancer Nat. Immunol. (IF 27.7) Pub Date : 2024-07-18 Caitlin C. Zebley, Dietmar Zehn, Stephen Gottshalk, Hongbo Chi
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Gα13 restricts nutrient driven proliferation in mucosal germinal centers Nat. Immunol. (IF 27.7) Pub Date : 2024-07-18 Hang T. Nguyen, Moyi Li, Rahul Vadakath, Keirstin A. Henke, Tam C. Tran, Huifang Li, Maryam Yamadi, Sriranjani Darbha, Yandan Yang, Juraj Kabat, Anne R. Albright, Enoc Granados Centeno, James D. Phelan, Sandrine Roulland, Da Wei Huang, Michael C. Kelly, Ryan M. Young, Stefania Pittaluga, Simone Difilippantonio, Jagan R. Muppidi
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Cross-talk between ILC2 and Gata3 high T regs locally constrains adaptive type 2 immunity Sci. Immunol (IF 17.6) Pub Date : 2024-07-19 Julie Stockis, Thomas Yip, Julia Moreno-Vicente, Oliver Burton, Youhani Samarakoon, Martijn J. Schuijs, Shwetha Raghunathan, Celine Garcia, Weike Luo, Sarah K. Whiteside, Shaun Png, Charlotte Simpson, Stela Monk, Ashley Sawle, Kelvin Yin, Johanna Barbieri, Panagiotis Papadopoulos, Hannah Wong, Hans-Reimer Rodewald, Timothy Vyse, Andrew N. J. McKenzie, Mark S. Cragg, Matthew Hoare, David R. Withers
Regulatory T cells (T regs ) control adaptive immunity and restrain type 2 inflammation in allergic disease. Interleukin-33 promotes the expansion of tissue-resident T regs and group 2 innate lymphoid cells (ILC2s); however, how T regs locally coordinate their function within the inflammatory niche is not understood. Here, we show that ILC2s are critical orchestrators of T reg function. Using spatial
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CD5 deletion enhances the antitumor activity of adoptive T cell therapies Sci. Immunol (IF 17.6) Pub Date : 2024-07-19 Ruchi P. Patel, Guido Ghilardi, Yunlin Zhang, Yi-Hao Chiang, Wei Xie, Puneeth Guruprasad, Ki Hyun Kim, Inkook Chun, Mathew G. Angelos, Raymone Pajarillo, Seok Jae Hong, Yong Gu Lee, Olga Shestova, Carolyn Shaw, Ivan Cohen, Aasha Gupta, Trang Vu, Dean Qian, Steven Yang, Aditya Nimmagadda, Adam E. Snook, Nicholas Siciliano, Antonia Rotolo, Arati Inamdar, Jaryse Harris, Ositadimma Ugwuanyi, Michael Wang
Most patients treated with US Food and Drug Administration (FDA)–approved chimeric antigen receptor (CAR) T cells eventually experience disease progression. Furthermore, CAR T cells have not been curative against solid cancers and several hematological malignancies such as T cell lymphomas, which have very poor prognoses. One of the main barriers to the clinical success of adoptive T cell immunotherapies
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Chromatin state and BACH2 control TH17 cell functional heterogeneity Nat. Immunol. (IF 27.7) Pub Date : 2024-07-17
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Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers Nat. Immunol. (IF 27.7) Pub Date : 2024-07-16 Thomas S. Fulford, Caroline Soliman, Rebecca G. Castle, Marc Rigau, Zheng Ruan, Olan Dolezal, Rebecca Seneviratna, Hamish G. Brown, Eric Hanssen, Andrew Hammet, Shihan Li, Samuel J. Redmond, Amy Chung, Michael A. Gorman, Michael W. Parker, Onisha Patel, Thomas S. Peat, Janet Newman, Andreas Behren, Nicholas A. Gherardin, Dale I. Godfrey, Adam P. Uldrich
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Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex Immunity (IF 25.5) Pub Date : 2024-07-15
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How bile acids and the microbiota interact to shape host immunity Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-15 Michael H. Lee, Sean-Paul Nuccio, Ipsita Mohanty, Lee R. Hagey, Pieter C. Dorrestein, Hiutung Chu, Manuela Raffatellu
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Advancements in pathogen immunity and signaling Nat. Immunol. (IF 27.7) Pub Date : 2024-07-15 Mads Gyrd-Hansen, Anna Kajaste-Rudnitski, Nicolas Manel, Jan Rehwinkel, Annemarthe G. van der Veen, Matteo Iannacone
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BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells Nat. Immunol. (IF 27.7) Pub Date : 2024-07-15 Pratiksha I. Thakore, Alexandra Schnell, Linglin Huang, Maryann Zhao, Yu Hou, Elena Christian, Sarah Zaghouani, Chao Wang, Vasundhara Singh, Anvita Singaraju, Rajesh Kumar Krishnan, Deneen Kozoriz, Sai Ma, Venkat Sankar, Samuele Notarbartolo, Jason D. Buenrostro, Federica Sallusto, Nikolaos A. Patsopoulos, Orit Rozenblatt-Rosen, Vijay K. Kuchroo, Aviv Regev
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The immunology of systemic lupus erythematosus Nat. Immunol. (IF 27.7) Pub Date : 2024-07-15 George C. Tsokos
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Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts Immunity (IF 25.5) Pub Date : 2024-07-12 Yoshitaka Taketomi, Takayoshi Higashi, Kuniyuki Kano, Yoshimi Miki, Chika Mochizuki, Shota Toyoshima, Yoshimichi Okayama, Yasumasa Nishito, Susumu Nakae, Satoshi Tanaka, Suzumi M. Tokuoka, Yoshiya Oda, Shigeyuki Shichino, Satoshi Ueha, Kouji Matsushima, Noriyuki Akahoshi, Satoshi Ishii, Jerold Chun, Junken Aoki, Makoto Murakami
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Elixir for DCs Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-12 Lucy Bird
Age-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipid to induce effective antitumour responses in mice.
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Understanding NK cell heterogeneity Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-12 Alexandra Flemming
Two papers in Nature Immunology provide a comprehensive atlas of human natural killer cells in health and in different types of cancer.
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Online immunology education for a global world Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-12 Nicolas Vabret, Jaime Mateus-Tique, Hélène Salmon, Jérôme C. Martin, Véronique Mateo, Sandra Serrano, François Lemoine, Roger Chammas, Miriam Merad
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Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis Nat. Immunol. (IF 27.7) Pub Date : 2024-07-12 Meng Sun, Jolie M. Phan, Nathan S. Kieswetter, Huang Huang, Krystle K. Q. Yu, Malisa T. Smith, Yiran E. Liu, Chuanqi Wang, Sanjana Gupta, Gerlinde Obermoser, Holden Terry Maecker, Akshaya Krishnan, Sundari Suresh, Neha Gupta, Mary Rieck, Peter Acs, Mustafa Ghanizada, Shin-Heng Chiou, Purvesh Khatri, W. Henry Boom, Thomas R. Hawn, Catherine M. Stein, Harriet Mayanja-Kizza, Mark M. Davis, Chetan Seshadri
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Infection and chronic disease activate a systemic brain-muscle signaling axis Sci. Immunol (IF 17.6) Pub Date : 2024-07-12 Shuo Yang, Meijie Tian, Yulong Dai, Rong Wang, Shigehiro Yamada, Shengyong Feng, Yunyun Wang, Deepak Chhangani, Tiffany Ou, Wenle Li, Xuan Guo, Jennifer McAdow, Diego E. Rincon-Limas, Xin Yin, Wanbo Tai, Gong Cheng, Aaron Johnson
Infections and neurodegenerative diseases induce neuroinflammation, but affected individuals often show nonneural symptoms including muscle pain and muscle fatigue. The molecular pathways by which neuroinflammation causes pathologies outside the central nervous system (CNS) are poorly understood. We developed multiple models to investigate the impact of CNS stressors on motor function and found that
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Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium Sci. Immunol (IF 17.6) Pub Date : 2024-07-12 Kaixin Liang, Katherine C. Barnett, Martin Hsu, Wei-Chun Chou, Sachendra S. Bais, Kristina Riebe, Yuying Xie, Tuong Thien Nguyen, Thomas H. Oguin, Kevin M. Vannella, Stephen M. Hewitt, Daniel S. Chertow, Maria Blasi, Gregory D. Sempowski, Amelia Karlsson, Beverly H. Koller, Deborah J. Lenschow, Scott H. Randell, Jenny P.-Y. Ting
Virus-induced cell death is a key contributor to COVID-19 pathology. Cell death induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well studied in myeloid cells but less in its primary host cell type, angiotensin-converting enzyme 2 (ACE2)–expressing human airway epithelia (HAE). SARS-CoV-2 induces apoptosis, necroptosis, and pyroptosis in HAE organotypic cultures. Single-cell
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A confusion of pathways: Discerning cell death mechanisms in SARS-CoV-2 infection Sci. Immunol (IF 17.6) Pub Date : 2024-07-12 Lok-Yin Roy Wong, Stanley Perlman
Upon SARS-CoV-2 infection, infected cells undergo necroptosis, whereas delayed apoptosis and pyroptosis occur in uninfected, bystander cells, thus providing a plausible explanation for the extensive injury among myriad uninfected cells.
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MHC heterozygosity limits T cell receptor variability in CD4 T cells Sci. Immunol (IF 17.6) Pub Date : 2024-07-12 Alexander J. Brown, Janice White, Laura Shaw, Jimmy Gross, Andrei Slabodkin, Ella Kushner, Victor Greiff, Jennifer Matsuda, Laurent Gapin, James Scott-Browne, John Kappler, Philippa Marrack
αβ T cell receptor (TCR) V(D)J genes code for billions of TCR combinations. However, only some appear on peripheral T cells in any individual because, to mature, thymocytes must react with low affinity but not high affinity with thymus expressed major histocompatibility (MHC)/peptides. MHC proteins are very polymorphic. Different alleles bind different peptides. Therefore, any individual might express
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Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes Nat. Immunol. (IF 27.7) Pub Date : 2024-07-11 Yuanyuan You, Josefine Dunst, Kewei Ye, Patrick A. Sandoz, Annika Reinhardt, Inga Sandrock, Natalia R. Comet, Rupak Dey Sarkar, Emily Yang, Estelle Duprez, Judith Agudo, Brian D. Brown, Paul J. Utz, Wolfgang Kastenmüller, Carmen Gerlach, Immo Prinz, Björn Önfelt, Taras Kreslavsky
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RIPK1: Inflamed if you do, inflamed if you don’t Immunity (IF 25.5) Pub Date : 2024-07-09 Nicholas W. Hubbard, Andrew Oberst
RIPK1 is known as a driver of cell death and inflammation. In this issue of Immunity, Imai et al. and Mannion et al. find that these same processes are also induced by RIPK1 inactivation and highlight the therapeutic potential of RIPK1 elimination.
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The pros and confs of IL-18 activation Immunity (IF 25.5) Pub Date : 2024-07-09 Danielle M. Clancy, Julie Andries, Savvas N. Savvides
Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.
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Scavengers in islets fuel diabetic autoimmunity Immunity (IF 25.5) Pub Date : 2024-07-09 Jadie Y. Moon, Katherine A. Gallagher
Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al.1 examine the role of the islet microenvironment in autoimmunity and find that the scavenging receptor CXCL16 on islet-resident macrophages uptakes oxidized low-density lipoproteins and promotes the differentiation and survival
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Skin deep: Epithelial cell metabolism and chronic skin inflammation Immunity (IF 25.5) Pub Date : 2024-07-09 Eliana R. Solis, Julie M. Jameson
Skin inflammation is potentiated by coordinated epithelial and immune cell metabolism. In this issue of Immunity, Subudhi and Konieczny et al. delineate how HIF1α regulates epithelial cell glycolysis during psoriasis. In turn, lactate is a byproduct that augments type 17 γδ T cell responses to sustain inflammatory skin disease.
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B cells! Don’t go the wrong way in this tumor Immunity (IF 25.5) Pub Date : 2024-07-09 Guilhem Pupier, Catherine Sautès-Fridman
The association of tertiary lymphoid structures (TLSs) with survival and immunotherapy response brought B cells to center stage. In a pan-cancer B cells atlas in Science, Ma et al. show that germinal center reaction generating anti-tumor antibody-secreting cells (ASCs) from B memory cells in mature TLSs co-exist in tumors with extra-follicular reaction generating auto-reactive ASCs from memory B cells
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Human determinants of age-dependent patterns of death from infection Immunity (IF 25.5) Pub Date : 2024-07-09 Laurent Abel, Jean-Laurent Casanova
Regardless of microbial virulence (i.e., the global infection-fatality ratio), age generally drives the prevalence of death from infection in unvaccinated humans. Four mortality patterns are recognized: the common U- and L-shaped curves of endemic infections and the unique W- and J-shaped curves of pandemic infections. We suggest that these patterns result from different sets of human genetic and immunological
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Antibody modulation of B cell responses—Incorporating positive and negative feedback Immunity (IF 25.5) Pub Date : 2024-07-09 Jason G. Cyster, Patrick C. Wilson
Antibodies are powerful modulators of ongoing and future B cell responses. While the concept of antibody feedback has been appreciated for over a century, the topic has seen a surge in interest due to the evidence that the broadening of antibody responses to SARS-CoV-2 after a third mRNA vaccination is a consequence of antibody feedback. Moreover, the discovery that slow antigen delivery can lead to
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Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-09 Isabelle C. Arnold, Ariel Munitz
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Stimulation history is epigenetically imprinted in memory B cells Nat. Immunol. (IF 27.7) Pub Date : 2024-07-09
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B cells instruct their own fate through IL-12 Nat. Immunol. (IF 27.7) Pub Date : 2024-07-09 Iñaki Sanz
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Chameleon impersonation of NK cells and ILC1s Nat. Immunol. (IF 27.7) Pub Date : 2024-07-09 M. Zeeshan Chaudhry, Gabrielle T. Belz
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Classical monocyte ontogeny dictates their functions and fates as tissue macrophages Immunity (IF 25.5) Pub Date : 2024-07-09 Sébastien Trzebanski, Jung-Seok Kim, Niss Larossi, Ayala Raanan, Daliya Kancheva, Jonathan Bastos, Montaser Haddad, Aryeh Solomon, Ehud Sivan, Dan Aizik, Jarmila Sekeresova Kralova, Mor Gross-Vered, Sigalit Boura-Halfon, Tsvee Lapidot, Ronen Alon, Kiavash Movahedi, Steffen Jung
No Abstract
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Defining myeloid-derived suppressor cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-05 Leila Akkari, Ido Amit, Vincenzo Bronte, Zvi G. Fridlender, Dmitry I. Gabrilovich, Florent Ginhoux, Catherine C. Hedrick, Suzanne Ostrand-Rosenberg
Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be
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Rethinking pDCs: a questionable ally in immunity? Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-04 Ester Gea-Mallorquí, Sarah Rowland-Jones
A preprint by Ngo et al. reports a new mouse model for the constitutive depletion of pDCs, showing that pDCs are dispensable for antiviral immunity.
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Microbiota licenses protective CD8+ T cell responses against neonatal influenza Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-04 Boyan K. Tsankov, Dana J. Philpott
A preprint by Stevens et al. establishes a novel mechanism by which the gut micobiota provides protection against neonatal respiratory tract infection.
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An ILC3-intrinsic, CTLA4-dependent intestinal checkpoint Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-04 Kirsty Minton
Ahmed et al. report that IL-23-dependent CTLA4 expression by ILC3s restrains T cell-mediated inflammation in the intestine.
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Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge Nat. Immunol. (IF 27.7) Pub Date : 2024-07-05 Wen Shao, Yifeng Wang, Qian Fang, Wenjuan Shi, Hai Qi
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Human life within a narrow range: The lethal ups and downs of type I interferons Sci. Immunol (IF 17.6) Pub Date : 2024-07-05 Yanick J. Crow, Jean-Laurent Casanova
The past 20 years have seen the definition of human monogenic disorders and their autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) activity. These disorders delineate the impact of type I IFNs in natural conditions and demonstrate that only a narrow window of type I IFN activity is beneficial. Insufficient type I IFN predisposes humans to life-threatening viral
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Early symptom-associated inflammatory responses shift to type 2 responses in controlled human schistosome infection Sci. Immunol (IF 17.6) Pub Date : 2024-07-05 Emma L. Houlder, Koen A. Stam, Jan Pieter R. Koopman, Marion H. König, Marijke C. C. Langenberg, Marie-Astrid Hoogerwerf, Paula Niewold, Friederike Sonnet, Jacqueline J. Janse, Miriam Casacuberta Partal, Jeroen C. Sijtsma, Laura H. M. de Bes-Roeleveld, Yvonne C. M. Kruize, Maria Yazdanbakhsh, Meta Roestenberg
Schistosomiasis is an infection caused by contact with Schistosoma -contaminated water and affects more than 230 million people worldwide with varying morbidity. The roles of T helper 2 (T H 2) cells and regulatory immune responses in chronic infection are well documented, but less is known about human immune responses during acute infection. Here, we comprehensively map immune responses during controlled
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IL-12 drives the differentiation of human T follicular regulatory cells Sci. Immunol (IF 17.6) Pub Date : 2024-07-05 Diana Castaño, Sidney Wang, Segovia Atencio-Garcia, Emily J. Shields, Maria C. Rico, Hannah Sharpe, Jacinta Bustamante, Allan Feng, Carole Le Coz, Neil Romberg, John W. Tobias, Paul J. Utz, Sarah E. Henrickson, Jean-Laurent Casanova, Roberto Bonasio, Michela Locci
T follicular regulatory (T fr ) cells can counteract the B cell helper activity of T follicular helper (T fh ) cells and hinder the production of antibodies against self-antigens or allergens. A mechanistic understanding of the cytokines initiating the differentiation of human regulatory T (T reg ) cells into T fr cells is still missing. Herein, we report that low doses of the pro-T fh cytokine interleukin-12
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Primary nasal influenza infection rewires tissue-scale memory response dynamics Immunity (IF 25.5) Pub Date : 2024-07-03 Samuel W. Kazer, Colette Matysiak Match, Erica M. Langan, Marie-Angèle Messou, Thomas J. LaSalle, Elise O’Leary, Jessica Marbourg, Katherine Naughton, Ulrich H. von Andrian, Jose Ordovas-Montanes
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Actin branching maintains tissue-resident mast cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-02 Louis Ngai, Arthur Mortha
A preprint by Kaltenbach et al. shows a role for cytoskeletal control mechanisms in contributing to the tissue maintenance of mast cells.
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PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells Nat. Immunol. (IF 27.7) Pub Date : 2024-07-03 Stephen M. Lanahan, Lucas Yang, Kate M. Jones, Zhihong Qi, Emylette Cruz Cabrera, Lauren Y. Cominsky, Anjali Ramaswamy, Anis Barmada, Gisela Gabernet, Dinesh Babu Uthaya Kumar, Lan Xu, Peiying Shan, Matthias P. Wymann, Steven H. Kleinstein, V. Koneti Rao, Peter Mustillo, Neil Romberg, Roshini S. Abraham, Carrie L. Lucas
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Diversity of group 1 innate lymphoid cells in human tissues Nat. Immunol. (IF 27.7) Pub Date : 2024-07-02 Natalia Jaeger, Alina Ulezko Antonova, Daniel Kreisel, Florence Roan, Erica Lantelme, Steven F. Ziegler, Marina Cella, Marco Colonna
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High-dimensional single-cell analysis of human natural killer cell heterogeneity Nat. Immunol. (IF 27.7) Pub Date : 2024-07-02 Lucas Rebuffet, Janine E. Melsen, Bertrand Escalière, Daniela Basurto-Lozada, Avinash Bhandoola, Niklas K. Björkström, Yenan T. Bryceson, Roberta Castriconi, Frank Cichocki, Marco Colonna, Daniel M. Davis, Andreas Diefenbach, Yi Ding, Muzlifah Haniffa, Amir Horowitz, Lewis L. Lanier, Karl-Johan Malmberg, Jeffrey S. Miller, Lorenzo Moretta, Emilie Narni-Mancinelli, Luke A. J. O’Neill, Chiara Romagnani
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Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping Nat. Immunol. (IF 27.7) Pub Date : 2024-07-02 Herman Netskar, Aline Pfefferle, Jodie P. Goodridge, Ebba Sohlberg, Olli Dufva, Sarah A. Teichmann, Demi Brownlie, Jakob Michaëlsson, Nicole Marquardt, Trevor Clancy, Amir Horowitz, Karl-Johan Malmberg
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Blocking EBV-driven lymphomageneis metabolism Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01 Paula Jauregui
Infection of B cells by Epstein Barr virus (EBV) leads to proliferation and transformation of these cells via the EBV protein EBNA2 that may contribute to immune dysregulation and lymphomagenesis. In Science, Müller-Durovic et al. identify a druggable virus-driven metabolic pathway that is required for latent transformation of B cells. Monitoring the metabolic and transcriptional responses to early
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Nociceptors enhance humoral immunity Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01 Laurie A. Dempsey
Increasing evidence indicates direct communication channels exist between the nervous and immune systems. In Cell, Wu et al. show that nociceptor sensory neurons originating in the dorsal root ganglia innervate the spleen along vascular networks to reach B cell zones and promote geminal center responses. Depletion of nociceptor neurons in mice led to reduced numbers of germinal cell B cells and plasmablasts
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PD-L1 senses fungi Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01 Ioana Staicu
Inflammatory conditions upregulate the expression of PD-L1 on phagocytes. In Nature, Li et al. used proximity labeling of phagosome contents to identify phagosomal proteins in GM-CSF-primed mouse bone marrow-derived macrophages (BMDMs) fed Staphylococcus aureus, Saccharomyces cerevisiae and Escherichia coli, and found that PD-L1 was specifically enriched in yeast-containing phagosomes. Human PD-L1
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Transcriptomic analysis of celiac disease treatment with transglutaminase 2 inhibitor Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01
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The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation Immunity (IF 25.5) Pub Date : 2024-07-01 Munesh K. Harioudh, Joseph Perez, Lomon So, Mayank Maheshwari, Thomas S. Ebert, Veit Hornung, Ram Savan, A. Rouf Banday, Michael S. Diamond, Vijay A. Rathinam, Saumendra N. Sarkar
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Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development Nat. Immunol. (IF 27.7) Pub Date : 2024-06-28 Xue Bai, Sijie Chen, Xinxin Chi, Bowen Xie, Xinyi Guo, Han Feng, Peng Wei, Di Zhang, Shan Xie, Tian Xie, Yongzhen Chen, Mengting Gou, Qin Qiao, Xinwei Liu, Wei Jin, Wei Xu, Zixuan Zhao, Qi Xing, Xiaohu Wang, Xuegong Zhang, Chen Dong
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Circulating KLRG1 + long-lived effector memory T cells retain the flexibility to become tissue resident Sci. Immunol (IF 17.6) Pub Date : 2024-06-28 Erin D. Lucas, Matthew A. Huggins, Changwei Peng, Christine O’Connor, Abigail R. Gress, Claire E. Thefaine, Emma M. Dehm, Yoshiaki Kubota, Stephen C. Jameson, Sara E. Hamilton
KLRG1 + CD8 T cells persist for months after clearance of acute infections and maintain high levels of effector molecules, contributing protective immunity against systemic pathogens. Upon secondary infection, these long-lived effector cells (LLECs) are incapable of forming other circulating KLRG1 − memory subsets such as central and effector memory T cells. Thus, KLRG1 + memory T cells are frequently
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Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulation Sci. Immunol (IF 17.6) Pub Date : 2024-06-28 Jennifer A. Foltz, Jennifer Tran, Pamela Wong, Changxu Fan, Evelyn Schmidt, Bryan Fisk, Michelle Becker-Hapak, David A. Russler-Germain, Jeanette Johnson, Nancy D. Marin, Celia C. Cubitt, Patrick Pence, Joseph Rueve, Sushanth Pureti, Kimberly Hwang, Feng Gao, Alice Y. Zhou, Mark Foster, Timothy Schappe, Lynne Marsala, Melissa M. Berrien-Elliott, Amanda F. Cashen, Jeffrey J. Bednarski, Elana Fertig
Activation of natural killer (NK) cells with the cytokines interleukin-12 (IL-12), IL-15, and IL-18 induces their differentiation into memory-like (ML) NK cells; however, the underlying epigenetic and transcriptional mechanisms are unclear. By combining ATAC-seq, CITE-seq, and functional analyses, we discovered that IL-12/15/18 activation results in two main human NK fates: reprogramming into enriched
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Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity Sci. Immunol (IF 17.6) Pub Date : 2024-06-28 Miguel de Jesus, Alexander H. Settle, Daan Vorselen, Thomas K. Gaetjens, Michael Galiano, Yevgeniy Romin, Esther Lee, Yung Yu Wong, Tian-Ming Fu, Endi Santosa, Benjamin Y. Winer, Fella Tamzalit, Mitchell S. Wang, Anthony Santella, Zhirong Bao, Joseph C. Sun, Pavak Shah, Julie A. Theriot, Steven M. Abel, Morgan Huse
Immune cells have intensely physical lifestyles characterized by structural plasticity and force exertion. To investigate whether specific immune functions require stereotyped mechanical outputs, we used super-resolution traction force microscopy to compare the immune synapses formed by cytotoxic T cells with contacts formed by other T cell subsets and by macrophages. T cell synapses were globally
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Vaccination prevents cognitive impairment after breakthrough infection with SARS-CoV-2 Nat. Immunol. (IF 27.7) Pub Date : 2024-06-25