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Biophysics of Frequency-Dependent Variation in Paresthesia and Pain Relief during Spinal Cord Stimulation J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Evan R. Rogers, Marco Capogrosso, Scott F. Lempka
The neurophysiological effects of spinal cord stimulation (SCS) for chronic pain are poorly understood, resulting in inefficient failure-prone programming protocols and inadequate pain relief. Nonetheless, novel stimulation patterns are regularly introduced and adopted clinically. Traditionally, paresthetic sensation is considered necessary for pain relief, although novel paradigms provide analgesia
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Linking Cognitive Integrity to Working Memory Dynamics in the Aging Human Brain J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Gina Monov, Henrik Stein, Leonie Klock, Juergen Gallinat, Simone Kühn, Tania Lincoln, Katarina Krkovic, Peter R. Murphy, Tobias H. Donner
Aging is accompanied by a decline of working memory, an important cognitive capacity that involves stimulus-selective neural activity that persists after stimulus presentation. Here, we unraveled working memory dynamics in older human adults (male and female) including those diagnosed with mild cognitive impairment (MCI) using a combination of behavioral modeling, neuropsychological assessment, and
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Transient Attention Gates Access Consciousness: Coupling N2pc and P3 Latencies Using Dynamic Time Warping J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Mahan Hosseini, Alon Zivony, Martin Eimer, Brad Wyble, Howard Bowman
The N2pc and P3 event-related potentials (ERPs), used to index selective attention and access to working memory and conscious awareness, respectively, have been important tools in cognitive sciences. Although it is likely that these two components and the underlying cognitive processes are temporally and functionally linked, such links have not yet been convincingly demonstrated. Adopting a novel methodological
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Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Alexandra K. Fischbach, Ajay B. Satpute, Karen Quigley, Philip A. Kragel, Danlei Chen, Marta Bianciardi, Larry Wald, Tor D. Wager, Ji-Kyung Choi, Jiahe Zhang, Lisa Feldman Barrett, Jordan E. Theriault
The periaqueductal gray (PAG) is a small midbrain structure that surrounds the cerebral aqueduct, regulates brain–body communication, and is often studied for its role in "fight-or-flight" and "freezing" responses to threat. We used ultra-high-field 7 T fMRI to resolve the PAG in humans and distinguish it from the cerebral aqueduct, examining its in vivo function during a working memory task (N = 87)
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Distinct SAP102 and PSD-95 Nano-organization Defines Multiple Types of Synaptic Scaffold Protein Domains at Single Synapses J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Sarah R. Metzbower, Aaron D. Levy, Poorna A. Dharmasri, Michael C. Anderson, Thomas A. Blanpied
MAGUK scaffold proteins play a central role in maintaining and modulating synaptic signaling, providing a framework to retain and position receptors, signaling molecules, and other synaptic components. In particular, the MAGUKs SAP102 and PSD-95 are essential for synaptic function at distinct developmental timepoints and perform both overlapping and unique roles. While their similar structures allow
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Suspending the Embodied Self in Meditation Attenuates Beta Oscillations in the Posterior Medial Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Fynn-Mathis Trautwein, Yoav Schweitzer, Yair Dor-Ziderman, Ohad Nave, Yochai Ataria, Stephen Fulder, Aviva Berkovich-Ohana
Human experience is imbued by the sense of being an embodied agent. The investigation of such basic self-consciousness has been hampered by the difficulty of comprehensively modulating it in the laboratory while reliably capturing ensuing subjective changes. The present preregistered study fills this gap by combining advanced meditative states with principled phenomenological interviews: 46 long-term
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The Time-Course of Food Representation in the Human Brain J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Denise Moerel, James Psihoyos, Thomas A. Carlson
Humans make decisions about food every day. The visual system provides important information that forms a basis for these food decisions. Although previous research has focused on visual object and category representations in the brain, it is still unclear how visually presented food is encoded by the brain. Here, we investigate the time-course of food representations in the brain. We used time-resolved
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Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Pauliina Yrjölä, Sampsa Vanhatalo, Anton Tokariev
The third trimester is a critical period for the development of functional networks that support the lifelong neurocognitive performance, yet the emergence of neuronal coupling in these networks is poorly understood. Here, we used longitudinal high-density electroencephalographic recordings from preterm infants during the period from 33 to 45 weeks of conceptional age (CA) to characterize early spatiotemporal
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Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Nooshin Abdollahi, Steven A. Prescott
Myelinated axons conduct action potentials, or spikes, in a saltatory manner. Inward current caused by a spike occurring at one node of Ranvier spreads axially to the next node, which regenerates the spike when depolarized enough for voltage-gated sodium channels to activate, and so on. The rate at which this process progresses dictates the velocity at which the spike is conducted and depends on several
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Systems Genetics Analyses Reveals Key Genes Related to Behavioral Traits in the Striatum of CFW Mice J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Zhe Han, Chunhua Yang, Hongjie He, Tingting Huang, Quanting Yin, Geng Tian, Yuyong Wu, Wei Hu, Lu Lu, Akhilesh Kumar Bajpai, Jia Mi, Fuyi Xu
The striatum plays a central role in directing many complex behaviors ranging from motor control to action choice and reward learning. In our study, we used 55 male CFW mice with rapid decay linkage disequilibrium to systematically mine the striatum-related behavioral functional genes by analyzing their striatal transcriptomes and 79 measured behavioral phenotypic data. By constructing a gene coexpression
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Striatal Dopamine Contributions to Skilled Motor Learning J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 Chris D. Phillips, Alexander T. Hodge, Courtney C. Myers, Daniel K. Leventhal, Christian R. Burgess
Coordinated multijoint limb and digit movements—"manual dexterity"—underlie both specialized skills (e.g., playing the piano) and more mundane tasks (e.g., tying shoelaces). Impairments in dexterous skill cause significant disability, as occurs with motor cortical injury, Parkinson's disease, and a range of other pathologies. Clinical observations, as well as basic investigations, suggest that corticostriatal
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Differential Activation States of Direct Pathway Striatal Output Neurons during L-DOPA-Induced Dyskinesia Development J. Neurosci. (IF 4.4) Pub Date : 2024-06-26 David A. Figge, Henrique de Amaral Oliveira, Jack Crim, Rita M. Cowell, David G. Standaert, Karen L. Eskow Jaunarajs
l-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine (DA) replacement therapy with l-DOPA for the treatment of Parkinson’s disease. LID is associated with supersensitivity of striatal dopaminergic signaling and fluctuations in synaptic DA following each l-DOPA dose, shrinking the therapeutic window. The heterogeneous composition of the striatum, including
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Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Guangyu Zhou, Gregory Lane, Thorsten Kahnt, Christina Zelano
The olfactory tubercle (TUB), also called the tubular striatum, receives direct input from the olfactory bulb and, along with the nucleus accumbens, is one of the two principal components of the ventral striatum. As a key component of the reward system, the ventral striatum is involved in feeding behavior, but the vast majority of research on this structure has focused on the nucleus accumbens, leaving
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C9ORF72 Deficiency Results in Neurodegeneration in the Zebrafish Retina J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Natalia Jaroszynska, Andrea Salzinger, Themistoklis M. Tsarouchas, Catherina G. Becker, Thomas Becker, David A. Lyons, Ryan B. MacDonald, Marcus Keatinge
Hexanucleotide repeat expansions within the gene C9ORF72 are the most common cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This disease-causing expansion leads to a reduction in C9ORF72 expression levels in patients, suggesting loss of C9ORF72 function could contribute to disease. To further understand the consequences of C9ORF72 deficiency
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Superagers Resist Typical Age-Related White Matter Structural Changes J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Marta Garo-Pascual, Linda Zhang, Meritxell Valentí-Soler, Bryan A. Strange
Superagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that age-related cognitive decline is not inevitable. In a sample of 64 superagers (mean age, 81.9; 59% women) and 55 typical older adults (mean age, 82.4; 64% women) from the Vallecas Project, we studied, cross-sectionally and longitudinally over 5 years with yearly follow-ups, the global cerebral
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Altered Hierarchical Gradients of Intrinsic Neural Timescales in Mild Cognitive Impairment and Alzheimer's Disease J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Aiying Zhang, Kenneth Wengler, Xi Zhu, Guillermo Horga, Terry E. Goldberg, Seonjoo Lee, For Alzheimer’s Disease Neuroimaging Initiative
Alzheimer's disease (AD) is a devastating neurodegenerative disease that affects millions of seniors in the United States. Resting-state functional magnetic resonance imaging (rs-fMRI) is widely used to study neurophysiology in AD and its prodromal condition, mild cognitive impairment (MCI). The intrinsic neural timescale (INT), which can be estimated through the magnitude of the autocorrelation of
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Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Zheng Chang, Jordan Skach, Kaiwen Kam
Inhibitory neurons embedded within mammalian neural circuits shape breathing, walking, and other rhythmic motor behaviors. At the core of the neural circuit controlling breathing is the preBötzinger Complex (preBötC), where GABAergic (GAD1/2+) and glycinergic (GlyT2+) neurons are functionally and anatomically intercalated among glutamatergic Dbx1-derived (Dbx1+) neurons that generate rhythmic inspiratory
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Edge-Community Entropy Is a Novel Neural Correlate of Aging and Moderator of Fluid Cognition J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Anita Shankar, Jacob C. Tanner, Tianrui Mao, Richard F. Betzel, Ruchika S. Prakash
Decreased neuronal specificity of the brain in response to cognitive demands (i.e., neural dedifferentiation) has been implicated in age-related cognitive decline. Investigations into functional connectivity analogs of these processes have focused primarily on measuring segregation of nonoverlapping networks at rest. Here, we used an edge-centric network approach to derive entropy, a measure of specialization
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Transcranial Alternating Current Stimulation over Frontal Eye Fields Mimics Attentional Modulation of Visual Processing J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Jonas Misselhorn, Marina Fiene, Jan-Ole Radecke, Andreas K. Engel, Till R. Schneider
Attentional control over sensory processing has been linked to neural alpha oscillations and related inhibition of cerebral cortex. Despite the wide consensus on the functional relevance of alpha oscillations for attention, precise neural mechanisms of how alpha oscillations shape perception and how this top-down modulation is implemented in cortical networks remain unclear. Here, we tested the hypothesis
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Separate Cue- and Alpha-Related Mechanisms for Distractor Suppression J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Zach V. Redding, Ian C. Fiebelkorn
Research on selective attention has largely focused on the enhancement of behaviorally important information, with less focus on the suppression of distracting information. Enhancement and suppression can operate through a push–pull relationship attributable to competitive interactions among neural populations. There has been considerable debate, however, regarding (1) whether suppression can be voluntarily
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The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3 J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Christin Hanke-Gogokhia, Thomas E. Zapadka, Stella Finkelstein, Mikael Klingeborn, Timothy K. Maugel, Joshua H. Singer, Vadim Y. Arshavsky, Jonathan B. Demb
Vertebrate vision begins with light absorption by rod and cone photoreceptors, which transmit signals from their synaptic terminals to second-order neurons: bipolar and horizontal cells. In mouse rods, there is a single presynaptic ribbon-type active zone at which the release of glutamate occurs tonically in the dark. This tonic glutamatergic signaling requires continuous exo- and endocytosis of synaptic
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Cortical Networks Relating to Arousal Are Differentially Coupled to Neural Activity and Hemodynamics J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Lisa Meyer-Baese, Arthur E. Morrissette, Yunmiao Wang, Brune Le Chatelier, Peter Y. Borden, Shella D. Keilholz, Garrett B. Stanley, Dieter Jaeger
Even in the absence of specific sensory input or a behavioral task, the brain produces structured patterns of activity. This organized activity is modulated by changes in arousal. Here, we use wide-field voltage imaging to establish how arousal relates to cortical network voltage and hemodynamic activity in spontaneously behaving head-fixed male and female mice expressing the voltage-sensitive fluorescent
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Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Flore Boscher, Katlyn Jumel, Tereza Dvořáková, Luc J. Gentet, Nadia Urbain
Rapid eye movement (REM) sleep, also referred to as paradoxical sleep for the striking resemblance of its electroencephalogram (EEG) to the one observed in wakefulness, is characterized by the occurrence of transient events such as limb twitches or facial and rapid eye movements. Here, we investigated the local activity of the primary somatosensory or barrel cortex (S1) in naturally sleeping head-fixed
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Erroneous Compensation for Long-Latency Feedback Delays as Origin of Essential Tremor J. Neurosci. (IF 4.4) Pub Date : 2024-06-19 Florence Blondiaux, Lise Colmant, Louisien Lebrun, Bernard Hanseeuw, Frédéric Crevecoeur
Essential tremor (ET), a movement disorder characterized by involuntary oscillations of the limbs during movement, remains to date not well understood. It has been recently suggested that the tremor originates from impaired delay compensation, affecting movement representation and online control. Here we tested this hypothesis directly with 24 ET patients (14 female; 10 male) and 28 neurologically
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Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Flora I. Hinz, Carmela Louise M. Villegas, Jasmine T. Roberts, Heming Yao, Shreya Gaddam, Anton Delwig, Samantha A. Green, Craig Fredrickson, Max Adrian, Raymond R. Asuncion, Tommy K. Cheung, Margaret Hayne, David H. Hackos, Christopher M. Rose, David Richmond, Casper C. Hoogenraad
Sterile alpha and TIR motif containing 1 (SARM1) is an inducible NADase that localizes to mitochondria throughout neurons and senses metabolic changes that occur after injury. Minimal proteomic changes are observed upon either SARM1 depletion or activation, suggesting that SARM1 does not exert broad effects on neuronal protein homeostasis. However, whether SARM1 activation occurs throughout the neuron
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Neural Correlates of Crowding in Macaque Area V4 J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Taekjun Kim, Anitha Pasupathy
Visual crowding refers to the phenomenon where a target object that is easily identifiable in isolation becomes difficult to recognize when surrounded by other stimuli (distractors). Many psychophysical studies have investigated this phenomenon and proposed alternative models for the underlying mechanisms. One prominent hypothesis, albeit with mixed psychophysical support, posits that crowding arises
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40 Hz Steady-State Response in Human Auditory Cortex Is Shaped by Gabaergic Neuronal Inhibition J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Alessandro Toso, Annika P. Wermuth, Ayelet Arazi, Anke Braun, Tineke Grent-‘t Jong, Peter J. Uhlhaas, Tobias H. Donner
The 40 Hz auditory steady-state response (ASSR), an oscillatory brain response to periodically modulated auditory stimuli, is a promising, noninvasive physiological biomarker for schizophrenia and related neuropsychiatric disorders. The 40 Hz ASSR might be amplified by synaptic interactions in cortical circuits, which are, in turn, disturbed in neuropsychiatric disorders. Here, we tested whether the
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Computational Mechanisms Underlying Motivation to Earn Symbolic Reinforcers J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Diana C. Burk, Craig Taswell, Hua Tang, Bruno B. Averbeck
Reinforcement learning is a theoretical framework that describes how agents learn to select options that maximize rewards and minimize punishments over time. We often make choices, however, to obtain symbolic reinforcers (e.g., money, points) that are later exchanged for primary reinforcers (e.g., food, drink). Although symbolic reinforcers are ubiquitous in our daily lives, widely used in laboratory
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Distinct Yet Proximal Face- and Body-Selective Brain Regions Enable Clutter-Tolerant Representations of the Face, Body, and Whole Person J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Libi Kliger, Galit Yovel
Faces and bodies are processed in separate but adjacent regions in the primate visual cortex. Yet, the functional significance of dividing the whole person into areas dedicated to its face and body components and their neighboring locations remains unknown. Here we hypothesized that this separation and proximity together with a normalization mechanism generate clutter-tolerant representations of the
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Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M. Karch, the Dominantly Inherited Alzheimer Network (DIAN),, Takeshi Iwatsubo, Hideyuki Okano
Genetic variants in the apolipoprotein E (APOE) gene affect the onset and progression of Alzheimer's disease (AD). The APOE Christchurch (APOE Ch) variant has been identified as the most prominent candidate for preventing the onset and progression of AD. In this study, we generated isogenic APOE3Ch/3Ch human-induced pluripotent stem cells (iPSCs) from APOE3/3 healthy control female iPSCs and induced
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Novel Electrophysiological Signatures of Learning and Forgetting in Human Rapid Eye Movement Sleep J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Alessandra E. Shuster, Pin-Chun Chen, Hamid Niknazar, Elizabeth A. McDevitt, Beth Lopour, Sara C. Mednick
Despite the known behavioral benefits of rapid eye movement (REM) sleep, discrete neural oscillatory events in human scalp electroencephalography (EEG) linked with behavior have not been discovered. This knowledge gap hinders mechanistic understanding of the function of sleep, as well as the development of biophysical models and REM-based causal interventions. We designed a detection algorithm to identify
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Stereotypical Hippocampal Clustering Predicts Navigational Success in Virtualized Real-World Environments J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Jason D. Ozubko, Madelyn Campbell, Abigail Verhayden, Brooke Demetri, Molly Brady, John Thorp, Iva Brunec
Structural differences along the hippocampal long axis are believed to underlie meaningful functional differences. Yet, recent data-driven parcellations of the hippocampus subdivide the hippocampus into a 10-cluster map with anterior-medial, anterior-lateral, and posteroanterior-lateral, middle, and posterior components. We tested whether task and experience could modulate this clustering using a spatial
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Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Torsten Bullmann, Thomas Kaas, Andreas Ritzau-Jost, Anne Wöhner, Toni Kirmann, Filiz Sila Rizalar, Max Holzer, Jana Nerlich, Dmytro Puchkov, Christian Geis, Jens Eilers, Robert J. Kittel, Thomas Arendt, Volker Haucke, Stefan Hallermann
Understanding the function of the human brain requires determining basic properties of synaptic transmission in human neurons. One of the most fundamental parameters controlling neurotransmitter release is the presynaptic action potential, but its amplitude and duration remain controversial. Presynaptic action potentials have so far been measured with high temporal resolution only in a limited number
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Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Alexandra Tsolias, Yuxin Zhou, Chromewell A. Mojica, Mitali Sakharkar, Marianna Z. Tsolias, Tara L. Moore, Douglas L. Rosene, Maria Medalla
Acetylcholine is a robust neuromodulator of the limbic system and a critical regulator of arousal and emotions. The anterior cingulate cortex (ACC) and the amygdala (AMY) are key limbic structures that are both densely innervated by cholinergic afferents and interact with each other for emotional regulation. The ACC is composed of functionally distinct dorsal (A24), rostral (A32), and ventral (A25)
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Synapse-Specific Trapping of SNARE Machinery Proteins in the Anesthetized Drosophila Brain J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Adam D. Hines, Amber B. Kewin, Matthew N. Van De Poll, Victor Anggono, Adekunle T. Bademosi, Bruno van Swinderen
General anesthetics disrupt brain network dynamics through multiple pathways, in part through postsynaptic potentiation of inhibitory ion channels as well as presynaptic inhibition of neuroexocytosis. Common clinical general anesthetic drugs, such as propofol and isoflurane, have been shown to interact and interfere with core components of the exocytic release machinery to cause impaired neurotransmitter
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A Reconsideration of the Core and Matrix Classification of Thalamocortical Projections J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 S. Murray Sherman, W. Martin Usrey
In 1998, Jones suggested a classification of thalamocortical projections into core and matrix divisions (Jones, 1998). In this classification, core projections are specific, topographical, innervate middle cortical layers, and serve to transmit specific information to the cortex for further analysis; matrix projections, in contrast, are diffuse, much less topographic, innervate upper layers, especially
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Memory Reactivation during Sleep Does Not Act Holistically on Object Memory J. Neurosci. (IF 4.4) Pub Date : 2024-06-12 Elizabeth M. Siefert, Sindhuja Uppuluri, Jianing Mu, Marlie C. Tandoc, James W. Antony, Anna C. Schapiro
Memory reactivation during sleep is thought to facilitate memory consolidation. Most sleep reactivation research has examined how reactivation of specific facts, objects, and associations benefits their overall retention. However, our memories are not unitary, and not all features of a memory persist in tandem over time. Instead, our memories are transformed, with some features strengthened and others
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Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Alejandra Hernández-Jaramillo, Elizabeth Illescas-Huerta, Francisco Sotres-Bayon
Foraging decisions involve assessing potential risks and prioritizing food sources, which can be challenging when confronted with changing and conflicting circumstances. A crucial aspect of this decision-making process is the ability to actively overcome defensive reactions to threats and focus on achieving specific goals. The ventral pallidum (VP) and basolateral amygdala (BLA) are two brain regions
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Celebrating the Birthday of AMPA Receptor Nanodomains: Illuminating the Nanoscale Organization of Excitatory Synapses with 10 Nanocandles J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Yuko Fukata, Masaki Fukata, Harold D. MacGillavry, Deepak Nair, Eric Hosy
A decade ago, in 2013, and over the course of 4 summer months, three separate observations were reported that each shed light independently on a new molecular organization that fundamentally reshaped our perception of excitatory synaptic transmission (Fukata et al., 2013; MacGillavry et al., 2013; Nair et al., 2013). This discovery unveiled an intricate arrangement of AMPA-type glutamate receptors
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Grandfathers-to-Grandsons Transgenerational Transmission of Exercise Positive Effects on Cognitive Performance J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Elisa Cintado, Patricia Tezanos, Manuela De las Casas, Pablo Muela, Kerry R. McGreevy, Ángela Fontán-Lozano, Eva Sacristán-Horcajada, Jaime Pignatelli, María L. de Ceballos, María Jesús del Hierro, Julia Fernández-Punzano, Lluís Montoliu, José Luis Trejo
Physical exercise is a robust lifestyle intervention known for its enhancement of cognitive abilities. Nevertheless, the extent to which these benefits can be transmitted across generations (intergenerational inheritance to F1, and transgenerational to F2 and beyond) remains a topic of limited comprehension. We have already shown that cognitive improvements resulting from physical exercise can be inherited
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Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Daniel Matúš, Jaybree M. Lopez, Richard C. Sando, Thomas C. Südhof
Latrophilin-1 (Lphn1, aka CIRL1 and CL1; gene symbol Adgrl1) is an adhesion GPCR that has been implicated in excitatory synaptic transmission as a candidate receptor for α-latrotoxin. Here we analyzed conditional knock-in/knock-out mice for Lphn1 that contain an extracellular myc epitope tag. Mice of both sexes were used in all experiments. Surprisingly, we found that Lphn1 is localized in cultured
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Revisiting the Potency of Tbx2 Expression in Transforming Outer Hair Cells into Inner Hair Cells at Multiple Ages In Vivo J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Zhenghong Bi, Minhui Ren, Yu Zhang, Shunji He, Lei Song, Xiang Li, Zhiyong Liu
The mouse auditory organ cochlea contains two types of sound receptors: inner hair cells (IHCs) and outer hair cells (OHCs). Tbx2 is expressed in IHCs but repressed in OHCs, and neonatal OHCs that misexpress Tbx2 transdifferentiate into IHC-like cells. However, the extent of this switch from OHCs to IHC-like cells and the underlying molecular mechanism remain poorly understood. Furthermore, whether
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Diffusion MRI of the Hippocampus J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Bradley G. Karat, Stefan Köhler, Ali R. Khan
The hippocampus is a brain structure that plays key roles in a variety of cognitive processes. Critically, a wide range of neurological disorders are associated with degeneration of the hippocampal microstructure, defined as neurons, dendrites, glial cells, and more. Thus, the hippocampus is a key target for methods that are sensitive to these microscale properties. Diffusion MRI is one such method
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Reconfiguration of Behavioral Signals in the Anterior Cingulate Cortex Based on Emotional State J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Adrian J. Lindsay, Isabella Gallello, Barak F. Caracheo, Jeremy K. Seamans
Behaviors and their execution depend on the context and emotional state in which they are performed. The contextual modulation of behavior likely relies on regions such as the anterior cingulate cortex (ACC) that multiplex information about emotional/autonomic states and behaviors. The objective of the present study was to understand how the representations of behaviors by ACC neurons become modified
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Two Prediction Error Systems in the Nonlemniscal Inferior Colliculus: "Spectral" and "Nonspectral" J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Guillermo V. Carbajal, Lorena Casado-Román, Manuel S. Malmierca
According to the predictive processing framework, perception emerges from the reciprocal exchange of predictions and prediction errors (PEs) between hierarchically organized neural circuits. The nonlemniscal division of the inferior colliculus (IC) is the earliest source of auditory PE signals, but their neuronal generators, properties, and functional relevance have remained mostly undefined. We recorded
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Circuit-Wide Gene Network Analysis Reveals Sex-Specific Roles for Phosphodiesterase 1b in Cocaine Addiction J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Collin D. Teague, Tamara Markovic, Xianxiao Zhou, Freddyson J. Martinez-Rivera, Angelica Minier-Toribio, Alexander Zinsmaier, Nathalia V. Pulido, Kyra H. Schmidt, Kelsey E. Lucerne, Arthur Godino, Yentl Y. van der Zee, Aarthi Ramakrishnan, Rita Futamura, Caleb J. Browne, Leanne M. Holt, Yun Young Yim, Corrine H. Azizian, Deena M. Walker, Li Shen, Yan Dong, Bin Zhang, Eric J. Nestler
Cocaine use disorder is a significant public health issue without an effective pharmacological treatment. Successful treatments are hindered in part by an incomplete understanding of the molecular mechanisms that underlie long-lasting maladaptive plasticity and addiction-like behaviors. Here, we leverage a large RNA sequencing dataset to generate gene coexpression networks across six interconnected
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Cholinergic Neuromodulation of Prefrontal Attractor Dynamics Controls Performance in Spatial Working Memory J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Alexandre Mahrach, David Bestue, Xue-Lian Qi, Christos Constantinidis, Albert Compte
The behavioral and neural effects of the endogenous release of acetylcholine following stimulation of the nucleus basalis (NB) of Meynert have been recently examined in two male monkeys (Qi et al., 2021). Counterintuitively, NB stimulation enhanced behavioral performance while broadening neural tuning in the prefrontal cortex (PFC). The mechanism by which a weaker mnemonic neural code could lead to
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Connected in Bad Times and in Good Times: Empathy Induces Stable Social Closeness J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Anne Saulin, Chih-Chung Ting, Jan B. Engelmann, Grit Hein
Humans need social closeness to prosper. There is evidence that empathy can induce social closeness. However, it remains unclear how empathy-related social closeness is formed and how stable it is as time passes. We applied an acquisition–extinction paradigm combined with computational modeling and fMRI, to investigate the formation and stability of empathy-related social closeness. Female participants
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An Aggressive Interaction Rapidly Increases Brain Androgens in a Male Songbird during the Non-breeding Season J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Cecilia Jalabert, Sofia L. Gray, Kiran K. Soma
Aggression is a crucial behavior that impacts access to limited resources in different environmental contexts. Androgens synthesized by the gonads promote aggression during the breeding season. However, aggression can be expressed during the non-breeding season, despite low androgen synthesis by the gonads. The brain can also synthesize steroids ("neurosteroids"), including androgens, which might promote
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CCK+ Interneurons Contribute to Thalamus-Evoked Feed-Forward Inhibition in the Prelimbic Prefrontal Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Aichurok Kamalova, Kasra Manoocheri, Xingchen Liu, Sanne M. Casello, Matthew Huang, Corey Baimel, Emily V. Jang, Paul G. Anastasiades, David P. Collins, Adam G. Carter
Interneurons in the medial prefrontal cortex (PFC) regulate local neural activity to influence cognitive, motivated, and emotional behaviors. Parvalbumin-expressing (PV+) interneurons are the primary mediators of thalamus-evoked feed-forward inhibition across the mouse cortex, including the anterior cingulate cortex, where they are engaged by inputs from the mediodorsal (MD) thalamus. In contrast,
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Vagus Nerve Stimulation (VNS) Modulates Synaptic Plasticity in the Infralimbic Cortex via Trk-B Receptor Activation to Reduce Drug-Seeking in Male Rats J. Neurosci. (IF 4.4) Pub Date : 2024-06-05 Christopher M. Driskill, Jessica E. Childs, Aarron J. Phensy, Sierra R. Rodriguez, John T. O’Brien, Kathy L. Lindquist, Aurian Naderi, Bogdan Bordieanu, Jacqueline F. McGinty, Sven Kroener
Drugs of abuse cause changes in the prefrontal cortex (PFC) and associated regions that impair inhibitory control over drug-seeking. Breaking the contingencies between drug-associated cues and the delivery of the reward during extinction learning reduces relapse. Vagus nerve stimulation (VNS) has previously been shown to enhance extinction learning and reduce drug-seeking. Here we determined the effects
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Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Angeliki Pollatou, Cristin M. Holland, Thirsten J. Stockton, Bradley S. Peterson, Dustin Scheinost, Catherine Monk, Marisa N. Spann
The autonomic nervous system (ANS) regulates the body's physiology, including cardiovascular function. As the ANS develops during the second to third trimester, fetal heart rate variability (HRV) increases while fetal heart rate (HR) decreases. In this way, fetal HR and HRV provide an index of fetal ANS development and future neurobehavioral regulation. Fetal HR and HRV have been associated with child
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Evidence for Two Subpopulations of Cerebrospinal Fluid-Contacting Neurons with Opposite GABAergic Signaling in Adult Mouse Spinal Cord J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Priscille Riondel, Nina Jurčić, Lourdes Mounien, Stéphanie Ibrahim, Jorge Ramirez-Franco, Sonia Stefanovic, Jérôme Trouslard, Nicolas Wanaverbecq, Riad Seddik
Spinal cerebrospinal fluid-contacting neurons (CSF-cNs) form an evolutionary conserved bipolar cell population localized around the central canal of all vertebrates. CSF-cNs were shown to express molecular markers of neuronal immaturity into adulthood; however, the impact of their incomplete maturation on the chloride (Cl–) homeostasis as well as GABAergic signaling remains unknown. Using adult mice
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The Brains Topographical Organization Shapes Dynamic Interaction Patterns That Support Flexible Behavior Based on Rules and Long-Term Knowledge J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Xiuyi Wang, Katya Krieger-Redwood, Baihan Lyu, Rebecca Lowndes, Guowei Wu, Nicholas E. Souter, Xiaokang Wang, Ru Kong, Golia Shafiei, Boris C. Bernhardt, Zaixu Cui, Jonathan Smallwood, Yi Du, Elizabeth Jefferies
Adaptive behavior relies both on specific rules that vary across situations and stable long-term knowledge gained from experience. The frontoparietal control network (FPCN) is implicated in the brain's ability to balance these different influences on action. Here, we investigate how the topographical organization of the cortex supports behavioral flexibility within the FPCN. Functional properties of
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Perception and Memory Reinstatement Engage Overlapping Face-Selective Regions within Human Ventral Temporal Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Yvonne Y. Chen, Aruni Areti, Daniel Yoshor, Brett L. Foster
Humans have the remarkable ability to vividly retrieve sensory details of past events. According to the theory of sensory reinstatement, during remembering, brain regions specialized for processing specific sensory stimuli are reactivated to support content-specific retrieval. Recently, several studies have emphasized transformations in the spatial organization of these reinstated activity patterns
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Impaired Cortical Tracking of Speech in Children with Developmental Language Disorder J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Anni Nora, Oona Rinkinen, Hanna Renvall, Elisabet Service, Eva Arkkila, Sini Smolander, Marja Laasonen, Riitta Salmelin
In developmental language disorder (DLD), learning to comprehend and express oneself with spoken language is impaired, but the reason for this remains unknown. Using millisecond-scale magnetoencephalography recordings combined with machine learning models, we investigated whether the possible neural basis of this disruption lies in poor cortical tracking of speech. The stimuli were common spoken Finnish
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Neural Correlates of Online Action Preparation J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Mahdiyar Shahbazi, Giacomo Ariani, Mehrdad Kashefi, J. Andrew Pruszynski, Jörn Diedrichsen
When performing movements in rapid succession, the brain needs to coordinate ongoing execution with the preparation of an upcoming action. Here we identify the processes and brain areas involved in this ability of online preparation. Human participants (both male and female) performed pairs of single-finger presses or three-finger chords in rapid succession, while 7T fMRI was recorded. In the overlap
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Diurnal Fluctuations in Steroid Hormones Tied to Variation in Intrinsic Functional Connectivity in a Densely Sampled Male J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Hannah Grotzinger, Laura Pritschet, Pavel Shapturenka, Tyler Santander, Elle M. Murata, Emily G. Jacobs
Most of mammalian physiology is under the control of biological rhythms, including the endocrine system with time-varying hormone secretion. Precision neuroimaging studies provide unique insights into how the endocrine system dynamically regulates aspects of the human brain. Recently, we established estrogen's ability to drive widespread patterns of connectivity and enhance the global efficiency of
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Belief Updating during Social Interactions: Neural Dynamics and Causal Role of Dorsomedial Prefrontal Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Patricia Christian, Jakob Kaiser, Paul Christopher Taylor, Michelle George, Simone Schütz-Bosbach, Alexander Soutschek
In competitive interactions, humans have to flexibly update their beliefs about another person's intentions in order to adjust their own choice strategy, such as when believing that the other may exploit their cooperativeness. Here we investigate both the neural dynamics and the causal neural substrate of belief updating processes in humans. We used an adapted prisoner's dilemma game in which participants
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Neuroanatomical Predictors of Transcranial Direct Current Stimulation (tDCS)-Induced Modifications in Neurocognitive Task Performance in Typically Developing Individuals J. Neurosci. (IF 4.4) Pub Date : 2024-05-29 Caroline Gurr, Maike Splittgerber, Oula Puonti, Julia Siemann, Christina Luckhardt, Helena C. Pereira, Joana Amaral, Joana Crisóstomo, Alexandre Sayal, Mário Ribeiro, Daniela Sousa, Astrid Dempfle, Kerstin Krauel, Christoph Borzikowsky, Hannah Brauer, Alexander Prehn-Kristensen, Carolin Breitling-Ziegler, Miguel Castelo-Branco, Ricardo Salvador, Giada Damiani, Giulio Ruffini, Michael Siniatchkin, Axel
Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation technique gaining more attention in neurodevelopmental disorders (NDDs). Due to the phenotypic heterogeneity of NDDs, tDCS is unlikely to be equally effective in all individuals. The present study aimed to establish neuroanatomical markers in typically developing (TD) individuals that may be used for the prediction of individual