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Neglected tropical diseases (NTD) are a diverse group of diseases, which are prevalent in tropical areas and caused by a variety of pathogens, including viruses, bacteria, parasites, and fungi. NTDs have a devastating impact on the lives of around one billion people across Africa, Asia, and Latin America, affecting not just the health but also the social and economic prospects of communities (Sullivan 2016;

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Microbial ecosystems are ubiquitous, populating virtually every place on earth. These communities are constituted by a wide range of microorganisms, including bacteria, archaea, viruses, fungi, and many other microscopic eukaryotes such as protists and protozoa. Together, they interact, cooperate, or compete to form highly dynamic and complex microbial communities in humans, animals, plants, or within

Bacteria have a remarkable ability to sense environmental stresses and to respond to these stressors by adapting their metabolism and physiology. In recent publications, investigators have suggested that multiple stresses that cause cell death share the mechanistic feature of stimulating the formation of reactive oxygen species (ROS). A central piece of evidence cited in these claims is the ability