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Inter-kingdom electromechanical communication Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-19 Joshua T. Atkinson
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Machine learning in preclinical drug discovery Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-19 Denise B. Catacutan, Jeremie Alexander, Autumn Arnold, Jonathan M. Stokes
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Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-19 Di Zhang, Jinjun Gao, Zhijun Zhu, Qianying Mao, Zhiqiang Xu, Pankaj K. Singh, Cornelius C. Rimayi, Carlos Moreno-Yruela, Shuling Xu, Gongyu Li, Yi-Cheng Sin, Yue Chen, Christian A. Olsen, Nathaniel W. Snyder, Lunzhi Dai, Lingjun Li, Yingming Zhao
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Direct observation of prion-like propagation of protein misfolding templated by pathogenic mutants Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-15 Krishna Neupane, Abhishek Narayan, Supratik Sen Mojumdar, Gaurav Adhikari, Craig R. Garen, Michael T. Woodside
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The power supply for biological nitrogen fixation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-10 Günter Fritz, Peter M. H. Kroneck, Julia Steuber
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Simultaneous multi-site editing of individual genomes using retron arrays Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-09 Alejandro González-Delgado, Santiago C. Lopez, Matías Rojas-Montero, Chloe B. Fishman, Seth L. Shipman
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An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-08
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Distinct phases of cellular signaling revealed by time-resolved protein synthesis Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-08 Gihoon Lee, Tom W. Muir
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Engineering miniature IscB nickase for robust base editing with broad targeting range Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-08 Linxiao Han, Yueer Hu, Qiqin Mo, Hao Yang, Feng Gu, Fang Bai, Yadong Sun, Hanhui Ma
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Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-08 Laixing Zhang, Hao Wang, Jianwei Zeng, Xueli Cao, Zhengyu Gao, Zihe Liu, Feixue Li, Jiawei Wang, Yi Zhang, Maojun Yang, Yue Feng
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Assessing and engineering the IscB–ωRNA system for programmed genome editing Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-08 Hao Yan, Xiaoqing Tan, Siyuan Zou, Yihong Sun, Ailong Ke, Weixin Tang
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Programmed RNA editing with an evolved bacterial adenosine deaminase Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-05 Hao Yan, Weixin Tang
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Genetically programmed synthetic cells for thermo-responsive protein synthesis and cargo release Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-05 Carolina Monck, Yuval Elani, Francesca Ceroni
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Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1 Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-04 Kwangwoon Lee, Marco Barone, Amanda L. Waterbury, Hanjie Jiang, Eunju Nam, Sarah E. DuBois-Coyne, Samuel D. Whedon, Zhipeng A. Wang, Jonatan Caroli, Katherine Neal, Brian Ibeabuchi, Zuzer Dhoondia, Mitzi I. Kuroda, Brian B. Liau, Samuel Beck, Andrea Mattevi, Philip A. Cole
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A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-04 Ananya A. Basu, Chenlu Zhang, Isabella A. Riha, Assa Magassa, Miguel A. Campos, Alana G. Caldwell, Felicia Ko, Xiaoyu Zhang
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Recruitment of FBXO22 for targeted degradation of NSD2 Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-04 David Y. Nie, John R. Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain, Ronan P. Hanley, Esther Wolf, Ethan Paulakonis, Tristan M. G. Kenney, Shili Duan, Suman Shrestha, Dominic D. G. Owens, Matthew E. R. Maitland, Ailing Pon, Magdalena Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z. Penn, Dalia Barsyte-Lovejoy, Nicholas G. Brown, Anthony M. Barsotti, Andrew W. Stamford
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Cryptic enzymatic assembly of peptides armed with β-lactone warheads Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-01 Guangcai Xu, Daniele Torri, Sebastian Cuesta-Hoyos, Deepanjan Panda, Luke R. L. Yates, Rémi Zallot, Kehan Bian, Dongxu Jia, Andreea I. Iorgu, Colin Levy, Sarah A. Shepherd, Jason Micklefield
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Transition transferases prime bacterial capsule polymerization Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-07-01 Christa Litschko, Valerio Di Domenico, Julia Schulze, Sizhe Li, Olga G. Ovchinnikova, Thijs Voskuilen, Andrea Bethe, Javier O. Cifuente, Alberto Marina, Insa Budde, Tim A. Mast, Małgorzata Sulewska, Monika Berger, Falk F. R. Buettner, Todd L. Lowary, Chris Whitfield, Jeroen D. C. Codée, Mario Schubert, Marcelo E. Guerin, Timm Fiebig
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The chemical language of protein glycation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-28 Meghan S. Martin, Jeremiah W. Jacob-Dolan, Vo Tri Tin Pham, Nicole M. Sjoblom, Rebecca A. Scheck
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Potent and specific antibiotic combination therapy against Clostridioides difficile Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-28 Vasiliki T. Chioti, Kirklin L. McWhorter, Tamra C. Blue, Yuchen Li, Fei Xu, Philip D. Jeffrey, Katherine M. Davis, Mohammad R. Seyedsayamdost
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Proteins dance to the tune of light Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-27 Christopher S. Waters
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Identifying p53-independent apoptosis Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-24 Yiyun Song
The p53 protein is a key transcription factor responsible for inducing apoptosis in response to DNA damage, such as damage induced by chemotherapeutics. However, cells with an impaired p53 pathway can still undergo apoptosis, suggesting the existence of alternative p53-independent apoptosis pathways in these cells. Boon et al. have now identified such a pathway, in which ribosomes stall on the rare
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A direct hit Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-24 Grant Miura
Treating Gram-negative bacteria with antibiotics remains difficult due to the lack of a target that is specific for this population while sparing other innocuous groups. Broad spectrum antibiotics are known to affect gut microbiome diversity which can result in secondary Clostridioides difficile infections. The Lol system, which mediates lipoprotein transport between the inner and outer membranes in
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On the quest for mescaline Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-24 Francesco Zamberlan
Mescaline, a substituted phenethylamine protoalkaloid, is the primary hallucinogenic compound in psychedelic cacti such as Lophophora williamsii (commonly known as peyote). The mescaline biosynthetic pathway has been postulated for half a century; it entails hydroxylation and decarboxylation of l-tyrosine to dopamine through tyramine or l-3,4-dihydroxyphenylalanine (l-DOPA), followed by a series of
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All roads lead to OSBP Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Po-Hsun Brian Chen, Jeremy M. Baskin
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Recording calcium concentrations Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Yuki Ito, Tetsuya Takano
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Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Nianzhe He, Laura Depta, Cecilia Rossetti, Lucie Caramelle, Marko Cigler, Hogan P. Bryce-Rogers, Marine Michon, Oliver Rafn Dan, Joseph Hoock, Julien Barbier, Daniel Gillet, Alison Forrester, Georg E. Winter, Luca Laraia
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Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Marko Cigler, Hana Imrichova, Fabian Frommelt, Lucie Caramelle, Laura Depta, Andrea Rukavina, Chrysanthi Kagiou, J. Thomas Hannich, Cristina Mayor-Ruiz, Giulio Superti-Furga, Sonja Sievers, Alison Forrester, Luca Laraia, Herbert Waldmann, Georg E. Winter
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The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-21 Vinayak Agarwal, Andrew C. McShan
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Rationally seeded computational protein design of ɑ-helical barrels Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-20 Katherine I. Albanese, Rokas Petrenas, Fabio Pirro, Elise A. Naudin, Ufuk Borucu, William M. Dawson, D. Arne Scott, Graham. J. Leggett, Orion D. Weiner, Thomas A. A. Oliver, Derek N. Woolfson
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Channeling kynurenine Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-19 Mollie I. Sweeney, David M. Tobin
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3-Hydroxykynurenine targets kainate receptors to promote defense against infection Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-19 Margarita Parada-Kusz, Anne E. Clatworthy, Emily R. Goering, Stephanie M. Blackwood, Jack Y. Shigeta, Eivgeni Mashin, Elizabeth J. Salm, Catherine Choi, Senya Combs, Jenny S. W. Lee, Carlos Rodriguez-Osorio, Clary Clish, Susumu Tomita, Deborah T. Hung
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Architecture of the RNF1 complex that drives biological nitrogen fixation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-18 Lin Zhang, Oliver Einsle
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Quantitative control of subcellular protein localization with a photochromic dimerizer Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-18 Takato Mashita, Toshiyuki Kowada, Hayashi Yamamoto, Satoshi Hamaguchi, Toshizo Sato, Toshitaka Matsui, Shin Mizukami
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The realization of CRISPR gene therapy Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-13 Yitong Ma, Lei S. Qi
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Optimizing multicopy chromosomal integration for stable high-performing strains Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-10 Fei Du, Zijia Li, Xin Li, Duoduo Zhang, Feng Zhang, Zixu Zhang, Yingshuang Xu, Jin Tang, Yongqian Li, Xingxu Huang, Yang Gu, Xiaoman Sun, He Huang
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A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1 Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-07 Jessica A. Cross, William M. Dawson, Shivam R. Shukla, Johannes F. Weijman, Judith Mantell, Mark P. Dodding, Derek N. Woolfson
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High-resolution structure of a novel fluorogenic RNA aptamer Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-06
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Mechanisms of neutralization of toxSAS from toxin–antitoxin modules Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-04 Lucia Dominguez-Molina, Tatsuaki Kurata, Albinas Cepauskas, Dannele Echemendia-Blanco, Safia Zedek, Ariel Talavera-Perez, Gemma C. Atkinson, Vasili Hauryliuk, Abel Garcia-Pino
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A bright green tag for RNA imaging Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-03 Dhrisya Sathyan, Murat Sunbul
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Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-03 Chun Gui, Edward Kalkreuter, Lukas Lauterbach, Dong Yang, Ben Shen
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De novo design of proteins housing excitonically coupled chlorophyll special pairs Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-06-03 Nathan M. Ennist, Shunzhi Wang, Madison A. Kennedy, Mariano Curti, George A. Sutherland, Cvetelin Vasilev, Rachel L. Redler, Valentin Maffeis, Saeed Shareef, Anthony V. Sica, Ash Sueh Hua, Arundhati P. Deshmukh, Adam P. Moyer, Derrick R. Hicks, Avi Z. Swartz, Ralph A. Cacho, Nathan Novy, Asim K. Bera, Alex Kang, Banumathi Sankaran, Matthew P. Johnson, Amala Phadkule, Mike Reppert, Damian Ekiert, Gira
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Antibody–peptide conjugates for targeted inhibition of cysteine proteases Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-31
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De novo design of buttressed loops for sculpting protein functions Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-30 Hanlun Jiang, Kevin M. Jude, Kejia Wu, Jorge Fallas, George Ueda, T. J. Brunette, Derrick R. Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M. Levine, Lance Stewart, K. Christopher Garcia, David Baker
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Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-30 Kaiyi Huang, Qianqian Song, Mengyue Fang, Deqiang Yao, Xin Shen, Xiaochen Xu, Xianjun Chen, Linyong Zhu, Yi Yang, Aiming Ren
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Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-29 Aaron Petruzzella, Marine Bruand, Albert Santamaria-Martínez, Natalya Katanayeva, Luc Reymond, Sarah Wehrle, Sandrine Georgeon, Damla Inel, Floris J. van Dalen, David Viertl, Kelvin Lau, Florence Pojer, Margret Schottelius, Vincent Zoete, Martijn Verdoes, Caroline Arber, Bruno E. Correia, Elisa Oricchio
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PROTAC-ing tuberculosis Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-23 Delia Preti, Valentina Albanese, Peggy Carla Raffaella Marconi
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Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-23 Fangting Zuo, Li Jiang, Ni Su, Yaqiang Zhang, Bingkun Bao, Limei Wang, Yajie Shi, Huimin Yang, Xinyi Huang, Ruilong Li, Qingmei Zeng, Zhengda Chen, Qiuning Lin, Yingping Zhuang, Yuzheng Zhao, Xianjun Chen, Linyong Zhu, Yi Yang
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Transcriptional regulation of living materials via extracellular electron transfer Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-23 Austin J. Graham, Gina Partipilo, Christopher M. Dundas, Ismar E. Miniel Mahfoud, Kathleen N. Halwachs, Alexis J. Holwerda, Trevor R. Simmons, Thomas M. FitzSimons, Sarah M. Coleman, Rebecca Rinehart, Darian Chiu, Avery E. Tyndall, Kenneth C. Sajbel, Adrianne M. Rosales, Benjamin K. Keitz
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One-way Integrator Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-21 Yiyun Song
Bidirectional transcription initiation occurs at promoters where two RNA polymerase II (RNAPII) pre-initiation complexes (PICs) are organized in opposite directions. For coding genes, this results in the production of precursor mRNAs (pre-mRNAs) in the sense direction and short unstable promoter upstream transcripts (PROMPTs) in the antisense direction. However, only transcription in the sense direction
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We don’t need no inflammation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-21 Gene Chong
The NF-κB pathway regulates inflammation in response to bacterial lipopolysaccharides (LPS) that are recognized by Toll-like receptor 4 (TLR4), triggering NF-κB signaling downstream. Hyperactivation of the NF-κB pathway is linked to sepsis, cancer and autoimmune diseases. Lampson, Ramírez et al. have reported a new druggable target specific to TLR4-mediated activation of the NF-κB pathway, the oli
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Trapping the helicase Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-21 Grant Miura
Cancers with microsatellite instability (MSI) are defined by the accumulation of insertion and/or deletion mutations in microsatellites due to loss of DNA mismatch repair activity. Synthetic lethal genetic screens previously identified a dependence of MSI on the Werner syndrome RecQ helicase WRN, which normally ensures the maintenance of genomic stability and DNA repair. Genetic inhibition of WRN in
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A key to unlock ubiquitin ligase function Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-21 Shaoshuai Xie, Gang Li
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A chemical probe to modulate human GID4 Pro/N-degron interactions Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-21 Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Martin P. Schwalm, Raquel A. C. Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F. Calabrese, Matthew S. Dowling, Jisun Lee, Justin I. Montgomery, Thomas N. O’Connell, Chakrapani Subramanyam, Feng Wang, Ella C. Adamson, Matthieu Schapira, Matthias
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RNA-binding protein PTENα blocks RIG-I activation to prevent viral inflammation Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-21 Yue Yin, Zeliang Yang, Yizhe Sun, Ying Yang, Xin Zhang, Xuyang Zhao, Wenyu Tian, Yaruo Qiu, Yuxin Yin, Fuping You, Dan Lu
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Antibodies expand the scope of angiotensin receptor pharmacology Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-14 Meredith A. Skiba, Sarah M. Sterling, Shaun Rawson, Shuhao Zhang, Huixin Xu, Haoran Jiang, Genevieve R. Nemeth, Morgan S. A. Gilman, Joseph D. Hurley, Pengxiang Shen, Dean P. Staus, Jihee Kim, Conor McMahon, Maria K. Lehtinen, Howard A. Rockman, Patrick Barth, Laura M. Wingler, Andrew C. Kruse
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The β-subunit of tryptophan synthase is a latent tyrosine synthase Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-05-14 Patrick J. Almhjell, Kadina E. Johnston, Nicholas J. Porter, Jennifer L. Kennemur, Vignesh C. Bhethanabotla, Julie Ducharme, Frances H. Arnold