In a recent study, Gaborieau, Vaysset, Tesson et al. developed a method to predict phage–host specificity using genomic data.

In a recent study, Liu, Huang, Guo, McCallum et al. present a method to create functional, customized coronavirus receptors, which could facilitate the development of infection models that do not rely on native receptors.

Loveridge and Sigala uncover a divalent metal transporter that is required for cellular iron metabolism in Plasmodium falciparum parasites.

Clinical Microbiology Reviews, Ahead of Print.

In this study, Tofani et al. demonstrate that the gut microbiota regulates stress responsiveness in mice via the circadian system.

This study provides insights into how adaptive changes in evolved microbial communities can affect pathogen invasion.

In this study, Ge et al. develop a mimic of natural killer cells to target and eliminate intracellular Staphylococcus aureus.

This Genome Watch discusses the use of metagenomic sequencing to investigate resistome dynamics in river ecosystems and their associations with the mobilome and microbiome, underscoring the role of rivers as reservoirs of antimicrobial resistance genes.

A strategic dialogue on ‘gender justice in the HIV response’ held at the 25th International AIDS Conference highlighted how bias and discrimination against women and girls in all their diversities disadvantages them in the HIV response. Ending AIDS requires increased participation and leadership by diverse women at all levels of the HIV response.

Clinical Microbiology Reviews, Ahead of Print.

Clinical Microbiology Reviews, Ahead of Print.

Clinical Microbiology Reviews, Ahead of Print.

Bacteriophages have evolved numerous mechanisms to evade targeting by CRISPR-Cas defense systems. However, the evolutionary origin of these so-called “anti-CRISPRs” remains poorly understood. In a recent issue of Nature, Katz et al.1 provide evidence that some anti-CRISPRs were derived from genes of the CRISPR-Cas systems themselves.

Vaginal lactobacilli are key regulators of host inflammation, yet the mechanisms remain understudied. In this issue of Cell Host & Microbe, Glick et al. identify a family of beta-carbolines as anti-inflammatory effectors produced by vaginal Lactobacillus species, highlighting their potential as therapeutics for vaginal inflammatory disorders.

The functions of non-coding small RNAs (sRNAs) within the human microbiome remain largely unexplored. In this Cell Host & Microbe issue, El Mouali et al. identify Segatella RNA colonization factor (SrcF), a sRNA from a prevalent gut bacterium Segatella copri. SrcF promotes colonization of S. copri by regulating bacterial degradation of complex dietary carbohydrates.

In this issue of Cell Host & Microbe, Zhong et al.1 uncover gut microbiota-host connections that promote cognitive function in honeybees. They discover the role of the microbiota in lipid metabolism and the synthesis of lipid-derived neurotransmitters, which modulate the endocannabinoid system.

Microcins are antibacterial small proteins secreted by gram-negative bacteria. In this issue of Cell Host & Microbe, Kim et al. report the discovery of a V. cholerae microcin, MvcC. MvcC shows antibacterial activity against non-self V. cholerae strains, which do not encode the cognate immunity protein.

Tuberculosis remains a formidable global health challenge, with Mycobacterium tuberculosis responsible for millions of cases and deaths annually. In this issue of Cell Host & Microbe, Worakitchanon et al. present a method to identify structural variants in Mtb and explore associations with bacterial phenotypes such as virulence and antibiotic resistance.

In recent work, Mucker et al.1 demonstrated that mRNA-1769 outperforms modified vaccinia Ankara (MVA), which has been deployed against recent mpox virus (MPXV) outbreaks, in reducing clinical symptoms and controlling viral replication, highlighting its potential as a scalable, safe, and effective next-generation platform for orthopoxvirus vaccination.

This study shows that high-level resistance in methicillin-resistant Staphylococcus aureus involves an alternative mode of cell division.

Free viruses are the most abundant type of biological particles in the biosphere, but the lack of quantitative knowledge about their consumption by heterotrophic protists and bacterial degradation has hindered the inclusion of virovory in biogeochemical models. Using isotope-labeled viruses added to three independent microcosm experiments with natural microbial communities followed by isotope measurements

The Microsporidia, an often overlooked fungal lineage, exhibit increasing diversity and taxonomic understanding with the use of genomic techniques. They are obligate parasites infecting a diversity of hosts, including crustaceans. Crustacea are, in essence, ancient insects and their relationship with the Microsporidia is both diverse and convoluted. Relationships between crayfish and their microsporidian

Host-gut microbiota interactions are more complex than good or bad. Both gut symbiotic bacteria and pathobionts can provide essential functions to their host in one scenario and yet be detrimental to host health in another. So, these gut-dwelling bacteria must be tightly controlled to avoid harmful effects on the host. However, how pathobionts and other symbiotic bacteria coordinate to establish a

Urea is hypothesized to be an important source of nitrogen and chemical energy to microorganisms in the deep sea; however, direct evidence for urea use below the epipelagic ocean is lacking. Here, we explore urea utilization from 50 to 4000 meters depth in the northeastern Pacific Ocean using metagenomics, nitrification rates, and single-cell stable-isotope-uptake measurements with nanoscale secondary

SAR86 is one of the most abundant groups of bacteria in the global surface ocean. However, since its discovery over 30 years ago, it has remained recalcitrant to isolation and many details regarding this group are still unknown. Here we report the cellular characteristics from the first SAR86 isolate brought into culture, Magnimaribacter mokuoloeensis strain HIMB1674, and use its closed genome in concert

Linear waste management systems are unsustainable and contribute to environmental degradation, economic inequity, and health disparities. Among the array of environmental challenges stemming from anthropogenic impacts, the management of human excrement (human feces and urine) stands as a significant concern. Over two billion people do not have access to adequate sanitation, signifying a global public

Our comprehension of membrane function has predominantly advanced through research on glycerophospholipids, also known as phosphoglycerides, which are glycerol phosphate-based lipids found across all three domains of life. However, in bacteria, a perplexing group of lipids distinct from glycerol phosphate-based ones also exists. These are amino acid-containing lipids that form an amide bond between

Clinical Microbiology Reviews, Ahead of Print.

Clinical Microbiology Reviews, Ahead of Print.