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Immunological imprinting and risks of influenza B virus infection Nat. Immunol. (IF 27.7) Pub Date : 2024-07-19 Isaac C. L. Chow, Sook-San Wong
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A humanized mouse that mounts specific and mature antibody and autoantibody responses Nat. Immunol. (IF 27.7) Pub Date : 2024-07-18
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T cell dysfunction and therapeutic intervention in cancer Nat. Immunol. (IF 27.7) Pub Date : 2024-07-18 Caitlin C. Zebley, Dietmar Zehn, Stephen Gottshalk, Hongbo Chi
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Gα13 restricts nutrient driven proliferation in mucosal germinal centers Nat. Immunol. (IF 27.7) Pub Date : 2024-07-18 Hang T. Nguyen, Moyi Li, Rahul Vadakath, Keirstin A. Henke, Tam C. Tran, Huifang Li, Maryam Yamadi, Sriranjani Darbha, Yandan Yang, Juraj Kabat, Anne R. Albright, Enoc Granados Centeno, James D. Phelan, Sandrine Roulland, Da Wei Huang, Michael C. Kelly, Ryan M. Young, Stefania Pittaluga, Simone Difilippantonio, Jagan R. Muppidi
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Chromatin state and BACH2 control TH17 cell functional heterogeneity Nat. Immunol. (IF 27.7) Pub Date : 2024-07-17
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Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers Nat. Immunol. (IF 27.7) Pub Date : 2024-07-16 Thomas S. Fulford, Caroline Soliman, Rebecca G. Castle, Marc Rigau, Zheng Ruan, Olan Dolezal, Rebecca Seneviratna, Hamish G. Brown, Eric Hanssen, Andrew Hammet, Shihan Li, Samuel J. Redmond, Amy Chung, Michael A. Gorman, Michael W. Parker, Onisha Patel, Thomas S. Peat, Janet Newman, Andreas Behren, Nicholas A. Gherardin, Dale I. Godfrey, Adam P. Uldrich
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Advancements in pathogen immunity and signaling Nat. Immunol. (IF 27.7) Pub Date : 2024-07-15 Mads Gyrd-Hansen, Anna Kajaste-Rudnitski, Nicolas Manel, Jan Rehwinkel, Annemarthe G. van der Veen, Matteo Iannacone
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BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells Nat. Immunol. (IF 27.7) Pub Date : 2024-07-15 Pratiksha I. Thakore, Alexandra Schnell, Linglin Huang, Maryann Zhao, Yu Hou, Elena Christian, Sarah Zaghouani, Chao Wang, Vasundhara Singh, Anvita Singaraju, Rajesh Kumar Krishnan, Deneen Kozoriz, Sai Ma, Venkat Sankar, Samuele Notarbartolo, Jason D. Buenrostro, Federica Sallusto, Nikolaos A. Patsopoulos, Orit Rozenblatt-Rosen, Vijay K. Kuchroo, Aviv Regev
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The immunology of systemic lupus erythematosus Nat. Immunol. (IF 27.7) Pub Date : 2024-07-15 George C. Tsokos
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Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis Nat. Immunol. (IF 27.7) Pub Date : 2024-07-12 Meng Sun, Jolie M. Phan, Nathan S. Kieswetter, Huang Huang, Krystle K. Q. Yu, Malisa T. Smith, Yiran E. Liu, Chuanqi Wang, Sanjana Gupta, Gerlinde Obermoser, Holden Terry Maecker, Akshaya Krishnan, Sundari Suresh, Neha Gupta, Mary Rieck, Peter Acs, Mustafa Ghanizada, Shin-Heng Chiou, Purvesh Khatri, W. Henry Boom, Thomas R. Hawn, Catherine M. Stein, Harriet Mayanja-Kizza, Mark M. Davis, Chetan Seshadri
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Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes Nat. Immunol. (IF 27.7) Pub Date : 2024-07-11 Yuanyuan You, Josefine Dunst, Kewei Ye, Patrick A. Sandoz, Annika Reinhardt, Inga Sandrock, Natalia R. Comet, Rupak Dey Sarkar, Emily Yang, Estelle Duprez, Judith Agudo, Brian D. Brown, Paul J. Utz, Wolfgang Kastenmüller, Carmen Gerlach, Immo Prinz, Björn Önfelt, Taras Kreslavsky
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Stimulation history is epigenetically imprinted in memory B cells Nat. Immunol. (IF 27.7) Pub Date : 2024-07-09
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B cells instruct their own fate through IL-12 Nat. Immunol. (IF 27.7) Pub Date : 2024-07-09 Iñaki Sanz
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Chameleon impersonation of NK cells and ILC1s Nat. Immunol. (IF 27.7) Pub Date : 2024-07-09 M. Zeeshan Chaudhry, Gabrielle T. Belz
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Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge Nat. Immunol. (IF 27.7) Pub Date : 2024-07-05 Wen Shao, Yifeng Wang, Qian Fang, Wenjuan Shi, Hai Qi
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PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells Nat. Immunol. (IF 27.7) Pub Date : 2024-07-03 Stephen M. Lanahan, Lucas Yang, Kate M. Jones, Zhihong Qi, Emylette Cruz Cabrera, Lauren Y. Cominsky, Anjali Ramaswamy, Anis Barmada, Gisela Gabernet, Dinesh Babu Uthaya Kumar, Lan Xu, Peiying Shan, Matthias P. Wymann, Steven H. Kleinstein, V. Koneti Rao, Peter Mustillo, Neil Romberg, Roshini S. Abraham, Carrie L. Lucas
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Diversity of group 1 innate lymphoid cells in human tissues Nat. Immunol. (IF 27.7) Pub Date : 2024-07-02 Natalia Jaeger, Alina Ulezko Antonova, Daniel Kreisel, Florence Roan, Erica Lantelme, Steven F. Ziegler, Marina Cella, Marco Colonna
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High-dimensional single-cell analysis of human natural killer cell heterogeneity Nat. Immunol. (IF 27.7) Pub Date : 2024-07-02 Lucas Rebuffet, Janine E. Melsen, Bertrand Escalière, Daniela Basurto-Lozada, Avinash Bhandoola, Niklas K. Björkström, Yenan T. Bryceson, Roberta Castriconi, Frank Cichocki, Marco Colonna, Daniel M. Davis, Andreas Diefenbach, Yi Ding, Muzlifah Haniffa, Amir Horowitz, Lewis L. Lanier, Karl-Johan Malmberg, Jeffrey S. Miller, Lorenzo Moretta, Emilie Narni-Mancinelli, Luke A. J. O’Neill, Chiara Romagnani
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Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping Nat. Immunol. (IF 27.7) Pub Date : 2024-07-02 Herman Netskar, Aline Pfefferle, Jodie P. Goodridge, Ebba Sohlberg, Olli Dufva, Sarah A. Teichmann, Demi Brownlie, Jakob Michaëlsson, Nicole Marquardt, Trevor Clancy, Amir Horowitz, Karl-Johan Malmberg
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Blocking EBV-driven lymphomageneis metabolism Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01 Paula Jauregui
Infection of B cells by Epstein Barr virus (EBV) leads to proliferation and transformation of these cells via the EBV protein EBNA2 that may contribute to immune dysregulation and lymphomagenesis. In Science, Müller-Durovic et al. identify a druggable virus-driven metabolic pathway that is required for latent transformation of B cells. Monitoring the metabolic and transcriptional responses to early
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Nociceptors enhance humoral immunity Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01 Laurie A. Dempsey
Increasing evidence indicates direct communication channels exist between the nervous and immune systems. In Cell, Wu et al. show that nociceptor sensory neurons originating in the dorsal root ganglia innervate the spleen along vascular networks to reach B cell zones and promote geminal center responses. Depletion of nociceptor neurons in mice led to reduced numbers of germinal cell B cells and plasmablasts
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PD-L1 senses fungi Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01 Ioana Staicu
Inflammatory conditions upregulate the expression of PD-L1 on phagocytes. In Nature, Li et al. used proximity labeling of phagosome contents to identify phagosomal proteins in GM-CSF-primed mouse bone marrow-derived macrophages (BMDMs) fed Staphylococcus aureus, Saccharomyces cerevisiae and Escherichia coli, and found that PD-L1 was specifically enriched in yeast-containing phagosomes. Human PD-L1
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Transcriptomic analysis of celiac disease treatment with transglutaminase 2 inhibitor Nat. Immunol. (IF 27.7) Pub Date : 2024-07-01
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Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development Nat. Immunol. (IF 27.7) Pub Date : 2024-06-28 Xue Bai, Sijie Chen, Xinxin Chi, Bowen Xie, Xinyi Guo, Han Feng, Peng Wei, Di Zhang, Shan Xie, Tian Xie, Yongzhen Chen, Mengting Gou, Qin Qiao, Xinwei Liu, Wei Jin, Wei Xu, Zixuan Zhao, Qi Xing, Xiaohu Wang, Xuegong Zhang, Chen Dong
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Vaccination prevents cognitive impairment after breakthrough infection with SARS-CoV-2 Nat. Immunol. (IF 27.7) Pub Date : 2024-06-25
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Lymphoid TCF1+CD39+CD8+ T cells maintain stem-like features and contribute to viral control Nat. Immunol. (IF 27.7) Pub Date : 2024-06-25
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A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses Nat. Immunol. (IF 27.7) Pub Date : 2024-06-25 Daniel P. Chupp, Carlos E. Rivera, Yulai Zhou, Yijiang Xu, Patrick S. Ramsey, Zhenming Xu, Hong Zan, Paolo Casali
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The balance of STING signaling orchestrates immunity in cancer Nat. Immunol. (IF 27.7) Pub Date : 2024-06-25 Klara Rasmussen Bollerup Lanng, Emil Leth Lauridsen, Martin Roelsgaard Jakobsen
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Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease Nat. Immunol. (IF 27.7) Pub Date : 2024-06-24 Valeriia Dotsenko, Bernhard Tewes, Martin Hils, Ralf Pasternack, Jorma Isola, Juha Taavela, Alina Popp, Jani Sarin, Heini Huhtala, Pauliina Hiltunen, Timo Zimmermann, Ralf Mohrbacher, Roland Greinwald, Knut E. A. Lundin, Detlef Schuppan, Markku Mäki, Keijo Viiri
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Nuclear squeezing wakes up dendritic cells Nat. Immunol. (IF 27.7) Pub Date : 2024-06-21 Sergio Lembo, Michael Sixt
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Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice Nat. Immunol. (IF 27.7) Pub Date : 2024-06-20 Abigail Vanderheiden, Jeremy D. Hill, Xiaoping Jiang, Ben Deppen, Gayan Bamunuarachchi, Nadia Soudani, Astha Joshi, Matthew D. Cain, Adrianus C. M. Boon, Robyn S. Klein
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Genetics determines how environmental change alters immune phenotypes Nat. Immunol. (IF 27.7) Pub Date : 2024-06-19
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Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans Nat. Immunol. (IF 27.7) Pub Date : 2024-06-19 Yingcong Li, Ciro Ramírez-Suástegui, Richard Harris, Francisco Emmanuel Castañeda-Castro, Gabriel Ascui, Tamara Pérez-Jeldres, Alejandro Diaz, Carla Morong, Daniel A. Giles, Jiani Chai, Gregory Seumois, Tilman Sanchez-Elsner, Fraser Cummings, Mitchell Kronenberg, Pandurangan Vijayanand
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Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence Nat. Immunol. (IF 27.7) Pub Date : 2024-06-17 Zachary Strongin, Laurence Raymond Marchand, Claire Deleage, M. Betina Pampena, Maria Andrea Cardenas, Christian Michel Beusch, Timothy N. Hoang, Elizabeth A. Urban, Mael Gourves, Kevin Nguyen, Gregory K. Tharp, Stacey Lapp, Andrew R. Rahmberg, Justin Harper, Perla M. del Rio Estrada, Mauricio Gonzalez-Navarro, Fernanda Torres-Ruiz, Yara Andrea Luna-Villalobos, Santiago Avila-Rios, Gustavo Reyes-Teran
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Genetic and environmental interactions contribute to immune variation in rewilded mice Nat. Immunol. (IF 27.7) Pub Date : 2024-06-14 Oyebola Oyesola, Alexander E. Downie, Nina Howard, Ramya S. Barre, Kasalina Kiwanuka, Kimberly Zaldana, Ying-Han Chen, Arthur Menezes, Soo Ching Lee, Joseph Devlin, Octavio Mondragón-Palomino, Camila Oliveira Silva Souza, Christin Herrmann, Sergei B. Koralov, Ken Cadwell, Andrea L. Graham, P’ng Loke
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Mycobacterial d-serine impairs TB control Nat. Immunol. (IF 27.7) Pub Date : 2024-06-13 Maxime Caouaille, Denis Hudrisier, Olivier Neyrolles
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Elusive early NK cell progenitor identified Nat. Immunol. (IF 27.7) Pub Date : 2024-06-13 Emma Patey, Niklas K. Björkström
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Eomes expression identifies the early bone marrow precursor to classical NK cells Nat. Immunol. (IF 27.7) Pub Date : 2024-06-13 Zhitao Liang, Hope D. Anderson, Veronica Locher, Crystal O’Leary, Samantha J. Riesenfeld, Bana Jabri, Benjamin D. McDonald, Albert Bendelac
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Distinct developmental pathways generate functionally distinct populations of natural killer cells Nat. Immunol. (IF 27.7) Pub Date : 2024-06-13 Yi Ding, Marieke Lavaert, Simon Grassmann, Victor I. Band, Liang Chi, Arundhoti Das, Sumit Das, Christelle Harly, Susannah C. Shissler, Justin Malin, Dingkang Peng, Yongge Zhao, Jinfang Zhu, Yasmine Belkaid, Joseph C. Sun, Avinash Bhandoola
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Colorectal cancer clocks in on TIME Nat. Immunol. (IF 27.7) Pub Date : 2024-06-12 Amelia M. Knudsen-Clark, Brian J. Altman
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IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell responses Nat. Immunol. (IF 27.7) Pub Date : 2024-06-11 Rebecca A. Elsner, Shuchi Smita, Mark J. Shlomchik
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Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes Nat. Immunol. (IF 27.7) Pub Date : 2024-06-04 Zahraa Alraies, Claudia A. Rivera, Maria-Graciela Delgado, Doriane Sanséau, Mathieu Maurin, Roberto Amadio, Giulia Maria Piperno, Garett Dunsmore, Aline Yatim, Livia Lacerda Mariano, Anna Kniazeva, Vincent Calmettes, Pablo J. Sáez, Alice Williart, Henri Popard, Matthieu Gratia, Olivier Lamiable, Aurélie Moreau, Zoé Fusilier, Lou Crestey, Benoit Albaud, Patricia Legoix, Anne S. Dejean, Anne-Louise Le
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The PASC microbiome Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03 Paula Jauregui
Diagnostic tools or biomarkers for the heterogenous post-acute COVID-19 syndrome (PASC; also known as long COVID) are needed. Research now published in Cell Host and Microbe shows that the gut microbiome is associated with phenotypic manifestations of PASC and could potentially be used to predict individual symptoms of PASC. Analyzing metagenomic and clinical data form three different cohorts of individuals
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Circadian checkpoint Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03 Nicholas J. Bernard
Immune cell function and responses to immune checkpoint blockade are affected by the time of day owing to circadian rhythms. Data now published in Cell examine the effects of circadian biology on the organization of immune cells in the tumor microenvironment and the response to immune checkpoint blocking therapy and chimeric antigen receptor (CAR) T cell therapy. The researchers used tumor mouse models
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Sex differences are skin deep Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03 Stephanie Houston
Sex differences in the prevalence of cancer and autoimmunity and susceptibility to infectious disease have long been observed, but the underlying mechanisms responsible have remained unclear. In Science, Chi et al. find that male sex hormones in the skin negatively regulate type 2 innate lymphoid cells (ILC2s), resulting in differences in the numbers of dendritic cells (DCs) and a decreased immune
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TREM1 is the new kid on the block for the aging-associated innate immune response and Alzheimer’s disease Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03 Michael T. Heneka
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Non-hierarchically related HSCs replenish platelets by distinct progenitor pathways Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03
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Two rare UNC93B1 variants contribute to childhood-onset lupus Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03
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The BTLA–HVEM axis restricts CAR T cell efficacy in cancer Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03 Puneeth Guruprasad, Alberto Carturan, Yunlin Zhang, Jong Hyun Cho, Kingsley Gideon Kumashie, Ruchi P. Patel, Ki-Hyun Kim, Jong-Seo Lee, Yoon Lee, Jong Hoon Kim, Junho Chung, Akshita Joshi, Ivan Cohen, Maksim Shestov, Guido Ghilardi, Jaryse Harris, Raymone Pajarillo, Mathew Angelos, Yong Gu Lee, Shan Liu, Jesse Rodriguez, Michael Wang, Hatcher J. Ballard, Aasha Gupta, Ositadimma H. Ugwuanyi, Seok Jae
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Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus Nat. Immunol. (IF 27.7) Pub Date : 2024-06-03 Mahmoud Al-Azab, Elina Idiiatullina, Ziyang Liu, Meng Lin, Katja Hrovat-Schaale, Huifang Xian, Jianheng Zhu, Mandy Yang, Bingtai Lu, Zhiyao Zhao, Yiyi Liu, Jingjie Chang, Xiaotian Li, Caiqin Guo, Yunfeng Liu, Qi Wu, Jiazhang Chen, Chaoting Lan, Ping Zeng, Jun Cui, Xia Gao, Wenhao Zhou, Yan Zhang, Yuxia Zhang, Seth L. Masters
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Germline-targeting immunogens guide bnAb development Nat. Immunol. (IF 27.7) Pub Date : 2024-05-30 Tobias V. Lanz
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Affinity gaps among B cells in germinal centers drive the selection of MPER precursors Nat. Immunol. (IF 27.7) Pub Date : 2024-05-30 Rashmi Ray, Torben Schiffner, Xuesong Wang, Yu Yan, Kimmo Rantalainen, Chang-Chun David Lee, Shivang Parikh, Raphael A. Reyes, Gordon A. Dale, Ying-Cing Lin, Simone Pecetta, Sophie Giguere, Olivia Swanson, Sven Kratochvil, Eleonora Melzi, Ivy Phung, Lisa Madungwe, Oleksandr Kalyuzhniy, John Warner, Stephanie R. Weldon, Ryan Tingle, Edward Lamperti, Kathrin H. Kirsch, Nicole Phelps, Erik Georgeson,
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Vaccination induces broadly neutralizing antibody precursors to HIV gp41 Nat. Immunol. (IF 27.7) Pub Date : 2024-05-30 Torben Schiffner, Ivy Phung, Rashmi Ray, Adriana Irimia, Ming Tian, Olivia Swanson, Jeong Hyun Lee, Chang-Chun D. Lee, Ester Marina-Zárate, So Yeon Cho, Jiachen Huang, Gabriel Ozorowski, Patrick D. Skog, Andreia M. Serra, Kimmo Rantalainen, Joel D. Allen, Sabyasachi Baboo, Oscar L. Rodriguez, Sunny Himansu, Jianfu Zhou, Jonathan Hurtado, Claudia T. Flynn, Katherine McKenney, Colin Havenar-Daughton
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Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells Nat. Immunol. (IF 27.7) Pub Date : 2024-05-30 Joana Carrelha, Stefania Mazzi, Axel Winroth, Michael Hagemann-Jensen, Christoph Ziegenhain, Kari Högstrand, Masafumi Seki, Margs S. Brennan, Madeleine Lehander, Bishan Wu, Yiran Meng, Ellen Markljung, Ruggiero Norfo, Hisashi Ishida, Karin Belander Strålin, Francesca Grasso, Christina Simoglou Karali, Affaf Aliouat, Amy Hillen, Edwin Chari, Kimberly Siletti, Supat Thongjuea, Adam J. Mead, Sten Linnarsson
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Antitumor progenitor exhausted CD8+ T cells are sustained by TCR engagement Nat. Immunol. (IF 27.7) Pub Date : 2024-05-30 Xin Lan, Tian Mi, Shanta Alli, Cliff Guy, Mohamed Nadhir Djekidel, Xueyan Liu, Shannon Boi, Partha Chowdhury, Minghong He, Dietmar Zehn, Yongqiang Feng, Ben Youngblood
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Glucose restriction in antiviral defence Nat. Immunol. (IF 27.7) Pub Date : 2024-05-29 Emily L. Goldberg
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An IFNγ-dependent immune–endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response Nat. Immunol. (IF 27.7) Pub Date : 2024-05-29 Marko Šestan, Sanja Mikašinović, Ante Benić, Stephan Wueest, Christoforos Dimitropoulos, Karlo Mladenić, Mia Krapić, Lea Hiršl, Yossef Glantzspiegel, Ana Rasteiro, Maria Aliseychik, Đurđica Cekinović Grbeša, Tamara Turk Wensveen, Marina Babić, Irit Gat-Viks, Henrique Veiga-Fernandes, Daniel Konrad, Felix M. Wensveen, Bojan Polić
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Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration Nat. Immunol. (IF 27.7) Pub Date : 2024-05-29 Andrew D. Jerome, Andrew R. Sas, Yan Wang, Luke A. Hammond, Jing Wen, Jeffrey R. Atkinson, Amy Webb, Tom Liu, Benjamin M. Segal
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Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade Nat. Immunol. (IF 27.7) Pub Date : 2024-05-28 Bridget M. Fortin, Shannon M. Pfeiffer, Jacob Insua-Rodríguez, Hamad Alshetaiwi, Alexander Moshensky, Wei A. Song, Alisa L. Mahieu, Sung Kook Chun, Amber N. Lewis, Alex Hsu, Isam Adam, Oliver S. Eng, Nicholas R. Pannunzio, Marcus M. Seldin, Ivan Marazzi, Francesco Marangoni, Devon A. Lawson, Kai Kessenbrock, Selma Masri
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Nociceptor-immune interactomes reveal insult-specific immune signatures of pain Nat. Immunol. (IF 27.7) Pub Date : 2024-05-28 Aakanksha Jain, Benjamin M. Gyori, Sara Hakim, Ashish Jain, Liang Sun, Veselina Petrova, Shamsuddin A. Bhuiyan, Shannon Zhen, Qing Wang, Riki Kawaguchi, Samuel Bunga, Daniel G. Taub, M. Carmen Ruiz-Cantero, Candace Tong-Li, Nicholas Andrews, Masakazu Kotoda, William Renthal, Peter K. Sorger, Clifford J. Woolf