Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-02010-9, published online 12 November 2024.

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-02018-1, published online 18 November 2024.

Retrotransposons are transposable DNA elements that in hematopoietic stem cells (HSC) can be activated by aging, irradiation or chemotherapy. In Science, Phan et al. report the upregulation of retrotransposons, including endogenous retroviruses and long interspersed nuclear elements and the induction of IFN-regulated genes in spleen, but not bone marrow HSCs, as well as phosphorylation of STING and

Ovarian cancer has high clonal heterogeneity and an immunosuppressed tumor microenvironment (TME) that contribute to resistance to immunotherapy. Research now published in Cell finds that IL-4 produced by cancer cells promotes resistance to immune checkpoint blockade (ICB). To identify extracellular factors that influence ICB resistance and ovarian tumor growth, the authors assessed the impact of specific

Type 2 diabetes (T2D) increases the risk of complications during respiratory viral infections and individuals with T2D fail to mount robust T helper 1 (TH1) responses. In Cell Metabolism, Gray et al. find that hyperglycemia drives mitochondrial dysfunction and lipid peroxidation (LPO) that leads to STAT4 degradation and results in diminished TH1 responses. In individuals with T2D and severe COVID-19

The blood–brain barrier was once thought to prevent the peripheral immune system interacting with the central nervous system (CNS), to limit autoimmunity. However, a lymphatic system exists at the borders where CNS antigens can be presented to circulating immune cells, so the question arises as to how immune tolerance to the structures of the brain is maintained. A mass spectrometry-based MHC II peptidomic

X chromosome inactivation (XCI) occurs in female mammals to normalize gene expression of sex chromosomes. This process is known to involve cis-mediated interactions by the long-noncoding RNA Xist on the inactive X (Xi) chromosome. This process is often incomplete with some genes that escape XCI (such as Xist) and many immune-relevant genes are expressed on the X chromosome, which might contribute to

Exhaustion and mitochondrial dysfunction can limit the effector function of T cells and their ability to kill solid tumors, an effect that tumor cells are thought to capitalize on by sucking mitochondria out of immune cells via tunneling nanotube connections (membrane protrusions that can connect cells over long distances). Data now published in Cell show how these nanotubes can be utilized in an immunotherapeutic

Aging is a risk factor for cancer but the mechanisms by which aging affects tumor control remain unclear. In Science, Park et al. find that aging is associated with enhanced emergency myelopoiesis, resulting in the accumulation of IL-1α-producing myeloid progenitor (MP)-like cells in tumors that drive tumor growth. Using a model of non-small-cell lung cancer (NSCLC), the authors find that old mice

Innate immune memory provides antigen-independent cross-protection against heterologous pathogens. In Immunity, Lercher et al. determine the effects of innate immune memory in airway-resident immune cells on disease outcome of a second heterologous viral infection. The authors use a mouse-adapted SARS-CoV-2 strain for a murine infection model of SARS-CoV-2 recovery. They investigate the epigenetic

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01819-8, published online 29 April 2024.

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01973-z, published online 2 October 2024.

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01906-w, published online 19 July 2024.