![](https://scdn.x-mol.com/css/images/icon-new-link.png)
样式: 排序: IF: - GO 导出 标记为已读
-
In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16
Proceedings of the National Academy of Sciences, Volume 121, Issue 29, July 2024.
-
A geometrical theory of gliding motility based on cell shape and surface flow Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-19 Leon Lettermann, Falko Ziebert, Ulrich S. Schwarz
Gliding motility proceeds with little changes in cell shape and often results from actively driven surface flows of adhesins binding to the extracellular environment. It allows for fast movement over surfaces or through tissue, especially for the eukaryotic parasites from the phylum apicomplexa, which includes the causative agents of the widespread diseases malaria and toxoplasmosis. We have developed
-
A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-19 Sandra L. Leibel, Rachael N. McVicar, Rabi Murad, Elizabeth M. Kwong, Alex E. Clark, Asuka Alvarado, Bethany A. Grimmig, Ruslan Nuryyev, Randee E. Young, Jamie C. Lee, Weiqi Peng, Yanfang P. Zhu, Eric Griffis, Cameron J. Nowell, Brian James, Suzie Alarcon, Atul Malhotra, Linden J. Gearing, Paul J. Hertzog, Cheska M. Galapate, Koen M. O. Galenkamp, Cosimo Commisso, Davey M. Smith, Xin Sun, Aaron F.
The prevalence of “long COVID” is just one of the conundrums highlighting how little we know about the lung’s response to viral infection, particularly to syndromecoronavirus-2 (SARS-CoV-2), for which the lung is the point of entry. We used an in vitro human lung system to enable a prospective, unbiased, sequential single-cell level analysis of pulmonary cell responses to infection by multiple SARS-CoV-2
-
On the friendship paradox and inversity: A network property with applications to privacy-sensitive network interventions Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-19 Vineet Kumar, David Krackhardt, Scott Feld
We provide the mathematical and empirical foundations of the friendship paradox in networks, often stated as “Your friends have more friends than you.” We prove a set of network properties on friends of friends and characterize the concepts of ego-based and alter-based means. We propose a network property called inversity that quantifies the imbalance in degrees across edges and prove that the sign
-
Information structure in Makhuwa: Electrophysiological evidence for a universal processing account Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-19 Rinus G. Verdonschot, Jenneke van der Wal, Ashley Lewis, Birgit Knudsen, Sarah von Grebmer zu Wolfsthurn, Niels O. Schiller, Peter Hagoort
There is evidence from both behavior and brain activity that the way information is structured, through the use of focus, can up-regulate processing of focused constituents, likely to give prominence to the relevant aspects of the input. This is hypothesized to be universal, regardless of the different ways in which languages encode focus. In order to test this universalist hypothesis, we need to go
-
Universal scaling in far-from-equilibrium quantum systems: An equivalent differential approach Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Lucas Madeira, Arnol D. García-Orozco, Michelle A. Moreno-Armijos, Amilson R. Fritsch, Vanderlei S. Bagnato
Recent progress in out-of-equilibrium closed quantum systems has significantly advanced the understanding of mechanisms behind their evolution toward thermalization. Notably, the concept of nonthermal fixed points (NTFPs)—responsible for the emergence of spatiotemporal universal scaling in far-from-equilibrium systems—has played a crucial role in both theoretical and experimental investigations. In
-
APC/C prevents a noncanonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor–induced arrest Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Brandon L. Mouery, Eliyambuya M. Baker, Liu Mei, Samuel C. Wolff, Christine A. Mills, Dalia Fleifel, Nebyou Mulugeta, Laura E. Herring, Jeanette Gowen Cook
Regulated cell cycle progression ensures homeostasis and prevents cancer. In proliferating cells, premature S phase entry is avoided by the E3 ubiquitin ligase anaphasepromoting complex/cyclosome (APC/C), although the APC/C substrates whose degradation restrains G1-S progression are not fully known. The APC/C is also active in arrested cells that exited the cell cycle, but it is not clear whether APC/C
-
Entropy drives the ligand recognition in G-protein-coupled receptor subtypes Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Xin Yang, Pei Zhou, Siyuan Shen, Qian Hu, Chenyu Tian, Anjie Xia, Yifei Wang, Zhiqian Yang, Jinshan Nan, Yangli Zhou, Shasha Chen, Xiaowen Tian, Chao Wu, Guifeng Lin, Liting Zhang, Kexin Wang, Tao Zheng, Jun Zou, Wei Yan, Zhenhua Shao, Shengyong Yang
Achieving ligand subtype selectivity within highly homologous subtypes of G-protein-coupled receptor (GPCR) is critical yet challenging for GPCR drug discovery, primarily due to the unclear mechanism underlying ligand subtype selectivity, which hampers the rational design of subtype-selective ligands. Herein, we disclose an unusual molecular mechanism of entropy-driven ligand recognition in cannabinoid
-
Phonon screening and dissociation of excitons at finite temperatures from first principles Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Antonios M. Alvertis, Jonah B. Haber, Zhenglu Li, Christopher J. N. Coveney, Steven G. Louie, Marina R. Filip, Jeffrey B. Neaton
The properties of excitons, or correlated electron–hole pairs, are of paramount importance to optoelectronic applications of materials. A central component of exciton physics is the electron–hole interaction, which is commonly treated as screened solely by electrons within a material. However, nuclear motion can screen this Coulomb interaction as well, with several recent studies developing model approaches
-
Oxygen-bridging Fe, Co dual-metal dimers boost reversible oxygen electrocatalysis for rechargeable Zn–air batteries Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Qixing Zhou, Wendan Xue, Xun Cui, Pengfei Wang, Sijin Zuo, Fan Mo, Chengzhi Li, Gaolei Liu, Shaohu Ouyang, Sihui Zhan, Juan Chen, Chao Wang
Rechargeable zinc–air batteries (ZABs) are regarded as a remarkably promising alternative to current lithium-ion batteries, addressing the requirements for large-scale high-energy storage. Nevertheless, the sluggish kinetics involving oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) hamper the widespread application of ZABs, necessitating the development of high-efficiency and durable
-
Geometry-induced friction at a soft interface Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Aashna Chawla, Deepak Kumar
Soft and biological matter come in a variety of shapes and geometries. When soft surfaces that do not fit into each other due to a mismatch in Gaussian curvatures form an interface, beautiful geometry-induced patterns are known to emerge. In this paper, we study the effect of geometry on the dynamical response of soft surfaces moving relative to each other. Using a simple experimental scheme, we measure
-
Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Haripriya Vaidehi Narayanan, Mark Y. Xiang, Yijia Chen, Helen Huang, Sukanya Roy, Himani Makkar, Alexander Hoffmann, Koushik Roy
Antibody responses require the proliferative expansion of B cells controlled by affinity-dependent signals. Yet, proliferative bursts are heterogeneous, varying between 0 and 8 divisions in response to the same stimulus. NFκB cRel is activated in response to immune stimulation in B cells and is genetically required for proliferation. Here, we asked whether proliferative heterogeneity is controlled
-
Dietary supplementation of vitamin B1 prevents the pathogenesis of osteoarthritis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-18 Shuying Shen, Yi Liang, Yuening Zhao, Ziang Hu, Youling Huang, Yizheng Wu, Yufei Liu, Shunwu Fan, Qingqing Wang, Peng Xiao
As the primary cause for chronic pain and disability in elderly individuals, osteoarthritis (OA) is one of the fastest-growing diseases due to the aging world population. To date, the impact of microenvironmental changes on the pathogenesis of OA remains poorly understood, greatly hindering the development of effective therapeutic approaches against OA. In this study, we profiled the differential metabolites
-
Unique stick–slip crack dynamics of double-network hydrogels under pure-shear loading Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Yong Zheng, Yiru Wang, Fucheng Tian, Tasuku Nakajima, Chung-Yuen Hui, Jian Ping Gong
In this work, we have found that a prenotched double-network (DN) hydrogel, when subjected to tensile loading in a pure-shear geometry, exhibits intriguing stick–slip crack dynamics. These dynamics synchronize with the oscillation of the damage (yielding) zone at the crack tip. Through manipulation of the loading rate and the predamage level of the brittle network in DN gels, we have clarified that
-
Resolving the overlooked photochemical nitrophenol transformation mechanism induced by nonradical species under visible light Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Shujun Liu, Hong Wang, Zehui Hu, Xin Zhang, Yanjuan Sun, Fan Dong
Nitrophenols present on the surface of particulates are ubiquitous in the atmosphere. However, its atmospheric photochemical transformation pathway remains unknown, for which the crucial effect of visible light is largely overlooked, resulting in an incomplete understanding of the effects of nitrophenols in the atmospheric environment. This study delves into the photolysis mechanism of 4-nitrophenol
-
Optical in situ deciphering of the surface reconstruction–assistant multielectron transfer event of single Co 3 O 4 nanoparticles Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Bo Jiang, Haoran Li, Wei Wang, Hui Wang
Surface reconstruction determines the fate of catalytic sites on the near-surface during the oxygen evolution reaction. However, deciphering the conversion mechanism of various intermediate-states during surface reconstruction remains a challenge. Herein, we employed an optical imaging technique to draw the landscape of dynamic surface reconstruction on individual Co 3 O 4 nanoparticles. By regulating
-
Dibutyl phthalate released by solitary female locusts mediates sexual communication at low density Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Weichan Cui, Jin Ge, Dafeng Chen, Xin Nie, Liushu Dong, Xianhui Wang, Le Kang
Sex pheromones play a crucial role in mate location and reproductive success. Insects face challenges in finding mates in low-density environments. The population dynamics of locusts vary greatly, ranging from solitary individuals to high-density swarms, leading to multiple-trait divergence between solitary and gregarious phases. However, differences in sexual communication between solitary and gregarious
-
A ~40-kb flavi-like virus does not encode a known error-correcting mechanism Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Mary E. Petrone, Joe Grove, Julien Mélade, Jonathon C. O. Mifsud, Rhys H. Parry, Ezequiel M. Marzinelli, Edward C. Holmes
It is commonly held that there is a fundamental relationship between genome size and error rate, manifest as a notional “error threshold” that sets an upper limit on genome sizes. The genome sizes of RNA viruses, which have intrinsically high mutation rates due to a lack of mechanisms for error correction, must therefore be small to avoid accumulating an excessive number of deleterious mutations that
-
Commercially traded fish portfolios mask household utilization of biodiversity in wild food systems Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Kathryn J. Fiorella, Elizabeth R. Bageant, Shakuntala H. Thilsted, Sebastian A. Heilpern
The global biodiversity that underpins wild food systems—including fisheries—is rapidly declining. Yet, we often have only a limited understanding of how households use and benefit from biodiversity in the ecosystems surrounding them. Explicating these relationships is critical to forestall and mitigate the effects of biodiversity declines on food and nutrition security. Here, we quantify how biodiversity
-
A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated K + channels in animals Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Timothy Jegla, Benjamin T. Simonson, J. David Spafford
The Shaker family of voltage-gated K + channels has been thought of as an animal-specific ion channel family that diversified in concert with nervous systems. It comprises four functionally independent gene subfamilies (Kv1-4) that encode diverse neuronal K + currents. Comparison of animal genomes predicts that only the Kv1 subfamily was present in the animal common ancestor. Here, we show that some
-
The evolution of social behaviors and risk preferences in settings with uncertainty Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Guocheng Wang, Qi Su, Long Wang, Joshua B. Plotkin
Humans update their social behavior in response to past experiences and changing environments. Behavioral decisions are further complicated by uncertainty in the outcome of social interactions. Faced with uncertainty, some individuals exhibit risk aversion while others seek risk. Attitudes toward risk may depend on socioeconomic status; and individuals may update their risk preferences over time, which
-
Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Ye Liu, Lily Ng, Hong Liu, Heike Heuer, Douglas Forrest
The key role of a thyroid hormone receptor in determining the maturation and diversity of cone photoreceptors reflects a profound influence of endocrine signaling on the cells that mediate color vision. However, the route by which hormone reaches cones remains enigmatic as cones reside in the retinal photoreceptor layer, shielded by the blood–retina barrier. Using genetic approaches, we report that
-
Metformin synergizes with PD-1 blockade to promote normalization of tumor vessels via CD8T cells and IFNγ Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Miho Tokumasu, Mikako Nishida, Weiyang Zhao, Ruoyu Chao, Natsumi Imano, Nahoko Yamashita, Kyoko Hida, Hisamichi Naito, Heiichiro Udono
Tumor blood vessels are highly leaky in structure and have poor blood perfusion, which hampers infiltration and function of CD8T cells within tumor. Normalizing tumor vessels is thus thought to be important in promoting the flux of immune T cells and enhancing ant-tumor immunity. However, how tumor vasculature is normalized is poorly understood. Metformin (Met) combined with ant-PD-1 therapy is known
-
Memory’s gatekeeper: The role of PFC in the encoding of congruent events Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-17 Inês C. Guerreiro, Claudia Clopath
Theoretical models conventionally portray the consolidation of memories as a slow process that unfolds during sleep. According to the classical Complementary Learning Systems theory, the hippocampus (HPC) rapidly changes its connectivity during wakefulness to encode ongoing events and create memory ensembles that are later transferred to the prefrontal cortex (PFC) during sleep. However, recent experimental
-
Transoceanic pathogen transfer in the age of sail and steam Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Elizabeth N. Blackmore, James O. Lloyd-Smith
In the centuries following Christopher Columbus’s 1492 voyage to the Americas, transoceanic travel opened unprecedented pathways in global pathogen circulation. Yet no biological transfer is a single, discrete event. We use mathematical modeling to quantify historical risk of shipborne pathogen introduction, exploring the respective contributions of journey time, ship size, population susceptibility
-
The receptor-like kinase ARK controls symbiotic balance across land plants Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Mara Sgroi, David Hoey, Karina Medina Jimenez, Sarah L. Bowden, Matthew Hope, Emma J. Wallington, Sebastian Schornack, Armando Bravo, Uta Paszkowski
The mutualistic arbuscular mycorrhizal (AM) symbiosis arose in land plants more than 450 million years ago and is still widely found in all major land plant lineages. Despite its broad taxonomic distribution, little is known about the molecular components underpinning symbiosis outside of flowering plants. The ARBUSCULAR RECEPTOR-LIKE KINASE (ARK) is required for sustaining AM symbiosis in distantly
-
A genome-guided strategy for climate resilience in American chestnut restoration populations Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Alexander M. Sandercock, Jared W. Westbrook, Qian Zhang, Jason A. Holliday
American chestnut ( Castanea dentata ) is a deciduous tree species of eastern North America that was decimated by the introduction of the chestnut blight fungus ( Cryphonectria parasitica ) in the early 20th century. Although millions of American chestnuts survive as root collar sprouts, these trees rarely reproduce. Thus, the species is considered functionally extinct. American chestnuts with improved
-
Amoebozoan testate amoebae illuminate the diversity of heterotrophs and the complexity of ecosystems throughout geological time Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Alfredo L. Porfirio-Sousa, Alexander K. Tice, Luana Morais, Giulia M. Ribeiro, Quentin Blandenier, Kenneth Dumack, Yana Eglit, Nicholas W. Fry, Maria Beatriz Gomes E Souza, Tristan C. Henderson, Felicity Kleitz-Singleton, David Singer, Matthew W. Brown, Daniel J. G. Lahr
Heterotrophic protists are vital in Earth’s ecosystems, influencing carbon and nutrient cycles and occupying key positions in food webs as microbial predators. Fossils and molecular data suggest the emergence of predatory microeukaryotes and the transition to a eukaryote-rich marine environment by 800 million years ago (Ma). Neoproterozoic vase-shaped microfossils (VSMs) linked to Arcellinida testate
-
Mfn2-dependent fusion pathway of PE-enriched micron-sized vesicles Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Daniel A. Peñalva, Ajay K. Monnappa, Paolo Natale, Iván López-Montero
Mitofusins (Mfn1 and Mfn2) are the mitochondrial outer-membrane fusion proteins in mammals and belong to the dynamin superfamily of multidomain GTPases. Recent structural studies of truncated variants lacking alpha helical transmembrane domains suggested that Mfns dimerize to promote the approximation and the fusion of the mitochondrial outer membranes upon the hydrolysis of guanine 5′-triphosphate
-
Transcriptional drift in aging cells: A global decontroller Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Tyler Matsuzaki, Corey Weistuch, Adam de Graff, Ken A. Dill, Gábor Balázsi
As cells age, they undergo a remarkable global change: In transcriptional drift, hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging Caenorhabditis elegans worms, we find that the up-regulated genes code for sensory proteins upstream of stress responses and down-regulated genes are growth- and
-
A silicon diode–based optoelectronic interface for bidirectional neural modulation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Xin Fu, Zhengwei Hu, Wenjun Li, Liang Ma, Junyu Chen, Muyang Liu, Jie Liu, Shuhan Hu, Huachun Wang, Yunxiang Huang, Guo Tang, Bozhen Zhang, Xue Cai, Yuqi Wang, Lizhu Li, Jian Ma, Song-Hai Shi, Lan Yin, Hao Zhang, Xiaojian Li, Xing Sheng
The development of advanced neural modulation techniques is crucial to neuroscience research and neuroengineering applications. Recently, optical-based, nongenetic modulation approaches have been actively investigated to remotely interrogate the nervous system with high precision. Here, we show that a thin-film, silicon (Si)-based diode device is capable to bidirectionally regulate in vitro and in
-
Tether-scanning the kinesin motor domain reveals a core mechanical action Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Rieko Sumiyoshi, Masahiko Yamagishi, Akane Furuta, Takayuki Nishizaka, Ken’ya Furuta, Robert A. Cross, Junichiro Yajima
Natural kinesin motors are tethered to their cargoes via short C-terminal or N-terminal linkers, whose docking against the core motor domain generates directional force. It remains unclear whether linker docking is the only process contributing directional force or whether linker docking is coupled to and amplifies an underlying, more fundamental force-generating mechanical cycle of the kinesin motor
-
GIGANTEA adjusts the response to shade at dusk by directly impinging on PHYTOCHROME INTERACTING FACTOR 7 function Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Carlos Martínez-Vasallo, Benjamin Cole, Jaime Pérez-Alemany, Clara I. Ortiz-Ramírez, Javier Gallego-Bartolomé, Joanne Chory, Steve A. Kay, Maria A. Nohales
For plants adapted to bright light, a decrease in the amount of light received can be detrimental to their growth and survival. Consequently, in response to shade from surrounding vegetation, they initiate a suite of molecular and morphological changes known as the shade avoidance response through which stems and petioles elongate in search for light. Under sunlight–night cycles, the plant’s responsiveness
-
Oxygenate-induced structural evolution of high-entropy electrocatalysts for multifunctional alcohol electrooxidation integrated with hydrogen production Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Jinfeng He, Yun Tong, Zhe Wang, Guorong Zhou, Xuhui Ren, Jiaye Zhu, Nan Zhang, Lu Chen, Pengzuo Chen
High-entropy compounds have been emerging as promising candidates for electrolysis, yet their controllable electrosynthesis strategy remains a formidable challenge because of the ambiguous ionic interaction and codeposition mechanism. Herein, we report a oxygenates directionally induced electrodeposition strategy to construct high-entropy materials with amorphous features, on which the structural evolution
-
Cell–cell transfer of adaptation traits benefits kin and actor in a cooperative microbe Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Kalpana Subedi, Pravas C. Roy, Brandon Saiz, Franco Basile, Daniel Wall
Microbes face many physical, chemical, and biological insults from their environments. In response, cells adapt, but whether they do so cooperatively is poorly understood. Here, we use a model social bacterium, Myxococcus xanthus , to ask whether adapted traits are transferable to naïve kin. To do so we isolated cells adapted to detergent stresses and tested for trait transfer. In some cases, strain-mixing
-
AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Isaac Zin, Arnab China, Krishnendu Khan, Jeetendra K. Nag, Kommireddy Vasu, Gauravi M. Deshpande, Prabar K. Ghosh, Debjit Khan, Iyappan Ramachandiran, Shinjini Ganguly, Ilaria Tamagno, Belinda Willard, Valentin Gogonea, Paul L. Fox
Glutamyl-prolyl-tRNA synthetase (EPRS1) is a bifunctional aminoacyl-tRNA-synthetase (aaRS) essential for decoding the genetic code. EPRS1 resides, with seven other aaRSs and three noncatalytic proteins, in the cytoplasmic multi-tRNA synthetase complex (MSC). Multiple MSC-resident aaRSs, including EPRS1, exhibit stimulus-dependent release from the MSC to perform noncanonical activities distinct from
-
The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Anne E. van Vlimmeren, Rashmi Voleti, Cassandra A. Chartier, Ziyuan Jiang, Deepti Karandur, Preston A. Humphries, Wan-Lin Lo, Neel H. Shah
Mutations in the tyrosine phosphatase Src homology-2 domain-containing protein tyrosine phosphatase-2 (SHP2) are associated with a variety of human diseases. Most mutations in SHP2 increase its basal catalytic activity by disrupting autoinhibitory interactions between its phosphatase domain and N-terminal SH2 (phosphotyrosine recognition) domain. By contrast, some disease-associated mutations located
-
Cytoplasmic stirring by active carpets Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16 Brato Chakrabarti, Manas Rachh, Stanislav Y. Shvartsman, Michael J. Shelley
Large cells often rely on cytoplasmic flows for intracellular transport, maintaining homeostasis, and positioning cellular components. Understanding the mechanisms of these flows is essential for gaining insights into cell function, developmental processes, and evolutionary adaptability. Here, we focus on a class of self-organized cytoplasmic stirring mechanisms that result from fluid–structure interactions
-
Substantial increase in perfluorocarbons CF 4 (PFC-14) and C 2 F 6 (PFC-116) emissions in China Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Minde An, Ronald G. Prinn, Luke M. Western, Bo Yao, Xingchen Zhao, Jooil Kim, Jens Mühle, Wenxue Chi, Christina M. Harth, Jianxin Hu, Anita L. Ganesan, Matthew Rigby
The perfluorocarbons tetrafluoromethane (CF 4 , PFC-14) and hexafluoroethane (C 2 F 6 , PFC-116) are potent greenhouse gases with near-permanent atmospheric lifetimes relative to human timescales and global warming potentials thousands of times that of CO 2 . Using long-term atmospheric observations from a Chinese network and an inverse modeling approach (top–down method), we determined that CF 4 emissions
-
Time-scale invariant contingency yields one-shot reinforcement learning despite extremely long delays to reinforcement Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Charles R. Gallistel, Timothy A. Shahan
Reinforcement learning inspires much theorizing in neuroscience, cognitive science, machine learning, and AI. A central question concerns the conditions that produce the perception of a contingency between an action and reinforcement—the assignment-of-credit problem. Contemporary models of associative and reinforcement learning do not leverage the temporal metrics (measured intervals). Our information-theoretic
-
Can names shape facial appearance? Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Yonat Zwebner, Moses Miller, Noa Grobgeld, Jacob Goldenberg, Ruth Mayo
Our given name is a social tag associated with us early in life. This study investigates the possibility of a self-fulfilling prophecy effect wherein individuals’ facial appearance develops over time to resemble the social stereotypes associated with given names. Leveraging the face–name matching effect, which demonstrates an ability to match adults’ names to their faces, we hypothesized that individuals
-
Physics of microscale freeform 3D printing of ice Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Akash Garg, Feimo Yang, O. Burak Ozdoganlar, Philip R. LeDuc
Ice is emerging as a promising sacrificial material in the rapidly expanding area of advanced manufacturing for creating precise 3D internal geometries. Freeform 3D printing of ice (3D-ICE) can produce microscale ice structures with smooth walls, hierarchical transitions, and curved and overhang features. However, controlling 3D-ICE is challenging due to an incomplete understanding of its complex physics
-
Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Daniel Maxim Iascone, Xue Zhang, Patricia Brafford, Clementina Mesaros, Yogev Sela, Samuel Hofbauer, Shirley L. Zhang, Sukanya Madhwal, Kieona Cook, Pavel Pivarshev, Ben Z. Stanger, Stewart Anderson, Chi V. Dang, Amita Sehgal
Crosstalk between metabolism and circadian rhythms is a fundamental building block of multicellular life, and disruption of this reciprocal communication could be relevant to disease. Here, we investigated whether maintenance of circadian rhythms depends on specific metabolic pathways, particularly in the context of cancer. We found that in adult mouse fibroblasts, ATP levels were a major contributor
-
Parallel vector memories in the brain of a bee as foundation for flexible navigation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Rickesh N. Patel, Natalie S. Roberts, Julian Kempenaers, Ana Zadel, Stanley Heinze
Insects rely on path integration (vector-based navigation) and landmark guidance to perform sophisticated navigational feats, rivaling those seen in mammals. Bees in particular exhibit complex navigation behaviors including creating optimal routes and novel shortcuts between locations, an ability historically indicative of the presence of a cognitive map. A mammalian cognitive map has been widely accepted
-
Dissonant music engages early visual processing Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Fernando Bravo, Jana Glogowski, Emmanuel Andreas Stamatakis, Kristina Herfert
The neuroscientific examination of music processing in audio-visual contexts offers a valuable framework to assess how auditory information influences the emotional encoding of visual information. Using fMRI during naturalistic film viewing, we investigated the neural mechanisms underlying the effect of music on valence inferences during mental state attribution. Thirty-eight participants watched the
-
Bacterial outer membrane vesicle nanorobot Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Songsong Tang, Daitian Tang, Houhong Zhou, Yangyang Li, Dewang Zhou, Xiqi Peng, Chunyu Ren, Yilin Su, Shaohua Zhang, Haoxiang Zheng, Fangchen Wan, Jounghyun Yoo, Hong Han, Xiaotian Ma, Wei Gao, Song Wu
Autonomous nanorobots represent an advanced tool for precision therapy to improve therapeutic efficacy. However, current nanorobotic designs primarily rely on inorganic materials with compromised biocompatibility and limited biological functions. Here, we introduce enzyme-powered bacterial outer membrane vesicle (OMV) nanorobots. The immobilized urease on the OMV membrane catalyzes the decomposition
-
The health risk of social disadvantage is transplantable into a new host Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Lucie M. Turcotte, Tao Wang, Kirsten M. Beyer, Steven W. Cole, Stephen R. Spellman, Mariam Allbee-Johnson, Eric Williams, Yuhong Zhou, Michael R. Verneris, J. Douglas Rizzo, Jennifer M. Knight
Low socioeconomic status (SES) is a risk factor for mortality and immune dysfunction across a wide range of diseases, including cancer. However, cancer is distinct in the use of allogeneic hematopoietic cell transplantation (HCT) as a treatment for hematologic malignancies to transfer healthy hematopoietic cells from one person to another. This raises the question of whether social disadvantage of
-
Climate impacts of alternative beef production systems depend on the functional unit used: Weight or monetary value Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Tong Wang, Urs Kreuter, Christopher Davis, Stephen Cheye
Beef production has been identified as a significant source of anthropogenic greenhouse gas (GHG) emissions in the agricultural sector. United States and Canada account for about a quarter of the world’s beef supply. To compare the GHG emission contributions of alternative beef production systems, we conducted a meta-analysis of 32 studies that were conducted between 2001 and 2023. Results indicated
-
Conformational dynamics underlying atypical chemokine receptor 3 activation Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Omolade Otun, Christelle Aljamous, Elise Del Nero, Marta Arimont-Segura, Reggie Bosma, Barbara Zarzycka, Tristan Girbau, Cédric Leyrat, Chris de Graaf, Rob Leurs, Thierry Durroux, Sébastien Granier, Xiaojing Cong, Cherine Bechara
Atypical Chemokine Receptor 3 (ACKR3) belongs to the G protein-coupled receptor family but it does not signal through G proteins. The structural properties that govern the functional selectivity and the conformational dynamics of ACKR3 activation are poorly understood. Here, we combined hydrogen/deuterium exchange mass spectrometry, site-directed mutagenesis, and molecular dynamics simulations to examine
-
Demystifying group-4 polyolefin hydrogenolysis catalysis. Gaseous propane hydrogenolysis mechanism over the same catalysts Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Alexander H. Mason, Alessandro Motta, Yosi Kratish, Tobin J. Marks
A kinetic/mechanistic investigation of gaseous propane hydrogenolysis over the single-site heterogeneous polyolefin depolymerization catalysts AlS/ZrNp 2 and AlS/HfNp 2 (AlS = sulfated alumina, Np = neopentyl), is use to probe intrinsic catalyst properties without the complexities introduced by time- and viscosity-dependent polymer medium effects. In a polymer-free automated plug-flow catalytic reactor
-
The increasingly dominant role of climate change on length of day variations Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Mostafa Kiani Shahvandi, Surendra Adhikari, Mathieu Dumberry, Siddhartha Mishra, Benedikt Soja
The melting of ice sheets and global glaciers results in sea-level rise, a pole-to-equator mass transport increasing Earth’s oblateness and resulting in an increase in the length of day (LOD). Here, we use observations and reconstructions of mass variations at the Earth’s surface since 1900 to show that the climate-induced LOD trend hovered between 0.3 and 1.0 ms/cy in the 20th century, but has accelerated
-
Actions chains and intention understanding in 3- to 6-year-old children Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Cinzia Di Dio, Laura Miraglia, Giulia Peretti, Antonella Marchetti, Giacomo Rizzolatti
In intentional behavior, the final goal of an action is crucial in determining the entire sequence of motor acts. Neurons have been described in the inferior parietal lobule of monkeys, which besides encoding a specific motor act (e.g., grasping), have their discharge modulated by the final goal of the intended action (e.g., grasping-to-eat). Many of these “action-constrained” neurons have mirror properties
-
Tropism for ciliated cells is the dominant driver of influenza viral burst size in the human airway Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Shanley N. Roach, Frances K. Shepherd, Clayton K. Mickelson, Jessica K. Fiege, Beth K. Thielen, Lauren M. Pross, Autumn E. Sanders, Jason S. Mitchell, Mason Robertson, Brian T. Fife, Ryan A. Langlois
Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics and burden in the airways is not fully understood. Using primary human airway cultures, which recapitulate the diverse epithelial cell landscape of the human airways, we investigated the impact of
-
Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Tetsuya Miyamoto, Sheida Hedjazi, Chika Miyamoto, Hubert Amrein
Neuropeptides (NPs) and their cognate receptors are critical effectors of diverse physiological processes and behaviors. We recently reported of a noncanonical function of the Drosophila Glucose-6-Phosphatase ( G6P ) gene in a subset of neurosecretory cells in the central nervous system that governs systemic glucose homeostasis in food-deprived flies. Here, we show that G6P- expressing neurons define
-
Mitochondrial antioxidants abate SARS-COV-2 pathology in mice Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Joseph W. Guarnieri, Timothy Lie, Yentli E. Soto Albrecht, Peter Hewin, Kellie A. Jurado, Gabrielle A. Widjaja, Yi Zhu, Meagan J. McManus, Todd J. Kilbaugh, Kelsey Keith, Prasanth Potluri, Deanne Taylor, Alessia Angelin, Deborah G. Murdock, Douglas C. Wallace
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection inhibits mitochondrial oxidative phosphorylation (OXPHOS) and elevates mitochondrial reactive oxygen species (ROS, mROS) which activates hypoxia-inducible factor-1alpha (HIF-1α), shifting metabolism toward glycolysis to drive viral biogenesis but also causing the release of mitochondrial DNA (mtDNA) and activation of innate immunity
-
Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Yong Li, Yiling Wen, Ying Li, Xinyi Tan, Shuaixin Gao, Peiyao Fan, Wenmin Tian, Catherine C.L. Wong, Yang Chen
Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal component of their cargoes. The mechanism underlying the transportation of these intraluminal vesicles to the migrasomes
-
A social foraging trade-off in echolocating bats reveals that they benefit from some conspecifics but are impaired when many are around Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Ksenia Krivoruchko, Jens C. Koblitz, Aya Goldshtein, Katarina Biljman, Antonio Guillén-Servent, Yossi Yovel
Social foraging is very common in the animal kingdom. Numerous studies have documented collective foraging in various species and many reported the attraction of various species to foraging conspecifics. It is nonetheless difficult to quantify the benefits and costs of collective foraging, especially in the wild. We examined the benefits and costs of social foraging using on-board microphones mounted
-
Enhancement of the anomalous Hall effect by distorting the Kagome lattice in an antiferromagnetic material Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-15 Subhajit Roychowdhury, Kartik Samanta, Sukriti Singh, Walter Schnelle, Yang Zhang, Jonathan Noky, Maia G. Vergniory, Chandra Shekhar, Claudia Felser
In topological magnetic materials, the topology of the electronic wave function is strongly coupled to the structure of the magnetic order. In general, ferromagnetic Weyl semimetals generate a strong anomalous Hall conductivity (AHC) due to a large Berry curvature that scales with their magnetization. In contrast, a comparatively small AHC is observed in noncollinear antiferromagnets. We investigated
-
In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-09
Proceedings of the National Academy of Sciences, Volume 121, Issue 28, July 2024.
-
Correction for Venø et al., A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-12
Proceedings of the National Academy of Sciences, Volume 121, Issue 29, July 2024.