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Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain Cell (IF 45.5) Pub Date : 2024-06-27 Nicole Scott-Hewitt, Matthew Mahoney, Youtong Huang, Nils Korte, T. Yvanka de Soysa, Daniel K. Wilton, Emily Knorr, Kevin Mastro, Allison Chang, Allison Zhang, David Melville, Monica Schenone, Christina Hartigan, Beth Stevens
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Temporal dynamics of woolly mammoth genome erosion prior to extinction Cell (IF 45.5) Pub Date : 2024-06-27 Marianne Dehasque, Hernán E. Morales, David Díez-del-Molino, Patrícia Pečnerová, J. Camilo Chacón-Duque, Foteini Kanellidou, Héloïse Muller, Valerii Plotnikov, Albert Protopopov, Alexei Tikhonov, Pavel Nikolskiy, Gleb K. Danilov, Maddalena Giannì, Laura van der Sluis, Tom Higham, Peter D. Heintzman, Nikolay Oskolkov, M. Thomas P. Gilbert, Anders Götherström, Tom van der Valk, Love Dalén
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Stress-dependent condensate formation regulated by the ubiquitin-related modifier Urm1 Cell (IF 45.5) Pub Date : 2024-06-27 Lucas V. Cairo, Xiaoyu Hong, Martin B.D. Müller, Patricia Yuste-Checa, Chandhuru Jagadeesan, Andreas Bracher, Sae-Hun Park, Manajit Hayer-Hartl, F. Ulrich Hartl
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The extracellular matrix integrates mitochondrial homeostasis Cell (IF 45.5) Pub Date : 2024-06-27 Hanlin Zhang, C. Kimberly Tsui, Gilberto Garcia, Larry K. Joe, Haolun Wu, Ayane Maruichi, Wudi Fan, Sentibel Pandovski, Peter H. Yoon, Brant M. Webster, Jenni Durieux, Phillip A. Frankino, Ryo Higuchi-Sanabria, Andrew Dillin
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Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale Cell (IF 45.5) Pub Date : 2024-06-26 Ruiwen Zhang, Zhou He, Yajing Shi, Xiangkun Sun, Xinyu Chen, Guoquan Wang, Yizhou Zhang, Pan Gao, Ying Wu, Shuhan Lu, Junyi Duan, Shangwu Sun, Na Yang, Wei Fan, Kaitao Zhao, Bei Yang, Yuchen Xia, Yan Zhang, Ying Zhang, Hao Yin
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Preclinical proof of principle for orally delivered Th17 antagonist miniproteins Cell (IF 45.5) Pub Date : 2024-06-26 Stephanie Berger, Franziska Seeger, Ta-Yi Yu, Merve Aydin, Huilin Yang, Daniel Rosenblum, Laure Guenin-Macé, Caleb Glassman, Lauren Arguinchona, Catherine Sniezek, Alyssa Blackstone, Lauren Carter, Rashmi Ravichandran, Maggie Ahlrichs, Michael Murphy, Ingrid Swanson Pultz, Alex Kang, Asim K. Bera, Lance Stewart, K. Christopher Garcia, David Baker
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Multiplexed single-cell characterization of alternative polyadenylation regulators Cell (IF 45.5) Pub Date : 2024-06-25 Madeline H. Kowalski, Hans-Hermann Wessels, Johannes Linder, Carol Dalgarno, Isabella Mascio, Saket Choudhary, Austin Hartman, Yuhan Hao, Anshul Kundaje, Rahul Satija
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Pan-cancer proteogenomics expands the landscape of therapeutic targets Cell (IF 45.5) Pub Date : 2024-06-24 Sara R. Savage, Xinpei Yi, Jonathan T. Lei, Bo Wen, Hongwei Zhao, Yuxing Liao, Eric J. Jaehnig, Lauren K. Somes, Paul W. Shafer, Tobie D. Lee, Zile Fu, Yongchao Dou, Zhiao Shi, Daming Gao, Valentina Hoyos, Qiang Gao, Bing Zhang
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The primitive endoderm supports lineage plasticity to enable regulative development Cell (IF 45.5) Pub Date : 2024-06-24 Madeleine Linneberg-Agerholm, Annika Charlotte Sell, Alba Redó-Riveiro, Marta Perera, Martin Proks, Teresa E. Knudsen, Antonio Barral, Miguel Manzanares, Joshua M. Brickman
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Open-ST: High-resolution spatial transcriptomics in 3D Cell (IF 45.5) Pub Date : 2024-06-24 Marie Schott, Daniel León-Periñán, Elena Splendiani, Leon Strenger, Jan Robin Licha, Tancredi Massimo Pentimalli, Simon Schallenberg, Jonathan Alles, Sarah Samut Tagliaferro, Anastasiya Boltengagen, Sebastian Ehrig, Stefano Abbiati, Steffen Dommerich, Massimiliano Pagani, Elisabetta Ferretti, Giuseppe Macino, Nikos Karaiskos, Nikolaus Rajewsky
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TERT activation targets DNA methylation and multiple aging hallmarks Cell (IF 45.5) Pub Date : 2024-06-21 Hong Seok Shim, Jonathan Iaconelli, Xiaoying Shang, Jiexi Li, Zheng D. Lan, Shan Jiang, Kayla Nutsch, Brittney A. Beyer, Luke L. Lairson, Adam T. Boutin, Michael J. Bollong, Peter G. Schultz, Ronald A. DePinho
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Systematic mapping of organism-scale gene-regulatory networks in aging using population asynchrony Cell (IF 45.5) Pub Date : 2024-06-21 Matthias Eder, Olivier M.F. Martin, Natasha Oswal, Lucia Sedlackova, Cátia Moutinho, Andrea Del Carmen-Fabregat, Simon Menendez Bravo, Arnau Sebé-Pedrós, Holger Heyn, Nicholas Stroustrup
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The evolution of developmental biology through conceptual and technological revolutions Cell (IF 45.5) Pub Date : 2024-06-20 Prisca Liberali, Alexander F. Schier
Developmental biology—the study of the processes by which cells, tissues, and organisms develop and change over time—has entered a new golden age. After the molecular genetics revolution in the 80s and 90s and the diversification of the field in the early 21st century, we have entered a phase when powerful technologies provide new approaches and open unexplored avenues. Progress in the field has been
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Parsing patterns: Emerging roles of tissue self-organization in health and disease Cell (IF 45.5) Pub Date : 2024-06-20 Raul Ramos, Benjamin Swedlund, Anand K. Ganesan, Leonardo Morsut, Philip K. Maini, Edwin S. Monuki, Arthur D. Lander, Cheng-Ming Chuong, Maksim V. Plikus
Patterned morphologies, such as segments, spirals, stripes, and spots, frequently emerge during embryogenesis through self-organized coordination between cells. Yet, complex patterns also emerge in adults, suggesting that the capacity for spontaneous self-organization is a ubiquitous property of biological tissues. We review current knowledge on the principles and mechanisms of self-organized patterning
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When boundaries benefit science and society Cell (IF 45.5) Pub Date : 2024-06-20 Amander T. Clark, Janet Rossant, Robin Lovell-Badge
In the rapidly moving field of stem cell and embryo research, research questions often sit at the intersection of scientific inquiry and ethical considerations. The International Society for Stem Cell Research (ISSCR) produces guidelines to help navigate decisions in this area. For Cell’s 50th Anniversary Focus on Developmental Biology, scientific editor Sarah Geisler discussed the importance of the
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Toward developing human organs via embryo models and chimeras Cell (IF 45.5) Pub Date : 2024-06-20
Developing functional organs from stem cells remains a challenging goal in regenerative medicine. Existing methodologies, such as tissue engineering, …
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Dynamic models of human development and concepts of the individual Cell (IF 45.5) Pub Date : 2024-06-20 Insoo Hyun
Stem cells can be coaxed to self-organize into dynamic models of human development and early embryo formation. Despite their scientific promise, might widespread use of these technologies alter people’s beliefs about what it means to be a human individual? Attention to some important philosophical distinctions may help navigate our thinking.
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Developmental and stem cell biology’s bright future Cell (IF 45.5) Pub Date : 2024-06-20 Jennifer Lewis, Melina Schuh, Jacob H. Hanna, Magdalena Zernicka-Goetz, Mansi Srivastava, Tao Tan, Sam Behjati, Zhen Liu, Nicoletta I. Petridou, Sasha Mendjan
The next 50 years of developmental biology will illuminate exciting new discoveries but are also poised to provide solutions to important problems society faces. Ten scientists whose work intersects with developmental biology in various capacities tell us about their vision for the future.
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Shinya Yamanaka Cell (IF 45.5) Pub Date : 2024-06-20 Shinya Yamanaka
Dr. Shinya Yamanaka is recognized for his discovery of the induction of pluripotent stem cells from fibroblasts by a combination of defined factors. In this interview with Cell, he discusses the progress of the field, what’s next for clinical applications of iPS cells, and the state of science in Japan and the rest of the world.
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Gut microbiome ecological topology as next-generation biomarkers for cancer immunotherapy Cell (IF 45.5) Pub Date : 2024-06-20 Lijun Ning, Jie Hong
Numerous studies have evaluated the gut microbiome as a biomarker for predicting cancer immunotherapy, but the heterogeneity among different studies has hindered its applications. In this issue of Cell, Derosa et al. report a biomarker based on the ecological topology of the gut microbiota that can predict immunotherapy efficacy effectively.
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A brainstem maestro conducting the somatic and autonomic motor symphony Cell (IF 45.5) Pub Date : 2024-06-20 Xiaolin Huang, Yang Dan
Somatic and sympathetic tones fluctuate together seamlessly across daily behaviors. In this issue of Cell, Zhang et al. describe populations of spinal projecting neurons in the rostral ventromedial medulla (rVMM) that harmonize somatic motor function and sympathetic activation. The coordinated regulation plays a vital role in supporting behaviors associated with various arousal states.
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FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis Cell (IF 45.5) Pub Date : 2024-06-20 Jannik Hugener, Jingwei Xu, Rahel Wettstein, Lydia Ioannidi, Daniel Velikov, Florian Wollweber, Adrian Henggeler, Joao Matos, Martin Pilhofer
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Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome Cell (IF 45.5) Pub Date : 2024-06-20 Lisa Derosa, Valerio Iebba, Carolina Alves Costa Silva, Gianmarco Piccinno, Guojun Wu, Leonardo Lordello, Bertrand Routy, Naisi Zhao, Cassandra Thelemaque, Roxanne Birebent, Federica Marmorino, Marine Fidelle, Meriem Messaoudene, Andrew Maltez Thomas, Gerard Zalcman, Sylvie Friard, Julien Mazieres, Clarisse Audigier-Valette, Denis Moro- Sibilot, François Goldwasser, Laurence Zitvogel
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Ring-shaped odor coding in the antennal lobe of migratory locusts Cell (IF 45.5) Pub Date : 2024-06-18 Xingcong Jiang, Eleftherios Dimitriou, Veit Grabe, Ruo Sun, Hetan Chang, Yifu Zhang, Jonathan Gershenzon, Jürgen Rybak, Bill S. Hansson, Silke Sachse
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Therapeutic potential of co-signaling receptor modulation in hepatitis B Cell (IF 45.5) Pub Date : 2024-06-18 Francesco Andreata, Chiara Laura, Micol Ravà, Caroline C. Krueger, Xenia Ficht, Keigo Kawashima, Cristian G. Beccaria, Federica Moalli, Bianca Partini, Valeria Fumagalli, Giulia Nosetto, Pietro Di Lucia, Ilaria Montali, José M. Garcia-Manteiga, Elisa B. Bono, Leonardo Giustini, Chiara Perucchini, Valentina Venzin, Serena Ranucci, Donato Inverso, Marco De Giovanni, Marco Genua, Renato Ostuni, Enrico
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The genomic and cellular basis of biosynthetic innovation in rove beetles Cell (IF 45.5) Pub Date : 2024-06-17
How evolution at the cellular level potentiates macroevolutionary change is central to understanding biological diversification. The >66,000 rove beet…
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A metabolomics pipeline highlights microbial metabolism in bloodstream infections Cell (IF 45.5) Pub Date : 2024-06-16 Jared R. Mayers, Jack Varon, Ruixuan R. Zhou, Martin Daniel-Ivad, Courtney Beaulieu, Amrisha Bhosle, Nathaniel R. Glasser, Franziska M. Lichtenauer, Julie Ng, Mayra Pinilla Vera, Curtis Huttenhower, Mark A. Perrella, Clary B. Clish, Sihai D. Zhao, Rebecca M. Baron, Emily P. Balskus
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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation Cell (IF 45.5) Pub Date : 2024-06-14 Balamurugan Sundaram, Nagakannan Pandian, Hee Jin Kim, Hadia M. Abdelaal, Raghvendra Mall, Omkar Indari, Roman Sarkar, Rebecca E. Tweedell, Emily Q. Alonzo, Jonathon Klein, Shondra M. Pruett-Miller, Peter Vogel, Thirumala-Devi Kanneganti
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis Cell (IF 45.5) Pub Date : 2024-06-14 Marcel S. Woo, Christina Mayer, Lars Binkle-Ladisch, Jana K. Sonner, Sina C. Rosenkranz, Artem Shaposhnykov, Nicola Rothammer, Volodymyr Tsvilovskyy, Svenja M. Lorenz, Lukas Raich, Lukas C. Bal, Vanessa Vieira, Ingrid Wagner, Simone Bauer, Markus Glatzel, Marcus Conrad, Doron Merkler, Marc Freichel, Manuel A. Friese
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An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms Cell (IF 45.5) Pub Date : 2024-06-13 Thomas M. Hart, Nicole D. Sonnert, Xiaotian Tang, Reetika Chaurasia, Paige E. Allen, Jason R. Hunt, Curtis B. Read, Emily E. Johnson, Gunjan Arora, Yile Dai, Yingjun Cui, Yu-Min Chuang, Qian Yu, M. Sayeedur Rahman, M. Tays Mendes, Agustin Rolandelli, Pallavi Singh, Abhai K. Tripathi, Choukri Ben Mamoun, Melissa J. Caimano, Aaron M. Ring
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Retraction Notice to: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers Cell (IF 45.5) Pub Date : 2024-06-12 G. Stefano Brigidi, Michael G.B. Hayes, Nathaniel P. Delos Santos, Andrea L. Hartzell, Lorane Texari, Pei-Ann Lin, Anna Bartlett, Joseph R. Ecker, Christopher Benner, Sven Heinz, Brenda L. Bloodgood
No Abstract
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A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis Cell (IF 45.5) Pub Date : 2024-06-12 Matthew P. Wilson, Takfarinas Kentache, Charlotte R. Althoff, Céline Schulz, Geoffroy de Bettignies, Gisèle Mateu Cabrera, Loreta Cimbalistiene, Birute Burnyte, Grace Yoon, Gregory Costain, Sandrine Vuillaumier-Barrot, David Cheillan, Daisy Rymen, Lucie Rychtarova, Hana Hansikova, Marina Bury, Joseph P. Dewulf, Francesco Caligiore, Jaak Jaeken, Vincent Cantagrel, Guido T. Bommer
No Abstract
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Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors Cell (IF 45.5) Pub Date : 2024-06-12 Dania Zhivaki, Stephanie N. Kennedy, Josh Park, Francesco Boriello, Pascal Devant, Anh Cao, Kristin M. Bahleda, Shane Murphy, Cristin McCabe, Charles L. Evavold, Kate L. Chapman, Ivan Zanoni, Orr Ashenberg, Ramnik J. Xavier, Jonathan C. Kagan
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TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons Cell (IF 45.5) Pub Date : 2024-06-11 Tae Wan Kim, So Yeon Koo, Markus Riessland, Fayzan Chaudhry, Benjamin Kolisnyk, Hyein S. Cho, Marco Vincenzo Russo, Nathalie Saurat, Sanjoy Mehta, Ralph Garippa, Doron Betel, Lorenz Studer
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Single-molecule imaging reveals the mechanism of bidirectional replication initiation in metazoa Cell (IF 45.5) Pub Date : 2024-06-11 Riki Terui, Scott E. Berger, Larissa A. Sambel, Dan Song, Gheorghe Chistol
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Minimal and hybrid hydrogenases are active from archaea Cell (IF 45.5) Pub Date : 2024-06-11 Chris Greening, Princess R. Cabotaje, Luis E. Valentin Alvarado, Pok Man Leung, Henrik Land, Thiago Rodrigues-Oliveira, Rafael I. Ponce-Toledo, Moritz Senger, Max A. Klamke, Michael Milton, Rachael Lappan, Susan Mullen, Jacob West-Roberts, Jie Mao, Jiangning Song, Marie Schoelmerich, Courtney W. Stairs, Christa Schleper, Rhys Grinter, Anja Spang, Gustav Berggren
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Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies Cell (IF 45.5) Pub Date : 2024-06-10 Natasha I. Edman, Ashish Phal, Rachel L. Redler, Thomas Schlichthaerle, Sanjay R. Srivatsan, Devon Duron Ehnes, Ali Etemadi, Seong J. An, Andrew Favor, Zhe Li, Florian Praetorius, Max Gordon, Thomas Vincent, Silvia Marchiano, Leslie Blakely, Chuwei Lin, Wei Yang, Brian Coventry, Derrick R. Hicks, Longxing Cao, David Baker
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MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels Cell (IF 45.5) Pub Date : 2024-06-07 Luis Carlos Tábara, Stephen P. Burr, Michele Frison, Suvagata R. Chowdhury, Vincent Paupe, Yu Nie, Mark Johnson, Jara Villar-Azpillaga, Filipa Viegas, Mayuko Segawa, Hanish Anand, Kasparas Petkevicius, Patrick F. Chinnery, Julien Prudent
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The rate and nature of mitochondrial DNA mutations in human pedigrees Cell (IF 45.5) Pub Date : 2024-06-07 Erla R. Árnadóttir, Kristján H.S. Moore, Valdís B. Guðmundsdóttir, S. Sunna Ebenesersdóttir, Kamran Guity, Hákon Jónsson, Kári Stefánsson, Agnar Helgason
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Resmetirom for treatment of MASH Cell (IF 45.5) Pub Date : 2024-06-06 Silvia Sookoian, Carlos Jose Pirola
Resmetirom is an oral selective THR-β agonist conditionally approved for the treatment of patients with noncirrhotic MASH with moderate to advanced fibrosis. Resmetirom restores mitochondrial and hepatic metabolic function; reduces atherogenic lipids; improves hepatic steatosis, inflammation, and fibrosis; and has no significant effect on THR-α. To view this Bench to Bedside, open or download the PDF
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On mechanical phase and form Cell (IF 45.5) Pub Date : 2024-06-06 Windie Höfs, Sara A. Wickström
Epithelial folding is a fundamental biological process that requires epithelial interactions with the underlying mesenchyme. In this issue of Cell, Huycke et al. investigate intestinal villus formation. They discover that water-droplet-like behavior of mesenchymal cells drives their coalescence into uniformly patterned aggregates, which generate forces on the epithelium to initiate folding.
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Redefining intestinal stemness: The emergence of a new ISC population Cell (IF 45.5) Pub Date : 2024-06-06 Mei-Lan Li, Kaelyn Sumigray
In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al.1 and Malagola, Vasciaveo, et al.2 identify a new ISC population in the upper crypt that can generate Lgr5+ stem cells during homeostasis.
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Unveiling of a messenger: Gut microbes make a neuroactive signal Cell (IF 45.5) Pub Date : 2024-06-06 Poulami Chatterjee, Laura M.K. Dassama
Gut microbes are known to impact host physiology in several ways. However, key molecular players in host-commensal interactions remain to be uncovered. In this issue of Cell, McCurry et al. reveal that gut bacteria perform 21-dehydroxylation to convert abundant biliary corticoids to neurosteroids using readily available H2 in their environment.
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A simple rule for predicting function of microbial communities Cell (IF 45.5) Pub Date : 2024-06-06 Sergey Kryazhimskiy
Microbial communities perform many important functions, such as carbon sequestration, decomposition, pathogen resistance, etc., but quantitatively predicting functions of new communities remains a major challenge. In this issue of Cell, Diaz-Colunga et al. report a new simple statistical regularity that enables such predictions.
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A developmental constraint model of cancer cell states and tumor heterogeneity Cell (IF 45.5) Pub Date : 2024-06-06 Ayushi S. Patel, Itai Yanai
Cancer is a disease that stems from a fundamental liability inherent to multicellular life forms in which an individual cell is capable of reneging on the interests of the collective organism. Although cancer is commonly described as an evolutionary process, a less appreciated aspect of tumorigenesis may be the constraints imposed by the organism’s developmental programs. Recent work from single-cell
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Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells Cell (IF 45.5) Pub Date : 2024-06-06 Claudia Capdevila, Jonathan Miller, Liang Cheng, Adam Kornberg, Joel J. George, Hyeonjeong Lee, Theo Botella, Christine S. Moon, John W. Murray, Stephanie Lam, Ruben I. Calderon, Ermanno Malagola, Gary Whelan, Chyuan-Sheng Lin, Arnold Han, Timothy C. Wang, Peter A. Sims, Kelley S. Yan
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Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury Cell (IF 45.5) Pub Date : 2024-06-06 Ermanno Malagola, Alessandro Vasciaveo, Yosuke Ochiai, Woosook Kim, Biyun Zheng, Luca Zanella, Alexander L.E. Wang, Moritz Middelhoff, Henrik Nienhüser, Lu Deng, Feijing Wu, Quin T. Waterbury, Bryana Belin, Jonathan LaBella, Leah B. Zamechek, Melissa H. Wong, Linheng Li, Chandan Guha, Chia-Wei Cheng, Kelley S. Yan, Timothy C. Wang
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Discovery of antimicrobial peptides in the global microbiome with machine learning Cell (IF 45.5) Pub Date : 2024-06-05 Célio Dias Santos-Júnior, Marcelo D.T. Torres, Yiqian Duan, Álvaro Rodríguez del Río, Thomas S.B. Schmidt, Hui Chong, Anthony Fullam, Michael Kuhn, Chengkai Zhu, Amy Houseman, Jelena Somborski, Anna Vines, Xing-Ming Zhao, Peer Bork, Jaime Huerta-Cepas, Cesar de la Fuente-Nunez, Luis Pedro Coelho
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Heterologous survey of 130 DNA transposons in human cells highlights their functional divergence and expands the genome engineering toolbox Cell (IF 45.5) Pub Date : 2024-06-05
Experimental studies on DNA transposable elements (TEs) have been limited in scale, leading to a lack of understanding of the factors influencing tran…
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The ribotoxic stress response drives UV-mediated cell death Cell (IF 45.5) Pub Date : 2024-06-05 Niladri K. Sinha, Connor McKenney, Zhong Y. Yeow, Jeffrey J. Li, Ki Hong Nam, Tomer M. Yaron-Barir, Jared L. Johnson, Emily M. Huntsman, Lewis C. Cantley, Alban Ordureau, Sergi Regot, Rachel Green
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Capturing totipotency in human cells through spliceosomal repression Cell (IF 45.5) Pub Date : 2024-06-05 Shiyu Li, Min Yang, Hui Shen, Li Ding, Xuehui Lyu, Kexin Lin, Jennie Ong, Peng Du
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Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss Cell (IF 45.5) Pub Date : 2024-06-04 Hui Wang, Kimon Divaris, Bohu Pan, Xiaofei Li, Jong-Hyung Lim, Gundappa Saha, Marko Barovic, Danai Giannakou, Jonathan M. Korostoff, Yu Bing, Souvik Sen, Kevin Moss, Di Wu, James D. Beck, Christie M. Ballantyne, Pradeep Natarajan, Kari E. North, Mihai G. Netea, Triantafyllos Chavakis, George Hajishengallis
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POT1 recruits and regulates CST-Polα/primase at human telomeres Cell (IF 45.5) Pub Date : 2024-06-04 Sarah W. Cai, Hiroyuki Takai, Arthur J. Zaug, Teague C. Dilgen, Thomas R. Cech, Thomas Walz, Titia de Lange
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DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells Cell (IF 45.5) Pub Date : 2024-06-04 Yuru Hu, Hongyun Li, Chen Zhang, Jingjing Feng, Wenxu Wang, Wei Chen, Miao Yu, Xinping Liu, Xinghua Zhang, Zheng Liu
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De novo and salvage purine synthesis pathways across tissues and tumors Cell (IF 45.5) Pub Date : 2024-05-31
Purine nucleotides are vital for RNA and DNA synthesis, signaling, metabolism, and energy homeostasis. To synthesize purines, cells use two principal …
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A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis Cell (IF 45.5) Pub Date : 2024-05-30 Matthew P. Wilson, Takfarinas Kentache, Charlotte R. Althoff, Céline Schulz, Geoffroy de Bettignies, Gisèle Mateu Cabrera, Loreta Cimbalistiene, Birute Burnyte, Grace Yoon, Gregory Costain, Sandrine Vuillaumier-Barrot, David Cheillan, Daisy Rymen, Lucie Rychtarova, Hana Hansikova, Marina Bury, Joseph P. Dewulf, Francesco Caligiore, Jaak Jaeken, Vincent Cantagrel, Emile Van Schaftingen, Gert Matthijs
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Periodic Remodeling in a Neural Circuit Governs Timing of Female Sexual Behavior Cell (IF 45.5) Pub Date : 2024-05-29 Sayaka Inoue, Renzhi Yang, Adarsh Tantry, Chung-ha Davis, Taehong Yang, Joseph R. Knoedler, Yichao Wei, Eliza L. Adams, Shivani Thombare, Samantha R. Golf, Rachael L. Neve, Marc Tessier-Lavigne, Jun B. Ding, Nirao M. Shah
No Abstract
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Limbic Neurons Shape Sex Recognition and Social Behavior in Sexually Naive Males Cell (IF 45.5) Pub Date : 2024-05-29 Daniel W. Bayless, Taehong Yang, Matthew M. Mason, Albert A.T. Susanto, Alexandra Lobdell, Nirao M. Shah
No Abstract
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RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly Cell (IF 45.5) Pub Date : 2024-05-29 Jasbeer S. Khanduja, Richard I. Joh, Monica M. Perez, Joao A. Paulo, Christina M. Palmieri, Jingyu Zhang, Alex O.D. Gulka, Willhelm Haas, Steven P. Gygi, Mo Motamedi