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An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-19
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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-18 Olivier Saulnier, Jamie Zagozewski, Lisa Liang, Liam D. Hendrikse, Paul Layug, Victor Gordon, Kimberly A. Aldinger, Parthiv Haldipur, Stephanie Borlase, Ludivine Coudière-Morrison, Ting Cai, Emma Martell, Naomi M. Gonzales, Gareth Palidwor, Christopher J. Porter, Stéphane Richard, Tanveer Sharif, Kathleen J. Millen, Brad W. Doble, Michael D. Taylor, Tamra E. Werbowetski-Ogilvie
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-15 Jiechao Zhou, Yang ‘an Chuang, Javier Redding-Ochoa, Rongzhen Zhang, Alexander J. Platero, Alexander H. Barrett, Juan C. Troncoso, Paul F. Worley, Wenchi Zhang
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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-15 Annemarie Schwab, Zhigang Rao, Jie Zhang, André Gollowitzer, Katharina Siebenkäs, Nino Bindel, Elisabetta D’Avanzo, Ruthger van Roey, Yussuf Hajjaj, Ece Özel, Isabell Armstark, Leonhard Bereuter, Fengting Su, Julia Grander, Ehsan Bonyadi Rad, Arwin Groenewoud, Felix B. Engel, George W. Bell, Whitney S. Henry, José Pedro Friedmann Angeli, Marc P. Stemmler, Simone Brabletz, Andreas Koeberle, Thomas Brabletz
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Full-length GSDME mediates pyroptosis independent from cleavage Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Bo Zhou, Zhi-hong Jiang, Meng-ran Dai, Yuan-li Ai, Li Xiao, Chuan-qi Zhong, Liu-Zheng Wu, Qi-tao Chen, Hang-zi Chen, Qiao Wu
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Pressure sensing of lysosomes enables control of TFEB responses in macrophages Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Whijin Kwon, Subothan Inpanathan, Blayne A. Sayed, Roberto J. Botelho, Amra Saric, Stefan Uderhardt, Spencer A. Freeman
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Neutrophil-derived migrasomes are an essential part of the coagulation system Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Dong Jiang, Lin Jiao, Qing Li, Renxiang Xie, Haohao Jia, ShiHui Wang, Yining Chen, Siyuan Liu, Dandan Huang, Jiajia Zheng, Wenhao Song, Ying Li, JianFeng Chen, Jinsong Li, Binwu Ying, Li Yu
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RNA scaffolds the Golgi ribbon by forming condensates with GM130 Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-11 Yijun Zhang, Joachim Seemann
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Mapping the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-08 Keyong Sun, Xin Liu, Runda Xu, Chang Liu, Anming Meng, Xun Lan
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A single-cell atlas of chromatin accessibility in mouse organogenesis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-08 Keyong Sun, Xin Liu, Xun Lan
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An organelle tango controls lipid metabolism Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-05 Johannes Pilic, Tatjana Kleele
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An activity-specificity trade-off encoded in human transcription factors Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-05 Julian Naderi, Alexandre P. Magalhaes, Gözde Kibar, Gregoire Stik, Yaotian Zhang, Sebastian D. Mackowiak, Hannah M. Wieler, Francesca Rossi, Rene Buschow, Marie Christou-Kent, Marc Alcoverro-Bertran, Thomas Graf, Martin Vingron, Denes Hnisz
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Functional multi-organelle units control inflammatory lipid metabolism of macrophages Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-05 Julia A. Zimmermann, Kerstin Lucht, Manuel Stecher, Chahat Badhan, Katharina M. Glaser, Maximilian W. Epple, Lena R. Koch, Ward Deboutte, Thomas Manke, Klaus Ebnet, Frauke Brinkmann, Olesja Fehler, Thomas Vogl, Ev-Marie Schuster, Anna Bremser, Joerg M. Buescher, Angelika S. Rambold
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Direct observation of translational activation by a ribonucleoprotein granule Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-04 Ruoyu Chen, William Stainier, Jeremy Dufourt, Mounia Lagha, Ruth Lehmann
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Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-03 Geng Qin, Zhenqi Liu, Jie Yang, Xiaofeng Liao, Chuanqi Zhao, Jinsong Ren, Xiaogang Qu
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Mechanistic insights into the basis of widespread RNA localization Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-02 Marina Chekulaeva
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Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-01 Yiyan Lin, Dhiman Sankar Pal, Parijat Banerjee, Tatsat Banerjee, Guanghui Qin, Yu Deng, Jane Borleis, Pablo A. Iglesias, Peter N. Devreotes
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VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-01 Chuchu Wang, Kai Zhang, Bin Cai, Jillian E. Haller, Kathryn E. Carnazza, Jiaojiao Hu, Chunyu Zhao, Zhiqi Tian, Xiao Hu, Daniel Hall, Jiali Qiang, Shouqiao Hou, Zhenying Liu, Jinge Gu, Yaoyang Zhang, Kim B. Seroogy, Jacqueline Burré, Yanshan Fang, Cong Liu, Axel T. Brunger, Dan Li, Jiajie Diao
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VAMP2 regulates phase separation of α-synuclein Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-01 Aishwarya Agarwal, Aswathy Chandran, Farheen Raza, Irina-Maria Ungureanu, Christine Hilcenko, Katherine Stott, Nicholas A. Bright, Nobuhiro Morone, Alan J. Warren, Janin Lautenschläger
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Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3 Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-26 Marco Seehawer, Zheqi Li, Jun Nishida, Pierre Foidart, Andrew H. Reiter, Ernesto Rojas-Jimenez, Marie-Anne Goyette, Pengze Yan, Shaunak Raval, Miguel Munoz Gomez, Paloma Cejas, Henry W. Long, Malvina Papanastasiou, Kornelia Polyak
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A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-26 Yuxin Sun, Xuan Tao, Yaping Han, Xubo Lin, Rui Tian, Haodong Wang, Pei Chang, Qiming Sun, Liang Ge, Min Zhang
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Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-25 Andrew J. Davidson, Rosalind Heron, Jyotirekha Das, Michael Overholtzer, Will Wood
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Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-24 Phillip Wulfridge, Kavitha Sarma
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The maintenance of oocytes in the mammalian ovary involves extreme protein longevity Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-20 Katarina Harasimov, Rebecca L. Gorry, Luisa M. Welp, Sarah Mae Penir, Yehor Horokhovskyi, Shiya Cheng, Katsuyoshi Takaoka, Alexandra Stützer, Ann-Sophie Frombach, Ana Lisa Taylor Tavares, Monika Raabe, Sara Haag, Debojit Saha, Katharina Grewe, Vera Schipper, Silvio O. Rizzoli, Henning Urlaub, Juliane Liepe, Melina Schuh
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Mitochondria and cell death Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-20 Hannah L. Glover, Annabell Schreiner, Grant Dewson, Stephen W. G. Tait
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CD63 sorts cholesterol into endosomes for storage and distribution via exosomes Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-17 Roberta Palmulli, Mickaël Couty, Melissa C. Piontek, Maharajah Ponnaiah, Florent Dingli, Frederik J. Verweij, Stéphanie Charrin, Matteo Tantucci, Sajitha Sasidharan, Eric Rubinstein, Anatol Kontush, Damarys Loew, Marie Lhomme, Wouter H. Roos, Graça Raposo, Guillaume van Niel
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Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-14 Zhentao Yang, Yan Wang, Yingying Zhang, Xiadi He, Chuan-Qi Zhong, Hengxiao Ni, Xin Chen, Yaoji Liang, Jianfeng Wu, Shimin Zhao, Dawang Zhou, Jiahuai Han
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Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-13 Meng Zhang, Martin Sjöström, Xiekui Cui, Adam Foye, Kyle Farh, Raunak Shrestha, Arian Lundberg, Ha X. Dang, Haolong Li, Phillip G. Febbo, Rahul Aggarwal, Joshi J. Alumkal, Eric J. Small, Christopher A. Maher, Felix Y. Feng, David A. Quigley
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Three-dimensional chromatin reorganization regulates B cell development during ageing Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-12 Fei Ma, Yaqiang Cao, Hansen Du, Fatima Zohra Braikia, Le Zong, Noah Ollikainen, Marc Bayer, Xiang Qiu, Bongsoo Park, Roshni Roy, Satabdi Nandi, Dimitra Sarantopoulou, Andrew Ziman, Aisha Haley Bianchi, Isabel Beerman, Keji Zhao, Rudolf Grosschedl, Ranjan Sen
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The glutathione S-transferase Gstt1 drives survival and dissemination in metastases Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-11 Christina M. Ferrer, Hyo Min Cho, Ruben Boon, Tiziano Bernasocchi, Lai Ping Wong, Murat Cetinbas, Elizabeth R. Haggerty, Irene Mitsiades, Gregory R. Wojtkiewicz, Daniel E. McLoughlin, Reem Aboushousha, Hend Abdelhamid, Sita Kugel, Esther Rheinbay, Ruslan Sadreyev, Dejan Juric, Yvonne M. W. Janssen-Heininger, Raul Mostoslavsky
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Exploiting ferroptosis vulnerabilities in cancer Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-10 Toshitaka Nakamura, Marcus Conrad
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Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-10 Lele Wu, Zheng Zhao, Yong Jae Shin, Yiyun Yin, Anandhkumar Raju, Thamil Selvan Vaiyapuri, Khaireen Idzham, Miseol Son, Yeri Lee, Jason K. Sa, Joelle Yi Heng Chua, Bilal Unal, You Zhai, Wenhua Fan, Lijie Huang, Huimin Hu, Jayantha Gunaratne, Do-Hyun Nam, Tao Jiang, Vinay Tergaonkar
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Translational control by VARS in melanoma Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-07 Qiushuang Wu, Sohail F. Tavazoie
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Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-07 Najla El-Hachem, Marine Leclercq, Miguel Susaeta Ruiz, Raphael Vanleyssem, Kateryna Shostak, Pierre-René Körner, Coralie Capron, Lorena Martin-Morales, Patrick Roncarati, Arnaud Lavergne, Arnaud Blomme, Silvia Turchetto, Eric Goffin, Palaniraja Thandapani, Ivan Tarassov, Laurent Nguyen, Bernard Pirotte, Alain Chariot, Jean-Christophe Marine, Michael Herfs, Francesca Rapino, Reuven Agami, Pierre Close
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Extraembryonic gut endoderm cells undergo programmed cell death during development Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-07 Julia Batki, Sara Hetzel, Dennis Schifferl, Adriano Bolondi, Maria Walther, Lars Wittler, Stefanie Grosswendt, Bernhard G. Herrmann, Alexander Meissner
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TCF3, TCF12 and distinct enhancers regulate oocyte transcription Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-05 Qiqi Cao, Edward J. Grow
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Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-05 Bofeng Liu, Yuanlin He, Xiaotong Wu, Zili Lin, Jing Ma, Yuexin Qiu, Yunlong Xiang, Feng Kong, Fangnong Lai, Mrinmoy Pal, Peizhe Wang, Jia Ming, Bingjie Zhang, Qiujun Wang, Jingyi Wu, Weikun Xia, Weimin Shen, Jie Na, Maria-Elena Torres-Padilla, Jing Li, Wei Xie
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MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes Nat. Cell Biol. (IF 17.3) Pub Date : 2024-06-05 Katharina Esther Julia Jungnickel, Océane Guelle, Miharu Iguchi, Wentao Dong, Vadim Kotov, Florian Gabriel, Cécile Debacker, Julien Dairou, Isabelle McCort-Tranchepain, Nouf N. Laqtom, Sze Ham Chan, Akika Ejima, Kenji Sato, David Massa López, Paul Saftig, Ahmad Reza Mehdipour, Monther Abu-Remaileh, Bruno Gasnier, Christian Löw, Markus Damme
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Unfolding emergency calls stress granules to the ER Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-31 David Pincus, Scott A. Oakes
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Cells dispose of cytoplasmic mitochondrial DNA by nucleoid-phagy Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-29
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Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-28 Mitsuhiro Machitani, Akira Nomura, Taro Yamashita, Mami Yasukawa, Saori Ueki, Ken-Ichi Fujita, Toshihide Ueno, Akio Yamashita, Yoshikazu Tanzawa, Masahiko Watanabe, Toshiyasu Taniguchi, Noriko Saitoh, Shuichi Kaneko, Yukinari Kato, Hiroyuki Mano, Kenkichi Masutomi
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Adding intrinsically disordered proteins to biological ageing clocks Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-23 Dorothee Dormann, Edward Anton Lemke
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TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-23 Hao Liu, Cien Zhen, Jianming Xie, Zhenhuan Luo, Lin Zeng, Guojun Zhao, Shaohua Lu, Haixia Zhuang, Hualin Fan, Xia Li, Zhaojie Liu, Shiyin Lin, Huilin Jiang, Yuqian Chen, Jiahao Cheng, Zhiyu Cao, Keyu Dai, Jinhua Shi, Zhaohua Wang, Yongquan Hu, Tian Meng, Chuchu Zhou, Zhiyuan Han, Huansen Huang, Qinghua Zhou, Pengcheng He, Du Feng
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Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-22 Nicolás Herranz, Suchira Gallage, Massimiliano Mellone, Torsten Wuestefeld, Sabrina Klotz, Christopher J. Hanley, Selina Raguz, Juan Carlos Acosta, Andrew J. Innes, Ana Banito, Athena Georgilis, Alex Montoya, Katharina Wolter, Gopuraja Dharmalingam, Peter Faull, Thomas Carroll, Juan Pedro Martínez-Barbera, Pedro Cutillas, Florian Reisinger, Mathias Heikenwalder, Richard A. Miller, Dominic Withers,
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Mitochondrial heterogeneity and adaptations to cellular needs Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-16 Melia Granath-Panelo, Shingo Kajimura
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Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-14 Lin Yang, Zhaoru Zhang, Penglei Jiang, Delin Kong, Zebin Yu, Danrong Shi, Yingli Han, Ertuo Chen, Weiyan Zheng, Jie Sun, Yanmin Zhao, Yi Luo, Jimin Shi, Hangping Yao, He Huang, Pengxu Qian
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Polyglutamine-mediated ribotoxicity disrupts proteostasis and stress responses in Huntington’s disease Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-13 Ranen Aviner, Ting-Ting Lee, Vincent B. Masto, Kathy H. Li, Raul Andino, Judith Frydman
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Mammalian IRE1α dynamically and functionally coalesces with stress granules Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-07 Songzi Liu, Xiaoge Zhang, Xin Yao, Guan Wang, Shijia Huang, Peng Chen, Mingliang Tang, Jie Cai, Zhuyin Wu, Yiliang Zhang, Rongzhi Xu, Kai Liu, Kangmin He, Yan Wang, Lei Jiang, Qiong A. Wang, Liangyou Rui, Jianmiao Liu, Yong Liu
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Cell-intrinsic and microenvironmental determinants of metastatic colonization Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-07 Arthur W. Lambert, Yun Zhang, Robert A. Weinberg
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Cerebral organoids display dynamic clonal growth and tunable tissue replenishment Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-07 Dominik Lindenhofer, Simon Haendeler, Christopher Esk, Jamie B. Littleboy, Clarisse Brunet Avalos, Julia Naas, Florian G. Pflug, Eline G. P. van de Ven, Daniel Reumann, Alexandre D. Baffet, Arndt von Haeseler, Jürgen A. Knoblich
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ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification Nat. Cell Biol. (IF 17.3) Pub Date : 2024-05-03 Seungbok Yang, Mahdi Golkaram, Seyoun Oh, Yujeong Oh, Yoonjae Cho, Jeehyun Yoe, Sungeun Ju, Matthew A. Lalli, Seung-Yeol Park, Yoontae Lee, Jiwon Jang
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Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-04-30 Tianchi Xin, Sara Gallini, Haoyang Wei, David G. Gonzalez, Catherine Matte-Martone, Hiroki Machida, Hironobu Fujiwara, H. Amalia Pasolli, Kathleen C. Suozzi, Lauren E. Gonzalez, Sergi Regot, Valentina Greco
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LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth Nat. Cell Biol. (IF 17.3) Pub Date : 2024-04-26 Ziwen Li, Yameng Hu, Haiqing Zheng, Man Li, Yuanji Liu, Rongni Feng, Xincheng Li, Shuxia Zhang, Miaoling Tang, Meisongzhu Yang, Ruyuan Yu, Yingru Xu, Xinyi Liao, Suwen Chen, Wanying Qian, Qiliang Zhang, Daolin Tang, Bo Li, Libing Song, Jun Li
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Regulation of mitochondrial fission by fatty acyl-coenzyme A Nat. Cell Biol. (IF 17.3) Pub Date : 2024-04-23
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Next questions in autophagy Nat. Cell Biol. (IF 17.3) Pub Date : 2024-04-19 Ana Maria Cuervo, Zvulun Elazar, Chantell Evans, Liang Ge, Malene Hansen, Marja Jäättelä, Jin Rui (Amos) Liang, Ben Loos, Noboru Mizushima, Anna Katharina Simon, Sharon Tooze, Tamotsu Yoshimori, Shuhei Nakamura
Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked emerging and established leaders in the field to discuss the questions and areas that they are most excited about to deepen our understanding of autophagy.
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Pooled multicolour tagging for visualizing subcellular protein dynamics Nat. Cell Biol. (IF 17.3) Pub Date : 2024-04-19 Andreas Reicher, Jiří Reiniš, Maria Ciobanu, Pavel Růžička, Monika Malik, Marton Siklos, Victoria Kartysh, Tatjana Tomek, Anna Koren, André F. Rendeiro, Stefan Kubicek
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Accelerating data sharing and reuse in volume electron microscopy Nat. Cell Biol. (IF 17.3) Pub Date : 2024-04-12 Kirk James Czymmek, Ilya Belevich, Johanna Bischof, Aastha Mathur, Lucy Collinson, Eija Jokitalo