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Nested compressed co-representations of multiple sequential experiences during sleep Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-19 Kefei Liu, Jeremie Sibille, George Dragoi
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Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-19 Chen Yan, Valentina Mercaldo, Alexander D. Jacob, Emily Kramer, Andrew Mocle, Adam I. Ramsaran, Lina Tran, Asim J. Rashid, Sungmo Park, Nathan Insel, A. David Redish, Paul W. Frankland, Sheena A. Josselyn
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Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-17 Bhanu P. Tewari, AnnaLin M. Woo, Courtney E. Prim, Lata Chaunsali, Dipan C. Patel, Ian F. Kimbrough, Kaliroi Engel, Jack L. Browning, Susan L. Campbell, Harald Sontheimer
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A nonoscillatory, millisecond-scale embedding of brain state provides insight into behavior Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-15 David F. Parks, Aidan M. Schneider, Yifan Xu, Samuel J. Brunwasser, Samuel Funderburk, Danilo Thurber, Tim Blanche, Eva L. Dyer, David Haussler, Keith B. Hengen
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Unlocking opioid neuropeptide dynamics with genetically encoded biosensors Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-15 Chunyang Dong, Raajaram Gowrishankar, Yihan Jin, Xinyi Jenny He, Achla Gupta, Huikun Wang, Nilüfer Sayar-Atasoy, Rodolfo J. Flores, Karan Mahe, Nikki Tjahjono, Ruqiang Liang, Aaron Marley, Grace Or Mizuno, Darren K. Lo, Qingtao Sun, Jennifer L. Whistler, Bo Li, Ivone Gomes, Mark Von Zastrow, Hugo A. Tejeda, Deniz Atasoy, Lakshmi A. Devi, Michael R. Bruchas, Matthew R. Banghart, Lin Tian
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Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-11
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The cerebellum modulates thirst Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-10 Ila Mishra, Bing Feng, Bijoya Basu, Amanda M. Brown, Linda H. Kim, Tao Lin, Mir Abbas Raza, Amelia Moore, Abigayle Hahn, Samantha Bailey, Alaina Sharp, Juan C. Bournat, Claire Poulton, Brian Kim, Amos Langsner, Aaron Sathyanesan, Roy V. Sillitoe, Yanlin He, Atul R. Chopra
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Morphine maladaptively modulates myelination Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Leonie Welberg
Myelin plasticity is involved in several forms of learning in mice. Yalçın et al. now show that it also contributes to maladaptive opioid reward learning. They first showed that phasic optogenetic stimulation of dopamine (DA) neurons in the ventral tegmental area (VTA) increased the number of proliferating oligodendroglia precursor cells (OPCs) selectively in the VTA; this resulted in an increase in
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Real control in virtual rats Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Luis A. Mejia
How neural activity controls naturalistic behavior is a fundamental question in neuroscience. Using deep reinforcement learning to implement inverse dynamics models, Aldarondo et al. trained artificial neural networks that control a biomechanically realistic rat model in a physics simulation engine to imitate the movements of real, freely moving rats. They then related neural activity recorded from
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New datasets from PsychENCODE Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Shari Wiseman
Recently, Science published the latest installment of papers from the PsychENCODE Consortium, a US National Institute of Mental Health (NIMH)-funded collaborative effort to generate genomic data from the brains of both neurotypical individuals and those with neuropsychiatric disorders, including autism spectrum disorder, schizophrenia, major depressive disorder, and post-traumatic stress disorder.
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Flexible multitask computation in recurrent networks utilizes shared dynamical motifs Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-09 Laura N. Driscoll, Krishna Shenoy, David Sussillo
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-08 Noam Gannot, Xingyu Li, Chrystian D. Phillips, Ayse Bilge Ozel, Karin Harumi Uchima Koecklin, John P. Lloyd, Lusi Zhang, Katie Emery, Tomer Stern, Jun Z. Li, Peng Li
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Microglia are dispensable for experience-dependent refinement of mouse visual circuitry Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-08 Thomas C. Brown, Emily C. Crouse, Cecilia A. Attaway, Dana K. Oakes, Sarah W. Minton, Bart G. Borghuis, Aaron W. McGee
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Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-05 Yizhak Sofer, Noga Zilkha, Elena Gimpel, Shlomo Wagner, Silvia Gabriela Chuartzman, Tali Kimchi
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Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-04 Patricia Bonnavion, Christophe Varin, Ghazal Fakhfouri, Pilar Martinez Olondo, Aurélie De Groote, Amandine Cornil, Ramiro Lorenzo Lopez, Elisa Pozuelo Fernandez, Elsa Isingrini, Quentin Rainer, Kathleen Xu, Eleni Tzavara, Erika Vigneault, Sylvie Dumas, Alban de Kerchove d’Exaerde, Bruno Giros
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Central nervous system-associated macrophages modulate the immune response following stroke in aged mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-03 Damien Levard, Célia Seillier, Mathys Bellemain-Sagnard, Antoine Philippe Fournier, Eloïse Lemarchand, Chantal Dembech, Gaëtan Riou, Karina McDade, Colin Smith, Conor McQuaid, Axel Montagne, Lukas Amann, Marco Prinz, Denis Vivien, Marina Rubio
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A feature-specific prediction error model explains dopaminergic heterogeneity Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-03 Rachel S. Lee, Yotam Sagiv, Ben Engelhard, Ilana B. Witten, Nathaniel D. Daw
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Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-03 Charltien Long, Kwang Lee, Long Yang, Theresia Dafalias, Alexander K. Wu, Sotiris C. Masmanidis
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Hippocampal neurons encode identities and positions of human experimenters Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-02
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Neural representation of human experimenters in the bat hippocampus Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-02 Madeleine C. Snyder, Kevin K. Qi, Michael M. Yartsev
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Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1 Nat. Neurosci. (IF 21.2) Pub Date : 2024-07-02 Allwyn Pereira, Jeisimhan Diwakar, Giacomo Masserdotti, Sude Beşkardeş, Tatiana Simon, Younju So, Lucía Martín-Loarte, Franziska Bergemann, Lakshmy Vasan, Tamas Schauer, Anna Danese, Riccardo Bocchi, Maria Colomé-Tatché, Carol Schuurmans, Anna Philpott, Tobias Straub, Boyan Bonev, Magdalena Götz
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A sensory–motor theory of the neocortex Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-27 Rajesh P. N. Rao
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Control and recalibration of path integration in place cells using optic flow Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-27 Manu S. Madhav, Ravikrishnan P. Jayakumar, Brian Y. Li, Shahin G. Lashkari, Kelly Wright, Francesco Savelli, James J. Knierim, Noah J. Cowan
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T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-27 Shreeya Kedia, Hao Ji, Ruoqing Feng, Peter Androvic, Lena Spieth, Lu Liu, Jonas Franz, Hanna Zdiarstek, Katrin Perez Anderson, Cem Kaboglu, Qian Liu, Nicola Mattugini, Fatma Cherif, Danilo Prtvar, Ludovico Cantuti-Castelvetri, Arthur Liesz, Martina Schifferer, Christine Stadelmann, Sabina Tahirovic, Ozgun Gokce, Mikael Simons
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Dissecting the epigenetic regulation of human brain organoid development in single cells Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-25
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A high-density 1,024-channel probe for brain-wide recordings in non-human primates Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-24 Yang Liu, Huilin Jia, Hongji Sun, Shengyi Jia, Ziqian Yang, Ao Li, Anqi Jiang, Yuji Naya, Cen Yang, Shengyuan Xue, Xiaojian Li, Bingyan Chen, Jingjun Zhu, Chenghao Zhou, Minning Li, Xiaojie Duan
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Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-24 Fides Zenk, Jonas Simon Fleck, Sophie Martina Johanna Jansen, Bijan Kashanian, Benedikt Eisinger, Małgorzata Santel, Jean-Samuel Dupré, J. Gray Camp, Barbara Treutlein
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Astrocytes at the border of repair Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-21 Hong-Gyun Lee, Francisco J. Quintana
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Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-21 Timothy M. O’Shea, Yan Ao, Shinong Wang, Yilong Ren, Amy L. Cheng, Riki Kawaguchi, Zechuan Shi, Vivek Swarup, Michael V. Sofroniew
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Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-19 Sneha Narasimhan, David M. Holtzman, Liana G. Apostolova, Carlos Cruchaga, Colin L. Masters, John Hardy, Victor L. Villemagne, Joanne Bell, Min Cho, Harald Hampel
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Reward prediction error neurons implement an efficient code for reward Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-19 Heiko H. Schütt, Dongjae Kim, Wei Ji Ma
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Medial entorhinal cortex mediates learning of context-dependent interval timing behavior Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-14 Erin R. Bigus, Hyun-Woo Lee, John C. Bowler, Jiani Shi, James G. Heys
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Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-13 Marios Abatis, Rodrigo Perin, Ruifang Niu, Erwin van den Burg, Chloe Hegoburu, Ryang Kim, Michiko Okamura, Haruhiko Bito, Henry Markram, Ron Stoop
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Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-11 Yue Chen, Pengwei Luan, Juan Liu, Yelan Wei, Chenyu Wang, Rui Wu, Zhaofa Wu, Miao Jing
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A shifting role of thalamocortical connectivity in the emergence of cortical functional organization Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-10 Shinwon Park, Koen V. Haak, Stuart Oldham, Hanbyul Cho, Kyoungseob Byeon, Bo-yong Park, Phoebe Thomson, Haitao Chen, Wei Gao, Ting Xu, Sofie Valk, Michael P. Milham, Boris Bernhardt, Adriana Di Martino, Seok-Jun Hong
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One cubic millimeter of human cortex, solved Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 Shari Wiseman
Shapson-Coe, Januszewski, Berger et al. recently reported in Science a major milestone in neuroanatomy and connectomics, reconstructing a cubic millimeter of human cortex using electron microscopy to achieve nanometer resolution. The sample they analyzed was from a 45 year-old woman’s left anterior middle temporal gyrus, which was resected to gain access to an underlying epileptic focus. Machine learning-based
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Sleeping with the zebrafishes Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 George Andrew S. Inglis
Researchers have speculated that sleep facilitates synaptic pruning to rebalance neuronal connections formed during waking hours. In a recent Nature study, Suppermpool et al. tracked the effect of sleep on synapse numbers for individual tectal neurons in larval zebrafish. The authors estimated the number of synapses using fluorescently labeled PSD95, a postsynaptic scaffolding protein, and imaged zebrafish
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Voluntary imaging goes magnetic Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 Luis A. Mejia
Multi-photon cellular imaging of neural activity in rodents typically requires head fixation. In this paper, the authors describe a magnet-based setup that allows for voluntary, self-controlled head fixation and, longitudinal imaging of the same population of neurons in rats, with reliable micrometer-scale registration across trials. This is combined with a reflective conical cannula that boosts the
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Boosting children’s cognitive control does not result in behavioral or neural changes Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07
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Each scar whispers a story Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 Vittorio Gallo, Panagiotis Kratimenos
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In conversation with Aniruddha Das Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 George Inglis
To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Aniruddha Das, an associate professor at Columbia University, New York, USA. Das’s research uses macaque models to explore the cognitive basis of visual processing, attention
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In conversation with Laura Huckins Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 George Inglis
To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Laura Huckins, an associate professor at Yale University School of Medicine, New Haven, USA. Huckins’ research focuses primarily on the genetics of eating disorders and
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In conversation with Alexandra Keinath Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 George Inglis
To celebrate Pride month in the USA, Nature Neuroscience is having conversations with LGBTQIA+ scientists across multiple career stages to discuss their personal and professional experiences in research. In this Q&A, we are talking to Alexandra Keinath, an assistant professor at the University of Illinois, Chicago, USA. Keinath’s research uses both rodent and human models to investigate the neural
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A recurrent network model of planning explains hippocampal replay and human behavior Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 Kristopher T. Jensen, Guillaume Hennequin, Marcelo G. Mattar
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Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 Daniel Holl, Wing Fung Hau, Anais Julien, Shervin Banitalebi, Jannis Kalkitsas, Soniya Savant, Enric Llorens-Bobadilla, Yann Herault, Guillaume Pavlovic, Mahmood Amiry-Moghaddam, David Oliveira Dias, Christian Göritz
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Developmental origin of oligodendrocytes determines their function in the adult brain Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-07 Sarah Foerster, Elisa M. Floriddia, David van Bruggen, Petra Kukanja, Bastien Hervé, Shangli Cheng, Eosu Kim, Benjamin U. Phillips, Christopher J. Heath, Richa B. Tripathi, Cody Call, Theresa Bartels, Katherine Ridley, Björn Neumann, Laura López-Cruz, Abbe H. Crawford, Cian J. Lynch, Manuel Serrano, Lisa Saksida, David H. Rowitch, Wiebke Möbius, Klaus-Armin Nave, Matthew N. Rasband, Dwight E. Bergles
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Cognitive control training with domain-general response inhibition does not change children’s brains or behavior Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-04 Keertana Ganesan, Abigail Thompson, Claire R. Smid, Roser Cañigueral, Yongjing Li, Grace Revill, Vanessa Puetz, Boris C. Bernhardt, Nico U. F. Dosenbach, Rogier Kievit, Nikolaus Steinbeis
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Glial plasticity dysregulation contributes to learning impairments in the neurogenetic disorder NF1 Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-03
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Multiomic profiling of transcription factor binding and function in human brain Nat. Neurosci. (IF 21.2) Pub Date : 2024-06-03 Jacob M. Loupe, Ashlyn G. Anderson, Lindsay F. Rizzardi, Ivan Rodriguez-Nunez, Belle Moyers, Katie Trausch-Lowther, Rashmi Jain, William E. Bunney, Blynn G. Bunney, Preston Cartagena, Adolfo Sequeira, Stanley J. Watson, Huda Akil, Gregory M. Cooper, Richard M. Myers
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Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-30 Yuan Pan, Jared D. Hysinger, Belgin Yalçın, James J. Lennon, Youkyeong Gloria Byun, Preethi Raghavan, Nicole F. Schindler, Corina Anastasaki, Jit Chatterjee, Lijun Ni, Haojun Xu, Karen Malacon, Samin M. Jahan, Alexis E. Ivec, Benjamin E. Aghoghovwia, Christopher W. Mount, Surya Nagaraja, Suzanne Scheaffer, Laura D. Attardi, David H. Gutmann, Michelle Monje
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Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-27 Yong Huang, Minghui Wang, Haofei Ni, Jinglong Zhang, Aiqun Li, Bin Hu, Chrystian Junqueira Alves, Shalaka Wahane, Mitzy Rios de Anda, Lap Ho, Yuhuan Li, Sangjo Kang, Ryan Neff, Ana Kostic, Joseph D. Buxbaum, John F. Crary, Kristen J. Brennand, Bin Zhang, Hongyan Zou, Roland H. Friedel
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NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-27 Yingjun Liu, Jingjing Guo, Maja Matoga, Marina Korotkova, Per-Johan Jakobsson, Adriano Aguzzi
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A single-vector intersectional AAV strategy for interrogating cellular diversity and brain function Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-27 Alex C. Hughes, Brittany G. Pittman, Beisi Xu, Jesse W. Gammons, Charis M. Webb, Hunter G. Nolen, Phillip Chapman, Jay B. Bikoff, Lindsay A. Schwarz
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Simple Behavioral Analysis (SimBA) as a platform for explainable machine learning in behavioral neuroscience Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-22 Nastacia L. Goodwin, Jia J. Choong, Sophia Hwang, Kayla Pitts, Liana Bloom, Aasiya Islam, Yizhe Y. Zhang, Eric R. Szelenyi, Xiaoyu Tong, Emily L. Newman, Klaus Miczek, Hayden R. Wright, Ryan J. McLaughlin, Zane C. Norville, Neir Eshel, Mitra Heshmati, Simon R. O. Nilsson, Sam A. Golden
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Orexin neurons track temporal features of blood glucose in behaving mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-21 Paulius Viskaitis, Alexander L. Tesmer, Ziyu Liu, Mahesh M. Karnani, Myrtha Arnold, Dane Donegan, Eva Bracey, Nikola Grujic, Tommaso Patriarchi, Daria Peleg-Raibstein, Denis Burdakov
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LINE-1 retrotransposons contribute to mouse PV interneuron development Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-21 Gabriela O. Bodea, Juan M. Botto, Maria E. Ferreiro, Francisco J. Sanchez-Luque, Jose de los Rios Barreda, Jay Rasmussen, Muhammed A. Rahman, Laura R. Fenlon, Natasha Jansz, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Darwin J. Da Costa Guevara, Linda Cumner, Charles C. Bell, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H. C. Kempen, Chloe J. Love, Karabi
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Dynamics of mature myelin Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-21 Lindsay A. Osso, Ethan G. Hughes
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Genetic ancestry contributes to gene expression in the brain Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-20
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Towards equitable brain genomics research, for us by us Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-20 Kafui Dzirasa, Gwenaëlle E. Thomas, Alvin C. Hathaway
The increased inclusion of samples from individuals from minoritized communities in biomedical research will help to mitigate health disparities that stem from a medical enterprise founded in racism and exclusion. In this issue of Nature Neuroscience, Benjamin et al. investigate how genetic ancestry influences the expression of genes in the brain, an effort supported by community leaders who raised
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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry Nat. Neurosci. (IF 21.2) Pub Date : 2024-05-20 Kynon J. M. Benjamin, Qiang Chen, Nicholas J. Eagles, Louise A. Huuki-Myers, Leonardo Collado-Torres, Joshua M. Stolz, Geo Pertea, Joo Heon Shin, Apuã C. M. Paquola, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe, Shizhong Han, Daniel R. Weinberger