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Dopamine-mediated interactions between short- and long-term memory dynamics Nature (IF 50.5) Pub Date : 2024-07-22 Cheng Huang, Junjie Luo, Seung Je Woo, Lucas A. Roitman, Jizhou Li, Vincent A. Pieribone, Madhuvanthi Kannan, Ganesh Vasan, Mark J. Schnitzer
In dynamic environments, animals make behavioral decisions based on the innate valences of sensory cues and information learnt about these cues across multiple timescales1–3. However, it remains unclear how the innate valence of a sensory stimulus affects acquisition of learnt valence information and subsequent memory dynamics. Here we show that in the Drosophila brain, interconnected short- and long-term
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Found: the hidden link between star-forming molecular clouds Nature (IF 50.5) Pub Date : 2024-07-19
Connections between three interstellar clouds of gas and dust offer a glimpse into their birth.
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From periphery to center stage: 50 years of advancements in innate immunity Cell (IF 45.5) Pub Date : 2024-07-16
No Abstract
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-16
Proceedings of the National Academy of Sciences, Volume 121, Issue 29, July 2024.
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An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-19
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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-18 Olivier Saulnier, Jamie Zagozewski, Lisa Liang, Liam D. Hendrikse, Paul Layug, Victor Gordon, Kimberly A. Aldinger, Parthiv Haldipur, Stephanie Borlase, Ludivine Coudière-Morrison, Ting Cai, Emma Martell, Naomi M. Gonzales, Gareth Palidwor, Christopher J. Porter, Stéphane Richard, Tanveer Sharif, Kathleen J. Millen, Brad W. Doble, Michael D. Taylor, Tamra E. Werbowetski-Ogilvie
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Biotech news from around the world Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
AstraZeneca and Pfizer will invest almost $1 billion in manufacturing in France. Pfizer will invest $539 million to build R&D capabilities, and AstraZeneca will spend $388 million to upgrade its Dunkirk site. The Coalition for Epidemic Preparedness Innovations awards BioNTech $145 million to build a network in Africa for producing mRNA-based vaccines for malaria, mpox, tuberculosis and other diseases
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Bezos backs taste-good lab proteins Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
Jeff Bezos is bankrolling two new centers to research and develop sustainable proteins that taste good and can be produced in the lab. The Amazon founder is donating $60 million from the Bezos Earth Fund to research, create and commercialize new dietary proteins that are environmentally friendly and affordable. The Bezos Centers for Sustainable Protein at Imperial College London and North Carolina
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Citizen chickpeas Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
The European Union’s biggest citizen science prize for an initiative with the most impact in advancing a sustainable society in Europe has been awarded — and it goes to legumes. The EU Prize for Citizen Science, funded by Horizon Europe, is given to projects in which the general public is engaged in scientific research. This year, the Grand Prize, worth about $64,000, was won by INCREASE, a project
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Vision–language AI assistance in human pathology Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17 Iris Marchal
Pathologists have access to increasingly accurate artificial intelligence (AI) models that can make task-specific or agnostic predictions based on images or genomic data, but a multimodal AI pilot tailored to pathology is still missing. Writing in Nature, Lu et al. introduce PathChat, a generative AI model that can handle both visual and natural language inputs, as a copilot for human pathology. The
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Roche bets on RNA exon editor Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
Roche has struck a partnership with neuro-focused biotech Ascidian Therapeutics over an RNA editing platform. The deal sees the Boston-based Ascidian, a startup with preclinical programs in retinal, neurological and neuromuscular disorders, receive $42 million up front and up to $1.8 billion in milestones and commercial royalties. Under the agreement, Ascidian provides the Swiss pharma with access
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Forum: Lancaster and Pașca Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
In this episode of Forum, Chief Editor Barbara Cheifet speaks with Madeline Lancaster and Sergiu Pașca about organoids — cell cultures derived from stem cells and crafted to replicate a particular organ or certain cell types that make up an organ. These two experts in the field discuss neural organoids specifically, and both how they are being used to study basic biology of the brain and their future
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Counteracting tissue aging through TERT activation Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17 Iris Marchal
Telomere dysfunction is one of the primary hallmarks of aging, causing molecular and cellular damage that is associated with aging-related diseases. A potential strategy to counteract this aging process is the reactivation of the core catalytic subunit of telomerase, telomerase reverse transcriptase (TERT), but compounds targeting TERT are lacking owing to a limited understanding of their downstream
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Cryo-EM structure of a prime editor complex in multiple states Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17 Iris Marchal
Prime editing systems combine a SpCas9 protein with a reverse transcriptase and a prime editing guide RNA (pegRNA) to install a wide variety of genome edits, circumventing the need for DNA double-strand breaks or a DNA donor template. How a prime editor complex initiates and terminates pegRNA-guided reverse transcription remains poorly understood. Now, in Nature, Shuto et al. use cryoelectron microscopy
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Super-resolution microscopy Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
Recent patents relating to systems and methods for super-resolution microscopy.
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From Bench to Podcast: Roman Sarrazin-Gendron Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
On this episode of From Bench to Podcast, our Associate Editor Cláudia Vilhena interviews Roman Sarrazin-Gendron, first author of an absolutely incredible story about … videogames! During this informal chat, Roman and Cláudia talked about the behind-the-scenes of Borderlands Science. They explored the concepts of citizen science, massively multiplayer online video games, and the impact of community
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The cost of drug patent expiration date errors Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17 S. Sean Tu, Dinis Cheian, Sarah Gabriele, Benjamin N. Rome, Aaron S. Kesselheim
Errors in the US Patent and Trademark Office’s automated program to calculate patent expiration dates could result in hundreds of millions of dollars in added costs to drug prices.
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People Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
Recent moves of note in and around the biotech and pharma industries.
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NIH Applicant Assistance Program counteracts decades of underrepresentation in SBIR grant awardees Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17 Katharine L. Korunes, Ethan C. Cissell, Tiger Xie, Eva R. Garland
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Fungal detox: investors eye mycelium bioremediation Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17
The digestive prowess of fungi to decontaminate natural environments from polluting plastics, oil spills, toxic waste and even radiation is gaining traction around the globe.
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Five questions with Ryan Flynn Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17 Michael Francisco
A physician-scientist exploring the mechanisms and physiological relevance of glycoRNAs talks about being useful, the challenges of running a laboratory, and translating foundational knowledge into products that will benefit people.
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A community effort to track commercial single-cell and spatial ’omic technologies and business trends Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-17 Joachim De Jonghe, James W. Opzoomer, Amaia Vilas-Zornoza, Peter Crane, Benedikt S. Nilges, Marco Vicari, Hower Lee, David Lara-Astiaso, Torsten Gross, Jörg Morf, Kim Schneider, Juliana Cudini, Lorenzo Ramos-Mucci, Dylan Mooijman, Katarína Tiklová, Sergio Marco Salas, Christoffer Mattsson Langseth, Nachiket D. Kashikar, Charles E. S. Roberts, Joakim Lundeberg, Mats Nilsson, Alex K. Shalek, Adam P.
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China–US research collaborations are in decline — this is bad news for everyone Nature (IF 50.5) Pub Date : 2024-07-19
Scientists say that the drop in partnerships between the scientific powerhouses will hold back research on priorities such as global warming.
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Hundreds of racist plant names will change after historic vote by botanists Nature (IF 50.5) Pub Date : 2024-07-18
Scientific designations containing a racial slur will be altered — the first time that any species names have been adjusted because of the offence they cause.
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NASA cancels $450-million mission to drill for ice on the Moon — surprising researchers Nature (IF 50.5) Pub Date : 2024-07-18
The already-built rover could now be scrapped for parts.
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Long COVID lung damage linked to immune system response Nature (IF 50.5) Pub Date : 2024-07-18
Inhibiting a protein associated with chronic inflammation improves lung health in mice with COVID-19.
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Three-year delay for Indian census frustrates researchers Nature (IF 50.5) Pub Date : 2024-07-18
Without up-to-date data on the population, scientists say studies on fertility, migration and health outcomes have become unreliable.
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Daily briefing: Blocking an inflammation protein lets mice live longer Nature (IF 50.5) Pub Date : 2024-07-18
Mice live longer and healthier when the inflammation-boosting protein IL-11 is blocked. Plus, how magic mushrooms reset your sense of time and self.
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What is it like to attend a predatory conference? Nature (IF 50.5) Pub Date : 2024-07-18
Nature sent a reporter to find out as part of an investigation into dud events.
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Even with no drug or vaccine, eradication of Guinea worm is in sight Nature (IF 50.5) Pub Date : 2024-07-18
Community-based efforts have reduced the parasitic infection to a handful of cases in humans each year, but the emergence of infections in dogs and other animals threatens to derail progress.
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This tiny solar-powered flyer weighs less than a paper plane Nature (IF 50.5) Pub Date : 2024-07-17
The 4.21g rotorcraft — dubbed CoulombFly — could forge a path to new kinds of tiny aerial vehicles.
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The enduring world forest carbon sink Nature (IF 50.5) Pub Date : 2024-07-17 Yude Pan, Richard A. Birdsey, Oliver L. Phillips, Richard A. Houghton, Jingyun Fang, Pekka E. Kauppi, Heather Keith, Werner A. Kurz, Akihiko Ito, Simon L. Lewis, Gert-Jan Nabuurs, Anatoly Shvidenko, Shoji Hashimoto, Bas Lerink, Dmitry Schepaschenko, Andrea Castanho, Daniel Murdiyarso
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Symbolic recording of signalling and cis-regulatory element activity to DNA Nature (IF 50.5) Pub Date : 2024-07-17 Wei Chen, Junhong Choi, Xiaoyi Li, Jenny F. Nathans, Beth Martin, Wei Yang, Nobuhiko Hamazaki, Chengxiang Qiu, Jean-Benoît Lalanne, Samuel Regalado, Haedong Kim, Vikram Agarwal, Eva Nichols, Anh Leith, Choli Lee, Jay Shendure
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Giant chiral magnetoelectric oscillations in a van der Waals multiferroic Nature (IF 50.5) Pub Date : 2024-07-17 Frank Y. Gao, Xinyue Peng, Xinle Cheng, Emil Viñas Boström, Dong Seob Kim, Ravish K. Jain, Deepak Vishnu, Kalaivanan Raju, Raman Sankar, Shang-Fan Lee, Michael A. Sentef, Takashi Kurumaji, Xiaoqin Li, Peizhe Tang, Angel Rubio, Edoardo Baldini
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Superconductivity in pressurized trilayer La4Ni3O10−δ single crystals Nature (IF 50.5) Pub Date : 2024-07-17 Yinghao Zhu, Di Peng, Enkang Zhang, Bingying Pan, Xu Chen, Lixing Chen, Huifen Ren, Feiyang Liu, Yiqing Hao, Nana Li, Zhenfang Xing, Fujun Lan, Jiyuan Han, Junjie Wang, Donghan Jia, Hongliang Wo, Yiqing Gu, Yimeng Gu, Li Ji, Wenbin Wang, Huiyang Gou, Yao Shen, Tianping Ying, Xiaolong Chen, Wenge Yang, Huibo Cao, Changlin Zheng, Qiaoshi Zeng, Jian-gang Guo, Jun Zhao
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Inhibition of IL-11 signalling extends mammalian healthspan and lifespan Nature (IF 50.5) Pub Date : 2024-07-17 Anissa A. Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh K. Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L. George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A. Sims, Norbert Hübner, Enrico Petretto, Dominic J. Withers, Lena Ho, Jesus Gil, David Carling, Stuart
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An engineered enzyme embedded into PLA to make self-biodegradable plastic Nature (IF 50.5) Pub Date : 2024-07-17 M. Guicherd, M. Ben Khaled, M. Guéroult, J. Nomme, M. Dalibey, F. Grimaud, P. Alvarez, E. Kamionka, S. Gavalda, M. Noël, M. Vuillemin, E. Amillastre, D. Labourdette, G. Cioci, V. Tournier, V. Kitpreechavanich, P. Dubois, I. André, S. Duquesne, A. Marty
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Thresholds for adding degraded tropical forest to the conservation estate Nature (IF 50.5) Pub Date : 2024-07-17 Robert M. Ewers, C. David L. Orme, William D. Pearse, Nursyamin Zulkifli, Genevieve Yvon-Durocher, Kalsum M. Yusah, Natalie Yoh, Darren C. J. Yeo, Anna Wong, Joseph Williamson, Clare L. Wilkinson, Fabienne Wiederkehr, Bruce L. Webber, Oliver R. Wearn, Leona Wai, Maisie Vollans, Joshua P. Twining, Edgar C. Turner, Joseph A. Tobias, Jack Thorley, Elizabeth M. Telford, Yit Arn Teh, Heok Hui Tan, Tom Swinfield
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Adaptation to photoperiod via dynamic neurotransmitter segregation Nature (IF 50.5) Pub Date : 2024-07-17 G. Maddaloni, Y. J. Chang, R. A. Senft, S. M. Dymecki
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A hot-Jupiter progenitor on a super-eccentric retrograde orbit Nature (IF 50.5) Pub Date : 2024-07-17 Arvind F. Gupta, Sarah C. Millholland, Haedam Im, Jiayin Dong, Jonathan M. Jackson, Ilaria Carleo, Jessica Libby-Roberts, Megan Delamer, Mark R. Giovinazzi, Andrea S. J. Lin, Shubham Kanodia, Xian-Yu Wang, Keivan Stassun, Thomas Masseron, Diana Dragomir, Suvrath Mahadevan, Jason Wright, Jaime A. Alvarado-Montes, Chad Bender, Cullen H. Blake, Douglas Caldwell, Caleb I. Cañas, William D. Cochran, Paul
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Psilocybin desynchronizes the human brain Nature (IF 50.5) Pub Date : 2024-07-17 Joshua S. Siegel, Subha Subramanian, Demetrius Perry, Benjamin P. Kay, Evan M. Gordon, Timothy O. Laumann, T. Rick Reneau, Nicholas V. Metcalf, Ravi V. Chacko, Caterina Gratton, Christine Horan, Samuel R. Krimmel, Joshua S. Shimony, Julie A. Schweiger, Dean F. Wong, David A. Bender, Kristen M. Scheidter, Forrest I. Whiting, Jonah A. Padawer-Curry, Russell T. Shinohara, Yong Chen, Julia Moser, Essa
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A eukaryotic-like ubiquitination system in bacterial antiviral defence Nature (IF 50.5) Pub Date : 2024-07-17 Lydia R. Chambers, Qiaozhen Ye, Jiaxi Cai, Minheng Gong, Hannah E. Ledvina, Huilin Zhou, Aaron T. Whiteley, Raymond T. Suhandynata, Kevin D. Corbett
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A holistic platform for accelerating sorbent-based carbon capture Nature (IF 50.5) Pub Date : 2024-07-17 Charithea Charalambous, Elias Moubarak, Johannes Schilling, Eva Sanchez Fernandez, Jin-Yu Wang, Laura Herraiz, Fergus Mcilwaine, Shing Bo Peh, Matthew Garvin, Kevin Maik Jablonka, Seyed Mohamad Moosavi, Joren Van Herck, Aysu Yurdusen Ozturk, Alireza Pourghaderi, Ah-Young Song, Georges Mouchaham, Christian Serre, Jeffrey A. Reimer, André Bardow, Berend Smit, Susana Garcia
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Identification of plant transcriptional activation domains Nature (IF 50.5) Pub Date : 2024-07-17 Nicholas Morffy, Lisa Van den Broeck, Caelan Miller, Ryan J. Emenecker, John A. Bryant, Tyler M. Lee, Katelyn Sageman-Furnas, Edward G. Wilkinson, Sunita Pathak, Sanjana R. Kotha, Angelica Lam, Saloni Mahatma, Vikram Pande, Aman Waoo, R. Clay Wright, Alex S. Holehouse, Max V. Staller, Rosangela Sozzani, Lucia C. Strader
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Position-dependent function of human sequence-specific transcription factors Nature (IF 50.5) Pub Date : 2024-07-17 Sascha H. Duttke, Carlos Guzman, Max Chang, Nathaniel P. Delos Santos, Bayley R. McDonald, Jialei Xie, Aaron F. Carlin, Sven Heinz, Christopher Benner
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Groundwater-dependent ecosystem map exposes global dryland protection needs Nature (IF 50.5) Pub Date : 2024-07-17 Melissa M. Rohde, Christine M. Albano, Xander Huggins, Kirk R. Klausmeyer, Charles Morton, Ali Sharman, Esha Zaveri, Laurel Saito, Zach Freed, Jeanette K. Howard, Nancy Job, Holly Richter, Kristina Toderich, Aude-Sophie Rodella, Tom Gleeson, Justin Huntington, Hrishikesh A. Chandanpurkar, Adam J. Purdy, James S. Famiglietti, Michael Bliss Singer, Dar A. Roberts, Kelly Caylor, John C. Stella
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Singular dielectric nanolaser with atomic-scale field localization Nature (IF 50.5) Pub Date : 2024-07-17 Yun-Hao Ouyang, Hong-Yi Luan, Zi-Wei Zhao, Wen-Zhi Mao, Ren-Min Ma
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Mechanical release of homogenous proteins from supramolecular gels Nature (IF 50.5) Pub Date : 2024-07-17 Simona Bianco, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Bart Dietrich, Matthew Wallace, Qiao Tang, Andrew J. Smith, Matthew I. Gibson, Dave J. Adams
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Clonal inactivation of TERT impairs stem cell competition Nature (IF 50.5) Pub Date : 2024-07-17 Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces, Patrick Neuhöfer, Victoria M. Gillespie, Peggie Cheung, Julia A. Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y. Chang, Steven E. Artandi
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Sources of gene expression variation in a globally diverse human cohort Nature (IF 50.5) Pub Date : 2024-07-17 Dylan J. Taylor, Surya B. Chhetri, Michael G. Tassia, Arjun Biddanda, Stephanie M. Yan, Genevieve L. Wojcik, Alexis Battle, Rajiv C. McCoy
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Sunlight-powered sustained flight of an ultralight micro aerial vehicle Nature (IF 50.5) Pub Date : 2024-07-17 Wei Shen, Jinzhe Peng, Rui Ma, Jiaqing Wu, Jingyi Li, Zhiwei Liu, Jiaming Leng, Xiaojun Yan, Mingjing Qi
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Tubulin code eraser CCP5 binds branch glutamates by substrate deformation Nature (IF 50.5) Pub Date : 2024-07-17 Jiayi Chen, Elena A. Zehr, James M. Gruschus, Agnieszka Szyk, Yanjie Liu, Martin E. Tanner, Nico Tjandra, Antonina Roll-Mecak
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Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly Nature (IF 50.5) Pub Date : 2024-07-17 Jens Hör, Sharon G. Wolf, Rotem Sorek
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In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution Nature (IF 50.5) Pub Date : 2024-07-17 Peter F. Renz, Umesh Ghoshdastider, Simona Baghai Sain, Fabiola Valdivia-Francia, Ameya Khandekar, Mark Ormiston, Martino Bernasconi, Clara Duré, Jonas A. Kretz, Minkyoung Lee, Katie Hyams, Merima Forny, Marcel Pohly, Xenia Ficht, Stephanie J. Ellis, Andreas E. Moor, Ataman Sendoel
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Split intein-mediated protein trans-splicing to express large dystrophins Nature (IF 50.5) Pub Date : 2024-07-17 Hichem Tasfaout, Christine L. Halbert, Timothy S. McMillen, James M. Allen, Theodore R. Reyes, Galina V. Flint, Dirk Grimm, Stephen D. Hauschka, Michael Regnier, Jeffrey S. Chamberlain
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The plastic that biodegrades in your home compost Nature (IF 50.5) Pub Date : 2024-07-17
Hear the biggest stories from the world of science | 17 July 2024
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Mice live longer when inflammation-boosting protein is blocked Nature (IF 50.5) Pub Date : 2024-07-17
Humans also have the protein, called IL-11, offering hope for a future longevity treatment.
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A psychedelic state arises from desynchronized brain activity Nature (IF 50.5) Pub Date : 2024-07-17 Petros D. Petridis
Psilocybin induces profound changes in brain connectivity.
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Daily briefing: The poetry hidden in PhD thesis acknowledgements Nature (IF 50.5) Pub Date : 2024-07-17
Science writer Tabitha Carvan explores the found poetry in the acknowledgement sections of PhD theses. Plus, researchers should explore the alternatives to animal research and can H5N1 spread through cow sneezes?
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The search for superconductivity just got wider Nature (IF 50.5) Pub Date : 2024-07-17 Weiwei Xie
Evidence of superconductivity in a nickelate under high pressure.