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Why so slow? Models of parkinsonian bradykinesia Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-27 David Williams
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Timescales of learning in prefrontal cortex Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-27 Jacob A. Miller, Christos Constantinidis
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The power of direct observation: discovery of REM sleep Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-20 Danqian Liu
In this Journal Club, Danqian Liu describes the 1953 paper that reported the discovery of rapid eye movement (REM) sleep.
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Gene therapy for CNS disorders: modalities, delivery and translational challenges Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-19 Jingjing Gao, Swetharajan Gunasekar, Ziting (Judy) Xia, Kiruba Shalin, Christopher Jiang, Hao Chen, Dongtak Lee, Sohyung Lee, Nishkal D. Pisal, James N. Luo, Ana Griciuc, Jeffrey M. Karp, Rudolph Tanzi, Nitin Joshi
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Lessons on predictive learning from the honeybee Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-11 Sabine Krabbe
Sabine Krabbe describes a 1993 study of classical conditioning in the honeybee that provided early insights into the mechanisms of predictive learning.
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Fear, anxiety and the functional architecture of the human central extended amygdala Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-10 Alexander J. Shackman, Shannon E. Grogans, Andrew S. Fox
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A pas de deux between the hippocampus and the cortex during sleep Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-05 Adrien Peyrache
In this Journal Club, Adrien Peyrache highlights a 1998 paper that showed memory formation as a dynamic process involving multiple brain areas.
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Pattern recognition using action potential timing Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-03 Izumi Fukunaga
In this Journal Club, Izumi Fukunaga discusses John Hopfield’s 1995 paper, which proposed a mechanism by which a continuously variable sensory stimulus can be transformed into a timing-based code.
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Common principles for odour coding across vertebrates and invertebrates Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-28 Kara A. Fulton, David Zimmerman, Aravi Samuel, Katrin Vogt, Sandeep Robert Datta
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The neuropathobiology of multiple sclerosis Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-24 Marcel S. Woo, Jan Broder Engler, Manuel A. Friese
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Network state transitions during cortical development Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-23 Michelle W. Wu, Nazim Kourdougli, Carlos Portera-Cailliau
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Brain functional networks and psychiatric disorders Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-17 Isobel Leake
Mendelian randomization analyses reveal potential causal associations between dysfunction of brain functional networks and psychiatric disorders.
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Mapping the social memory network Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-15 Maria Papatriantafyllou
Social memory enables animals to recognize familiar conspecifics and determines behaviours that are crucial for survival. Wang et al. now describe a neural circuit in mice that links the thalamic reticular nucleus (TRN) to social memory. Neuroanatomical and functional tracing identified cells of the parafascicular thalamic nucleus (PF) as the main postsynaptic targets of sTRNPvalb, and glutamatergic
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The speech neuroprosthesis Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-14 Alexander B. Silva, Kaylo T. Littlejohn, Jessie R. Liu, David A. Moses, Edward F. Chang
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Unravelling nature and nurture in cortical (re)organization Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-08 Tina T. Liu
In this Journal Club, Tina Liu describes a 1988 paper that revealed the capacity of the sensory cortex for functional reorganization
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Remapping revisited: how the hippocampus represents different spaces Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-07 André A. Fenton
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Stress drives seeking of starvation Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-02 Katherine Whalley
A subset of female mice that show anxiety-related traits seek out a starvation-like state when exposed to repeated stress
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Engram mechanisms of memory linking and identity Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-25 Ali Choucry, Masanori Nomoto, Kaoru Inokuchi
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Skill switching Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-25 Sian Lewis
The main direction of motor skill-specific information between rat primary motor cortex and dorsolateral striatum is shown to switch from cortex-predominant before learning to striatum-predominant after learning.
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The molecular determinants of microglial developmental dynamics Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-24 Liam Barry-Carroll, Diego Gomez-Nicola
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Attentional capture Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-15 Isobel Leake
A large network of brain regions is involved in salient distractor processing.
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The language network as a natural kind within the broader landscape of the human brain Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-12 Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev
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Key genes and convergent pathogenic mechanisms in Parkinson disease Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-10 Robert Coukos, Dimitri Krainc
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From compulsivity to compulsion: the neural basis of compulsive disorders Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-09 Trevor W. Robbins, Paula Banca, David Belin
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Natural primate neurobiology Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-04 Jake Rogers
A new study captures nearly the full repertoire of primate natural behaviour and reveals that highly distributed cortical activity maintains multifaceted dynamic social relationships.
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A structural role for SynGAP Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-04 Darran Yates
The synaptic protein SynGAP exerts its effects on synaptic plasticity via a structural role rather than its GTPase-activating protein activity.
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Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-04 Martin Kampmann
The selective vulnerability of specific neuronal subtypes is a hallmark of neurodegenerative diseases. In this Review, I summarize our current understanding of the brain regions and cell types that are selectively vulnerable in different neurodegenerative diseases and describe the proposed underlying cell-autonomous and non-cell-autonomous mechanisms. I highlight how recent methodological innovations
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mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-26 Teresa Ravizza, Mirte Scheper, Rossella Di Sapia, Jan Gorter, Eleonora Aronica, Annamaria Vezzani
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Coding corners Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-14 Katherine Whalley
Neurons in the mouse subiculum encode concave and convex geometrical environmental features.
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Barriers and brain fog Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-14 Sian Lewis
One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this study to be linked to systemic inflammation and leakiness of the blood–brain barrier.
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How the brain’s primary processing units compute to give rise to intelligence Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-13 Ning-long Xu
Ning-long Xu discusses a 1999 paper that outlined a mechanism by which cortical pyramidal neurons integrate layer-specific inputs.
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Fear bypasses the amygdala Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-08 Sian Lewis
Innate fear-like responses are thought to involve the amygdala, but here a tetra-synaptic pathway is identified that mediates odour-evoked innate fear in mice.
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Preparatory activity and the expansive null-space Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-05 Mark M. Churchland, Krishna V. Shenoy
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Overnight neuronal plasticity and adaptation to emotional distress Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-05 Yesenia Cabrera, Karin J. Koymans, Gina R. Poe, Helmut W. Kessels, Eus J. W. Van Someren, Rick Wassing
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MMP8 and stress susceptibility Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-04 Darran Yates
Increased levels of matrix metalloproteinase 8, expressed by circulating myeloid cells, may have a role in stress-induced changes in social behaviour in mice.
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Social representation Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-04 Katherine Whalley
Populations of neurons in the mouse hippocampus use distinct representational strategies to encode familiarity and episodic social memory.
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Olfactory neurons can feel the (heart) beat Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-02-26 Katherine Whalley
Blood pressure pulsations modulate the activity of neurons in the rodent olfactory bulb via the mechanosensitive ion channel PIEZO2
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Response sub-additivity and variability quenching in visual cortex Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-02-19 Robbe L. T. Goris, Ruben Coen-Cagli, Kenneth D. Miller, Nicholas J. Priebe, Máté Lengyel
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Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-02-19 Inna Slutsky
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The human hippocampus beyond episodic memory Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-02-08 Valeria Della-Maggiore
In this Journal Club, Valeria Della-Maggiore highlights a 2017 paper that provided key evidence for a role for the hippocampus in motor skill learning
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Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-02-05 Clarissa M. D. Mota, Christopher J. Madden
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The cognitive impact of light: illuminating ipRGC circuit mechanisms Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-26 Heather L. Mahoney, Tiffany M. Schmidt
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Neurons in the hypothalamus counteract ageing in mice Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-25 Joseph Willson
In mice, a subset of neurons in the dorsomedial hypothalamus control sympathetic nervous system signalling to adipose tissue and are dysregulated with age; activating these neurons prolongs lifespan and slows the decline in physical activity associated with ageing.
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Curiosity: primate neural circuits for novelty and information seeking Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-23 Ilya E. Monosov
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Goal-directed learning in adolescence: neurocognitive development and contextual influences Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-23 Linda Wilbrecht, Juliet Y. Davidow
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Tightening synaptic relations Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-19 Lisa Heinke
A study analyses the nanotopography of presynaptic calcium channels and release sensors and the degree of their coupling during maturation of an inhibitory synapse.
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Causation in neuroscience: keeping mechanism meaningful Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-11 Lauren N. Ross, Dani S. Bassett
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Cell type-specific roles of APOE4 in Alzheimer disease Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-08 Jessica Blumenfeld, Oscar Yip, Min Joo Kim, Yadong Huang
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Data-driven modelling of neurodegenerative disease progression: thinking outside the black box Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-08 Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Nick C. Fox, Frederik Barkhof, Jonathan M. Schott, Daniel C. Alexander
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A neuronal cluster involved in arousal and breathing Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-04 Darran Yates
A study reveals a subpopulation of neuropeptide S-expressing neurons that regulates arousal and breathing.
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Mistaken identity Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-05 Sian Lewis
Around 10% of individuals with frontotemporal lobar dementia have amyloid filament inclusions that lack tau and TDP-43 and were thought to contain the protein FUS, but are found instead to contain the FUS homologue TAF15.
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A neuronal subcompartment view of ATP production Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-05 Darran Yates
A study indicates that different mechanisms of ATP production predominate in different cellular subcompartments in neurons.
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Orchestrating axonal organization Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-05 Lisa Heinke
Cytoplasmic mislocalization of TDP-43 in neurodegenerative disease affects mRNA maturation and protein levels of stathmin-2, leading to a reduction in axon diameter and tearing of outer myelin layers and thereby disrupting neuronal function.
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Promoting axon regeneration after injury Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-04 Darran Yates
A study in mice identifies formin 2 as a regulator of axon regeneration and a potential target for promoting nerve repair after peripheral nerve injury.
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Understanding neural circuit function through synaptic engineering Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-01-03 Ithai Rabinowitch, Daniel A. Colón-Ramos, Michael Krieg
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Self-recognition mirrored from others Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2023-12-22 Jake Rogers
A mark test of self-recognition in mice reveals that self-responding ventral CA1 neurons underlie mirror-induced self-directed behaviour and are shaped by social experience with conspecifics.
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Controlling communication Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2023-12-19 Katherine Whalley
A small population of neurons in the mouse brainstem coordinate sound production and volume control during vocalizations.
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Benefit worth the cost Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2023-12-15 Jake Rogers
A study in mice helps to resolve a debate surrounding striatal DA dynamics and reward benefit or cost and also reveals motivation and transient striatal DA release have a bidirectional causal relationship.
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Preparing for motherhood Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2023-12-08 Katherine Whalley
In mice, specific pools of adult neural stem cells are recruited during pregnancy to support postpartum maternal behaviour.
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The neurobiology of SARS-CoV-2 infection Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2023-12-04 Jenny Meinhardt, Simon Streit, Carsten Dittmayer, Regina v. Manitius, Helena Radbruch, Frank L. Heppner