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Gene therapy for deafness: we can do more Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-12-18 Yuxin Chen, Jiake Zhong, Yilai Shu
Challenges in the development of treatments for hereditary hearing loss include the exploration of the underlying pathological mechanisms, the comprehensive evaluation of safety and efficacy of gene therapies in clinical trials, the optimization of surgical approaches for drug delivery, and effective collaboration between industry and academia. Gene therapy for congenital deafness has made a breakthrough
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Genomic landscape of cancer in racially and ethnically diverse populations Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-28 Claire E. Thomas, Ulrike Peters
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The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-25 Mina L. Kojima, Caroline Hoppe, Antonio J. Giraldez
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The lives of cells, recorded Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-25 Amjad Askary, Wei Chen, Junhong Choi, Lucia Y. Du, Michael B. Elowitz, James A. Gagnon, Alexander F. Schier, Sophie Seidel, Jay Shendure, Tanja Stadler, Martin Tran
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Biobanking with genetics shapes precision medicine and global health Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-20 C. Scott Gallagher, Geoffrey S. Ginsburg, Anjené Musick
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Plant pattern recognition receptors: from evolutionary insight to engineering Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-11 Simon Snoeck, Oliver Johanndrees, Thorsten Nürnberger, Cyril Zipfel
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Exploring biodiversity through museomics Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-06 Charles C. Davis, Sandra Knapp
Natural history collections are unparalleled resources for studying biodiversity across multiple dimensions. As multi-omic tools are being applied to museum specimens, the emerging field of museomics is undergoing a rapid and exciting transformation, with new opportunities, challenges and confrontations with past legacies. In this Comment, the authors showcase how the emerging field of museomics —
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Genetic conflict and its resolution between the sexes Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-06 Abderrahman Khila
Abderrahman Khila highlights an important 2015 paper by Barson et al. that demonstrated how sexual conflict in Atlantic salmon affects genetic evolution.
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The design and engineering of synthetic genomes Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-06 Joshua S. James, Junbiao Dai, Wei Leong Chew, Yizhi Cai
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Slide-tags enables spatial single-nucleus sequencing Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-04 Andrew J. C. Russell
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Context-specific regulatory variants in precision medicine and agriculture Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-29 Lingzhao Fang
Lingzhao Fang recalls how a 2002 paper by Brem et al., which investigated the genetic basis of natural variation in gene expression in budding yeast, and the GTEx atlas of genetic regulatory effects across human tissues inspired the FarmGTEx project to accelerate precision agriculture.
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The phenotypic consequences of enhancer evolution Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-29 Julie Jung, Thomas King
In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes underlying recurrent phenotypic evolution in stickleback fish.
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Cohesin and CTCF emerge as building blocks of 3D genome structure Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-25 Julia Horsfield
In this Journal Club, Julia Horsfield recounts two papers that demonstrated how cohesin and CTCF together organize the genome and regulate gene expression.
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Functional specificity in biomolecular condensates revealed by genetic complementation Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-21 Benjamin R. Sabari, Anthony A. Hyman, Denes Hnisz
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How the waxing and waning of a mutation determines HIV treatment success Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-21 Pleuni S. Pennings
In this Journal Club, Pleuni Pennings recalls two papers that connected the evolutionary dynamics of HIV variants with therapeutic outcomes, illustrating how evolutionary insights can inform public health decisions.
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Ethical governance for genomic data science in the cloud Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-18 Vasiliki Rahimzadeh, Sarah C. Nelson, Adrian Thorogood, Jonathan Lawson, Stephanie M. Fullerton
Cloud platforms offer distinct advantages, but questions remain about how to ethically and efficiently manage human genomic data in the cloud. Data governance needs to be adapted to ensure transparency and security for research participants, as well as equitable and sustainable access for researchers. Rahimzadeh et al. discuss the ethical, legal and social implications of storing and analysing human
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A brief history of metabolic gradient theory Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-16 Berna Sozen
In this Journal Club, Berna Sozen recalls the metabolic gradient theory proposed by Charles Manning Child in the early 20th century, which posited that metabolic gradients drive cellular differentiation and tissue patterning.
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Single-cell expression profiling has its roots in in situ techniques Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-09 Shila Ghazanfar
In this Journal Club, Shila Ghazanfar highlights a seminal paper by Levsky et al. that paved the way for contemporary single-cell spatial transcriptomics.
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Systemic cell–cell communication in cancer Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-08 Edroaldo Lummertz da Rocha
In this Journal Club article, Edroaldo Lummertz da Rocha discusses two papers that provided important insights into how tumour cells communicate with distant organs to establish pre-metastatic niches.
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Genome-wide association testing beyond SNPs Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-07 Laura Harris, Ellen M. McDonagh, Xiaolei Zhang, Katherine Fawcett, Amy Foreman, Petr Daneck, Panagiotis I. Sergouniotis, Helen Parkinson, Francesco Mazzarotto, Michael Inouye, Edward J. Hollox, Ewan Birney, Tomas Fitzgerald
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A call to action to scale up research and clinical genomic data sharing Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-07 Zornitza Stark, David Glazer, Oliver Hofmann, Augusto Rendon, Christian R. Marshall, Geoffrey S. Ginsburg, Chris Lunt, Naomi Allen, Mark Effingham, Jillian Hastings Ward, Sue L. Hill, Raghib Ali, Peter Goodhand, Angela Page, Heidi L. Rehm, Kathryn N. North, Richard H. Scott
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Endogenous retroviruses: unveiling new targets for cancer immunotherapy Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-03 Shengbao Suo
In this Journal Club, Shengbao Suo highlights two publications that underscore the importance of genetic regulation of endogenous retrovirus expression in tumours.
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From computational models of the splicing code to regulatory mechanisms and therapeutic implications Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-10-02 Charlotte Capitanchik, Oscar G. Wilkins, Nils Wagner, Julien Gagneur, Jernej Ule
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Inference and applications of ancestral recombination graphs Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-30 Rasmus Nielsen, Andrew H. Vaughn, Yun Deng
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Selection on structural variation in the amylase locus Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-27 Kirsty Minton
Bolognini et al. report evidence of positive selection for human amylase gene duplications associated with the agricultural revolution.
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The evolution of DNA sequencing with microfluidics Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-27 Camille L. G. Lambert, Guido van Mierlo, Johannes J. Bues, Orane J. Guillaume-Gentil, Bart Deplancke
The adoption of microfluidics was fundamental to the development of cost-effective, high-throughput DNA sequencing. As the field progresses towards multi-omics, we reflect on the key concepts underlying microfluidics and how resulting engineering advances at the microscale drove the evolution of genomic sequencing. The adoption of microfluidics was fundamental to the development of cost-effective,
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Genome-scale models in human metabologenomics Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-19 Adil Mardinoglu, Bernhard Ø. Palsson
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Tumbling bacteria and non-genetic individuality Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-18 Alejo E. Rodriguez-Fraticelli
In this Journal Club, Alejo Rodriguez-Fratelli discusses a paper by Spudich and Koshland Jr that characterized non-genetic cell individuality in bacteria, a concept with emerging relevance to cancer progression.
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Gene synthesis from a non-coding RNA Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-18 Linda Koch
A study in Science investigating bacterial defence mechanisms against phages reports a novel mode of gene regulation through reverse transcription of a non-coding RNA template, leading to the formation of a toxic repetitive gene.
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Identifying off-target effects of genome editing with Tracking-seq Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-17 Ming Zhu
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Reshaping Waddington’s developmental landscape Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-17 Yimiao Qu, Kyle M. Loh
Yimiao Qu and Kyle Loh discuss a 2004 paper by Xie et al., who demonstrated that B cells can be reprogrammed into macrophages through the enforced expression of a single transcription factor, providing insights into cellular plasticity and lineage conversion.
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Why geneticists should care about male infertility Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-16 Joris A. Veltman, Frank Tüttelmann
The widespread use of medically assisted reproduction fosters the false impression that the underlying causes of male infertility are not important to know. However, to improve men’s reproductive and long-term health, as well as the health of their offspring, large-scale genetic studies are essential. Thus, reproductive genomics should be implemented in diagnostics as soon as possible. In this Comment
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Progress in toxicogenomics to protect human health Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-09-02 Matthew J. Meier, Joshua Harrill, Kamin Johnson, Russell S. Thomas, Weida Tong, Julia E. Rager, Carole L. Yauk
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The complex non-genetic inheritance of complex traits Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-08-29 Merly C. Vogt
Merly C. Vogt recalls a seminal paper by Greer et al., who demonstrated the transgenerational inheritance of longevity, a complex trait, in Caenorhabditis elegans by manipulating the trimethylation of histone H3 lysine 4 (H3K4me3) in the parental generation.
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Convergent evolution of prickles across crops Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-08-22 Henry Ertl
Satterlee et al. employ several approaches to demonstrate that prickle evolution has a common genetic basis among several plant lineages.
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Mosaic variegated aneuploidy in development, ageing and cancer Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-08-21 Marcos Malumbres, Carolina Villarroya-Beltri
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Multifunctional histone variants in genome function Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-08-13 Lee H. Wong, David J. Tremethick
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Position-dependent effects of transcription factor binding Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-08-12 Kirsty Minton
Duttke et al. show that transcription factors have position-dependent effects relative to their distance from the transcription start site, which suggests that a 'spatial grammar' could be used to encode multiple gene-regulatory programmes.
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DNA methylation in mammalian development and disease Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-08-12 Zachary D. Smith, Sara Hetzel, Alexander Meissner
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Reconstructing generation intervals over time Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-08-05 Pablo Librado
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Chromosomal instability as a driver of cancer progression Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-29 Xuelan Chen, Albert S. Agustinus, Jun Li, Melody DiBona, Samuel F. Bakhoum
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Epigenetic editing works like a CHARM Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-22 Kirsty Minton
Neumann, Bertozzi et al. describe a novel epigenetic editor termed CHARM and report its use to silence prion protein expression in the brain.
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Evolution and regulation of animal sex chromosomes Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-18 Zexian Zhu, Lubna Younas, Qi Zhou
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Programmable DNA rearrangements using bridge RNAs Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-12 Henry Ertl
Two studies in Nature reveal the mechanistic and structural properties of a family of mobile genetic elements that can be reprogrammed to engineer genome modifications.
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Publisher Correction: How germ granules promote germ cell fate Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-09 Melissa C. Pamula, Ruth Lehmann
Correction to: Nature Reviews Genetics https://doi.org/10.1038/s41576-024-00744-8, published online 18 June 2024.
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Decoding protein–RNA interactions using CLIP-based methodologies Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-09 Joy S. Xiang, Danielle M. Schafer, Katherine L. Rothamel, Gene W. Yeo
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Decoding the language of chromatin modifications with MARCS Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-05 Andrey Tvardovskiy, Saulius Lukauskas
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Revealing gene function with statistical inference at single-cell resolution Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-07-01 Cole Trapnell
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Charting the evolutionary history of malaria Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-26 Linda Koch
A study in Nature charts the history of malaria in the Americas from ancient Plasmodium parasite genomes.
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Methods and applications of genome-wide profiling of DNA damage and rare mutations Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-25 Gerd P. Pfeifer, Seung-Gi Jin
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Sequencing-based analysis of microbiomes Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-25 Yishay Pinto, Ami S. Bhatt
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A digital marker for coronary artery disease Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-24 Linda Koch
Petrazzini et al. leverage exome sequencing data and a novel machine learning-based marker to identify rare and ultra-rare coding variants associated with coronary artery disease.
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Tandem repeats in the long-read sequencing era Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-19
Tandem repeats are ubiquitous in the human genome and hold crucial information about our genetic diversity, evolution and susceptibility to disease.
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How germ granules promote germ cell fate Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-18 Melissa C. Pamula, Ruth Lehmann
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BRCA1 and friends 30 years on Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-17 William D. Foulkes
With the benefit of hindsight, recognition of the cancer susceptibility gene BRCA1 and its later cloning were defining moments for breast and ovarian cancer genetics that should be celebrated. Thirty years after the discovery and cloning of the cancer susceptibility gene BRCA1, William Foulkes reflects on this defining moment for breast and ovarian cancer genetics and how far the field has come.
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DNA packaging by molecular motors: from bacteriophage to human chromosomes Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-17 Bram Prevo, William C. Earnshaw
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Next-generation data filtering in the genomics era Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-14 William Hemstrom, Jared A. Grummer, Gordon Luikart, Mark R. Christie
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From Mendel’s laws to non-Mendelian inheritance Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-12 Laura Ross
In this Journal Club article, Laura Ross discusses several seminal papers that describe the discovery of germline-specific chromosomes and paternal genome elimination, striking examples of non-Mendelian genetics.
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Mini-colons unlock tumour development outside the body Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-06-05 L. Francisco Lorenzo-Martín, Matthias P. Lutolf
更新日期：2024-11-25
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