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Microviridae bacteriophages in the gut microbiome and food addiction in humans Nat. Metab. (IF 18.9) Pub Date : 2024-11-20
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Human PERIOD3 variants lead to winter depression-like behaviours via glucocorticoid signalling Nat. Metab. (IF 18.9) Pub Date : 2024-11-11 Qian Gao, Zhiwei Tang, Haili Wang, Maya Yamazaki, Jia Jiang, Ying-Hui Fu, Louis J. Ptacek, Luoying Zhang
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AI-READI: rethinking AI data collection, preparation and sharing in diabetes research and beyond Nat. Metab. (IF 18.9) Pub Date : 2024-11-08
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Diabetes, IL-10 and the brain’s microvascular crisis Nat. Metab. (IF 18.9) Pub Date : 2024-11-04 Celine E. Riera
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A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes Nat. Metab. (IF 18.9) Pub Date : 2024-11-04 Sorabh Sharma, Manjinder Cheema, Patrick L. Reeson, Kamal Narayana, Roobina Boghozian, Ana Paula Cota, Tara P. Brosschot, Rachael D. FitzPatrick, Jakob Körbelin, Lisa A. Reynolds, Craig E. Brown
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Effect of acute exercise in carriers of TBC1D4 mutation Nat. Metab. (IF 18.9) Pub Date : 2024-10-31 Leslie J. Baier, Clifton Bogardus
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Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise Nat. Metab. (IF 18.9) Pub Date : 2024-10-31 Jonas M. Kristensen, Rasmus Kjøbsted, Trine J. Larsen, Christian S. Carl, Janne R. Hingst, Johan Onslev, Jesper B. Birk, Anette Thorup, Dorte E. Steenberg, Jonas R. Knudsen, Nicolai S. Henriksen, Elise J. Needham, Jens F. Halling, Anders Gudiksen, Carsten F. Rundsten, Kristian E. Hanghøj, Sara E. Stinson, Birgitte Hoier, Camilla C. Hansen, Thomas E. Jensen, Ylva Hellsten, Henriette Pilegaard, Niels
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Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells Nat. Metab. (IF 18.9) Pub Date : 2024-10-29 Wusheng Xiao, Nishith Shrimali, Niv Vigder, William M. Oldham, Clary B. Clish, Huamei He, Samantha J. Wong, Bradley M. Wertheim, Elena Arons, Marcia C. Haigis, Jane A. Leopold, Joseph Loscalzo
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TrkB signalling regulates dopamine circuits and motor function through metabolic pathways Nat. Metab. (IF 18.9) Pub Date : 2024-10-28
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Impaired striatal glutathione–ascorbate metabolism induces transient dopamine increase and motor dysfunction Nat. Metab. (IF 18.9) Pub Date : 2024-10-28 Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N. Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E. Walton, Peter J. Magill, Claus Nerlov, Liliana Minichiello
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Quantitation of metabolic activity from isotope tracing data using automated methodology Nat. Metab. (IF 18.9) Pub Date : 2024-10-25 Shiyu Liu, Xiaojing Liu, Jason W. Locasale
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Publisher Correction: Exploring pancreatic beta-cell subgroups and their connectivity. Nat. Metab. (IF 18.9) Pub Date : 2024-10-23 Guy A Rutter,Anne Gresch,Luis Delgadillo Silva,Richard K P Benninger
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Farnesyl pyrophosphate modulates dendritic cell migration in lupus autoimmunity Nat. Metab. (IF 18.9) Pub Date : 2024-10-18
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Farnesyl pyrophosphate potentiates dendritic cell migration in autoimmunity through mitochondrial remodelling Nat. Metab. (IF 18.9) Pub Date : 2024-10-18 Xiaomin Zhang, Yali Chen, Geng Sun, Yankang Fei, Ha Zhu, Yanfang Liu, Junyan Dan, Chunzhen Li, Xuetao Cao, Juan Liu
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Genetics brings new insight to β-cell function Nat. Metab. (IF 18.9) Pub Date : 2024-10-17 Amélie Bonnefond, Philippe Froguel
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Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology Nat. Metab. (IF 18.9) Pub Date : 2024-10-17 A. L. Madsen, S. Bonàs-Guarch, S. Gheibi, R. Prasad, J. Vangipurapu, V. Ahuja, L. R. Cataldo, O. Dwivedi, G. Hatem, G. Atla, M. Guindo-Martínez, A. M. Jørgensen, A. E. Jonsson, I. Miguel-Escalada, S. Hassan, A. Linneberg, Tarunveer S. Ahluwalia, T. Drivsholm, O. Pedersen, T. I. A. Sørensen, A. Astrup, D. Witte, P. Damm, T. D. Clausen, E. Mathiesen, T. H. Pers, R. J. F. Loos, L. Hakaste, M. Fex, N.
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Cytosolic acetyl-CoA synthesis shields mitochondria from stress in brown adipocytes Nat. Metab. (IF 18.9) Pub Date : 2024-10-15
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Itaconate modulates mitochondria for antiviral IFN-β Nat. Metab. (IF 18.9) Pub Date : 2024-10-15 Thekla Cordes, Karsten Hiller
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Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase Nat. Metab. (IF 18.9) Pub Date : 2024-10-15 Shane M. O’Carroll, Christian G. Peace, Juliana E. Toller-Kawahisa, Yukun Min, Alexander Hooftman, Sara Charki, Louise Kehoe, Maureen J. O’Sullivan, Aline Zoller, Anne F. Mcgettrick, Emily A. Day, Maria Simarro, Neali Armstrong, Justin P. Annes, Luke A. J. O’Neill
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David H. Wasserman (1958–2024) Nat. Metab. (IF 18.9) Pub Date : 2024-10-14 Julio E. Ayala, Owen P. McGuinness, Antentor Hinton
We have lost a distinguished scientist who made indelible contributions to our knowledge of exercise physiology and diabetes and was an advocate for mentoring and transparency in research.
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Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress Nat. Metab. (IF 18.9) Pub Date : 2024-10-14 Ekaterina D. Korobkina, Camila Martinez Calejman, John A. Haley, Miranda E. Kelly, Huawei Li, Maria Gaughan, Qingbo Chen, Hannah L. Pepper, Hafsah Ahmad, Alexander Boucher, Shelagh M. Fluharty, Te-Yueh Lin, Anoushka Lotun, Jessica Peura, Sophie Trefely, Courtney R. Green, Paula Vo, Clay F. Semenkovich, Jason R. Pitarresi, Jessica B. Spinelli, Ozkan Aydemir, Christian M. Metallo, Matthew D. Lynes, Cholsoon
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Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis Nat. Metab. (IF 18.9) Pub Date : 2024-09-27 Sandeep Das, Alexandra C. Finney, Sumit Kumar Anand, Sumati Rohilla, Yuhao Liu, Nilesh Pandey, Alia Ghrayeb, Dhananjay Kumar, Kelley Nunez, Zhipeng Liu, Fabio Arias, Ying Zhao, Brenna H. Pearson-Gallion, M. Peyton McKinney, Koral S. E. Richard, Jose A. Gomez-Vidal, Chowdhury S. Abdullah, Elizabeth D. Cockerham, Joseph Eniafe, Andrew D. Yurochko, Tarek Magdy, Christopher B. Pattillo, Christopher G.
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Causal drivers of human proteome variation in health and disease Nat. Metab. (IF 18.9) Pub Date : 2024-09-26 Paul W. Franks, Daniel E. Coral
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Humans without GDF15 reassure drug developers Nat. Metab. (IF 18.9) Pub Date : 2024-09-26 Samuel N. Breit, Stephen O’Rahilly
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Identification and characterization of human GDF15 knockouts Nat. Metab. (IF 18.9) Pub Date : 2024-09-26 Allan M. Gurtan, Shareef Khalid, Christopher Koch, Maleeha Zaman Khan, Lindsey B. Lamarche, Igor Splawski, Elizabeth Dolan, Ana M. Carrion, Richard Zessis, Matthew E. Clement, Zhiping Chen, Loren D. Lindsley, Yu-Hsin Chiu, Ryan S. Streeper, Daniel P. Denning, Allison B. Goldfine, Brian Doyon, Ali Abbasi, Jennifer L. Harrow, Kazuhisa Tsunoyama, Makoto Asaumi, Ikuyo Kou, Alan R. Shuldiner, Juan L. Rodriguez-Flores
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Mapping biological influences on the human plasma proteome beyond the genome Nat. Metab. (IF 18.9) Pub Date : 2024-09-26 Julia Carrasco-Zanini, Eleanor Wheeler, Burulça Uluvar, Nicola Kerrison, Mine Koprulu, Nicholas J. Wareham, Maik Pietzner, Claudia Langenberg
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Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health Nat. Metab. (IF 18.9) Pub Date : 2024-09-25 Sam M. Lockhart, Milan Muso, Ilona Zvetkova, Brian Y. H. Lam, Alessandra Ferrari, Erik Schoenmakers, Katie Duckett, Jack Leslie, Amy Collins, Beatriz Romartínez-Alonso, John A. Tadross, Raina Jia, Eugene J. Gardner, Katherine Kentistou, Yajie Zhao, Felix Day, Alexander Mörseburg, Kara Rainbow, Debra Rimmington, Matteo Mastantuoni, James Harrison, Meritxell Nus, Khalid Guma’a, Sam Sherratt-Mayhew, Xiao
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Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota Nat. Metab. (IF 18.9) Pub Date : 2024-09-25 Shi-Long Zhang, Xin Wang, Qing-Qing Cai, Chen Chen, Zheng-Yan Zhang, Ya-Yun Xu, Meng-Xuan Yang, Qing-An Jia, Yan Wang, Zhi-Ming Wang
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Exercise inhibits cellular senescence in pancreatic islets Nat. Metab. (IF 18.9) Pub Date : 2024-09-24 Gregory D. Cartee
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Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence Nat. Metab. (IF 18.9) Pub Date : 2024-09-24 Priscila Carapeto, Kanako Iwasaki, Francesko Hela, Jiho Kahng, Ana B. Alves-Wagner, Roeland J. W. Middelbeek, Michael F. Hirshman, Guy A. Rutter, Laurie J. Goodyear, Cristina Aguayo-Mazzucato
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Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes Nat. Metab. (IF 18.9) Pub Date : 2024-09-23 Thomas G. Hill, Rui Gao, Anna Benrick, Lakshmi Kothegala, Nils Rorsman, Cristiano Santos, Samuel Acreman, Linford J. Briant, Haiqiang Dou, Nikhil R. Gandasi, Claudia Guida, Elizabeth Haythorne, Marsha Wallace, Jakob G. Knudsen, Caroline Miranda, Johan Tolö, Anne Clark, Lucy Davison, Joachim Størling, Andrei Tarasov, Frances M. Ashcroft, Patrik Rorsman, Quan Zhang
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Reply to: Milk intake, lactase non-persistence and type 2 diabetes risk in Chinese adults Nat. Metab. (IF 18.9) Pub Date : 2024-09-18 Kai Luo, Yanbo Zhang, Robert C. Kaplan, Qibin Qi
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Milk intake, lactase non-persistence and type 2 diabetes risk in Chinese adults Nat. Metab. (IF 18.9) Pub Date : 2024-09-18 Maria G. Kakkoura, Robin G. Walters, Robert Clarke, Zhengming Chen, Huaidong Du
arising from K. Luo et al. Nature Metabolism https://doi.org/10.1038/s42255-023-00961-1 (2024) In the 2024 January issue of Nature Metabolism, Luo et al.1 reported an inverse association between milk intake and risk of type 2 diabetes (T2D) among individuals who were lactase non-persistent (LNP), as determined by the lactase (LCT) rs4988235 homozygous GG genotype. The authors also reported inverse
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O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production Nat. Metab. (IF 18.9) Pub Date : 2024-09-11
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Organization of a functional glycolytic metabolon on mitochondria for metabolic efficiency Nat. Metab. (IF 18.9) Pub Date : 2024-09-11 Haoming Wang, John W. Vant, Andrew Zhang, Richard G. Sanchez, Youjun Wu, Mary L. Micou, Vincent Luczak, Zachary Whiddon, Natasha M. Carlson, Seungyoon B. Yu, Mirna Jabbo, Seokjun Yoon, Ahmed A. Abushawish, Majid Ghassemian, Takeya Masubuchi, Quan Gan, Shigeki Watanabe, Eric R. Griffis, Marc Hammarlund, Abhishek Singharoy, Gulcin Pekkurnaz
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Long-term exercise training has positive effects on adipose tissue in overweight or obesity Nat. Metab. (IF 18.9) Pub Date : 2024-09-10
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Years of endurance exercise training remodel abdominal subcutaneous adipose tissue in adults with overweight or obesity Nat. Metab. (IF 18.9) Pub Date : 2024-09-10 Cheehoon Ahn, Tao Zhang, Gayoung Yang, Thomas Rode, Pallavi Varshney, Sophia J. Ghayur, Olivia K. Chugh, Hui Jiang, Jeffrey F. Horowitz
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Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer Nat. Metab. (IF 18.9) Pub Date : 2024-09-09 Elena Buglakova, Måns Ekelöf, Michaela Schwaiger-Haber, Lisa Schlicker, Martijn R. Molenaar, Mohammed Shahraz, Lachlan Stuart, Andreas Eisenbarth, Volker Hilsenstein, Gary J. Patti, Almut Schulze, Marteinn T. Snaebjornsson, Theodore Alexandrov
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Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution Nat. Metab. (IF 18.9) Pub Date : 2024-09-06 Santosh R. Sukka, Patrick B. Ampomah, Lancia N. F. Darville, David Ngai, Xiaobo Wang, George Kuriakose, Yuling Xiao, Jinjun Shi, John M. Koomen, Robert H. McCusker, Ira Tabas
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Career pathways, part 15 Nat. Metab. (IF 18.9) Pub Date : 2024-09-03 Marina Garcia-Macia, Fei Yin
In this new instalment of our Career Pathways series, Marina García-Macia and Fei Yin highlight the impact and joys of building a team and share with us key milestones that have shaped their careers so far, including the importance of making the most of every situation, finding the right mentors, and pursuing the questions that they are passionate about.
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Mitochondrial transplants to treat mitochondrial dysfunction Nat. Metab. (IF 18.9) Pub Date : 2024-09-02 Alessandro Bitto
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Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome Nat. Metab. (IF 18.9) Pub Date : 2024-09-02 Ritsuko Nakai, Stella Varnum, Rachael L. Field, Henyun Shi, Rocky Giwa, Wentong Jia, Samantha J. Krysa, Eva F. Cohen, Nicholas Borcherding, Russell P. Saneto, Rick C. Tsai, Masashi Suganuma, Hisashi Ohta, Takafumi Yokota, Jonathan R. Brestoff
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Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo Nat. Metab. (IF 18.9) Pub Date : 2024-08-29 Nina Grankvist, Cecilia Jönsson, Karin Hedin, Nicolas Sundqvist, Per Sandström, Bergthor Björnsson, Arjana Begzati, Evgeniya Mickols, Per Artursson, Mohit Jain, Gunnar Cedersund, Roland Nilsson
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Feeding into cardiometabolic health Nat. Metab. (IF 18.9) Pub Date : 2024-08-27
Although Western societies are mesmerized by the power of new anti-obesity drugs, we must not forget how diet can affect metabolic outcomes. In this Focus issue, and accompanying web collection, we showcase a series of Reviews, Comments and original research articles that present up-to-date evidence on how dietary interventions can affect cardiometabolic health.
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Affinity war: PSAT1 outcompetes the rest Nat. Metab. (IF 18.9) Pub Date : 2024-08-27 Richard Possemato
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The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade Nat. Metab. (IF 18.9) Pub Date : 2024-08-27 Yijian Qiu, Olivia T. Stamatatos, Qingting Hu, Jed Ruiter Swain, Suzanne Russo, Ava Sann, Ana S. H. Costa, Sara Violante, David L. Spector, Justin R. Cross, Michael J. Lukey
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A brief guide to studying extracellular vesicle function in the context of metabolism Nat. Metab. (IF 18.9) Pub Date : 2024-08-26 Daniel Stephen Lark, Kerstin Stemmer, Wei Ying, Clair Crewe
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Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis Nat. Metab. (IF 18.9) Pub Date : 2024-08-22 Elizabeth Schneider, Kenneth J. O’Riordan, Gerard Clarke, John F. Cryan
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Regulated insulin secretion from human and mouse islets exclusively composed of β-cells Nat. Metab. (IF 18.9) Pub Date : 2024-08-21
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Regulated and adaptive in vivo insulin secretion from islets only containing β-cells Nat. Metab. (IF 18.9) Pub Date : 2024-08-21 Marta Perez-Frances, Eva Bru-Tari, Christian Cohrs, Maria Valentina Abate, Léon van Gurp, Kenichiro Furuyama, Stephan Speier, Fabrizio Thorel, Pedro L. Herrera
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On the pathogenesis of obesity: causal models and missing pieces of the puzzle Nat. Metab. (IF 18.9) Pub Date : 2024-08-20 Faidon Magkos, Thorkild I. A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J. F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup
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A safety guide for transgenic Cre drivers in metabolism Nat. Metab. (IF 18.9) Pub Date : 2024-08-19 Carla Horvath, Christian Wolfrum, Pawel Pelczar
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Cancer tissue of origin constrains the growth and metabolism of metastases Nat. Metab. (IF 18.9) Pub Date : 2024-08-19 Sharanya Sivanand, Yetis Gultekin, Peter S. Winter, Sidney Y. Vermeulen, Konstantine M. Tchourine, Keene L. Abbott, Laura V. Danai, Florian Gourgue, Brian T. Do, Kayla Crowder, Tenzin Kunchok, Allison N. Lau, Alicia M. Darnell, Alexandria Jefferson, Satoru Morita, Dan G. Duda, Andrew J. Aguirre, Brian M. Wolpin, Nicole Henning, Virginia Spanoudaki, Laura Maiorino, Darrell J. Irvine, Omer H. Yilmaz
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GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management Nat. Metab. (IF 18.9) Pub Date : 2024-08-19 Jens Juul Holst
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Insights into optimal BMI from the GlasVEGAS study Nat. Metab. (IF 18.9) Pub Date : 2024-08-16 Chun-Kwan O, Juliana C. N. Chan
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Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study Nat. Metab. (IF 18.9) Pub Date : 2024-08-16 James McLaren, Xuan Gao, Nazim Ghouri, Dilys J. Freeman, Janice Richardson, Naveed Sattar, Jason M. R. Gill
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Homeostatic feeding in hedonic centres Nat. Metab. (IF 18.9) Pub Date : 2024-08-15 Zhe Zhao, Sarah A. Stern
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A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis Nat. Metab. (IF 18.9) Pub Date : 2024-08-15 Yiqiong Liu, Ying Wang, Zheng-dong Zhao, Guoguang Xie, Chao Zhang, Renchao Chen, Yi Zhang
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LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration Nat. Metab. (IF 18.9) Pub Date : 2024-08-15 Yalan Deng, Zilong Zhao, Marisela Sheldon, Yang Zhao, Hongqi Teng, Consuelo Martinez, Jie Zhang, Chunru Lin, Yutong Sun, Fan Yao, Michael A. Curran, Hao Zhu, Li Ma
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S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes Nat. Metab. (IF 18.9) Pub Date : 2024-08-14 Yuping Zheng, Jishun Chen, Vinitha Macwan, Charneal L. Dixon, Xinran Li, Shengjie Liu, Yuyun Yu, Pinglong Xu, Qiming Sun, Qi Hu, Wei Liu, Brian Raught, Gregory D. Fairn, Dante Neculai