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Brain responses to intermittent fasting and the healthy living diet in older adults Cell Metab. (IF 27.7) Pub Date : 2024-07-16
No Abstract
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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation Cell Metab. (IF 27.7) Pub Date : 2024-07-09 Lynn Bonetti, Veronika Horkova, Melanie Grusdat, Joseph Longworth, Luana Guerra, Henry Kurniawan, Davide G. Franchina, Leticia Soriano-Baguet, Carole Binsfeld, Charlène Verschueren, Sabine Spath, Anouk Ewen, Eric Koncina, Jean-Jacques Gérardy, Takumi Kobayashi, Catherine Dostert, Sophie Farinelle, Janika Härm, Yu-Tong Fan, Ying Chen, Dirk Brenner
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TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response Cell Metab. (IF 27.7) Pub Date : 2024-07-05 Mengqi Zheng, Yunjiao Zhai, Yanbo Yu, Jing Shen, Shuzheng Chu, Enrico Focaccia, Wenyu Tian, Sui Wang, Xuesong Liu, Xi Yuan, Yue Wang, Lixiang Li, Bingcheng Feng, Zhen Li, Xiaohuan Guo, Ju Qiu, Cuijuan Zhang, Jiajie Hou, Yiyuan Sun, Xiaoyun Yang, Shiyang Li
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Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes Cell Metab. (IF 27.7) Pub Date : 2024-07-03 Travis Nemkov, Daniel Stephenson, Eric J. Earley, Gregory R. Keele, Ariel Hay, Alicia Key, Zachary B. Haiman, Christopher Erickson, Monika Dzieciatkowska, Julie A. Reisz, Amy Moore, Mars Stone, Xutao Deng, Steven Kleinman, Steven L. Spitalnik, Eldad A. Hod, Krystalyn E. Hudson, Kirk C. Hansen, Bernhard O. Palsson, Gary A. Churchill, Angelo D’Alessandro
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Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Jelena Kolic, WenQing Grace Sun, Haoning Howard Cen, Jessica D. Ewald, Jason C. Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Han Xia, Renata Moravcova, Søs Skovsø, Aliya F. Spigelman, Jocelyn E. Manning Fox, James Lyon, Leanne Beet, Jianguo Xia, Francis C. Lynn, Anna L. Gloyn, Leonard J. Foster, Patrick E. MacDonald, James D. Johnson
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The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Ralph Patrick, Marina Naval-Sanchez, Nikita Deshpande, Yifei Huang, Jingyu Zhang, Xiaoli Chen, Ying Yang, Kanupriya Tiwari, Mohammadhossein Esmaeili, Minh Tran, Amin R. Mohamed, Binxu Wang, Di Xia, Jun Ma, Jacqueline Bayliss, Kahlia Wong, Michael L. Hun, Xuan Sun, Benjamin Cao, Denny L. Cottle, Christian M. Nefzger
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From whence it came: Mitochondrial mRNA leaves, a protein returns Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Kevin A. Janssen, Angela Song
Small peptides have previously been reported to be encoded in mitochondrial rRNA and translated by cytosolic ribosomes. In this issue of Cell Metabolism, Hu et al. use mass spectrometry to identify a cytosolically translated protein, encoded instead in mitochondrial mRNA, that is surprisingly targeted back into the mitochondrial matrix.
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Fit for purpose: Selecting the best mitochondrial DNA for the job Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Sarah J. Pickett, Robert W. Taylor, Robert McFarland
The factors determining levels of pathogenic mitochondrial DNA in cells and tissues are critical to disease pathology but remain poorly understood and contentious. In Nature, Kotrys et al. published a single-cell-based analysis casting fresh light on this thorny problem and introduced a powerful new investigative tool.
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Human cardiac metabolism Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Marc R. Bornstein, Rong Tian, Zoltan Arany
The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models. The objective of this review is to summarize specifically what is known about cardiac metabolism in humans. Techniques available to study human cardiac metabolism are first discussed, followed by a review of human cardiac
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Thermal facial image analyses reveal quantitative hallmarks of aging and metabolic diseases Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Zhengqing Yu, Yong Zhou, Kehang Mao, Bo Pang, Kai Wang, Tang Jin, Haonan Zheng, Haotian Zhai, Yiyang Wang, Xiaohan Xu, Hongxiao Liu, Yi Wang, Jing-Dong J. Han
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Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Min Seo Kim, Injeong Shim, Akl C. Fahed, Ron Do, Woong-Yang Park, Pradeep Natarajan, Amit V. Khera, Hong-Hee Won
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Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor Cell Metab. (IF 27.7) Pub Date : 2024-06-29 Ajit Regmi, Eitaro Aihara, Michael E. Christe, Gabor Varga, Thomas P. Beyer, Xiaoping Ruan, Emily Beebe, Libbey S. O’Farrell, Melissa A. Bellinger, Aaron K. Austin, Yanzhu Lin, Haitao Hu, Debra L. Konkol, Samantha Wojnicki, Adrienne K. Holland, Jessica L. Friedrich, Robert A. Brown, Amanda S. Estelle, Hannah S. Badger, Gabriel S. Gaidosh, William Roell
No Abstract
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation Cell Metab. (IF 27.7) Pub Date : 2024-06-20 Jian Zhou, Lifang Zhang, Jianhua Peng, Xianhui Zhang, Fan Zhang, Yuanyuan Wu, An Huang, Fengling Du, Yuyan Liao, Yijing He, Yuke Xie, Long Gu, Chenghao Kuang, Wei Ou, Maodi Xie, Tianqi Tu, Jinwei Pang, Dingkun Zhang, Kecheng Guo, Yue Feng, Yong Jiang
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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer Cell Metab. (IF 27.7) Pub Date : 2024-06-19 Min Zhu, Yunguan Wang, Tianshi Lu, Jason Guo, Lin Li, Meng-Hsiung Hsieh, Purva Gopal, Yi Han, Naoto Fujiwara, Darren P. Wallace, Alan S.L. Yu, Xiangyi Fang, Crystal Ransom, Sara Verschleisser, David Hsiehchen, Yujin Hoshida, Amit G. Singal, Adam Yopp, Tao Wang, Hao Zhu
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Brain responses to intermittent fasting and the healthy living diet in older adults Cell Metab. (IF 27.7) Pub Date : 2024-06-19 Dimitrios Kapogiannis, Apostolos Manolopoulos, Roger Mullins, Konstantinos Avgerinos, Francheska Delgado-Peraza, Maja Mustapic, Carlos Nogueras-Ortiz, Pamela J. Yao, Krishna A. Pucha, Janet Brooks, Qinghua Chen, Shalaila S. Haas, Ruiyang Ge, Lisa M. Hartnell, Mark R. Cookson, Josephine M. Egan, Sophia Frangou, Mark P. Mattson
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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer Cell Metab. (IF 27.7) Pub Date : 2024-06-18 Yu Jiang, Yawen Wang, Guofeng Chen, Fei Sun, Qijing Wu, Qiong Huang, Dongqiang Zeng, Wenjun Qiu, Jiao Wang, Zhiqi Yao, Bishan Liang, Shaowei Li, Jianhua Wu, Na Huang, Yuanyuan Wang, Jingsong Chen, Xiaohui Zhai, Li Huang, Beibei Xu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Wangjun Liao, Min Shi
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Short-term cold exposure induces persistent epigenomic memory in brown fat Cell Metab. (IF 27.7) Pub Date : 2024-06-17 Shin-ichi Inoue, Matthew J. Emmett, Hee-Woong Lim, Mohit Midha, Hannah J. Richter, Isaac J. Celwyn, Rashid Mehmood, Maria Chondronikola, Samuel Klein, Amy K. Hauck, Mitchell A. Lazar
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Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor Cell Metab. (IF 27.7) Pub Date : 2024-06-14 Ajit Regmi, Eitaro Aihara, Michael E. Christe, Gabor Varga, Thomas P. Beyer, Xiaoping Ruan, Emily Beebe, Libbey S. O’Farrell, Melissa A. Bellinger, Aaron K. Austin, Yanzhu Lin, Haitao Hu, Debra L. Konkol, Samantha Wojnicki, Adrienne K. Holland, Jessica L. Friedrich, Robert A. Brown, Amanda S. Estelle, Hannah S. Badger, Gabriel S. Gaidosh, William Roell
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Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periostin Cell Metab. (IF 27.7) Pub Date : 2024-06-14 Wei Xie, Jing Gan, Xiaodong Zhou, Huiying Tian, Xingchao Pan, Wenyue Liu, Xiaokun Li, Jie Du, Aimin Xu, Minghua Zheng, Fan Wu, Yulin Li, Zhuofeng Lin
No Abstract
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Electron transport chain inhibition increases cellular dependence on purine transport and salvage Cell Metab. (IF 27.7) Pub Date : 2024-06-13 Zheng Wu, Divya Bezwada, Feng Cai, Robert C. Harris, Bookyung Ko, Varun Sondhi, Chunxiao Pan, Hieu S. Vu, Phong T. Nguyen, Brandon Faubert, Ling Cai, Hongli Chen, Misty Martin-Sandoval, Duyen Do, Wen Gu, Yuanyuan Zhang, Yuannyu Zhang, Bailey Brooks, Sherwin Kelekar, Lauren G. Zacharias, Ralph J. DeBerardinis
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Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH Cell Metab. (IF 27.7) Pub Date : 2024-06-07 Jing Zhang, Yu Wang, Meiyang Fan, Yanglong Guan, Wentao Zhang, Fumeng Huang, Zhengqiang Zhang, Xiaomeng Li, Bingyu Yuan, Wenbin Liu, Manman Geng, Xiaowei Li, Jing Xu, Congshan Jiang, Wenjuan Zhao, Feng Ye, Wenhua Zhu, Liesu Meng, Shemin Lu, Rikard Holmdahl
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Personalized metabolic whole-body models for newborns and infants predict growth and biomarkers of inherited metabolic diseases Cell Metab. (IF 27.7) Pub Date : 2024-06-03 Elaine Zaunseder, Ulrike Mütze, Jürgen G. Okun, Georg F. Hoffmann, Stefan Kölker, Vincent Heuveline, Ines Thiele
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Nuclear SMAD5 dances to a different tune in regulating insulin secretion Cell Metab. (IF 27.7) Pub Date : 2024-06-04 John Orlowski
In this issue of Cell Metabolism, Fang et al.1 report a novel pH-sensitive cellular signaling mechanism involving the transcription factor SMAD5 that regulates the vesicular secretion of insulin from pancreatic β cells in response to dietary challenges. Dysregulation of this pathway may contribute to metabolic disorders such as type 2 diabetes mellitus.
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Hungry for fat: Metabolic crosstalk with lipid-rich CAFs fuels pancreatic cancer Cell Metab. (IF 27.7) Pub Date : 2024-06-04 Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Some cancers prefer to metabolize lipids for their growth and metastasis. In a recent Cancer Cell study, Niu et al. revealed that SET domain containing 2, histone lysine methyltransferase (SETD2)-deficient pancreatic cancer cells induce the differentiation of lipid-laden cancer-associated fibroblasts (CAFs), which, in turn, transport lipids to promote tumor growth.
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Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periostin Cell Metab. (IF 27.7) Pub Date : 2024-06-04 Wei Xie, Jing Gan, Xiaodong Zhou, Huiying Tian, Xingchao Pan, Wenyue Liu, Xiaokun Li, Jie Du, Aimin Xu, Minghua Zheng, Fan Wu, Yulin Li, Zhuofeng Lin
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The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair Cell Metab. (IF 27.7) Pub Date : 2024-06-04 Junrong Cai, Yuping Quan, Shaowei Zhu, Jiayan Lin, Qian Zhang, Juzi Liu, Zhuokai Liang, Yunjun Liao, Wenqing Jiang, Yufei He, Ting Su, Feng Lu
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Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule Cell Metab. (IF 27.7) Pub Date : 2024-06-04 Moufida Ben Nasr, Vera Usuelli, Sergio Dellepiane, Andy Joe Seelam, Teresa Vanessa Fiorentino, Francesca D’Addio, Emma Fiorina, Cong Xu, Yanan Xie, Hari Baskar Balasubramanian, Eduardo Castillo-Leon, Lara Loreggian, Anna Maestroni, Emma Assi, Cristian Loretelli, Ahmed Abdelsalam, Basset El Essawy, Silvia Uccella, Ida Pastore, Maria Elena Lunati, Gianmarco Sabiu, Adriana Petrazzuolo, Giacomo Ducci,
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Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells Cell Metab. (IF 27.7) Pub Date : 2024-06-04 Jing-Lin Liu, Xu Xu, Youlutuziayi Rixiati, Chu-Yi Wang, Heng-Li Ni, Wen-Shu Chen, Hui-Min Gong, Zi-Long Zhang, Shi Li, Tong Shen, Jian-Ming Li
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Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency Cell Metab. (IF 27.7) Pub Date : 2024-06-04 Isaac Marin-Valencia, Arif Kocabas, Carlos Rodriguez-Navas, Vesselin Z. Miloushev, Manuel González-Rodríguez, Hannah Lees, Kelly E. Henry, Jake Vaynshteyn, Valerie Longo, Kofi Deh, Roozbeh Eskandari, Arsen Mamakhanyan, Marjan Berishaj, Kayvan R. Keshari
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Metabolic reprogramming in liver fibrosis Cell Metab. (IF 27.7) Pub Date : 2024-05-31 Paul Horn, Frank Tacke
Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease (MASLD), harmful use of alcohol, or viral hepatitis, may result in liver fibrosis, cirrhosis, and cancer. Hepatic fibrogenesis is a complex process with interactions between different resident and non-resident heterogeneous liver cell populations, ultimately leading to deposition of extracellular matrix and organ
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Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis Cell Metab. (IF 27.7) Pub Date : 2024-05-20 Fei Peng, Jinxin Lu, Keyu Su, Xinyu Liu, Huandong Luo, Bin He, Cenxin Wang, Xiaoyu Zhang, Fan An, Dekang Lv, Yuanyuan Luo, Qitong Su, Tonghui Jiang, Ziqian Deng, Bin He, Lingzhi Xu, Tao Guo, Jin Xiang, Chundong Gu, Ling Wang, Quentin Liu
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Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating Cell Metab. (IF 27.7) Pub Date : 2024-05-17 Molly McDougle, Alan de Araujo, Arashdeep Singh, Mingxin Yang, Isadora Braga, Vincent Paille, Rebeca Mendez-Hernandez, Macarena Vergara, Lauren N. Woodie, Abhishek Gour, Abhisheak Sharma, Nikhil Urs, Brandon Warren, Guillaume de Lartigue
No Abstract
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A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion Cell Metab. (IF 27.7) Pub Date : 2024-05-09 Radiana Ferrero, Pernille Yde Rainer, Marie Rumpler, Julie Russeil, Magda Zachara, Joern Pezoldt, Guido van Mierlo, Vincent Gardeux, Wouter Saelens, Daniel Alpern, Lucie Favre, Nathalie Vionnet, Styliani Mantziari, Tobias Zingg, Nelly Pitteloud, Michel Suter, Maurice Matter, Kai-Uwe Schlaudraff, Carles Canto, Bart Deplancke
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Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Tim F. Dorweiler, Arjun Singh, Aditya Ganju, Todd A. Lydic, Louis C. Glazer, Richard N. Kolesnick, Julia V. Busik
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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1 Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Nogayhan Seymen, Pierluigi Ramadori, Vera Joerke, Laimdota Zizmare, David Aicher, Indresh K. Gopalsamy, Winnie Fong, Jan Kosla, Enrico Focaccia, Xin Li, Suhail Yousuf, Tjeerd Sijmonsma, Mohammad Rahbari, Katharina S. Kommoss, Adrian Billeter, Sandra Prokosch, Ulrike Rothermel, Florian Mueller, Jenny Hetzer, Danijela Heide, Benjamin Schinkel, Tim
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Gut microbial alterations in arginine metabolism determine bone mechanical adaptation Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Dan Wang, Jing Cai, Qilin Pei, Zedong Yan, Feng Zhu, Zhe Zhao, Ruobing Liu, Xiangyang Guo, Tao Sun, Juan Liu, Yulan Tian, Hongbo Liu, Xi Shao, Jinghui Huang, Xiaoxia Hao, Qi Chang, Zhuojing Luo, Da Jing
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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Qingwen Qian, Mark Li, Zeyuan Zhang, Shannon W. Davis, Kamal Rahmouni, Andrew W. Norris, Huojun Cao, Wen-Xing Ding, Gökhan S. Hotamisligil, Ling Yang
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Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Qiang Cai, Yihao Tian, Quazi T.H. Shubhra
Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase’s crucial role in regulating lipid metabolism in CD8+ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.
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Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Shane J.F. Cronin
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive, malignant, and lethal cancers, displaying strong resistance to immunotherapy. In this issue of Cell Metabolism, a study by Liu et al. identifies tetrahydrobiopterin metabolic dysregulation as a key driver for the immunosuppressive PDAC environment in mouse and human.
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Understanding osteokine biology Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Mone Zaidi, Samir Zaidi, Tony Yuen
Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and during mechanical stress.
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Branching out beyond canonical brown adipocyte function Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Helaina Von Bank, Judith Simcox
Brown adipose tissue has long been functionally characterized as an organ that regulates thermogenesis, body weight set point, and glucose homeostasis. In the May 9, 2024, issue of Cell, Verkerke et al. discover a novel function for brown adipose tissue in processing branched-chain amino acids into antioxidant metabolites that enter the circulation and regulate insulin signaling in the liver.
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Hepatic selective insulin resistance at the intersection of insulin signaling and metabolic dysfunction-associated steatotic liver disease Cell Metab. (IF 27.7) Pub Date : 2024-05-07 Tao Bo, Ling Gao, Zhenyu Yao, Shanshan Shao, Xuemin Wang, Christopher G. Proud, Jiajun Zhao
Insulin resistance (IR) is a major pathogenic factor in the progression of MASLD. In the liver, insulin suppresses gluconeogenesis and enhances lipogenesis (DNL). During IR, there is a defect in insulin-mediated suppression of gluconeogenesis, but an unrestrained increase in hepatic lipogenesis persists. The mechanism of increased hepatic steatosis in IR is unclear and remains controversial. The key
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A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development Cell Metab. (IF 27.7) Pub Date : 2024-05-03 Zhijuan Hu, Liang Yang, Maolei Zhang, Haite Tang, Yile Huang, Yujie Su, Yingzhe Ding, Chong Li, Mengfei Wang, Yunhao Zhou, Qing Zhang, Liman Guo, Yue Wu, Qianqian Wang, Ning Liu, Haoran Kang, Yi Wu, Deyang Yao, Yukun Li, Zifeng Ruan, Xingguo Liu
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The mitochondrial multi-omic response to exercise training across rat tissues Cell Metab. (IF 27.7) Pub Date : 2024-05-02 David Amar, Nicole R. Gay, David Jimenez-Morales, Pierre M. Jean Beltran, Megan E. Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A. Gaul, Steven G. Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M. Fernández, Stephen B. Montgomery, Andrea L. Hevener, Euan A. Ashley, Martin J. Walsh, Lauren M. Sparks, Charles F. Burant, R. Scott Rector, John Thyfault, Matthew
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Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness Cell Metab. (IF 27.7) Pub Date : 2024-05-02 Nesrine S. Rachedi, Ying Tang, Yi-Yin Tai, Jingsi Zhao, Caroline Chauvet, Julien Grynblat, Kouamé Kan Firmin Akoumia, Leonard Estephan, Stéphanie Torrino, Chaima Sbai, Amel Ait-Mouffok, Joseph D. Latoche, Yassmin Al Aaraj, Frederic Brau, Sophie Abélanet, Stephan Clavel, Yingze Zhang, Christelle Guillermier, Naveen V.G. Kumar, Sina Tavakoli, Olaf Mercier, Michael G. Risbano, Zhong-Ke Yao, Guangli Yang
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TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis Cell Metab. (IF 27.7) Pub Date : 2024-04-25 Roi Isaac, Gautam Bandyopadhyay, Theresa V. Rohm, Sion Kang, Jinyue Wang, Narayan Pokhrel, Sadatsugu Sakane, Rizaldy Zapata, Avraham M. Libster, Yaron Vinik, Asres Berhan, Tatiana Kisseleva, Zea Borok, Yehiel Zick, Francesca Telese, Nicholas J.G. Webster, Jerrold M. Olefsky
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Immunological regulation of skeletal muscle adaptation to exercise Cell Metab. (IF 27.7) Pub Date : 2024-04-25 P. Kent Langston, Diane Mathis
Exercise has long been acknowledged for its powerful disease-preventing, health-promoting effects. However, the cellular and molecular mechanisms responsible for the beneficial effects of exercise are not fully understood. Inflammation is a component of the stress response to exercise. Recent work has revealed that such inflammation is not merely a symptom of exertion; rather, it is a key regulator
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New and emerging treatments for metabolic dysfunction-associated steatohepatitis Cell Metab. (IF 27.7) Pub Date : 2024-04-25 Monica A. Tincopa, Quentin M. Anstee, Rohit Loomba
No Abstract
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Exploratory physiological experiments are not clinical trials Cell Metab. (IF 27.7) Pub Date : 2024-04-25 Erik A. Richter, David E. James, John P. Kirwan, Juleen R. Zierath
No Abstract
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Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK Cell Metab. (IF 27.7) Pub Date : 2024-04-23 Yajuan Li, Daniel Munoz-Mayorga, Yuhang Nie, Ningxin Kang, Yuren Tao, Jessica Lagerwall, Carla Pernaci, Genevieve Curtin, Nicole G. Coufal, Jerome Mertens, Lingyan Shi, Xu Chen
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Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation Cell Metab. (IF 27.7) Pub Date : 2024-04-22 Alasdair Leeson-Payne, Jean Iyinikkel, Cameron Malcolm, Brian Y.H. Lam, Nadine Sommer, Georgina K.C. Dowsett, Pablo B. Martinez de Morentin, Dawn Thompson, Alasdair Mackenzie, Raffaella Chianese, Katherine Kentistou, Eugene J. Gardner, John R.B. Perry, Felix Grassmann, John R. Speakman, Justin J. Rochford, Giles S.H. Yeo, Fiona Murray, Lora K. Heisler
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QDPR deficiency drives immune suppression in pancreatic cancer Cell Metab. (IF 27.7) Pub Date : 2024-04-19 Ji Liu, Xiaowei He, Shuang Deng, Sihan Zhao, Shaoping Zhang, Ziming Chen, Chunling Xue, Lingxing Zeng, Hongzhe Zhao, Yifan Zhou, Ruihong Bai, Zilan Xu, Shaoqiu Liu, Quanbo Zhou, Mei Li, Jialiang Zhang, Xudong Huang, Rufu Chen, Liqin Wang, Dongxin Lin, Jian Zheng
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The intersection of frailty and metabolism Cell Metab. (IF 27.7) Pub Date : 2024-04-12 Manish Mishra, Judy Wu, Alice E. Kane, Susan E. Howlett
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be “frail.” Here, we explore
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New and emerging treatments for metabolic dysfunction-associated steatohepatitis Cell Metab. (IF 27.7) Pub Date : 2024-04-11 Monica A. Tincopa, Quentin M. Anstee, Rohit Loomba
Metabolic dysfunction-associated steatohepatitis (MASH) is a leading etiology of chronic liver disease worldwide, with increasing incidence and prevalence in the setting of the obesity epidemic. MASH is also a leading indication for liver transplantation, given its associated risk of progression to end-stage liver disease. A key challenge in managing MASH is the lack of approved pharmacotherapy. In
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ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes Cell Metab. (IF 27.7) Pub Date : 2024-04-11 Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs
Abstract not available
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Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators Cell Metab. (IF 27.7) Pub Date : 2024-04-10 Wanyu Tao, Zhengqing Yu, Jing-Dong J. Han
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Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity Cell Metab. (IF 27.7) Pub Date : 2024-04-05 Mingliang Zhao, Zhenxing Ren, Aihua Zhao, Yajun Tang, Junliang Kuang, Mengci Li, Tianlu Chen, Shouli Wang, Jieyi Wang, Huiheng Zhang, Jijun Wang, Tianhong Zhang, Jiahui Zeng, Xiaohua Liu, Guoxiang Xie, Penghong Liu, Ning Sun, Tianhao Bao, Tongtong Nie, Jingchao Lin, Ping Liu, Yuanyi Zheng, Xiaojiao Zheng, Tiemin Liu, Wei Jia
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An integrated multi-omics analysis reveals osteokines involved in global regulation Cell Metab. (IF 27.7) Pub Date : 2024-04-03 Wenquan Liang, Tiantian Wei, Le Hu, Meijun Chen, Liping Tong, Wu Zhou, Xingwei Duan, Xiaoyang Zhao, Weijie Zhou, Qing Jiang, Guozhi Xiao, Weiguo Zou, Di Chen, Zhipeng Zou, Xiaochun Bai
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A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis Cell Metab. (IF 27.7) Pub Date : 2024-04-02 Yimin Dong, Honglei Kang, Renpeng Peng, Zheming Liu, Fuben Liao, Shi-an Hu, Weizhong Ding, Pengju Wang, Pengchao Yang, Meipeng Zhu, Sibo Wang, Minglong Wu, Dawei Ye, Xin Gan, Feng Li, Kehan Song
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Developing a national nutrition policy strategy to advance cardiometabolic health and health equity Cell Metab. (IF 27.7) Pub Date : 2024-04-02 Dariush Mozaffarian, Emily A. Callahan, Dan Glickman, Melissa Maitin-Shepard
Abstract not available