Our brain is not an immune-privileged island isolated from peripheries, but how non-neuronal brain cells interact with the peripheral system is not well understood. Wei et al. report that microglia in the hypothalamic paraventricular nucleus (PVN) with unique vasculature can detect ATP derived from hemodynamic disturbance. These microglia in the PVN regulate the response to hypertension via ATP-P2Y12-C/EBPβ signaling.

中文翻译：

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小胶质细胞连接大脑活动和血压

我们的大脑并不是一个与周围环境隔离的免疫特权岛，但非神经元脑细胞如何与周围系统相互作用尚不清楚。魏等人。报道称，下丘脑室旁核（PVN）中的小胶质细胞具有独特的脉管系统，可以检测来自血流动力学紊乱的 ATP。 PVN 中的这些小胶质细胞通过 ATP-P2Y12-C/EBPβ 信号传导调节对高血压的反应。