Insight into how the immune system recognizes and responds to pathogens had led to landmark advances in biology and medicine in the last decades. This year’s Albert Lasker Award for Basic Medical Research honors Zhijian “James” Chen for the discovery of cGAS, the enzyme that senses foreign and “pathogenic” self-DNA—self-DNA aberrantly located in intracellular compartments. The definition of the cGAS-STING pathway opens new horizons for the understanding and treatment of human disease.

中文翻译：

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将 DNA 感知为危险：cGAS 的发现


对免疫系统如何识别和响应病原体的洞察导致了过去几十年生物学和医学的里程碑式进步。今年的阿尔伯特·拉斯克基础医学研究奖授予 Zhijian “James” Chen，以表彰他发现了 cGAS，这种酶可以感知外来和“致病性”自身 DNA——异常位于细胞内区室中的自身 DNA。cGAS-STING 通路的定义为理解和治疗人类疾病开辟了新的视野。