It’s crucial for skin to establish efficient defense strategies. Liu et al. reveal that the transcription factor ZNF750 recruits the histone demethylase KDM1A to silence pattern recognition receptors in the outer epidermis, making their expression limited to deeper, undifferentiated keratinocytes to address threats penetrating the skin.

中文翻译：

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浅表冰和深层火焰：皮肤的防御策略


皮肤建立有效的防御策略至关重要。Liu 等人揭示，转录因子 ZNF750 募集组蛋白去甲基化酶 KDM1A 以沉默表皮外层的模式识别受体，使它们的表达仅限于更深的、未分化的角质形成细胞，以应对穿透皮肤的威胁。