Insufficient influx of T cells into the tumor microenvironment, including brain metastasis, dramatically limits efficacy of conventional immunotherapy. In this issue of Immunity, Messmer et al. interrogate spatiotemporal dependencies of melanoma brain metastasis T cell infiltration by intravital microscopy. They find that T cells enter these brain tumors through peritumoral venous vessels and can be stimulated with immunotherapy.

中文翻译：

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站在脑转移大门口的 T 细胞


T 细胞流入肿瘤微环境（包括脑转移）不足，极大地限制了传统免疫疗法的疗效。在本期《免疫》中，Messmer 等人通过活体显微镜询问了黑色素瘤脑转移 T 细胞浸润的时空依赖性。他们发现 T 细胞通过瘤周静脉血管进入这些脑肿瘤，并且可以通过免疫疗法进行刺激。