The mechanisms by which oncogenic mutations and anatomical locations work together to influence the immune environment within tumors are not well understood. In this issue of Immunity, Ross et al. show that H3.3K27M diffuse midline gliomas (DMGs) are enriched with disease-associated myeloid cells (DAMs). Myeloid-targeted strategies reprogram DAMs to a homeostatic state, reduce myeloid infiltration into tumors, and prolong survival.

中文翻译：

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在突变迷宫中导航：巨噬细胞重编程的致癌驱动指南


致癌突变和解剖位置共同影响肿瘤内免疫环境的机制尚不清楚。在本期《免疫》杂志中，Ross 等人表明，H3.3K27M 弥漫性中线胶质瘤 （DMG） 富含疾病相关髓细胞 （DAM）。髓样靶向策略将 DAM 重编程为稳态，减少髓样浸润到肿瘤中，并延长生存期。