Understanding the nature of human autoantigen-specific CD4⁺ T cells is limited by the difficulty of characterizing these cells ex vivo. In this issue of Immunity, Saggau et al. use ARTE technology to profile CD4⁺ T cells specific to disease-relevant autoantigens and find that such cells develop an exhausted phenotype that includes FOXP3 expression and persist for extended periods of time.

中文翻译：

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自身反应性 T 细胞对富饶土地的感知


由于难以在体外 表征这些细胞，因此了解人自身抗原特异性 CD4 ⁺ T 细胞的性质受到限制。在本期《免疫》杂志中，Saggau 等人使用 ARTE 技术对疾病相关自身抗原具有特异性的 CD4⁺ T 细胞进行分析，发现这些细胞会发展出包括 FOXP3 表达在内的耗竭表型，并持续较长时间。