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Getting RAMPed up: Neuropeptides boost T helper 1 cell fate
Immunity ( IF 25.5 ) Pub Date : 2024-12-10 , DOI: 10.1016/j.immuni.2024.11.013
Camille A. Spinner, Vanja Lazarevic

CD4+ T helper (Th) cell differentiation depends on regulatory networks that enforce lineage commitment while suppressing alternative fates. In a recent issue of Nature, Hou et al. reveal that calcitonin gene-related peptide (CGRP) directs Th1 commitment, highlighting neuro-immune crosstalk in T cell fate decisions.

中文翻译:


加速:神经肽促进辅助性 T 细胞 1 的命运



CD4+ 辅助性 T 细胞 (Th) 细胞分化取决于调节网络,这些网络在抑制替代命运的同时强制执行谱系承诺。在最近一期的 Nature 杂志上,Hou 等人揭示了降钙素基因相关肽 (CGRP) 指导 Th1 定型,突出了 T 细胞命运决定中的神经免疫串扰。
更新日期:2024-12-10
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