Fungal disease poses a growing threat to public health that our current antifungal therapies are not well equipped to meet. As the population of immunocompromised hosts expands, and ecological changes favor the emergence of fungal pathogens, the development of new antifungal agents, including vaccines, becomes a global priority. Here, we summarize recent advancements in the understanding of fungal pathogenesis, key features of the host antifungal immune response, and how these findings could be leveraged to design novel approaches to deadly fungal disease.

中文翻译：

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对真菌的免疫力和疫苗注意事项


真菌病对公共卫生构成的威胁越来越大，我们目前的抗真菌疗法无法很好地满足这一需求。随着免疫功能低下宿主种群的增加，以及生态变化有利于真菌病原体的出现，开发新的抗真菌药物（包括疫苗）成为全球优先事项。在这里，我们总结了对真菌发病机制、宿主抗真菌免疫反应的关键特征的理解的最新进展，以及如何利用这些发现来设计治疗致命真菌病的新方法。