The sensing of pathogens is the first step for any immune response. A recent paper in Cell reveals that the bacterial Hachiman anti-phage defense system deploys a helicase subunit to sense phage invasion via 3′ DNA recognition and subsequent domain rotation to enable nuclease activation.

中文翻译：

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HAMpering 感染：解旋酶棘轮作为噬菌体感应机制出现


病原体的感应是任何免疫反应的第一步。最近发表在《细胞》上的一篇论文显示，细菌 Hachiman 抗噬菌体防御系统部署了一个解旋酶亚基，通过 3' DNA 识别和随后的结构域旋转来感知噬菌体入侵，从而激活核酸酶。