Sargen and Helaine discover a prophage competition element in Salmonella that inhibits the lytic cycle of co-resident prophages by cleaving a subset of cellular tRNAs. During Salmonella pathogenesis in macrophages, a persister subset experiences prophage induction and competition, reducing release of immunogenic cellular components and altering macrophage response to infection.

中文翻译：

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坏邻居：巨噬细胞感染期间沙门氏菌的噬菌体竞争


Sargen 和 Helaine 在 Salmonella 中发现了一种原噬菌体竞争元件，该元件通过切割细胞 tRNA 的一个子集来抑制共存原噬菌体的裂解循环。在巨噬细胞的沙门氏菌发病机制中，持续存在者亚群经历原噬菌体诱导和竞争，减少免疫原性细胞成分的释放并改变巨噬细胞对感染的反应。