Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.

中文翻译：

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细菌更新 OLD 蛋白以切割宿主 tRNA 并阻断噬菌体翻译


抗噬菌体防御必须快速感知并响应各种病毒。最近发表在《自然》杂志上的两篇论文通过结构和功能分析揭示了 PARIS 防御系统（一种最近发现的毒素-抗毒素系统）如何感知噬菌体相关分子模式 （PhAMP），从而激活切割 tRNA 以阻断噬菌体复制的核酸内切酶毒素。