Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization,Cell Host & Microbe

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Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization
Cell Host & Microbe ( IF 20.6 ) Pub Date : 2024-09-17 , DOI: 10.1016/j.chom.2024.08.014
Zhi Yi Fang ₁ , Sara A Stickley ₁ , Amirthagowri Ambalavanan ₁ , Yang Zhang ₂ , Amanda M Zacharias ₁ , Kelsey Fehr ₃ , Shirin Moossavi ₃ , Charisse Petersen ₄ , Kozeta Miliku ₅ , Piushkumar J Mandhane ₆ , Elinor Simons ₇ , Theo J Moraes ₈ , Malcolm R Sears ₉ , Michael G Surette ₁₀ , Padmaja Subbarao ₁₁ , Stuart E Turvey ₄ , Meghan B Azad ₃ , Qingling Duan ₁₂

Affiliation

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
School of Computing, Queen's University, Kingston, ON K7L 3N6, Canada.
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada.
Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC V6H 3N1, Canada.
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada.
Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; Section of Allergy and Immunology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Department of Pediatrics, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada.
Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Department of Pediatrics, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada; Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada.
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada; School of Computing, Queen's University, Kingston, ON K7L 3N6, Canada.

The human milk microbiota (HMM) is thought to influence the long-term health of offspring. However, its role in asthma and atopy and the impact of host genomics on HMM composition remain unclear. Through the CHILD Cohort Study, we followed 885 pregnant mothers and their offspring from birth to 5 years and determined that HMM was associated with maternal genomics and prevalence of childhood asthma and allergic sensitization (atopy) among human milk-fed infants. Network analysis identified modules of correlated microbes in human milk that were associated with subsequent asthma and atopy in preschool-aged children. Moreover, reduced alpha-diversity and increased Lawsonella abundance in HMM were associated with increased prevalence of childhood atopy. Genome-wide association studies (GWASs) identified maternal genetic loci (e.g., ADAMTS8, NPR1, and COTL1) associated with HMM implicated with asthma and atopy, notably Lawsonella and alpha-diversity. Thus, our study elucidates the role of host genomics on the HMM and its potential impact on childhood asthma and atopy.

中文翻译：

母乳微生物群网络与宿主基因组学、儿童哮喘和过敏性致敏有关

母乳微生物群（HMM）被认为会影响后代的长期健康。然而，它在哮喘和特应性中的作用以及宿主基因组学对 HMM 组成的影响仍不清楚。通过 CHILD 队列研究，我们跟踪了 885 名孕妇及其后代，从出生到 5 岁，并确定 HMM 与母体基因组学以及人类母乳喂养婴儿儿童哮喘和过敏敏化（atopicy）的患病率相关。网络分析确定了母乳中相关微生物的模块，这些模块与学龄前儿童随后的哮喘和特应性有关。此外，HMM 中 α 多样性降低和 Lawsonella 丰度增加与儿童特应性患病率增加有关。全基因组关联研究（GWASs）确定了与哮喘和特应性 HMM 相关的母体遗传位点（例如，ADAMTS8、NPR1 和 COTL1），特别是 Lawsonella 和 α 多样性。因此，我们的研究阐明了宿主基因组学对 HMM 的作用及其对儿童哮喘和特应性的潜在影响。

更新日期：2024-09-17

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