Paneth cells located within intestinal crypts support epithelial stem cells and immunity through growth factors and antimicrobial peptides. In this issue of Cell Host & Microbe, Wallaeys et al. report that TNF sensing by Paneth cells disrupts the unfolded protein response and decreases antimicrobial peptides, causing bacterial translocation and sepsis.

中文翻译：

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感与否，潘氏细胞对黏膜免疫的调节


位于肠隐窝内的潘氏细胞通过生长因子和抗菌肽支持上皮干细胞和免疫力。在本期的Cell Host & Microbe中，Wallaeys等人报告说，Paneth细胞的TNF感应破坏了展开的蛋白质反应，减少了抗菌肽，导致细菌易位和败血症。