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Encoding immune responses: the moonlighting function of alanyl-tRNA synthetase
Cell Research ( IF 28.1 ) Pub Date : 2024-11-28 , DOI: 10.1038/s41422-024-01055-7 Pin Wang, Xiaoyu Hu
中文翻译:
编码免疫反应:丙氨酰-tRNA 合成酶的兼职功能
更新日期:2024-11-29
Cell Research ( IF 28.1 ) Pub Date : 2024-11-28 , DOI: 10.1038/s41422-024-01055-7 Pin Wang, Xiaoyu Hu
The emerging role of L-lactate and L-lactylation has been functionally reported in various biological processes. In a recent Nature paper, Li et al. identified alanyl-tRNA synthetases 1/2 as the sensors of L-lactate and lactyltransferases of L-lactylation, conveying repression of innate immune surveillance.
中文翻译:
编码免疫反应:丙氨酰-tRNA 合成酶的兼职功能
L-乳酸和 L-乳酰化的新兴作用已在各种生物过程中的功能报道。在最近的一篇Nature论文中,Li 等人确定丙氨酰-tRNA 合成酶 1/2 是 L-乳酸的传感器和 L-乳酰化的乳基转移酶,传达对先天免疫监视的抑制。