Deciphering the role of immune system in the obesity–cancer relationship,Cell Research

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Deciphering the role of immune system in the obesity–cancer relationship
Cell Research ( IF 28.1 ) Pub Date : 2024-07-30 , DOI: 10.1038/s41422-024-01008-0
Camille Blériot _{1,

2} , Gerasimos Anagnostopoulos ₁ , Florent Ginhoux _{1,

3,

4,

5}

Affiliation

Obesity and its associated meta-inflammation lead to metabolic and functional reprogramming of immune cells. In a recent Nature paper, Bader et al. show that obesity selectively induced PD-1 expression on tumor-associated macrophages, which triggers a feedback mechanism impairing tumor immune surveillance by notably metabolically reprogramming cytotoxic T cells.

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