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Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
Cell Research ( IF 28.1 ) Pub Date : 2024-10-14 , DOI: 10.1038/s41422-024-01040-0 Benoit Viollet, Bruno Guigas
中文翻译:
促进代谢适应:溶酶体 AMPK 点燃谷氨酰胺溶解
更新日期:2024-10-14
Cell Research ( IF 28.1 ) Pub Date : 2024-10-14 , DOI: 10.1038/s41422-024-01040-0 Benoit Viollet, Bruno Guigas
The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability, proliferation, and function. Recent discoveries in Cell Research have highlighted the role of the lysosomal pool of AMPK in promoting glutaminolysis during glucose shortage through the activation of a PDZD8-GLS1 axis.
中文翻译:
促进代谢适应:溶酶体 AMPK 点燃谷氨酰胺溶解
有效使新陈代谢适应环境需求的能力对于细胞活力、增殖和功能至关重要。Cell Research 的最新发现强调了 AMPK 溶酶体库通过激活 PDZD8-GLS1 轴在葡萄糖短缺期间促进谷氨酰胺分解的作用。