Upon announcing the completion of the Human Genome Project (HGP) in 2003, scientific leaders envisaged the transformative promise of the human genome for health and society.¹ They anticipated genomics breakthroughs that could touch all of humanity and empower people to have longer healthier lives, ultimately creating a more prosperous society that also wields the human genome responsibly. Two decades on, human genomics now underpins the prospects of precision medicine and precision public health (Box 1). However, as further impactful advances increasingly depend on world-wide representation and collaboration, global-scale challenges that shackle progress must now be addressed. These are mainly economic, organizational, infrastructural, scientific, and Ethical, Legal and Social Implications (ELSI) challenges. Existing efforts lack coordination at the scale and scope required to overcome these challenges. In a time of heightened geopolitical uncertainty and legitimate citizen concern over the conscientious use of data and data-analysis methodologies, which include genomics big data and artificial intelligence (AI), we must draw inspiration from precedents where bold goals organized humanity to responsibly employ the best technologies and collaborative science toward their solution.² In an era where intense corporate competition and geopolitical agendas threaten global collaboration, we must galvanize efforts to make precision medicine a universal gift — available and accessible to all of humanity for the generations to come.

在 2003 年宣布完成人类基因组计划 （HGP） 后，科学领导者设想了人类基因组对健康和社会的变革性前景。¹ 他们预见到基因组学的突破可能会触及全人类，使人们能够过上更长寿、更健康的生活，最终创造一个更繁荣的社会，同时也负责任地使用人类基因组。二十年过去了，人类基因组学现在支撑着精准医疗和精准公共卫生的前景（框 1）。然而，随着进一步的有影响力的进步越来越依赖于全球范围内的代表性和合作，现在必须解决阻碍进步的全球性挑战。这些主要是经济、组织、基础设施、科学以及道德、法律和社会影响 （ELSI） 挑战。现有的努力缺乏克服这些挑战所需的规模和范围的协调。在地缘政治不确定性加剧以及公民对认真使用数据和数据分析方法（包括基因组学、大数据和人工智能 （AI））的合理担忧的时代，我们必须从先例中汲取灵感，在这些先例中，大胆的目标组织人类负责任地采用最好的技术和协作科学来寻求解决方案。² 在一个激烈的企业竞争和地缘政治议程威胁全球合作的时代，我们必须努力使精准医疗成为一份普遍的礼物——为子孙后代的全人类提供和获得。