The enhanced myeloid lineage bias of old hematopoietic stem cells (HSCs) has been implicated to underpin the compromised immunity observed upon aging. In a recent paper in Cell, Poscablo and coworkers now present experimental support for also the dysregulated function of platelets seen during aging, emanating at the aged HSC level; they identified an aging- and platelet-specific differentiation pathway in mice, which, compared to the canonical pathway dominating in young mice, replenishes megakaryocyte progenitors which with faster kinetics and enhanced regenerative potential produce hyper-reactive platelets.

中文翻译：

---

保持血小板常青的年轻之路？

老年造血干细胞（HSC）增强的骨髓谱系偏向性与衰老过程中观察到的免疫力受损有关。在最近发表在《细胞》杂志上的一篇论文中，Poscablo 和他的同事现在提出了实验支持，表明衰老过程中出现的血小板功能失调，体现在衰老的 HSC 水平上。他们在小鼠中发现了一种衰老和血小板特异性分化途径，与年轻小鼠中占主导地位的典型途径相比，该途径补充了巨核细胞祖细胞，这些祖细胞具有更快的动力学和增强的再生潜力，产生高反应性血小板。